it Towards just transition in Africa By www.chathamhouse.org Published On :: Fri, 23 Dec 2022 08:59:21 +0000 Towards just transition in Africa Interview Video NCapeling 23 December 2022 Highlighting key interventions from African policymakers, business leaders, researchers, and civil society voices on green financing and implementation plans. African countries face collective climate and employment-related challenges. However, policymaking often remains regionally siloed according to differing political, energy sector, and ecological realities. There is a need for transformational strategic thinking and context-specific action from African governments, civil society, businesses, and financiers, in their green financing demands and national implementation plans. This video highlights key interventions from policymakers, business leaders, researchers, and civil society voices at a series of events hosted by the Chatham House Africa programme in Nairobi, Libreville, and Addis Ababa in the lead-up to COP27. The events series, Towards just transition: Connecting green financing and sustainable job creation in Africa, was supported by the Chatham House Sustainability Accelerator and the United Nations Development Programme. Full Article
it Africa in 2023: Continuing political and economic volatility By www.chathamhouse.org Published On :: Fri, 06 Jan 2023 11:20:58 +0000 Africa in 2023: Continuing political and economic volatility Expert comment NCapeling 6 January 2023 Despite few African trade and financial links with Russia and Ukraine, the war in Ukraine will cause civil strife in Africa due to food and energy inflation. Africa’s economy was recovering from the COVID-19 pandemic in 2022 when a range of internal and external shocks struck such as adverse weather conditions, a devastating locust invasion, and the Russian invasion of Ukraine – all of which worsened already rapidly-rising rates of inflation and borrowing costs. Although the direct trade and financial linkages of Africa with Russia and Ukraine are small, the war has damaged the continent’s economies through higher commodity prices, higher food, fuel, and headline inflation. The main impact is on the increasing likelihood of civil strife because of food and energy-fuelled inflation amid an environment of heightened political instability. Key African economies such as South Africa and Nigeria were already stuck with low growth and many African governments have seen their debt burdens increase – some such as Ethiopia and Ghana now have dollar debt trading at distressed levels – and more countries will follow in 2023. On average the public sector debt-to-GDP ratio of African countries stood at above 60 per cent in 2022. The era of Chinese state-backed big loans and mega-projects which started 20 years ago in Angola after the end of its civil war may be coming to an end but Chinese private sector investments on the continent will continue through its Belt and Road Initiative and dual circulation model of development. Great and middle powers building influence Geopolitical competition in Africa has intensified in 2022, particularly among great powers such as China, Russia, the US, and the EU but also by middle powers such as Turkey, Japan, and the Gulf states. The sixth AU-EU summit held in Brussels in February 2022 agreed on the principles for a new partnership, although the Russian invasion of Ukraine which followed disrupted these ambitions. Japan’s pledge of $30 billion in aid for Africa at TICAD 8 in August 2022 was clearly made due to the $40 billion pledged at the China–Africa summit in November 2021. The geopolitical and geoeconomic ramifications of the war in Ukraine has directly impacted the African continent by contributing to food and cooking oil inflation and humanitarian aid delivery The US also launched a new strategy to strengthen its partnership and held a second US-Africa Leaders’ summit in Washington in December, the first since 2014. Russia’s ambition has been curtailed by its invasion of Ukraine, postponing its second summit with African states to 2023. The imposition of international sanctions complicated its trade and investments, and military support such as that provided by Russian paramilitary group Wagner focused on Mali, Libya and the Central African Republic (CAR) has been curtailed. The strategic importance of Africa has resulted in all the UN P5 members calling on the G20 to make the African Union (AU) its 21st member in 2023 under India’s presidency. International competition to secure Africa’s critical and strategic minerals and energy products intensified in 2022 and, in the energy sector, European countries are seeking to diversify away from Russian oil and gas with alternative supplies, such as those from Africa. Western mining companies and commodity traders are also increasingly seeking alternative supplies from Africa. Decarbonization is becoming a driver of resource nationalism and geopolitical competition in certain African mining markets, home to large deposits of critical ‘transition minerals’ such as copper, cobalt, graphite, lithium, or nickel. COP27 was hosted in Egypt in November and gave African leaders an opportunity to shape climate discussions by pushing priority areas such as loss and damage, stranded assets, access to climate finance, adaptation, and desertification. Climate adaptation in Africa is a key condition to preserving economic growth and maintaining social cohesion. The Horn of Africa, particularly Somalia, is suffering from one of the worst droughts in memory. The geopolitical and geoeconomic ramifications of the war in Ukraine has directly impacted the African continent by contributing to food and cooking oil inflation and humanitarian aid delivery. Thoughout 2022 the AU was undergoing intensive reform and it struggled to respond to the growing number of security crises across the continent. Hotspots in 2023 will be in the western Sahel and Lake Chad Basin, eastern DRC, and northern Mozambique, all of them crossing state borders. In Mozambique, a 2019 peace deal assisted by the United Nations (UN) will see the last ex-guerrillas from Renamo demobilized in 2023 to reintegrate into civilian life – some having been recruited in 1978. Jihadist activity may spread further into coastal states which has resulted in international partners such as France and the UK redesigning their security assistance strategies for the region In eastern Congo, M23 – one of around 120 armed groups – resumed its conflict against the central government. After lying dormant for several years, it took up arms again in 2021 and has been leading an offensive in eastern DRC against the Congolese army. According to the UN, Rwanda has been supporting M23, and Kenya’s parliament approved in November the deployment of about 900 soldiers to the DRC as part of a joint military force from the East African Community (EAC) bloc – DRC joined the EAC in March. In the Horn of Africa, Ethiopia saw an uneasy ceasefire agreed between the federal government and the Tigray People’s Liberation Front (TPLF). Islamist militant groups in Africa further expanded their territorial reach in 2022, particularly in the western Sahel where al-Qaeda and Islamic State affiliates are competing for influence and continued to make inroads. The drawdown and exit of western forces from Mali, both the French Operation Barkane and international contributions for the UN’s MINUSMA mission there, adds new dimensions to regional security challenges. Mali’s decision in May to withdraw from the G5 Sahel has also eroded the regional security architecture. Jihadist activity may spread further into coastal states which has resulted in international partners such as France and the UK redesigning their security assistance strategies for the region. Coups on the increase again Since 2020, there have been successful military coups in Burkina Faso (twice), Chad, Guinea, Mali (twice), and Sudan, and failed ones in the CAR, Djibouti, Guinea-Bissau, Madagascar, Niger, and possibly Gambia and São Tomé and Príncipe. Three national elections illustrate the state of African democracy in 2022. In Angola’s August elections, the ruling MPLA lost its absolute majority with the opposition UNITA winning the majority in Luanda for the first time. Full Article
it Africa’s strategic priorities and global role By www.chathamhouse.org Published On :: Wed, 18 Jan 2023 15:17:15 +0000 Africa’s strategic priorities and global role 27 January 2023 — 1:00PM TO 2:00PM Anonymous (not verified) 18 January 2023 Chatham House and Online At this hybrid event, HE John Dramani Mahama, former president of the Republic of Ghana, will discuss his ideas on the key economic and governance reforms required for economic stability and prosperity across Africa. Ghana recently became the fourth country, after Chad, Ethiopia and Zambia, to seek debt treatment under the G20 Common Framework in January 2023 – reflecting the culmination of a series of internal and external shocks affecting the wider region, including extreme weather events, the COVID-19 pandemic and the Russia-Ukraine crisis. Prospects for economic recovery and growth, nevertheless, remain positive in many parts of the continent, with the African Development Bank (AfDB), for example, reforecasting economic growth of 5.5 per cent in East Africa in 2023. Coordinated reforms can help to deepen regional integration and promote long-term economic prosperity, particularly in light of Africa’s evolving regional economic governance structures, notably the fledgling African Continental Free Trade Area (AfCFTA) headquartered in Accra. At this hybrid event, HE John Dramani Mahama, former president of the Republic of Ghana, will discuss his ideas on the key economic and governance reforms required for economic stability and prosperity across Africa. He will also discuss priorities for regional integration and Africa’s role and responsibilities in global economic governance. Full Article
it Africa Aware: Towards just transition in Africa By www.chathamhouse.org Published On :: Wed, 01 Mar 2023 16:47:47 +0000 Africa Aware: Towards just transition in Africa Audio NCapeling 1 March 2023 African countries face collective climate and job creation-related challenges, yet policymaking often remains regionally siloed. This podcast reflects on the key policy messages from the Africa programme’s series on Towards just transition: Connecting green financing and sustainable job creation in Africa. African countries face collective climate and job creation-related challenges. Yet policymaking often remains regionally siloed according to differing political, energy sector and ecological realities. This output is part of a stream of work supported by the Chatham House Sustainability Accelerator and the United Nations Development Programme (UNDP). Full Article
it A critical juncture for Sudan’s democratic transition By www.chathamhouse.org Published On :: Tue, 28 Mar 2023 14:36:40 +0000 A critical juncture for Sudan’s democratic transition Expert comment LJefferson 28 March 2023 International pressure is essential to reach an agreement that establishes a credible civilian government. The signing of the Framework Agreement (FA) on 5 December 2022 between Sudan’s military leaders and its leading pro-democracy parties is a major step to reversing the damage done by the disastrous military coup in October 2021. The FA removes any formal role for the military in Sudan’s politics. A civilian head of state and prime minister will select the cabinet and chair the Defence and Security Council. The armed forces will be prohibited from non-military business activities and security sector reform will lead to a unified, professional and non-partisan national army. Elections are due to take place at the end of a two-year transitional period. Signatories included General Abdel Fatah Al Burhan, chair of the Sovereign Council and head of the Sudanese Armed Forces (SAF), General Mohamed Hamdan Dagalo (known as Hemedti), his deputy and Commander of the paramilitary Rapid Support Forces (RSF) and more than 40 civilian entities, including the Forces of Freedom and Change- Central Council (FFC-CC), a few other political parties, former armed movements, civil society organizations and professional associations. However, the agreement has faced criticism from the street for not being sufficiently radical, has been overshadowed at times by heightened tension between the two military leaders, and has seen sabotage attempts by supporters of the Bashir regime. Building consensus on the Framework Agreement The agreement meets most of the demands of the anti-coup camp, at least on paper. Yet doubts persist as to whether the military are genuine about handing over power, particularly among the neighbourhood-based resistance committees – the heart of the youth-led mobilization that forced the military to recognize the failure of their power grab. Peaceful protests against the coup have seen 125 killed and over 8,000 injured by government security forces. Many want to see Burhan and Hemedti held accountable. Doubts persist as to whether the military are genuine about handing over power, particularly among the neighbourhood-based resistance committees. Recognizing the need to expand popular support, FFC-CC leaders have been reaching out to other pro-democracy forces to build a united civilian front. They report increased buy-in from some resistance committees in the last few months, recognizing that street protests alone were not sufficient to overthrow the coup, and that engagement with the military is necessary to find a way out of the impasse. The FA offers the only currently available path to embedding civilian politics in Sudan and has received active diplomatic support from UNITAMS, AU and IGAD (who form the Tripartite Mechanism), the Troika of the US, UK and Norway, alongside the EU, as well as Saudi Arabia and the UAE (who are members of ‘the Quad’ with the US and UK). Broader public participation has also been developed through a series of conferences, facilitated by the Tripartite Mechanism, on five contentious issues – dismantling the old regime, the Juba Peace Agreement, Eastern Sudan, Transitional Justice and Security Sector Reform. Recommendations will be incorporated in a final political agreement. In a significant breakthrough, both sides have agreed to draft the final agreement and transitional constitution, with the aim of forming a civilian government by 11 April. The political process has been overshadowed by increasingly visible tension between Burhan and Hemedti, seen in parallel foreign visits, conflicting public statements, and a heavy military presence in Khartoum. But concerns that SAF and the RSF were heading towards confrontation appear to have been assuaged thanks to international pressure and preliminary agreements reached between military and civilian signatories of the FA on security sector reform and integration. In a significant breakthrough, both sides have now agreed to draft the final agreement and transitional constitution, with the aim of forming a civilian government by 11 April. Potential spoilers and interests from Sudan’s regions Progress has been made, but significant challenges remain, notably from supporters of the former Bashir regime in ‘the deep state’ and from Sudan’s historically marginalized peripheries. Old regime elements have been intensifying social media campaigns to derail the agreement and drive a wedge between the SAF and RSF, and have been accused of deliberately inciting instability in the peripheries to undermine the democratic transition. The Popular Defence Forces, established by the National Islamic Front in the 1990s, have been reactivated under different names in several parts of the country and there are reports of mobilization and recruitment of armed militias in Darfur. The recent public appearance of Ali Karti, the Secretary-General of the Islamic Movement, who has close relations with Islamists in SAF, has also caused renewed concern. Two Darfuri armed movement leaders who signed the October 2020 Juba Peace Agreement (JPA) and are members of the current military-led government, have not signed the FA, allegedly due to concerns about their representation in the next government. Despite intensive efforts to bring them on board, there is continuing disagreement over the inclusion of other members of ‘the Democratic Bloc’, a political alliance backed by Sudan’s influential neighbour Egypt, which is reportedly angry at being excluded from the Quad. The FFC-CC say that the door is open for the two Darfuri leaders and some other political parties, but they will not allow the agreement to be ‘diluted’ with political forces who intend to torpedo the transition, including by imposing a weak prime minister. Supporters of the pro-democracy movement outside Khartoum, particularly the resistance committees, recognize the organic link between peace and democracy. Both Burhan and Hemedti have courted support from the regions. Burhan used the 2020 SAF takeover of Al Fashaga in the contested eastern border region with Ethiopia to boost his national standing and secure backing from local tribal leaders; while Hemedti has sought to position himself as a champion of the peripheries, particularly in his Darfur heartlands, while simultaneously advancing his business interests. Competition between them in building domestic powerbases, as well as alliances with neighbouring states, risks reigniting tensions, particularly given deep grievances and contrasting ambitions between and among Sudan’s diverse regional leaders and communities. Full Article
it Fighting over ‘white gold’: Sesame in Ethiopia and Sudan By www.chathamhouse.org Published On :: Mon, 03 Apr 2023 17:57:35 +0000 Fighting over ‘white gold’: Sesame in Ethiopia and Sudan Expert comment LJefferson 3 April 2023 The supply chain of a seemingly innocuous cash crop – sesame – has intersected with transnational conflict dynamics, exacerbating tensions between Ethiopia and Sudan. Late 2020 saw the beginning of the devastating war in Tigray and the occupation of a disputed region on the Ethiopia–Sudan border – Al Fashaga – by the Sudanese army. These shocks disrupted settled patterns of land ownership and control in both Ethiopia’s volatile north and Sudan’s borderlands, historically the heart of the sesame and oilseed production that is economically vital to both countries. These seemingly harmless cash crops are now embedded in local, subnational and national political contestations in both countries. Sesame value chains are being reshaped, with power and profits being used to entrench the grip of political and armed actors who are reinforcing new patterns of land control and driving informal and illicit trade – impacting the coping mechanisms of local communities and threatening to fuel further conflict. Regional rivalries drive contestation over the Ethiopia supply chain Internal borders between most of Ethiopia’s regions are marked by boundary disputes, which often degenerate into violent conflict. The most important is between the Tigray and Amhara regions. Since the war began in 2020, the Amhara region has annexed vast areas of western and southern Tigray, which the Amhara region claims were taken from them by Tigray 30 years ago, after the Tigray People’s Liberation Front (TPLF) dominated ethnic coalition came to power. Conflict has exacerbated a steady decline in formal revenues from sesame exports, dropping over $115 million from 2016 to 2021. Ethiopia’s exports of spices, oilseeds and pulses brought in over half a billion dollars in 2021, roughly a quarter of the country’s total export revenues and second only to coffee. The sector has been rocked by the war in the north, which accounted for much of Ethiopia’s sesame production, with an estimated 500,000 hectares of sesame fields taken out of cultivation during the 2021 growing season. Conflict has exacerbated a steady decline in formal revenues from sesame exports, dropping over $115 million from 2016 to 2021. Alongside falling production, the previously integrated value chain has been disrupted and decentralized by political fragmentation and land competition between Amharas and Tigrayans. Before the war, the agricultural sector in Western Tigray/Welkait was dominated by Tigrayan business interests, through the TPLF’s regional endowment fund EFFORT, a business conglomerate including subsidiaries such as Guna Trading House, and Hiwot Agricultural Mechanization. " class="video-embed-field-lazy"> Two-minute video explainer: Supply chains, land contestation and conflict in the Horn of Africa The taking of the area by Amhara forces in late 2020 saw the control over agricultural supply chains shift to actors from the Amhara region, amid contestation between regional officials, businessmen and security actors, backed by political elites. Thousands of displaced ethnic Tigrayan inhabitants of the area have been replaced by ethnic Amharas, enticed to settle there by the Amhara regional government’s offer of grants and leases for land which promise better livelihoods. The sesame they farm is now largely exported through informal and illicit channels, with profits used to reinforce de facto regional control. But there is also contestation within the Amhara region over the land and sesame supply chain between sub-regional elites from Gojjam, Gondar and indigenous Welkaites. Welkaites, who were marginalized under TPLF rule, believed that by aligning themselves with powerful Amharas they would reclaim land and influence. But this has not been fully realized, with the local administration reliant on Amhara region subsidies, rather than the federal budget. With little support from the federal government, local Welkait officials are strengthening their ties with Eritrea. The Ethiopian government’s pursuit of peace with Tigray may lead it to turn away from the Amhara region, which could result in a renewed showdown between Amhara and Tigrayan forces. At the national level, regional contestation over the control over Western Tigray/Welkait feeds into shifting political alliances between the Amhara, Tigrayans and Oromo which threaten the sustainability of the peace agreement struck between the federal government and TPLF in November 2022 – despite efforts by the government to defer the thorny issue. While the constitutional return of the land to Tigray remains unlikely anytime soon, there is a feeling that Amhara control over Western Tigray/Welkait is no longer certain. The Ethiopian government’s pursuit of peace with Tigray may lead it to turn away from the Amhara region, despite their alliance during and before the war, which could result in a renewed showdown between Amhara and Tigrayan forces. The prospect of losing territory could also heighten Amhara nationalist claims on Al Fashaga – the loss of which was partly offset by gaining Western Tigray/Welkait – leading to renewed conflagration with Sudan, outside of federal direction. Eritrea’s presence and alliance with Amhara militias remains a concern, given Asmara’s demonstrable ability to inflame tensions. Sudan’s securocrats battle over resources to entrench political power The war in northern Ethiopia was also used opportunistically by the Sudanese Armed Forces (SAF) to take control of the fertile Al Fashaga borderland. This roughly 250 sq km area had been awarded to Sudan when the boundary was initially demarcated by the British in 1903, a ruling that remained contested by Ethiopia. An uneasy truce had seen Ethiopian farmers cultivate the land under nominal Sudanese administration; a settlement that collapsed in 2020 when thousands of predominantly Amhara farmers were evicted. Local Sudanese farmers have also lost out – with some not compensated for the loss of lands to their own military, with land given to people from other parts of the country, and through lost relationships with Ethiopian farmers, labourers and investors. The Sudanese military now allegedly controls more than 90 per cent of the disputed areas and security-linked companies and investors have moved into the lucrative sesame sector, re-routing the supply chain, which used to flow largely through Ethiopian markets. These companies are connected to Sudan’s Military Industrial Corporation, a vast conglomerate of business subsidiaries controlled by SAF – which is headed by General Abdel Fattah al-Burhan. Competition between Sudanese security actors fuels volatile political rivalries, and further entrenches military control of economic resources. The commander of the paramilitary Rapid Support Forces, General Mohamed Hamdan Dagolo (or Hemedti), also has interests in agriculture, through his family business Al-Junaid. Both sit at the top of Sudan’s Sovereign Council. Hemedti’s competition with Burhan has seen him develop relations with Ethiopia’s prime minister – counter-balanced by recent rapprochement between Abiy and Burhan – as well as senior Amhara leaders, including over business activities. Moreover, competition between Sudanese security actors fuels volatile political rivalries, and further entrenches military control of economic resources, undermining civilians at a time when pro-democracy forces are seeking to restore a reform-minded government. One of the key challenges for a new civilian government will be to quickly build up a domestic revenue base to compete with the economic heft of the country’s prominent security institutions, which will demand taking on military-controlled holdings in civic sectors such as agriculture, including sesame. Informal and illicit trade reinforces conflict dynamics This context has driven the informalization of trade, with cash crops such as sesame increasingly exported outside of formal channels and connected to other illicit cross-border activities between Ethiopia and Sudan. Indications are that sesame production in Western Tigray/Welkait has recovered significantly during the current 2022/23 harvest season. However, rather than contributing much needed currency to soften Ethiopia’s forex crisis, the Amhara elite-controlled supply chain is primarily being used to secure a variety of regional interests. Full Article
it The added value of 18F-FDG PET/CT compared to 68Ga-PSMA PET/CT in patients with castration-resistant prostate cancer By jnm.snmjournals.org Published On :: 2021-04-23T13:46:28-07:00 Purpose: The 68Ga-PSMA PET/CT is a commonly used imaging modality in prostate cancers. However, few studies have compared the diagnostic efficiency between 68Ga-PSMA and 18F-FDG PET/CT and evaluated whether a heterogeneous metabolic phenotype (especially PSMA-FDG+ lesions) exists in patients with castration-resistant prostate cancer (CRPC). We determined the added value of 18F-FDG PET/CT compared to 68Ga-PSMA PET/CT in CRPC patients and identified CRPC patients who may benefit from additional 18F-FDG PET/CT. Methods: Data of 56 patients with CRPC who underwent both 68Ga-PSMA and 18F-FDG PET/CT from May 2018 to February 2021 were retrospectively analysed. Patients were classified into two groups with or without PSMA-FDG+ lesions. The differences in patient characteristics between the two groups and predictors of patients who having at least one PSMA-FDG+ lesion were analysed. Results: Although both the detection rate (75.0% vs. 51.8%, P = 0.004) and positive lesion number (135 vs. 95) of 68Ga-PSMA PET/CT were higher than 18F-FDG PET/CT, there were still 13/56 (23.2%) patients with at least one PSMA-FDG+ lesion. The prostate-specific antigen (PSA) and Gleason score were both higher in the patients with PSMA-FDG+ lesions than in those without PSMA-FDG+ lesions (P = 0.04 and P<0.001, respectively). Multivariate regression analysis showed that the Gleason score (≥8) and PSA (≥7.9 ng/mL) were associated with the detection rate of patients who had PSMA-FDG+ lesions (P = 0.01 and P = 0.04, respectively). The incidences of having PSMA-FDG+ lesions in low-probability (Gleason score<8 and PSA<7.9 ng/mL), medium-probability (Gleason score≥8 and PSA<7.9 ng/mL or Gleason score<8 and PSA≥7.9 ng/mL), and high-probability (Gleason score≥8 and PSA≥7.9 ng/mL) groups were 0%, 21.7%, and 61.5%, respectively (P<0.001). Conclusion: Gleason score and PSA are significant predictors for PSMA-FDG+ lesions, and CRPC patients with high Gleason score and PSA may benefit from additional 18F-FDG PET/CT. Full Article
it The Translation of Dosimetry into Clinical Practice: What It Takes to Make Dosimetry a Mandatory Part of Clinical Practice By jnm.snmjournals.org Published On :: 2024-09-05T07:37:49-07:00 Full Article
it Challenges with 177Lu-PSMA-617 Radiopharmaceutical Therapy in Clinical Practice By jnm.snmjournals.org Published On :: 2024-09-19T06:38:07-07:00 Full Article
it Pattern of Failure in Patients with Biochemical Recurrence After PSMA Radioguided Surgery By jnm.snmjournals.org Published On :: 2024-09-26T12:46:37-07:00 Visual Abstract Full Article
it Impact of 18F-FDG PET/MRI on Therapeutic Management of Women with Newly Diagnosed Breast Cancer: Results from a Prospective Double-Center Trial By jnm.snmjournals.org Published On :: 2024-10-10T08:33:38-07:00 Visual Abstract Full Article
it One Bite from the Apple, One Bite from the Orange in the PRECISE-MDT Study By jnm.snmjournals.org Published On :: 2024-10-17T09:03:09-07:00 Full Article
it Reply: One Bite from the Apple, One Bite from the Orange in the PRECISE-MDT Study and Limitations of Retrospective Study Design and Potential Bias in the PRECISE-MDT Study By jnm.snmjournals.org Published On :: 2024-10-17T09:03:09-07:00 Full Article
it Limitations of Retrospective Study Design and Potential Bias in the PRECISE-MDT Study By jnm.snmjournals.org Published On :: 2024-10-17T09:03:09-07:00 Full Article
it Modeling PET Data Acquired During Nonsteady Conditions: What If Brain Conditions Change During the Scan? By jnm.snmjournals.org Published On :: 2024-10-24T11:58:49-07:00 Researchers use dynamic PET imaging with target-selective tracer molecules to probe molecular processes. Kinetic models have been developed to describe these processes. The models are typically fitted to the measured PET data with the assumption that the brain is in a steady-state condition for the duration of the scan. The end results are quantitative parameters that characterize the molecular processes. The most common kinetic modeling endpoints are estimates of volume of distribution or the binding potential of a tracer. If the steady state is violated during the scanning period, the standard kinetic models may not apply. To address this issue, time-variant kinetic models have been developed for the characterization of dynamic PET data acquired while significant changes (e.g., short-lived neurotransmitter changes) are occurring in brain processes. These models are intended to extract a transient signal from data. This work in the PET field dates back at least to the 1990s. As interest has grown in imaging nonsteady events, development and refinement of time-variant models has accelerated. These new models, which we classify as belonging to the first, second, or third generation according to their innovation, have used the latest progress in mathematics, image processing, artificial intelligence, and statistics to improve the sensitivity and performance of the earliest practical time-variant models to detect and describe nonsteady phenomena. This review provides a detailed overview of the history of time-variant models in PET. It puts key advancements in the field into historical and scientific context. The sum total of the methods is an ongoing attempt to better understand the nature and implications of neurotransmitter fluctuations and other brief neurochemical phenomena. Full Article
it Head-to-Head Comparison of [68Ga]Ga-NOTA-RM26 and [18F]FDG PET/CT in Patients with Gastrointestinal Stromal Tumors: A Prospective Study By jnm.snmjournals.org Published On :: 2024-10-24T11:58:49-07:00 Visual Abstract Full Article
it [18F]F-AraG Uptake in Vertebral Bone Marrow May Predict Survival in Patients with Non-Small Cell Lung Cancer Treated with Anti-PD-(L)1 Immunotherapy By jnm.snmjournals.org Published On :: 2024-10-24T11:58:48-07:00 Visual Abstract Full Article
it Intraarterial Administration of Peptide Receptor Radionuclide Therapy in Patients with Advanced Meningioma: Initial Safety and Efficacy By jnm.snmjournals.org Published On :: 2024-10-24T11:58:49-07:00 Visual Abstract Full Article
it Comparison of Posttherapy 4- and 24-Hour [177Lu]Lu-PSMA SPECT/CT and Pretherapy PSMA PET/CT in Assessment of Disease in Men with Metastatic Castration-Resistant Prostate Cancer By jnm.snmjournals.org Published On :: 2024-10-30T08:04:16-07:00 Visual Abstract Full Article
it Outcomes for Patients with Metastatic Castration-Resistant Prostate Cancer and Liver Metastasis Receiving [177Lu]Lu-PSMA-617 By jnm.snmjournals.org Published On :: 2024-10-30T08:04:14-07:00 Visual Abstract Full Article
it Clinical, Pathologic, and Imaging Variables Associated with Prostate Cancer Detection by PSMA PET/CT and Multiparametric MRI By jnm.snmjournals.org Published On :: 2024-10-30T08:04:14-07:00 Visual Abstract Full Article
it Oncologist, Business Leader, and Investor Arie S. Belldegrun Discusses a Career in Innovative Medical Entrepreneurship: A Conversation with Ken Herrmann and Johannes Czernin By jnm.snmjournals.org Published On :: 2024-10-30T08:04:15-07:00 Full Article
it [18F]FDG and [68Ga]Ga-FAPI-04-Directed Imaging for Outcome Prediction in Patients with High-Grade Neuroendocrine Neoplasms By jnm.snmjournals.org Published On :: 2024-10-30T08:04:15-07:00 Visual Abstract Full Article
it Feasibility, Tolerability, and Preliminary Clinical Response of Fractionated Radiopharmaceutical Therapy with 213Bi-FAPI-46: Pilot Experience in Patients with End-Stage, Progressive Metastatic Tumors By jnm.snmjournals.org Published On :: 2024-10-30T08:04:15-07:00 Visual Abstract Full Article
it Performance Characteristics of a New Generation 148-cm Axial Field-of-View uMI Panorama GS PET/CT System with Extended NEMA NU 2-2018 and EARL Standards By jnm.snmjournals.org Published On :: 2024-11-07T04:28:32-08:00 Visual Abstract Full Article
it SPECT/CT in Early Response Assessment of Patients with Metastatic Castration-Resistant Prostate Cancer Receiving 177Lu-PSMA-617 By jnm.snmjournals.org Published On :: 2024-11-07T04:28:32-08:00 Visual Abstract Full Article
it Feasibility of 177Lu-PSMA Administration as Outpatient Procedure for Prostate Cancer By jnm.snmjournals.org Published On :: 2024-11-07T04:28:31-08:00 Full Article
it SophosAI team presents three papers on AI applied to cybersecurity at CAMLIS By news.sophos.com Published On :: Wed, 23 Oct 2024 15:02:39 +0000 On October 24 and 25, SophosAI presents ideas on how to use models large and small—and defend against malignant ones. Full Article AI Research AI Trojans anti-phishing CAMLIS featured Google LLM small model machine learning
it Digital Detritus: The engine of Pacific Rim and a call to the industry for action By news.sophos.com Published On :: Thu, 31 Oct 2024 12:34:51 +0000 Decades of obsolete and unpatched hardware and software endanger us all Full Article Security Operations digital detritus featured Pacific Rim Pacific Rim thought leadership Sophos X-Ops
it Pacific Rim: Learning to eat soup with a knife By news.sophos.com Published On :: Thu, 31 Oct 2024 12:36:53 +0000 What our incident responders know from five years of fighting an octopus Full Article Security Operations Pacific Rim Pacific Rim Defense PSIRT Sophos X-Ops
it Pacific Rim: What’s it to you? By news.sophos.com Published On :: Thu, 31 Oct 2024 12:38:52 +0000 Thirty-five years after the first great cat-and-mouse infosecurity story, here we are again Full Article Security Operations Pacific Rim Pacific Rim thought leadership Sophos X-Ops
it VEEAM exploit seen used again with a new ransomware: “Frag” By news.sophos.com Published On :: Fri, 08 Nov 2024 17:10:12 +0000 Last month, Sophos X-Ops reported several MDR cases where threat actors exploited a vulnerability in Veeam backup servers. We continue to track the activities of this threat cluster, which recently included deployment of a new ransomware. The vulnerability, CVE-2024-40711, was used as part of a threat activity cluster we named STAC 5881. Attacks leveraged compromised […] Full Article Security Operations Threat Research crypto-ransomware junk gun Veeam VPNs
it Re: Scandal of “newborn gang” that put profits ahead of babies’ lives rocks Turkey’s health system By www.bmj.com Published On :: Tuesday, November 12, 2024 - 14:09 Full Article
it Re: Scandal of “newborn gang” that put profits ahead of babies’ lives rocks Turkey’s health system By www.bmj.com Published On :: Tuesday, November 12, 2024 - 14:09 Full Article
it Re: Scandal of “newborn gang” that put profits ahead of babies’ lives rocks Turkey’s health system By www.bmj.com Published On :: Tuesday, November 12, 2024 - 14:09 Full Article
it Re: Scandal of “newborn gang” that put profits ahead of babies’ lives rocks Turkey’s health system By www.bmj.com Published On :: Tuesday, November 12, 2024 - 14:09 Full Article
it Re: Decompression alone or with fusion for degenerative lumbar spondylolisthesis (Nordsten-DS): five year follow-up of a randomised, multicentre, non-inferiority trial By www.bmj.com Published On :: Tuesday, November 12, 2024 - 16:16 Full Article
it Citrus Vascular Proteomics Highlights the Role of Peroxidases and Serine Proteases during Huanglongbing Disease Progression By www.mcponline.org Published On :: 2020-12-01 Jessica Y. FrancoDec 1, 2020; 19:1936-1951Research Full Article
it Novel Proteomic Profiling of Epididymal Extracellular Vesicles in the Domestic Cat Reveals Proteins Related to Sequential Sperm Maturation with Differences Observed between Normospermic and Teratospermic Individuals By www.mcponline.org Published On :: 2020-12-01 Tricia RowlisonDec 1, 2020; 19:2090-2103Research Full Article
it High-throughput and site-specific N-glycosylation analysis of human alpha-1-acid glycoprotein offers a great potential for new biomarker discovery By www.mcponline.org Published On :: 2020-12-29 Toma KeserDec 29, 2020; 0:RA120.002433v1-mcp.RA120.002433Research Full Article
it Identification of novel serological autoantibodies in Takayasu arteritis patients using HuProt arrays By www.mcponline.org Published On :: 2020-12-17 Xiao-Ting WenDec 17, 2020; 0:RA120.002119v1-mcp.RA120.002119Research Full Article
it Interspecies differences in proteome turnover kinetics are correlated with lifespans and energetic demands By www.mcponline.org Published On :: 2020-12-28 Kyle SwovickDec 28, 2020; 0:RA120.002301v1-mcp.RA120.002301Research Full Article
it OpenPepXL: An Open-Source Tool for Sensitive Identification of Cross-Linked Peptides in XL-MS By www.mcponline.org Published On :: 2020-12-01 Eugen NetzDec 1, 2020; 19:2157-2167Technological Innovation and Resources Full Article
it Kinome Profiling of Primary Endometrial Tumors Using Multiplexed Inhibitor Beads and Mass Spectrometry Identifies SRPK1 as Candidate Therapeutic Target By www.mcponline.org Published On :: 2020-12-01 Alison M. KurimchakDec 1, 2020; 19:2068-2089Research Full Article
it The role of Data-Independent Acquisition for Glycoproteomics By www.mcponline.org Published On :: 2020-12-28 Zilu YeDec 28, 2020; 0:R120.002204v1-mcp.R120.002204Review Full Article
it Temporal Quantitative Proteomics of mGluR-induced Protein Translation and Phosphorylation in Neurons By www.mcponline.org Published On :: 2020-12-01 Charlotte A. G. H. van GelderDec 1, 2020; 19:1952-1967Research Full Article
it Systematic identification of P. falciparum sporozoite membrane protein interactions reveals an essential role for the p24 complex in host infection By www.mcponline.org Published On :: 2020-12-22 Julia KnöckelDec 22, 2020; 0:RA120.002432v1-mcp.RA120.002432Research Full Article
it Thyroglobulin interactome profiling defines altered proteostasis topology associated with thyroid dyshormonogenesis By www.mcponline.org Published On :: 2020-11-18 Madison T WrightNov 18, 2020; 0:RA120.002168v1-mcp.RA120.002168Research Full Article
it A potential role for the Gsdf-eEF1{alpha} complex in inhibiting germ cell proliferation: A protein-interaction analysis in medaka (Oryzias latipes) from a proteomics perspective By www.mcponline.org Published On :: 2020-12-08 Xinting ZhangDec 8, 2020; 0:RA120.002306v1-mcp.RA120.002306Research Full Article
it Quantitative proteomics reveal neuron projection development genes ARF4, KIF5B and RAB8A associated with Hirschsprung disease By www.mcponline.org Published On :: 2020-11-17 Qin ZhangNov 17, 2020; 0:RA120.002325v1-mcp.RA120.002325Research Full Article