A bottle aerator of the type having a venturi tube having a constricted section with a narrower cross-sectional section and a fluid inlet section having a wider cross-sectional section, such that the fluid pressure is lower in the constricted section compared to the pressure in the fluid inlet section, and the fluid speed is higher in the constricted section compared to the fluid speed in the fluid inlet section, which is improved by the constricted section being constructed and arranged so that when the bottle aerator is inserted into a bottle, the constricted section is positioned inside the bottle. The air inlet is provided at or below the constricted section, which allows air from outside the bottle to mix with the fluid as it passes through the constricted section, so that the fluid is aerated while still inside the bottle.

The invention proposes a device for decaffeinating a liquid. The device includes at least one cathode electrode and at least one anode electrode which are spaced apart and which are immersed in the liquid; a power supply coupled to the at least one cathode electrode and the at least one anode electrode and configured to apply power thereto, wherein the at least one cathode electrode and the at least one anode electrode are configured to generate an electric field in the liquid upon application of the power to attract caffeine molecules in the liquid to the at least one cathode electrode; wherein the at least one cathode electrode is made of or coated with an absorbing material configured to absorb at least part of the caffeine molecules that are attracted to the at least one cathode electrode.

The present invention includes a novel method capable of identifying a compound as an imaging agent using a DAZAX-based scaffold or derivative thereof. The present invention further includes novel imaging agents. The present invention further includes a method of modifying a DAZAX-based scaffold or derivative thereof. The present invention further includes a method for imaging a sample.

A molecule comprising a lipid, a peptide and a linker to bind the lipid to the peptide which have specific amino acid sequence to bind to Epidermal Growth Factor Receptor (EGFR) of tumor cells, and a liposomal composition which is targeted by the molecule, and method for preparing thereof is disclosed.

Agents that specifically bind to an opioid receptor in a conformationally specific way can be used to induce a conformational change in the receptor. Such agents have therapeutic applications and can be used in X-ray crystallography studies of the receptor. Such agents can also be used to improve drug discovery via compound screening and/or structure-based drug design.

The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders.

Non-naturally occurring peptides are provided that act as a Src SH2 domain antagonist of cardiotonic steroids. Pharmaceutical compositions comprising the peptides are also provided along with vectors encoding the peptides. Methods of treating a Src-associated disease and reducing Src activity in a cell are further provided and include administering or contacting a cell with an effective amount of the peptide.

The invention relates to polynucleotide agents targeting the complement component C5 gene, and methods of using such polynucleotide agents to inhibit expression of C5 and to treat subjects having a complement component C5-associated disease, e.g., paroxysmal nocturnal hemoglobinuria.

In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobic ally modified oligonucleotide cargo, and uses thereof, are also provided.

Provided herein are compositions and methods for modifying a predetermined nucleic acid sequence. A programmable nucleoprotein molecular complex containing a polypeptide moiety and a specificity conferring nucleic acid (SCNA) which assembles in-vivo, in a target cell, and is capable of interacting with the predetermined target nucleic acid sequence is provided. The programmable nucleoprotein molecular complex is capable of specifically modifying and/or editing a target site within the target nucleic acid sequence and/or modifying the function of the target nucleic acid sequence.

A button system and method of manufacturing the same are provided for identifying fiber from which an article of apparel is manufactured. Initially, an article of apparel manufactured with a predetermined fiber is identified. Next, indicia indicative of the predetermined fiber is selected. Next, at least one button is manufactured with the indicia thereon for identifying the fiber from which the article of apparel is manufactured.

A method for removing 4-methylimidazole (4-MEI) from solution may include contacting an alkaline earth metal silicate with a solution containing 4-MEI and adsorbing at least some of the 4-MEI using the alkaline earth metal silicate. The method may further include removing at least some of the alkaline earth metal silicate having the adsorbed 4-MEI from the solution. The alkaline earth metal silicate may include magnesium silicate or calcium silicate. A method for removing 4-MEI from solution may include contacting an adsorbent clay material with a solution containing 4-MEI and adsorbing at least some of the 4-MEI using the adsorbent clay material. The method may further include removing at least some of the adsorbent clay material having the adsorbed 4-MEI from the solution. The adsorbent clay material may include smectite, bentonite, or an activated or un-activated AOCS day material.

Rebaudioside M compositions with improved aqueous solubility and methods for preparing the same are provided herein. The rebaudioside M compositions include (i) disordered crystalline compositions comprising rebaudioside M and rebaudioside D, (ii) spray-dried compositions comprising rebaudioside M, rebaudioside D and steviol glycoside mixtures and/or rebaudioside B and/or NSF-02, (iii) spray-dried compositions comprising rebaudioside M, rebaudioside D and at least one surfactant, polymer, saponin, carbohydrate, polyol, preservative or a combination thereof. Sweetened compositions, such a beverages, containing the rebaudioside M compositions with improved water solubility are also provided herein.

The invention concerns a sweetened dairy product comprising a dairy material, at least one steviol glycoside, at least one additive selected from a polysaccharide of fructose units and a salt.

Disclosed herein is a nutrient delivery system that provides a nutritional formula for consumption. The nutrient delivery system includes a pod and a nutritional powder comprising at least one phospholipid. The nutritional formula has improved characteristics, such as decreased foaming.

A cartridge (10) containing a dose (12) of at least one substance for preparing a liquid product, e.g., coffee, by means of liquid and/or steam introduced into the cartridge (10). The cartridge comprises a body (14) containing the aforesaid dose (12), with a bottom wall (142), through which the liquid product is able to flow out of the cartridge (10), and a cover (16) that closes the body of the cartridge (10) at the end of the body opposite to the bottom wall (142). The body (14) comprises a crushed-plant-fibre material (e.g., with a base of rice husk), which may also be used for producing the cover. Alternatively, the cover (16) may be made of paper material (e.g., filter paper). The body (14) and the cover (16) are connected together via purely mechanical connection, it thus being possible to avoid gluing or welding.

The present invention is directed to a Modular Liquid Infusing, Flavoring and Dispensing Device that provides a means to infuse flavor into liquids for variable periods of time prior to dispensing, and after the brewing process, wherein the system provides a means to control the rate at which the liquid is dispensed, reduces the trauma to the dispensed liquid, and reduces the amount of foaming in the dispensed liquid. The present invention further provides a method for using the Modular Liquid Infusing, Flavoring, and Dispensing Device.

The present invention is directed to recombinant thraustochytrids that grow on sucrose and cell cultures comprising the recombinant thraustochytrids as well as methods of producing cell cultures, biomasses, microbial oils, compositions, and biofuels using the recombinant thraustochytrids.

The invention relates to a guiding device for guiding an oblong intermediate element while joining at least two decorative elements by means of this intermediate element.

One embodiment of the present invention relates to a machine for sewing, embroidering, quilting and/or the like. Another embodiment of the present invention relates to a method for sewing, embroidering, quilting and/or the like. In one example, the present invention may be applied (e.g., as a machine and/or method) to a multi-needle machine or method. In another example, the present invention may provide for automatic lower (or bottom) thread cutting. In another example, the present invention may provide for automatic lower (or bottom) thread cutting by utilizing the phase (that is, movement phase) of a return of a looper (or hook) to cut the lower (or bottom) thread.

Method for creating a crystal/rhinestone template utilizing a sewing/embroidery machine to perforate a medium in a desired pattern. In the case of a multiple-needle sewing/embroidery machine, the machine's needle is replaced by a perforator blade and perforator blade holder which are attached to machine's needle bar. Machine's needle plate is replaced by perforator plate and waste holder. With a single-needle sewing/embroidery machine, machine's needle is replaced by a pressing tool attached to the machine's needle bar. A contact point, a spring, and an arm are attached to machine's presser foot. Machine's needle plate is replaced by perforator plate. A template medium is placed on a work surface of machine. Machine is operated by software that reads a user-specified pattern/motif outline for filling stones in vector form, using innate rules to move machine frame and control hole placement.

An embroidery data processor includes a color information acquiring unit configured to acquire color information of a workpiece cloth on which an embroidery pattern composed of a plurality of color-based pattern portions is sewn, a color storage unit configured to store data of defined colors, an assignment unit configured to randomly extract colors from the colors stored by the color storage unit for every color-based pattern portion, the extracted colors being used as thread color data specifying colors of the color-based pattern portions respectively, the assignment unit assigning the extracted colors to the respective color-based pattern portions, and a setting unit configured to set a predetermined extraction range containing a similar color or a contrast color based on the color information acquired by the acquiring unit. The assignment unit is configured to extract the color stored by the color storage unit in the set extraction range.

A embroidery clamp for thick fabric includes a movable clamping window support that is pivotally connected to a frame and extends around a pivotal axis. An actuating system applies a force to the end of the clamping window support and rotates the support around to pivotal axis to move clamping windows together. The clamping window supports have resilient properties and are configured for flexure.

A sewing apparatus and method therefor includes a drive mechanism, a thread feed mechanism, and a needle engagement mechanism for engaging the thread feed mechanism. The drive mechanism comprises a drive motor configured to transmit power from the drive motor to the needle engagement mechanism such that it drives a needle within a cartridge without moving the entire cartridge. A method and sewing apparatus includes a plurality of thread feed mechanisms and a needle engagement mechanism for selecting and engaging each of the thread feed mechanisms.

A plasma processing chamber having capacitive and inductive coupling of RF power. An RF power source is connected to an inductive coil and to a top electrode via a variable capacitor to control the ratio of power applied to the coil and electrode. The bottom electrode, which is part of the chuck holding the substrates, is floating, but has parasitive capacitance coupling to ground. No RF bias is applied to the chuck and/or the substrate, but the substrate is chucked using DC power. In a system utilizing the chamber, the chuck is movable and is loaded with substrates outside the chamber, enter the chamber from one side for processing, exit the chamber from an opposite side after the processing, and is unloaded in an unloading chamber. The chuck is then transported back to the loading chamber. Substrates are delivered to and removed from the system using conveyor belts.

A method for making a water-degradable paper sheet involves the following: providing at least one strip of a water-soluble binding material in the form of a dry film; providing at least two strips each made of at least one ply of cellulose wadding; placing the strip of water-soluble binding material between the two strips of cellulose wadding; humidifying, assembling and pressing the three strips; and drying the complex strip thus obtained. The sheet thus obtained can be used for making a roll carrier mandrel by helically winding one or more strips from the sheet about a cylinder. Articles produced from the sheet can particularly be used in the field of products for sanitary or domestic use.

A hybrid plasma reactor includes a reactor body having a plasma discharge space, a gas inlet, and a gas outlet; a hybrid plasma source including an inductive antenna inductively coupled to plasma formed in the plasma discharge space and a primary winding coil transformer coupled to the plasma and wound in a magnetic core; and an alternating switching power supply for supplying plasma generation power to the inductive antenna and the primary winding coil. The hybrid plasma reactor induces a plasma discharge using the inductively coupled plasma source and the transformer coupled plasma source, so that it has a wide operational area from a low pressure area to a high pressure area.

A system for fluid partitioning for chemical amplification or other chemical processing or separations of a sample, comprising a first dispenser of a first polymeric sheet, wherein the first polymeric sheet contains chambers; a second dispenser of a second polymeric sheet wherein the first dispenser and the second dispenser are positioned so that the first polymeric sheet and the second polymeric sheet become parallel; a dispenser of the fluid positioned to dispense the fluid between the first polymeric sheet and the second polymeric sheet; and a seal unit that seals the first polymeric sheet and the second polymeric sheet together thereby sealing the sample between the first polymeric sheet and the second polymeric sheet and partitioning the fluid for chemical amplification or other chemical processing or separations.

A method includes performing a patterning step on a layer using a process gas. When the patterning step is performed, a signal strength is monitored, wherein the signal strength is from an emission spectrum of a compound generated from the patterning step. The compound includes an element in the patterned layer. At a time the signal strength is reduced to a pre-determined threshold value, the patterning step is stopped.

A ‘bioactive’ composition that has one or more oligogalacturonans ((1→4)-α-D-galacturonan) or any other oligosaccharides (oligoguluronans) that may present an ‘egg box’ conformation, this conformation being further stabilized by one or more polycationic saccharide(s), preferably either a chitosan oligosaccharide or a chitosan polysaccharide. A method prepares this composition and it is used, in medical, pharmaceutical, agricultural, nutraceutical, food, feed, textile, cosmetic, industrial and/or environmental applications.

The present invention relates to a method for removing sulfur from a gaseous or liquid mixture. This method involves contacting the gaseous or liquid mixture with an iron-enriched matrix under conditions effective to remove sulfur from the mixture through adsorption of the sulfur to the matrix. The iron-enriched matrix used in this method is a lignocellulosic material that is enriched with iron. The present invention also relates to a system, composition, and plant fertilizer that contain the iron-enriched matrix. Methods of making the composition and preparing a plant fertilizer are also disclosed.

An esteramide compound of the following formula (I): R1OOC-A-CONR2R3 (I) is described, wherein: A is a covalent bond or a methylene group —CH2—;R1 is an optionally substituted, saturated or unsaturated aliphatic or cycloaliphatic hydrocarbon group including from 5 to 36 carbon atoms,R2 and R3, either identical or different, are groups selected from a hydrogen atom, and optionally substituted hydrocarbon groups, preferably including from 1 to 36 carbon atoms, andR2 and R3 not being simultaneously hydrogen atoms. Also described, are applications for using the esteramide compound, notably as a solvent.

The present invention relates to a method and arrangement for the treatment of liquid material based on organic waste products, in particular sludge from sewage disposal plants and the like, wherein the sludge material is added and mixed with chemicals, in particular sulphuric acid, nitric acid, and/or ammonia, during the vaporization and degasification of liquid from the material to increase the solids content thereof. The present invention is characterized, inter alia, in that the material is continuously introduced at the upper part of a vertical mixing vessel (1), in which the material is subject to mixing, after which the material is passed on into a reactor tank (8) for sulphuric acid treatment and at the same time, while sinking through the sulphuric acid treatment reactor tank (8), is exposed to an impact action from a number of rotary processing means (9) disposed in the reactor tank (8), after which the material is passed on into a reactor tank (14) for ammonia treatment and at the same time, while sinking through the ammonia treatment reactor tank (14), is exposed to an impact action from a number of rotary processing means (9) disposed in the reactor tank (14), after which the material is finally passed on into a drier (15) in which the material is dried until a desired solids content is achieved.

A destination information provider server is disclosed. The destination information provider server is configured to obtain position information of an information providing target vehicle, recognize a target link, which corresponds to a link of a road on which the information providing target vehicle is traveling, based on the position information, and transmit destination information to the information providing target vehicle, the destination information being indicative of destinations of other vehicles which travel on the target link.

The invention relates to a method for guiding an aircraft along a reference path, said method comprising: a) when the altitude of the aircraft is greater than a threshold, estimating (E1) a relative location of the aircraft in relation to a taxiing starting point using a map of the platform and reference points on the ground, b) when the altitude of the aircraft is less than said threshold and before the aircraft is located at the taxiing starting point, estimating (E2) a relative location of the aircraft in relation to the taxiing starting point using data relating to the absolute location of the aircraft and the last relative location estimated at step a), c) when the aircraft is located at the taxiing starting point, guiding (E3) the aircraft on the basis of a location of the aircraft relative to the reference path as estimated using data relating to a set of indicators on the ground.

A method for quantifying classification confidence of obstructions applied to a perception mergence system of a vehicular computer in a vehicle. The method includes steps of: the vehicular computer receiving obstruction information of at least obstruction, image information corresponding to the obstruction information and vehicle body signals, and using a classifier to classify them; calculating a detection result of each range sensor to calculate a existence confidence; using the existence confidences and precision of the classifier to calculate a classification belief assignment of each range sensor corresponding to each obstruction; performing mergence calculation on the classification belief assignments to respectively quantify an obstruction classification confidence of all the range sensor corresponding to each obstruction; and performing a classification ineffectiveness filtering mechanism to exclude the obstruction whose obstruction classification confidence less than a predetermined value. The present invention quantifies the obstruction classification confidence to improve the classification precision.

A system and method for monitoring operation of vehicle automation systems utilizes an electronic vehicle monitor configured to connect to a computer system of a vehicle via the on board diagnostics (“OBD”) port of the vehicle. The electronic vehicle monitor is configured to obtain operational status information of the activation or use of vehicle automation systems of the vehicle, such as of an automated braking system, automated acceleration system, automated steering system, automated vehicle navigation system, automated collision avoidance system, and an automated cruise control system. The electronic vehicle monitor transmits the obtained operational status information to a computing device, such as a mobile computer of a passenger or the vehicle driver, or to a remotely located computer. The electronic vehicle monitor may include a wireless transmitter, and may include a global positioning system module or be configured to obtain location information from a global positioning system of the vehicle

A method is provided for traffic lane and traffic signal control identification and traffic flow management. Methods may identify traffic lights controlling lane movements, cataloging the information through analysis of traffic light signal phase and timing, and analyzing traffic movement through an intersection during specific periods of time. In particular, example methods may include identifying each of a plurality of paths through an intersection; identifying states of one or more traffic lights controlling traffic through the intersection; determining vehicle throughput data for the intersection through a predetermined number of cycles of the one or more traffic lights; and matching the vehicle throughput data to each of the plurality of paths of the intersection. The method may optionally include identifying times of movement and times of non-movement of vehicles across the intersection for each of the plurality of paths.

A system that provides a safety rating for a driver or a vehicle to a rider of the vehicle. Information including diagnostic information such as sensor information and location information is used to determine the safety rating. By having a high safety rating, the rider of the vehicle has some level of assurance that the vehicle will arrive at a designated location.

A vehicle passive entry side door latch release system engageable with a release cable connected a door latch includes a moveable linkage assembly engageable with the cable, and a motor including an output shaft engaged with a tensioning gear for driving a ratcheting gearwheel rotatably affixed to a coil spring, with the gearwheel including external teeth engageable with a rack affixed to the linkage to move the cable to unlatch the door latch. A pivotable ratcheting pawl may be engageable with the gearwheel to allow or prevent rotation of the gearwheel. Operation of the motor may drive the gear to drive the gearwheel in a rotary direction to energize the spring, and disengagement of the pawl from the gearwheel may allow stored energy in the spring to drive the gearwheel in an opposite rotary direction to thereby drive the rack to move the cable to unlatch the door latch.

A spring-based mechanism for saving labor of a bicycle rider is disclosed and in one embodiment includes an axle operatively connected to a chain wheel and a first set of bearings via a gear assembly; a housing for mounting a shaft therein wherein the first set of bearings is provided at one end of the shaft; a second set of bearings provided at the other end of the shaft; a spring in the housing and having one end attached to one end of the shaft and the other end attached to the other end of the housing; and a clutch provided externally of the other end of the housing, the clutch being operatively connected to the second set of bearings and including a lock lever. The mechanism can store elastic force by counterclockwise pedaling and release the stored energy by disengaging a clutch from the mechanism when riding uphill.

A vehicle passive entry side door latch release system engageable with a release cable connected a door latch includes a moveable linkage assembly engageable with the cable, and a motor including an output shaft engaged with a tensioning gear for driving a ratcheting gearwheel rotatably affixed to a coil spring, with the gearwheel including external teeth engageable with a rack affixed to the linkage to move the cable to unlatch the door latch. A pivotable ratcheting pawl may be engageable with the gearwheel to allow or prevent rotation of the gearwheel. Operation of the motor may drive the gear to drive the gearwheel in a rotary direction to energize the spring, and disengagement of the pawl from the gearwheel may allow stored energy in the spring to drive the gearwheel in an opposite rotary direction to thereby drive the rack to move the cable to unlatch the door latch.

A fluid dispensing system provides a sprayer. The system has a container with liquid fluid, such as used in lawn and garden weed control and fertilization. The sprayer has a handle containing a spring engine and a pump for liquid from the container. The spring engine has a flat spring having a spring band extending from two coils wound on two shafts. One of the coils is manually wound by a crank connected to a shaft on which the coil is connected. The other shaft is connected to the pump by a rotary cam driver. Liquid is sucked by the pump into a pump chamber during part of a cycle of rotation of the other shaft when the coils are unwound and the liquid is pumped out of the chamber during the other part of the cycle of rotation to a sprayer head on the sprayer handle.

An actuator for a wheel guiding element of motor vehicle wheel suspensions, with a first, preferably electrically driven actuating drive which selectively changes the length of the wheel guiding element, in the actuator there being a compensation spring which counteracts the compressive forces acting on the wheel guiding element. According to the invention, the pretensioning force of the compensation spring can be changed by means of a second, preferably electrically driven actuating drive.

A patient side-system includes a column with a rail and a counterbalance subsystem. The patient side-system may further include a braking subsystem. The counterbalance subsystem includes a spring assembly coupled at one end to the column with a spring member, and a housing movably coupled to the rail. The housing includes a drum to receive the spring member and a plurality of roller elements to guide a movement of the spring member winding or unwinding on the drum. If present, the braking subsystem includes a first pulley rotatably coupled to the column, a second pulley with a locking mechanism spaced apart from the first pulley and rotatably coupled to the column, and at least one brake cable wrapped around the first pulley and the second pulley with ends coupled to the housing. The locking mechanism can set a position of the housing along the column.

A liquid discharge apparatus includes: a head unit that has a plurality of nozzles that discharge a column-shaped liquid; a liquid droplet generating unit that applies cyclically changing energy to positions of the column-shaped liquids discharged from the plurality of nozzles, respectively, which are separated from the plurality of nozzles, respectively, and that generates liquid droplets; and a direction changing unit that changes a flying direction of at least some liquid droplets of the generated liquid droplets.

A liquid discharge apparatus includes: a head unit that discharges a liquid from each of a plurality of nozzles and causes a liquid column to extend downwardly; a liquid droplet generating unit that irradiates the liquid column with a laser beam from a position separated from the plurality of nozzles and separates liquid droplets from the liquid column; and a direction changing unit that applies energy to the liquid droplets and changes a flying direction of the liquid droplets.

An aqueous ink for ink jet containing a self-dispersible pigment, a compound represented by General Formula (I): where in General Formula (I) each R1 independently represents a hydrogen atom or an alkyl group.

An aqueous ink for ink jet containing a self-dispersible pigment, an aromatic sulfinic acid or a salt thereof and an aromatic sulfonic acid or a salt thereof.