Stage III nonsmall cell lung cancer (NSCLC) represents a wide range of tumour (T1 to T4) and nodal (N0 to N3) components, requiring variable management and a multidisciplinary approach. Recent advancements in minimally invasive techniques, molecular biology and novel drug discoveries have accelerated the refinement of stage III NSCLC management. The latest developments in staging include the forthcoming update of the nodal component in the 9th TNM (tumour–node–metastasis) edition, which emphasises the critical role for endobronchial ultrasonography in mediastinal staging. Recent treatment developments include the use of immunotherapy and targeted molecular therapy in both the neoadjuvant and adjuvant setting, either in combination with other modalities or used alone as consolidation. Surgical and radiotherapy advancements have further enhanced patient outcomes. These developments have significantly improved the prognosis for patients with stage III NSCLC. Fast-changing recommendations have also brought about a challenge, with clinicians facing a number of options to choose from. Therefore, a multimodal approach by a multidisciplinary team has become even more crucial in managing stage III NSCLC.

Central sleep apnoea (CSA) is characterised by recurrent episodes of airway cessation or reduction in the absence of respiratory effort. Although CSA is less common than obstructive sleep apnoea, it shares similar symptoms. CSA can be secondary to various medical conditions, high altitude and medication exposure. CSA can also emerge during obstructive sleep apnoea therapy. There are a range of treatment options and selecting the right therapy requires an understanding of the pathophysiology of CSA. This review explores the aetiology, pathophysiology and clinical management of non-hypercapnic CSA.

Chronic pulmonary aspergillosis has a range of manifestations from indolent nodules to semi-invasive infection. Patients may be asymptomatic or have chronic symptoms such as cough and weight loss or present with life-threatening haemoptysis. The physician can choose from a range of available therapies including medical therapy with antifungals, minimally invasive therapy with intracavitary antifungal therapy and surgery involving open thoracotomy or video-assisted thoracoscopic surgery. The patients with the most severe forms of pulmonary infection may not be surgical candidates due to their underlying pulmonary condition. The management of haemoptysis can include tranexamic acid, bronchial artery embolisation, antifungals or surgery. There are few controlled studies to inform clinicians managing complex cases, so a multidisciplinary approach may be helpful.

The respiratory literature, both written and in online formats, is growing exponentially. Capturing quality content, to meet the learning needs of those working in all fields of respiratory medicine and delivering it in a palatable, accessible format is challenging but paramount. In this article we discuss ways to determine the information content and review different methods of delivering this content to those who need it.

Palliative care pertains to the holistic multidimensional concept of "patient-centred" care. It is an interprofessional specialty, primarily aiming to improve quality of care for cancer patients and their families, from the time of diagnosis of malignant disease, over the continuum of cancer care, and extending after the patient's death to the period of bereavement to support the patient's family. There are various complex and frequently unmet needs of lung cancer patients and their families/caregivers, not only physical but also psychological, social, spiritual and cultural. Systematic monitoring of patients’ symptoms using validated questionnaires and patient-reported outcomes (PROs), on a regular basis, is highly encouraged and recommended in recent guidelines on the role of PRO measures in the continuum of cancer clinical care. It improves patient–physician communication, physician awareness of symptoms, symptom control, patient satisfaction, health-related quality of life and cost-effectiveness. This implies that all treating physicians should improve their skills in communication with lung cancer patients/relatives and become more familiar with this multidimensional assessment, repeatedly screening patients for palliative care needs. Therefore, they should receive education and training to develop palliative care knowledge, skills and attitudes. This review is dedicated to lung cancer palliative care essentials that should be within the competences of treating physicians, i.e. pneumologists/thoracic oncologists.

Imaging methods are fundamental tools to detect and diagnose lung diseases, monitor their treatment and detect possible complications. Each modality, starting from classical chest radiographs and computed tomography, as well as the ever more popular and easily available thoracic ultrasound, magnetic resonance imaging and nuclear medicine methods, and new techniques such as photon counting computed tomography, radiomics and application of artificial intelligence, has its strong and weak points, which we should be familiar with to properly choose between the methods and interpret their results. In this review, we present the indications, strengths and main limitations of methods for chest imaging.

New research shows that levels of overall and heavy drinking among Americans are still higher than they were in 2018.

The two robots, working alone and far apart from one another, are struggling on their respective treks along the Red Planet's rough terrain.

The leak caught national intelligence officials by surprise and led to an embarrassing Air Force Inspector General investigation.

The head of one of the world's largest oil companies has had it with government flip-flopping.

Netflix's mega-violent mega-hit series returns December 26.

It will likely release in 2026 and feature Apple Intelligence, according to a reliable analyst.

Video game workers face challenges from employers in their efforts to unionize in Canada.

The post Dual boss battle: video game workers face-off multiple employers at once appeared first on rabble.ca.

Watch President Donald Trump and the Greek prime minister’s joint news conference in the player above.

WASHINGTON — President Donald Trump says the U.S. stands with Greece as they recover from their economic crisis. He is speaking with Prime Minister Alexis Tsipras at the White House in a joint news conference.

The U.S. president says the two leaders have discussed defense, energy, commerce and trade.

Trump is praising Greece for its defense spending under NATO and is noting a potential sale to Greece to upgrade its F-16 aircraft, which he says would be worth up to $2.4 billion and generate thousands of U.S. jobs.

Tsipras says his country has made economic strides and is “leaving behind the economic model that led to the crisis.” He says Greece’s relationship with the U.S. is “more important than ever.”

The post WATCH: Trump and Greek prime minister hold joint news conference appeared first on PBS NewsHour.

Andrey Bogut’s knee injury has potentially sidelined him for the NBA playoffs and casts doubt on his role for the Boomers.

Two thirds of Celtic fans believe the club should have an independently elected Fan Advisory Board according to new research from the University of Glasgow.

Human rights campaigners are calling on SNP ministers to do all they can to “mitigate” Prevent, the UK Government's controversial anti-terror strategy.

"I look forward to any contest, where of course it will be for branch members to select those they wish to represent them in Holyrood in the 2026 Scottish Parliament elections.”

Sir Keir Starmer's beleaguered former chief of staff will no longer take up the position of “envoy to the nations and regions.”

Stephen Flynn has been criticised by SNP colleagues after saying he would stay on at Westminster, even if elected to Holyrood.

Ministers must follow the UK Government and extend rates relief for businesses in Scotland, Anas Sarwar has said.

As parts of Spain are on alert for new flood warnings, Dominic Hinde meets the volunteers still involved in the aftermath and recovery following the initial disaster

A former aid to Tony Blair has been criticised by the SNP after he said the Government "should do farmers what Thatcher did to the miners".

International numbers are on the up but not everything in tourism is rosy

Two runners saved by the same public defibrillator appeal for all the life-saving devices to be publicly available. Tens of thousands of defibs are unregistered so ‘invisible’ in an emergency.

The flats are described as the first new homes on the Scottish town's High Street 'in living memory'

Scotland was second out of 12 UK nations and regions on one key measure

A rural housing project branded as ‘truly transformative’ has been completed

The SNP's Westminster leader has announced he is to contest a seat at Holyrood – and will ‘double-job’ as an MP and MSP if he wins.

A rail service linking Scotland, Wales and England with one train journey is to start running for the first time. 

The technology will deliver enhanced day-to-day and major incident response capability

Scottish investment giant abrdn has sold its Focus Solutions software business and is said to be eyeing other potential disposals

A baroque fiddle believed to have been played by Robert Burns will be performed live on stage in the United States for the first time.

It’s a slightly more potty mouthed cast than usual, as Alice joins Peter, Kelley, Anna Marie and Chris to discuss what the cast has been playing for the week. Anna Marie’s 5-hour rule resurfaces and we explore what crazy black holes Chris has been down this week, alongside the news and your feedback.

The post RPG Cast – Episode 543: “Go Find Gnome, Dumb***” appeared first on RPGamer.

Things are looking grim: we get thrown out cars, assassinated for our kingdoms, drowned underwater, and struck out. If you’re scratching your head, don’t worry! Everything will make sense once you listen to this week’s podcast.

The post RPG Cast – Episode 544: “You Will NOT Bucket Shame Me” appeared first on RPGamer.

With many media events getting pushed back, the news is a little trim this week. But we still manage to pull together our basket of zany personalities for a podcast we hope brings a smile to your face.

The post RPG Cast – Episode 545: “Did You Infect My Game With Harvest Moon?” appeared first on RPGamer.

New Game Plus Expo comprises the bulk of this week’s news, while the crew ponders their love and hate for Phantasy Star Online 2. Just what has Anna Marie been playing the last two weeks? You’ll have to listen to the episode to find out!

The post RPG Cast – Episode 548: “Do Not Karen on Me” appeared first on RPGamer.

The last two weeks have had an interesting mix of news, and it just might break Chris by the end of the show. Anna Marie is hijacking the Question of the Week, but it's definitely a unique question! Alex stealths his way into the cast alongside Kelley and Peter. How is it still only July?

The post RPG Cast – Episode 550: “Gamer Girl Glue” appeared first on RPGamer.

Jonathan Stringer joins this week and helps Major Tomcat recruit Kelley and Chris for a PC RPG. Chris will likely just hack the planet instead. Kelley, meanwhile, will tend to her cat's bad habits.

The post RPG Cast – Episode 554: “Cat Smoker Meow” appeared first on RPGamer.

This week we finally figure out if Dark Souls ripped off Breath of the Wild. We also get really worked up over Bethesda. When is Game Pass coming to PS5, again?

The post RPG Cast – Episode 557: “PS5 Crunchwrap Supreme!” appeared first on RPGamer.

We're rounding up two weeks of news with Robert, Kelley, Jonathan, Chris, and Anna Marie. Everything is delayed, so in response everything else is...also delayed...? Can we just cancel the rest of 2020 and skip right to next year, please?

The post RPG Cast – Episode 561: “Pour Some Syrup on Me” appeared first on RPGamer.

It's Extra Life 2020. Chris is dying in Hades. Anna Marie thinks orange is pretty sus. Kelley can't let go of Laharl. Josh is back on the Trails. And Alex is outta here to pursue his new racing career.

The post RPG Cast – Episode 562: “Don’t Disgaea Shame Me” appeared first on RPGamer.

From beefcakes to thirsty NPCs, we cover the gamut of the most important awards of the year. Wheels finally gets his due. And everyone comes to terms with their feelings about visual novels.

The post RPG Cast – Episode 573: “Game of the Year 2020” appeared first on RPGamer.

It's another explicit week, as Sam calls Chris poopy. Anna Marie can't understand Dutch (even though she likes to think she does), while Pascal imagines he's eating a sausage. Josh is slowly falling under the spell of Mass Effect Stockholm Syndrome, and somehow Chris is equally obsessed with shoes, jeggings, and dead Google products. Save us.

The post RPG Cast – Episode 581: “Love Me, I Himbo” appeared first on RPGamer.

Chris snuggles his Teddy body pillow. Kelley signs up for rare Pokémon. Josh sacrifices children (what?!). Meanwhile Anna Marie is off celebrating her birthday by spreading the hork.

The post RPG Cast – Episode 593: “Banished to the Prince Dimension” appeared first on RPGamer.

Kelley watches DVDs like a caveman. Josh chews on all the expensive things. Meanwhile, Chris stands by some barrels.

The post RPG Cast – Episode 609: “Throwing Corpses at the Door Till You Let Me In” appeared first on RPGamer.

Kelley graduates from Canada. Josh discovers Tactics Advance is an isekai. Meanwhile Chris calculates the skill check for suplexing a train.

The post RPG Cast – Episode 619: “That One Time I Got Reincarnated as a Canadian Yankee in King Arthur’s Court” appeared first on RPGamer.

Anna gets her tentacle on, but doesn't notice any performance issues. Chris learns what a wheelbarrow is while putting his sink on the ceiling. And Kelley covers Vahn with cats and steals the unexpected Dragon Age: Inquisition!

The post RPG Cast – Episode 634: “That Bea Arthur Wig Gives Me a +5 to Int” appeared first on RPGamer.

Phil wonders if you can pet the gator. Jason says that the wiener dog in a wheelchair is best companion. Kelley wishes there was CTRL+F in real life. Ryan wants a Trails of Cold Steel Wrestling Game.

The post RPG Cast – Episode 679: “Some People Call Me Toe Fungus” appeared first on RPGamer.

Chris suffers from "The Curse of the Steam Deck." Kelley can't pickpocket, so she mugs people at night. And Ryan likes practical grave robbers. Curl up in your clothmap quilt and enjoy our cozy '60s demon world.

The post RPG Cast – Episode 681: “Ganon Is Afraid of Homemade Apple Pie” appeared first on RPGamer.