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PIX: Messi's Miami stunned by Atlanta in MLS play-offs

Miami were overwhelming favourites to win it all after producing a league record 74 points in the regular season but could not keep the momentum after Matias Rojas' close-range goal in the 17th minute and Messi's score in the 65th minute.




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EPL PIX: United thrash Leicester; Ipswich stun Spurs

IMAGES from the English Premier League matches played on Sunday.




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13/13:01 EDT Severe Thunderstorm Warning for parts of East Gippsland Forecast District.




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Digital transformation solutions player UST named Workday services deployment partner 

UST will leverage its cross-platform SaaS expertise, Generative AI thought leadership, industry solutions, and automation tools to enable customers get the most from their Workday experience




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CMS Info Systems reports 8% increase in consolidated net profit at ₹91 crore

The company said slower consumption, elections and intense rains in the first half (H1) of FY25, which impacted realisations




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Bharti Airtel Q2 preview: Consolidated net profit expected to grow multifold

According to analysts, industry-leading ARPU and support from other businesses bode well for Airtel’s revenue growth during the quarter




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Airtel’s new MD & CEO has spearheaded multiple innovations




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Cognizant reports 22% profit jump in Q3, bolstered by health sciences and financial services growth

Revenue also increased by 3% year-on-year, totalling $5 billion




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The rise of digital arrest scams: What you need to know

Cybercriminals generally initiate contact through phone calls or emails sometimes. One or two audio calls will be followed by a video call from multiple locations – from an ‘airport’, from the police station, or even from a court




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HCLTech to launch AI Lab in Singapore, partners with EDB 

HCLTech has maintained a presence in Singapore for over 40 years, serving as its Southeast Asian operations hub




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IT/ITEeS demand for hybrid work model continuation in SEZs beyond Dec 31 being considered: Govt sources

Some units want long-term flexibility but government only open to only periodic extension




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Centre writes to Wikipedia over complaints of inaccuracies, biases

Sources said the Information and Broadcasting ministry has sent a notice to Wikipedia regarding complaints that it has received about alleged inaccuracies and bias of information on the site




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Indian IT industry confident amid potential Trump return, sees reduced H1B visa dependency

 The U.S. remains the largest market for India’s IT exports, contributing 55% of its $200 billion in IT-BPM exports.




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Satcom spectrum: TRAI sidestepped level field issue with terrestrial services, says Justice Nageswara Rao

His legal opinion, requested by Reliance Jio, highlights TRAI’s failure to invite stakeholder comments on the important issue of creating a level playing field between terrestrial access services and satellite communication networks




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AI startup Pulse raises $1.4 million in seed round




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With Trump win, DoT gears up to sort out issues related to Elon Musk’s Starlink

The department of telecommunications is looking into security aspects while considering the demands made by two American companies — Starlink and Amazon (project Kuiper), say sources




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This is naked greed, nothing less: Zoho’s Sridhar Vembu on Freshworks layoff

‘This is why choose to remain private. We put our customers and employees first. Shareholders should come last,’ Vembu




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Zuckerberg not personally liable in lawsuits over social media harm to children

A US District Judge rejected accusations that Zuckerberg directed Meta's efforts to conceal from children the serious mental health risks of using Facebook and Instagram




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AppLovin CEO once spurned by VC firms now worth $11 billion

Shares of Palo Alto, California-based AppLovin have surged seven-fold this year, giving co-founder Adam Foroughi a net worth of $10.9 billion




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Make a pledge

Priyal Jain and Prateek Mahesh have just made it easier for you to make a difference. Check out their new app.




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Dream realised

One man decided to do something different. He travelled, studied the needs of people and finally set down roots to create a self-sufficient village and create abundance.




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Bird brained

YW storyteller contest: We were flooded with stories for the YW Storyteller contest announced on June 24. Here are some of the entries that almost made it… Congratulations!




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Well-dressed notes

What if I told you that a musical note is technically a chord? Well, I’m partially right.




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The eagle has landed

On July 19, 1969, three astronauts, and the entire globe, celebrated the giant leap for mankind as they set foot on the Moon.




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Deconstructive annulation mediated one-pot synthesis of xanthene derivatives

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00093E, Paper
Balasubramaniyam Manikandan, Subbiah Thamotharan, Olivier Blacque, Subramaniapillai Selva Ganesan
One-pot, two-step methodology utilized for the sequential C–O/C–N cleavage followed by intramolecular/intermolecular annulation reaction.
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Synthesis of 3,5-disubstituted isoxazoles by domino reductive Nef reaction/cyclization of β-nitroenones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00232F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Muhammad Ehtisham Ibraheem Khan, Tomas Lighuen Cassini, Marino Petrini, Alessandro Palmieri
β-Nitroenones were converted into 3,5-disubstituted isoxazoles via a domino reaction promoted by tin(II) dichloride. The protocol efficiently works under both microwave and flow conditions.
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Siloxane-containing phosphine (oxide) ligands for enhanced catalytic activity of cobalt complexes for hydrosilylation reactions

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00333K, Paper
Peng Liu, Jiajian Peng, Ying Bai, Jiayun Li
A series of siloxane-containing phosphine (oxide) ligands have been designed and synthesized.
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Click synthesis of dendronized malonates for the preparation of amphiphilic dendro[60]fullerenes

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D3OB01986A, Paper
Carlos Cruz-Hernández, Perla Y. López-Camacho, Gustavo Basurto-Islas, Aaron Rojas, Patricia Guadarrama, Melchor Martínez-Herrera
Click chemistry is a valuable methodology for obtaining dendronized malonate derivatives to derivatize C60 using the Bingel–Hirsch reaction.
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BODIPY(aryl)iodonium salts in the efficient synthesis of diversely functionalized BODIPYs and selective detection of serum albumin

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00336E, Paper
Open Access
Bintu Kumar, Anindita Bhatta, Prakriti Saraf, Taur Prakash Pandurang, Krishnan Rangan, Madhushree Sarkar, Sivaprasad Mitra, Dalip Kumar
Using readily available BODIPY and iodoarenes various BODIPY(aryl)iodonium salts were prepared and successfully utilized for the direct syntheses of functionalized BODIPYs, bis-BODIPYs and for the selective detection of serum protein.
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A water mediated multicomponent reaction for the synthesis of novel spirooxindole derivatives and their antifungal activity

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00256C, Paper
Min Zhang, Liang Shi, Li Chen, Zhengyu Liu, Ting Zhao, Chunyin Zhu, Liuqing Yang
A total of 27 novel spirooxindoles were synthesized through a water mediated three-component reaction of isatin, 4-aminocoumarin, and 1,3-cyclodicarbonyl compounds. Several compounds showed excellent antifungal activity against Physalospora piricola.
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New 2-pyridone-based donor–acceptor dyes: the effect of the donor group position, type of π-linker and acid–base characteristics of the medium on the photophysical properties

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00177J, Paper
Saveliy P. Sorokin, Mikhail Yu. Ievlev, Oleg V. Ershov
Synthesis of a series of new donor–acceptor dyes based on 2-pyridone and the study of the effect of the position of the donor group, the type of π-linker and the acid–base characteristics of the medium on their photophysical properties.
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Dehydrative alkynylation of 3-hydroxyisoindolinones with terminal alkynes for the synthesis of 3-alkynylated 3,3-disubstituted isoindolinones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00190G, Paper
Kai-Cheng Yang, Shi-Lu Zheng, Zhong Wen, Yu-Shan Zhang, Hai-Liang Ni, Long Chen
A HOTf or Fe(OTf)3-catalyzed dehydrative alkynylation of 3-hydroxyisoindolinones with terminal alkynes was developed, which represents a brand-new procedure for the synthesis of 3-alkynylated 3,3-disubstituted isoindolinones.
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Diastereoselective synthesis of functionalized spiroindolines via intramolecular ipso-iodocyclization/nucleophile addition cascade reactions of indole-tethered ynones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00112E, Paper
Debojyoti Bag, Sanghapal D. Sawant
Herein, we describe a highly diastereoselective approach for synthesizing polyfunctionalized spiroindolines from indolyl-ynones involving an ipso-iodocyclization/nucleophile addition cascade.
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Kinetic resolution of 1,1'-binaphthyl-2,2'-diamine derivatives by chiral calcium phosphate-catalyzed acylation

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00355A, Paper
Tatsuhiro Uchikura, Yuki Kanno, Yukino Fukuda, Mikoto Sato, Takahiko Akiyama
Chiral calcium phosphate-catalyzed kinetic resolution of BINAM derivatives.
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Copper catalyzed dehydrogenative cyclization, alkenylation towards dihydroquinolinones

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00134F, Paper
Pari Keerthana, Fazlur-Rahman Nawaz Khan
An efficient copper-catalysized one-pot sequential synthesis of alkenylated quinolinyldihydroquinolinones is reported utilizing ketones, 1,3-cyclohexanediones, and benzyl alcohols via dehydrogenative cyclisation, followed by alkenylation. This highly straightforward method provides a mild...
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On the mechanism of carboxylate elimination from carbohydrate monoester-derived radicals

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00241E, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Julia A. Turner, Hendrik Zipse, Mark S. Taylor
Computational analysis of the HAT-induced expulsion of carboxylic acids from monoacylated pyranosides implicates concerted elimination through a hydrogen-bonded transition state.
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Selective recognition between aromatics and aliphatics by cage-shaped borates supported by a machine learning approach

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00408F, Paper
Open Access
Yuya Tsutsui, Issei Yanaka, Kazuhiro Takeda, Masaru Kondo, Shinobu Takizawa, Ryosuke Kojima, Akihito Konishi, Makoto Yasuda
Exploration of a Lewis acid with high selectivity for hydrocarbon moieties is assisted by a machine learning approach. Molecular polarizability is an essential factor, leading to design guidelines for Lewis acid catalysts with dispersion forces.
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An efficient synthesis of mono-, di-, and tri-substituted 1,3-thiazoles employing functionalized thioamides as thiocarbonyl precursors

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00229F, Paper
Kalleshappa Sheela, Chikkappaiahnayaka Santhosh, Krishna Ravi Singh, Kalleshappa Sharath, Maralinganadoddi P. Sadashiva
Herein, we report an efficient strategy to synthesize functionalized 1,3-thiazoles using alkyl 2-amino-2-thioxoacetates.
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A rhodium-catalyzed cascade C–H activation/annulation strategy for the expeditious assembly of pyrrolidinedione-fused 1,2-benzothiazines

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00193A, Paper
Yinsong Wu, Guanghao Shi, Yanan Liu, Yangzilin Kong, Mengdi Wu, Demao Wang, Xiaobing Wu, Yongjia Shang, Xinwei He
We have developed a cascade annulation strategy triggered by rhodium(III)-catalyzed C–H activation for the expeditious assembly of pyrrolidinedione-fused 1,2-benzothiazines from free NH-sulfoximines with maleimides under mild conditions.
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Generation of sulfones utilizing β-sulfinyl esters as masked aryl sulfinates under redox-neutral conditions

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00238E, Communication
Yixin Zhang, Zhu Yang, Hongjun Yang, Xuefeng Li, Lu Yang
A method for generation of SVI sulfones from β-sulfinyl esters (SIV) under transition-metal-free non-oxidative mild conditions is presented.
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Correction: Recent progress of core-substituted naphthalenediimides: highlights from 2010

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB90045F, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Sheshanath V. Bhosale, Sidhanath V. Bhosale, Suresh K. Bhargava
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Photoinduced decatungstate-catalyzed C(sp3)–H thioetherification by sulfinate salts

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00394B, Paper
Pengcheng Li, Jia-Lin Tu, Ao-Men Hu, Lin Guo, Chao Yang, Wujiong Xia
A visible light photoinduced decatungstate-catalyzed C(sp3)–H thioetherification of hydrocarbons by sodium sulfite is herein reported.
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HFIP-mediated C-3-alkylation of indoles and synthesis of indolo[2,3-b]quinolines & related natural products

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00414K, Paper
Auqib Rashid, Waseem I. Lone, Preeti Dogra, Showkat Rashid, Bilal A. Bhat
An expeditious metal free C-3 alkylation of indoles and its NIS-mediated deviation to indolo[2,3-b]quinolines is reported. Applications of these strategies in accessing bioactive natural products have also been demonstrated.
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A copper-catalyzed asymmetric Friedel–Crafts hydroxyalkylation of pyrazole-4,5-diones with 5-aminoisoxazoles

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00322E, Communication
Siyu Gao, Xiang Sun, Sijie Peng, Zhenggen Zha, Qi Sun, Zhiyong Wang
An asymmetric Friede-Crafts hydroxyalkylation reaction was developed under the catalysis of chiral copper complexes. A variety of pyrazolone derivatives were obtained with excellent yields and enantioselectivities.
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Copper-catalyzed ortho-thiocyanation of aromatic amines

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00137K, Communication
Monak Patel, Nitish Kumar, Hussain Bhukya, Bharatkumar Z. Dholakiya, Togati Naveen
Here, we described an efficient ortho- C(sp2)-H thiocyanation of anilines for the synthesis of aryl thiocyanates. This protocol tolerates a variety of aromatic amines to provide the desired products in good to excellent yields.
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Chemoenzymatic total synthesis of rotigotine via IRED-catalyzed reductive amination

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00072B, Communication
Dongyu Tang, Yaqing Ma, Jinping Bao, Shushan Gao, Shuli Man, Chengsen Cui
An engineered imine reductase (IRED) was developed specifically for 2-tetralone substrate, and utilized in the total synthesis of rotigotine.
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Rh(III)-catalysed C-H annulation of cis-stilbene acids with 2-diazo-1,3-diketones: A facile access to 6,7-dihydrobenzofuran-4(5H)-one and α-pyrone scaffolds

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00151F, Paper
Shankaraiah Nagula, Mary Sravani Galla, Nandini B. Kale, Akshay Kumawat, Darshana Bora
An efficient Rh(III)-catalysed C-H functionalization, tandem annulation of cis-stilbene acids using 2-diazo-1,3-diketones was devised. The protocol has solely afforded 6,7-dihydrobenzofuran-4(5H)-ones using alicyclic diazocarbonyls via decarbonylation and α-pyrones with aliphatic diazo...
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The synthesis of alk-2-ynl Weinreb amides via Pd/Cu-catalysed oxidative carbonylation of terminal alkynes

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00290C, Paper
Bharati Mourya, Sandip T. Gadge, Bhalchandra M. Bhanage
Synthesis of alk-2-ynl-Weinreb amides via Pd-catalyzed oxidative carbonylation of terminal alkynes and N,O-dimethylhydroxylamine hydrochloride at room temperature under low CO/O2 pressure is reported for the first time.
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DMSO promoted catalyst-free oxidative C–N/C–O couplings towards synthesis of imidazoles and oxazoles

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00383G, Paper
Debasish Bera, Rajib Sarkar, Tiyasa Dhar, Pinaki Saha, Prasanta Ghosh, Chhanda Mukhopadhyay
Dimethyl sulfoxide (DMSO)-promoted catalyst-free oxidative C–N coupling and C–O coupling under oxidant-free conditions are outlined.
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Synthesis of Asp-based lactam cyclic peptides using an amide-bonded diaminodiacid to prevent aspartimide formation

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00472H, Communication
Wen-Jie Li, Jun-You Chen, Hui-Xia Zhu, Yi-Ming Li, Yang Xu
A diaminodiacid (DADA) containing an amide bond can be used in Fmoc solid-phase peptide synthesis (SPPS) of an Asp-based lactam cyclic peptide with no aspartimide formation.
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