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Electro-oxidative three-component cascade coupling of isocyanides with elemental sulfur and amines for the synthesis of 2-aminobenzothiazoles

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00432A, Paper
Peng-Fei Huang, Jia-Le Fu, Ying Peng, Jian-Hong Fan, Long-Jin Zhong, Kewen Tang, Yu Liu
2-Aminobenzothiazoles are commonly encountered in various functional compounds. Herein, we disclose an electro-oxidative three-component reaction for the effective synthesis of 2-aminobenzothiazoles under mild conditions, utilizing non-toxic and abundant elemental sulfur...
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Revisiting Biginelli-like Reactions: Solvent Effects, Mechanisms, Biological Applications and Correction of Several Literature Reports

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00272E, Paper
Brenno A. D. Neto, Pedro Beck, Arthur Leitão, Yasmin Santana, Jose R. Correa, Carime Vitória da Silva Rodrigues, Daniel Machado, Guilherme Matos, Luciana Machado Ramos, Claudia Cristina Gatto, Carlos Kleber Z. Andrade, Sarah Caldas
This study critically reevaluates reported Biginelli-like reactions using a Kamlet-Abboud-Taft-based solvent effect model. Surprisingly, structural misassignments were discovered in certain multicomponent reactions, leading to the identification of pseudo three-component derivatives...
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Photoproperties of Favipiravir and their 6-Substituted Analogues: Fluorescence Controlled through Halogen Substitution and Tautomerism

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00397G, Paper
Angel H Romero, Marcos Couto, Ivan E Romero, German Fuentes, Matías N. Möller
Herein, we showed the photophysical properties of the favipiravir and their 6-substituted analogues. Also, we interpreted the origin of the fluorescence of the favipiravir and their 6-substituted analogues as function...
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Design, synthesis, biological evaluation and molecular docking studies of quinoline-anthranilic acid hybrids as potent anti-inflammatory drugs

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00040D, Paper
Sidra Siddique, Khalid Hussain, Naureen Shehzadi, Muhammad Arshad, Muhammad Nadeem Arshad, Sadaf Iftikhar, Farhat Saghir, Ayisha Shaukat, Muhammad Sarfraz, Nisar Ahmed
Despite the high global prevalence, rheumatoid arthritis lacks a satisfactory treatment.
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Synthesis of Deuteriodifluoromethylthiolated Isocoumarins-1- imines and Isocoumarins Enabled by Multi-Component Reagents System (MCRS)

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00328D, Communication
Xuemin Li, Haofeng Shi, Jiaxin He, Jialiang Wu, Fengxia Sun, Yunfei Du
The combining use of BnSCF2D, mCPBA and Tf2O serves as an efficient multi-component reagents system (MCRS) for the synthesis of deuteriodifluoromethylthiolated isocoumarins-1-imines/isocoumarins via intramolecular cyclization/ deuteriodifluoromethylthiolation of 2-alkynylbenzamide/2-alkynylbenzoates. The approach...
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Natural products from human microbiome: an emergent frontier in organic synthesis and drug discovery

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00236A, Review Article
Goverdhan Mehta, Saumitra Sengupta, Srihari Pabbaraja
Often referred to as “second genome”, human microbiome is at the epicenter of a complex inter-habitat biochemical network, such as the “gut-brain axis”, which have emerged as significant determinant of...
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TEMPO/PhI(OAc)2 promotes the α-aminophosphinoylation of alcohols with amines and H-phosphine oxides in aqueous medium

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00302K, Communication
Qiang Huang, Xin Jin, Lvjia Wu, Jiangdong Li, Qianlu Xing, Xianheng Wang, Changkuo Zhao
The aminophosphinoylation of alcohols with amines and H-phosphine oxides provides an efficient and mild approach to access various α-aminoalkylphosphine oxides in good yields with good tolerance of functional groups using H2O as a clean solvent.
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Design, synthesis, and biological application of A–D–A-type boranil fluorescent dyes

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00297K, Paper
Wei Luo, Yiling Li, Liang Wang, Yanhua Qin, Qiao Cheng, Guochang Hu, Chaoyi Yao, Xiangzhi Song
Acceptor–donor–acceptor boranil fluorescent dyes, CSU-BF-R (R = H, CH3, and OCH3), were developed with strong red fluorescence and large Stokes shifts. CSU-BF-OCH3 could selectively sense intracellular hypochlorous acid in living cells and zebrafish.
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Measuring local pH at interfaces from molecular tumbling: A concept for designing EPR-active pH-sensitive labels and probes

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00167B, Paper
Open Access
Maxim A. Voinov, Nicholas Nunn, Roshan Rana, Atli Davidsson, Alex I. Smirnov, Tatyana I. Smirnova
EPR-based local pH measurements based on changes in rotational dynamics of spin-bearing molecules upon protonation.
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Sustainable preparation of 2-acylbenzothiazoles under the cooperation of ionic liquids and microwave irradiation

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00315B, Paper
Shoushun Wang, Mengjie Liu, Yiyuan Yue, Xiude Hu, Yalin Zhang, Guodong Shen, Ruiguo Dong, Lilong Shi, Bing Yu, Xianqiang Huang
A series of 2-acylbenzothiazole derivatives were sustainably synthesized for the first time under the cooperation of ionic liquids and microwave irradiation, metal- and extra-additives-free conditions.
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Tetrabutylammonium decatungstate (TBADT), a compelling and trailblazing catalyst for visible-light-induced organic photocatalysis

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00171K, Review Article
Bor-Cherng Hong, Ranadheer Reddy Indurmuddam
This review summarizes recent developments in visible-light or near-visible-light photocatalysis reactions enabled by the TBADT catalyst.
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Base- and sulfur-promoted oxidative lactonization of chalcone-acetate Michael adducts: access to pyran-2-ones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00479E, Communication
Cao Nguyen Nguyen, Duc Toan Nguyen, Ha An Tran, Dinh Hung Mac, Thi Thu Tram Nguyen, Pascal Retailleau, Thanh Binh Nguyen
A cost-effective, practical, straightforward and scalable synthesis of α-pyrones via base- and sulfur-promoted annulation of phenylacetates and chalcones is reported.
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Piloting through the pandemic

How AirAsia India innovated with a distance-learning training programme for its cockpit crew




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Pandemic: Contactless technology on an overdrive

As demand for travel rises, industry must meet it while ensuring passenger safety




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Omicron: Airlines on a wing and prayer

Over 3,000 flights were cancelled on the eve of Christmas and cancellations are expected to double as New Year approaches




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Demand for more flight schools soars

Pilot shortage is hurting airline operations in India, with the industry expected to need at least 1,000 to 1,500 pilots every year




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Breaking down airline engineering and maintenance

An aircraft has three critical phases; induction, in-service and redelivery




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Profits offer hope of soft landing to Spicejet

Apart from swift settlement with former owners, the airline urgently needs an immediate infusion of cash




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Mishandled baggage rates spike

Transfer bags continue to account for most mishandled bags




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5 things Indian airlines must do to break their way out of pandemic blues

Post pandemic, the airlines must revamp strategies and resort to long-term measures to recover from the crisis 




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Embraer expects capacity dynamics to tilt demand in its favour

The plane maker’s current foray attempts to shed the tentativeness that overshadowed its earlier endeavours




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Post-pandemic, OTAs are coming of age

Are they finally paying up or paying off?




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Youtube introduces shopping affiliate programme for eligible Indian creators via Flipkart and Myntra

As more platforms allow creators to earn from viewers’ purchases of featured products, YouTube also announced its Shopping affiliate programme in India




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Microsoft Teams to launch threaded conversations, combined chats and channels features

The app has also added other changes in the interface so users can organise their chats better




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Google brings AI-powered Gmail writing tools and ‘Polish’ to more users

Google is expanding its generative AI-powered email drafting tools to more users with new and enhanced shortcuts on web and mobile




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OpenAI builds first chip with Broadcom and TSMC, scales back foundry ambition

OpenAI is working with Broadcom and TSMC to build its first in-house chip designed to support its artificial intelligence systems, per sources




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Google expands AI Overviews in Search to more than 100 countries

Earlier this month, the search giant rolled out ads in AI Overviews on mobile but only in the U.S.




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Google Maps adds AI features to help users explore and navigate the world around them

Google Maps is heading down a new road steered by artificial intelligence




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Microsoft, Meta, Apple, Amazon, and the burden of expectations knock Wall Street sharply lower

Drops for Big Tech companies including Microsoft and Facebook’s parent company Meta Platforms led Wall Street lower




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Will not allow dilution of AIIMS brand: Union Health Minister J. P. Nadda

The Health Minister said no compromises will be made in faculty recruitments or standards of teaching at any of the new AIIMS institutes being set up across the country




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Drugs regulator finds 49 samples not of standard quality, manufacturers asked to withdraw their products

Four spurious drugs were also found and action has been initiated against the makers, the DCGI said




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Covid lessons learned? U.N. summit mulls plan for healthy planet, and humans

At the U.N. summit in Cali, delegates are working on a “biodiversity and health action plan” proposed for adoption by the 196 member nations of the Convention on Biological Diversity




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$25-million Pandemic Fund aims to curb ‘zoonotic’ diseases

The Centre will implement the G20 Pandemic Fund, which is aimed at enhancing the country’s “animal health security”, in partnership with the Asian Development Bank (ADB), the World Bank and the Food and Agriculture Organization (FAO).




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Malaria elimination: Egypt’s success and a roadmap for India’s WHO certification

India has made remarkable strides in reducing malaria, with reported cases dropping over the years; however, there is a long journey ahead, with climate change raising the potential for malaria transmission in areas that have already achieved elimination




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Wellness retreat that King Charles and Queen Camilla visited in Bengaluru to soon expand to Portugal 

King Charles III and Queen Camilla, who left the retreat after a three-day rejuvenation session, are happy with the expansion plans as this would be closer to the UK, says holistic health practitioner Issac Mathai, who runs the facility




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What is breast density and how is it associated with cancer? Explained

Breast density matters because of two main reasons: it may make it harder to detect signs of cancer on a mammogram, and it is linked with an increased risk of breast cancer




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More than 50,000 vaccinated against mpox in DR Congo, Rwanda: WHO

The outbreak is still not under control, the African Union’s health watchdog has warned, appealing for resources to avoid a “more severe” pandemic than Covid-19




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How to overcome your device dependency and manage a successful digital detox

There are four key strategies that are key to helping you achieve a healthier digital balance: replacement practices, social bonds, mindfulness and viewing digital well-being as a journey




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Understanding orphan drugs: what are they, how are they classified and what are their challenges in the Indian context

While orphan drugs are crucial to treating rare, sometimes debilitating conditions, the high cost of their research and development is a major barrier to their development in India




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Stop abuse of patent monopolies in rare diseases, say patient representatives and treatment activists 

They seek urgent intervention by government, courts, and lawmakers into the issue  




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Lassa fever: Understanding the risk, response and global threat

The Lassa virus causes Lassa fever, a zoonotic disease; humans usually contract the virus through contact with food or items contaminated by the the Mastomys rat’s urine or faeces.




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Osteoporosis can shorten your life − here’s how to prevent fractures and keep bones healthy

The key to having healthy bones for a lifetime is to take some simple preventive measures – and the earlier, the better




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Severe staff shortage leaves Tamil Nadu’s obstetricians and gynaecologists overworked

Doctors are forced to take turns doing frequent 24-hour shifts — in some cases two to three 24-hour shifts a week. Inquiries with government OB-GYNs reveal that several health facilities have been short-staffed for years, and vacant posts remain unfilled




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'Fireworks between Sushmita and me'

'People started noticing me again. OTT is a good platform for serious actors. In the olden days, unless you are the heroine, actors would have screen deaths. But now, there are so many good roles for women.'




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'Life is all about ups and downs'

'When one is low, all you can do is buckle up and get up and prepare for the next challenge.'




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Making Waves In India And Hollywood

'On the set, Ranveer and I got along really well. Ten days after the release, Ranveer messaged me and said, you have killed the scene! For someone like him to message me just says how supportive person he is of newcomers.'




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'Women don't have to only sing and dance'

'When you are new, you don't know how the industry works'. 'But when you know where you are headed, the possibilities of being conned or facing unpleasant instances is reduced.'




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'Real love comes and goes'

'What happened to Raj and Simran after running away on the train at the end of DDLJ 20 years later? Have they become flatmates instead of lovers? What happens when the initial chemistry has worn off and love becomes a habit? This has always fascinated me.'




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'Bhansali teaches you without a danda'

'When you walk on to a Sanjay Leela Bhansali set, it is complete surrender. You have to become a sponge.'