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Cuproptosis in cancer therapy: mechanisms, therapeutic application and future prospects

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01877J, Review Article
Jiawei Hu, Junfei Zhu, Tao Chen, Yudie Zhao, Qingwen Xu, Yan Wang
Cuproptosis is a regulated form of cell death induced by the accumulation of metal ions and is closely linked to aspects of cellular drug resistance, cellular metabolism, and signalling pathways.
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Advancing cancer therapy with a heptamethine carbocyanine dye-conjugated radionuclide drug

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01798F, Paper
Mingxing Huang, Weichen Wang, Yingwei Wang, Rang Wang, Lili Pan, Xin Li, Bo Li, Jingsong Zhang, Ruoxiang Wang, Yi Zhang, Rong Tian
Malignant tumors pose substantial treatment challenges due to their heterogeneity, metastatic potential, and therapeutic resistance, underscoring the urgent need for more effective treatment options.
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Illuminating cisplatin-induced ferroptosis in non-small-cell lung cancer with biothiol-activatable fluorescent/photoacoustic bimodal probes

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01656D, Paper
Li Xu, Hongwen Liu, Yi Kong, Lingyun Li, Jia Li, Kang Li, Shuzhi Liang, Bolin Chen
Using activatable NIR fluorescent/PA bimodal probes, we successfully monitored real-time biothiol changes during ferroptosis in NSCLC cells and tumors, revealing enhanced ferroptosis with the combined use of erastin and cisplatin.
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Bimetallic doped carbon dot nanozymes for enhanced sonodynamic and nanocatalytic therapy

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB01916D, Paper
Yandong Huang, Lanting Jia, Shiqi Zhang, Lan Yan, Lei Li
The conventional inorganic semiconductors are not suitable for acting as nanozymes or sonosensitizers for in vivo therapeutic nanomedicine owing to the lack of excellent biocompatibility. Biocompatible carbon dots (CDs) exhibit...
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Recent Advances in Polymer-based Thin-film Electrode for ECoG Applications

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB02090A, Review Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Zhengchen Xiang, Liangtao Yang, Bin Yu, Qi Zeng, Tao Huang, Shuo Shi, Hao Yu, Yi Zhang, Jinglong Wu, Meifang Zhu
Electrocorticography (ECoG) has garnered widespread attention due to its superior signal resolution compared to conventional electroencephalogram (EEG). While ECoG signal acquisition entails invasiveness, the invasive rigid electrode inevitably inflicts damage...
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Micah Parsons insists he wasn't throwing "Mike McCarthy under the bus" with postgame comments

Cowboys edge rusher Micah Parsons pushed back against the perception he was taking a shot at coach Mike McCarthy in his postgame comments Sunday.









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Bigg Boss 11: 'It's important for Hina to maintain her calm'

'If you have worked hard for so many years, you don't have to get validation from these people, right? Believe in yourself and your work, that's it. The celebrities in the house are well known and they shouldn't care about what other people say.' Lopamudra Raut gives Bigg Boss 11 contestants sound advice.







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Bigg Boss 11: 'I can't believe I am evicted!'

'Arshi never crossed her boundary.''Initially, Akash was entertaining but slowly, he's become irritating because he changes groups without being loyal to anyone.' Hiten Tejwani discusses the contestants on Bigg Boss 11, and reserves the worst for Hina Khan.







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After Bigg Boss, it's now Cabaret for Sreesanth

'It's almost more than 6 years now that I lost my love and passion, which is cricket.''So it is high time that I make a bright career this year in the entertainment industry.'




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'We can't say TV is regressive'

'The content on television is directly proportional to what the audience likes.'





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'Can you imagine dancing with Madhuri Dixit?'

Madhuri Dixit, Karan Johar and Nora Fatehi will judge Jhalak Dikhhla Jaa.




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'I am very scared to be in Bigg Boss'

'It takes a lot of courage to be in that house. It's entertaining for some and horrifying for others.'




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Bigg Boss 16: Shalin-Nimrat Fight For Captaincy

While Nimrat Kaur Ahluwalia retains her captaincy, Gori Nagori wins the entertainment task.




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Can Ankit Gupta Win Bigg Boss 16?

'Even if I last in the house for a few weeks/months, it would be great as I am somebody who doesn't like to be with too many people. If I achieve that, it will be a trophy for me.'




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Bigg Boss 16: Meet the New Captain

Monday's episode was full of drama and fights but still, some adorable moments thanks to Abdu Roziq's antics.




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BB16: Sumbul Wants To Become Captain

Now that there's a new captain, will we see new alliances in Bigg Boss 16?




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The Strange Case Of Abdu Rozik

Bigg Boss 16 has turned out to be quite different from its previous seasons.




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Bigg Boss: 'I am glad I came out'

'I am lucky I didn't spoil anybody's dream.'




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'Why don't you call Salman a TV actor?'

'Salman is on television for the last 15 years.''Why don't you call Amitabh Bachchan a TV actor? He's been doing Kaun Banega Crorepati for 20 years.'





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Bigg Boss 10's Sapna Choudhary At Cannes

'It's been a long journey full of sweat, sacrifice, and determination, but it's all worth it.'




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'You can't prepare to jump off a building'

'We are getting a show to do stuff like jumping off a helicopter.''Even if you pay, you won't get to do these things.'




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'I get so many calls I get irritated'

'Be it politicians, actors or from any other walk of life, I get calls from everyone saying that Bigg Boss is a great platform for their career and they would love to be a part of the show.'




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Sunny-Bobby's Revelation: The Men They Called For Help

From talking about their highs and lows to discussing their father Dharmendra's much-talked-about kiss in KJo's Rocky Aur Rani Kii Prem Kahaani, the Deol brothers were a laugh riot on the show.




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Palliative care in demand

The sector is emerging as a viable option for students looking for careers in healthcare.




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Bharat Biotech releases Covaxin Phase-3 trial data, claims 77.8% efficacy

Vaccine also offers 65% protection against Delta variant, according to firm




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97 national awardee teachers for 2020 and 2021 write to President, PM to honour them in physical ceremony on September 5

All these teachers had received the award in a virtual event due to the COVID-19 restrictions. Of them, 47 teachers had received the award in 2020 and the rest in 2021




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At K Sureshkumar’s pedagogical laboratory in Thiruvananthapuram students understand basic concepts of Physics by doing experiments on their own

National award-winning science teacher K Sureshkumar’s pedagogical laboratory in Thiruvananthapuram enables students of high school to conduct experiments in Physics and learn the concepts themselves



  • Life & Style

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The Hindu EducationPlus International Education Fair in Bengaluru




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The Hindu International Education Fair opens with huge response

Hundreds of students and parents visited the stalls and interacted with colleges, universities, consulates, and agencies from across the globe, and got information about overseas education




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Metallica, U2 and albums that built a band

The one watershed album that spurred bands to stardom and changed their fortunes forever




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The curious case of the bullish stock markets in the pandemic

The relationship between growing inequality and booming asset markets has never been this stark




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Sulli deals: Women caught in the tentacles of the dark Web

Doxxing, or sharing a woman’s picture online without her consent, is a crime that has proliferated during the pandemic — chillingly, against one particular community




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‘You go to meet the prime minister and all you can talk about is my bluddy swimming pool?’

When prime minister Rajiv Gandhi was lectured on free market economics, and cornered about the luxury addition in Satish Sharma’s farmhouse




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Worried about post-Olympics blues? These podcasts promise to keep the flame alive

Inspired by the Tokyo Olympics, here is a round-up of podcasts that celebrate sports and those who devote their lives to the pursuit of sporting greatness




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Radioactive — How Ushaben’s broadcasts transmitted the message of freedom

The spirited 22-year-old woman, who earned the sobriquet Radioben, was an integral part of the underground radio service during the Quit India movement




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Turning the lens on the most iconic camera made in India

A nostalgic look at the vintage Vageeswari camera invented in Alappuzha — back in focus as it is spotlighted at the ongoing Lokame Tharavadu art event




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Around the world in savoury cakes

From cauliflower cakes, sushi cakes to prawn cakes, international and regional cuisines have a range of delicious salty bakes