el

A non-equivalent Ni doped La-MOF for enhanced photocatalytic CO2 reduction through oxygen vacancy regulation and electronic structure optimization

Inorg. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QI02143F, Research Article
Tongzheng Zhang, Zhaohui Huang, Guanshun Xie, Le Liao, Changqiang Yu, Xiuqiang Xie, Nan Zhang
La/Ni-MOF with oxygen vacancies and regulated electronic structures is prepared and exhibits enhanced visible-light photocatalytic activity for CO2-to-CO conversion.
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Enhancing CO2 electroreduction with decamethylcucurbit[5]uril-alkaline earth metal modified Pd nanoparticles

Inorg. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QI02135E, Research Article
Tao Shao, Xianmeng Song, Zongnan Wei, Shuaibing Yang, Siying Zhang, Rong Cao, Minna Cao
Pd NP modification with Me10CB[5]–M capsules boosted CO2RR by enhancing CO2 adsorption, tuning Pd's electronic structure, and optimizing *COOH/*CO binding.
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A moss-like CoB/CeO2 heterojunction as an efficient electrocatalyst for the oxygen evolution reaction under alkaline conditions

Inorg. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QI02325K, Research Article
Weijie Fang, Chaofan Liu, Jiang Wu, Weikai Fan, Le Chen, Zaiguo Fu, Lin Peng, Ping He, Jia Lin, Zhongwei Chen
The moss-like amorphous CoB/crystalline CeO2 heterojunction nanosheets synthesized in this study have excellent OER activity and stability.
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Multistage construction of Gd-doped g-C3N4/Mo15S19 composites enabled both N2 activation and multiple electron transfer for an enhanced photocatalytic nitrogen reduction reaction

Inorg. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QI02016B, Research Article
Xiaoyu Jiang, Boran Tao, Hongda Li
A multistage construction of the Gd-doped g-C3N4/Mo15S19 catalyst, with Gd3+ as redox centers and Mo15S19 as N2 activation sites, synergistically enhances its photocatalytic NRR performance.
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Ammonia and formate cosynthesis via nitrate electroreduction combined with methanol electrooxidation over nitrogen-doped carbon-encapsulated nickel iron phosphide

Inorg. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QI02350A, Research Article
Zongyi Wang, Jiuli Chang, Zhiyong Gao
Nitrate–methanol co-electrolysis by the pairwise cathodic NO3RR and anodic MOR is a viable way to coproduce ammonia (NH3) and formate via gentle, sustainable and energy-saving “E-refining” and “E-reforming” means.
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Multifunctional separator modified with catalytic multishelled structural CoS2 enables a stable lithium–sulfur battery

Inorg. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QI02340D, Research Article
Open Access
Ruyi Bi, Jilu Zhao, Mei Yang, Jiangyan Wang, Ranbo Yu, Dan Wang
A multifunctional separator modified with a multi-shelled CoS2 structure is developed to simultaneously inhibit the shuttle effect and effectively catalyze the redox reactions.
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el

Advances in nanoengineering of cathodes for next-generation solid oxide fuel cells

Inorg. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QI02451F, Review Article
Chunwen Sun
The progress of nanoengineering of electrodes fabricated by various methods for SOFCs operating at low and intermediate temperatures is reviewed. Future research directions on nanoengineering of cathodes for next-generation SOFCs are also provided.
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Pentagonal-bipyramidal Dysprosium(III) complexes with two apical phosphine oxide ligands and equatorial pentadentate N3O2 Schiff-base ligands: Breakdown of the apical magnetic axiality by strong equatorial crystal field†

Inorg. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QI02262A, Research Article
Tamara A. Bazhenova, Vyacheslav Kopotkov, Denis V. Korchagin, Elena Yureva, Michael V. Zhidkov, Alexey I Dmitriev, Ilya Yakushev, N. N. Efimov, Konstantin Andreevich Babeshkin, Vladimir Sergeevich Mironov, Eduard B. Yagubskii
A series of three new seven-coordinate pentagonal-bipyramidal (PBPY-7) Dy(III) complexes [Dy(LCH3)(Cy3PO)2]ClO4∙CH3CN (1), [Dy(L2(t-Bu))(Ph3PO)2]ClO4∙0.63C2H5OH (2), [Dy(LOCH3)(Ph3PO)2]ClO4∙2H2O (3) including various chelating pentadentate ligands with a [N3O2]2− binding node in the equatorial plane,...
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Unraveling the Correlation between Biological Effects and Halogen Substituents in Cobalt bis(dicarbollide)

Inorg. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QI02296C, Research Article
Katarzyna Zakret-Drozdowska, Bożena Szermer-Olearnik, Waldemar Goldeman, Michalina Gos, Dawid Drozdowski, Anna Gągor, Tomasz M. Goszczyński
Over the past decade, considerable scientific attention has been given to adapting cobalt bis(dicarbollides) as innovative agents with various biomedical applications. Although the studied compounds show great potential in this...
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Dynamic behavior of floating magnetic liquid marbles under steady and pulse-width-modulated magnetic fields

Lab Chip, 2024, 24,2005-2016
DOI: 10.1039/D3LC00578J, Paper
Hossein Dayyani, Alireza Mohseni, Mohamad Ali Bijarchi
The manipulation of biocompatible magnetic liquid marbles, formed by wrapping magnetic nanoparticles around water droplets, on the water surface under the steady and variable magnetic fields.
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el

Nanoscale sorting of extracellular vesicles via optically-induced dielectrophoresis on an integrated microfluidic system

Lab Chip, 2024, 24,1965-1976
DOI: 10.1039/D3LC01007D, Paper
Wei-Jen Soong, Chih-Hung Wang, Chihchen Chen, Gwo-Bin Lee
We devised an innovative method for automated sorting of extracellular vesicles (EVs) employing optically-induced dielectrophoresis on an integrated microfluidic chip. EVs of three distinct size categories could be isolated in 1 h at a purity of 86%.
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A miniprotein receptor electrochemical biosensor chip based on quantum dots

Lab Chip, 2024, 24,1875-1886
DOI: 10.1039/D3LC01100C, Paper
Yunong Zhao, Juan Han, Jing Huang, Qing Huang, Yanbing Tao, Ruiqin Gu, Hua-Yao Li, Yang Zhang, Houjin Zhang, Huan Liu
We developed an on-chip laboratory for biomolecule interactions and kinetics analysis based on the three-electrode and high electron mobility transistor (HEMT) chip platform.
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Capturing of extracellular vesicles derived from single cells of Escherichia coli

Lab Chip, 2024, 24,2049-2057
DOI: 10.1039/D3LC00707C, Paper
Open Access
Fumiaki Yokoyama, André Kling, Petra S. Dittrich
A microdevice with narrow winding channels is introduced to trap and culture single bacterial cells. It is used to study growth patterns of the cells and to monitor secretion of extracellular vesicles under treatment with an antibiotic drug.
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Wearable intelligent sweat platform for SERS-AI diagnosis of gout

Lab Chip, 2024, 24,1996-2004
DOI: 10.1039/D3LC01094E, Paper
Zhaoxian Chen, Wei Wang, Hao Tian, Wenrou Yu, Yu Niu, Xueli Zheng, Shihong Liu, Li Wang, Yingzhou Huang
A wearable intelligent SERS platform enables the sensitive detection of UA (0.1 μM) in sweat for AI diagnosis of gout.
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A flexible electrode Array for genetic transfection of different layers of the retina by electroporation

Lab Chip, 2024, 24,1957-1964
DOI: 10.1039/D3LC01014G, Paper
Yu Zhang, Tao Peng, Yu Ge, Mengda Li, Chendi Li, Jiyu Xi, Zixi Li, Zewen Wei, Yuntao Hu
Stratified delivery into specific retinal layers was realized by a flexible electrode array that exhibited high compatibility with surgical procedures.
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Confining calcium oxalate crystal growth in a carbonated apatite-coated microfluidic channel to better understand the role of Randall's plaque in kidney stone formation

Lab Chip, 2024, 24,2017-2024
DOI: 10.1039/D3LC01050C, Paper
Samantha Bourg, Karol Rakotozandriny, Ivan T. Lucas, Emmanuel Letavernier, Christian Bonhomme, Florence Babonneau, Ali Abou-Hassan
The successful formation of a carbonated apatite coating inside a micrometer channel is described, which was used to investigate its role on the formation of calcium oxalate crystals in the context of kidney stones.
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AMF-SporeChip provides new insights into arbuscular mycorrhizal fungal asymbiotic hyphal growth dynamics at the cellular level

Lab Chip, 2024, 24,1930-1946
DOI: 10.1039/D3LC00859B, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Felix Richter, Maryline Calonne-Salmon, Marcel G. A. van der Heijden, Stéphane Declerck, Claire E. Stanley
A new microfluidic platform – the AMF-SporeChip – enables immobilisation of arbuscular mycorrhizal fungal spores and confrontation of asymbiotic hyphae with physical obstacles, allowing the identification of various exploration strategies.
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Microfluidic impedance cytometry with flat-end cylindrical electrodes for accurate and fast analysis of marine microalgae

Lab Chip, 2024, 24,2058-2068
DOI: 10.1039/D3LC00942D, Paper
Xiaoming Chen, Mo Shen, Shun Liu, Chungang Wu, Liangliang Sun, Zhipeng Song, Jishun Shi, Yulong Yuan, Yong Zhao
We develop a novel microfluidic impedance cytometer for analysis of marine microalgae by inserting ground flat-end cylindrical electrodes into microchannels.
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Multifunctional cardiac microphysiological system based on transparent ITO electrodes for simultaneous optical measurement and electrical signal monitoring

Lab Chip, 2024, 24,1903-1917
DOI: 10.1039/D3LC00908D, Paper
Zhangjie Li, Kai Niu, Chenyang Zhou, Feifan Wang, Kangyi Lu, Yijun Liu, Lian Xuan, Xiaolin Wang
We developed a multifunctional cardiac microphysiological system on transparent electrodes, enabling simultaneous electrical signal monitoring and optical observations of cardiac tissue, holding promise for applications in cardiac drug development.
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Comparison between dynamic versus static models and real-time monitoring of neuronal dysfunction in an amyloid-β induced neuronal toxic model on a chip platform

Lab Chip, 2024, 24,1887-1902
DOI: 10.1039/D3LC00507K, Paper
Open Access
Chu-Chun Liang, Po-Yen Chen, Nien-Che Liu, I-Chi Lee
A 3D neural spheroid-based system with an interstitial level of flow for simulating the brain microenvironment toward a dynamic amyloid-β induced neuronal toxic model was established. A real-time impedance recording was used to monitor the neural network formation and disconnection.
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SeParate: multiway fluorescence-activated droplet sorting based on integration of serial and parallel triaging concepts

Lab Chip, 2024, 24,2107-2121
DOI: 10.1039/D3LC01075A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Wannes Verbist, Jolien Breukers, Sapna Sharma, Iene Rutten, Hans Gerstmans, Lotte Coelmont, Francesco Dal Dosso, Kai Dallmeier, Jeroen Lammertyn
A novel platform, called SeParate, enabling accurate multiplex droplet sorting by integrating serial and parallel sorting principles for three model systems with increasing complexity and intra-subpopulation variation in fluorescence intensities.
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Microphysiological pancreas-on-chip platform with integrated sensors to model endocrine function and metabolism

Lab Chip, 2024, 24,2080-2093
DOI: 10.1039/D3LC00838J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Katharina Schlünder, Madalena Cipriano, Aline Zbinden, Stefanie Fuchs, Torsten Mayr, Katja Schenke-Layland, Peter Loskill
Pancreatic in vitro models are crucial for research on diseases such as diabetes mellitus. A novel thermoplastic organ-on-chip with integrated real-time read-outs models the complex microphysiological structure and function of the endocrine pancreas.
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Deciphering fibroblast-induced drug resistance in non-small cell lung carcinoma through patient-derived organoids in agarose microwells

Lab Chip, 2024, 24,2025-2038
DOI: 10.1039/D3LC01044A, Paper
Qiyue Luan, Ines Pulido, Angelique Isagirre, Julian Carretero, Jian Zhou, Takeshi Shimamura, Ian Papautsky
Agarose microwell platform for modeling lung carcinoma using patient-derived tissues to decipher cancer associated fibroblast-induced drug resistance.
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Tonicity-induced cargo loading into extracellular vesicles

Lab Chip, 2024, 24,2069-2079
DOI: 10.1039/D3LC00830D, Paper
Open Access
Chaeeun Lee, Sumit Kumar, Juhee Park, Yongjun Choi, Elizabeth Maria Clarissa, Yoon-Kyoung Cho
Tonicity-induced cargo loading into extracellular vesicles (EVs) is achieved through controlled membrane permeability, ensuring cargo incorporation without causing damage to the EV membrane.
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Recent developments and future perspectives of microfluidics and smart technologies in wearable devices

Lab Chip, 2024, 24,1833-1866
DOI: 10.1039/D4LC00089G, Critical Review
Sasikala Apoorva, Nam-Trung Nguyen, Kamalalayam Rajan Sreejith
Wearable devices are increasingly popular in health monitoring, diagnosis, and drug delivery. Advances allow real-time analysis of biofluids like sweat, tears, saliva, wound fluid, and urine.
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Droplet microfluidic system for high throughput and passive selection of bacteria producing biosurfactants

Lab Chip, 2024, 24,1947-1956
DOI: 10.1039/D3LC00656E, Paper
Open Access
Klaudia Staskiewicz, Maria Dabrowska-Zawada, Lukasz Kozon, Zofia Olszewska, Lukasz Drewniak, Tomasz S. Kaminski
Novel microfluidic technique for functional selection of biosurfactant-producing microorganisms. Single bacterial cells are encapsulated into picoliter droplets for clonal cultivation and passively sorted at high throughput by interfacial tension.
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Tuneable hydrogel patterns in pillarless microfluidic devices

Lab Chip, 2024, 24,2094-2106
DOI: 10.1039/D3LC01082A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Claudia Olaizola-Rodrigo, Sujey Palma-Florez, Teodora Ranđelović, Clara Bayona, Mehran Ashrafi, Josep Samitier, Anna Lagunas, Mònica Mir, Manuel Doblaré, Ignacio Ochoa, Rosa Monge, Sara Oliván
A novel methodology utilizing plasma surface treatment enables the construction of cell culture chambers featuring abutment-free patterns, facilitating the precise distribution of shear stress.
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A self-assembly and cellular migration based fabrication of high-density 3D tubular constructs of barrier forming membranes

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00006D, Paper
Seyedaydin Jalali, Ponnambalam Ravi Selvaganapathy
A scalable method for creating perfusable 3D tissue constructs using self-assembly is introduced. Unlike conventional cell injection methods, here we leverage cell migration to form tissue barriers of low permeability, mimicking in vivo environments.
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Spatially controlled diffusion range of tumor-associated angiogenic factors to develop a tumor model using a microfluidic resistive circuit

Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC00891F, Paper
Yu-Hsiang Hsu, Wen-Chih Yang, Yi-Ting Chen, Che-Yu Lin, Chiou-Fong Yang, Wei-Wen Liu, Subhashree Shivani, Pai-Chi Li
The DC-MPS device uses a velocity V-clamp to create a partition with a steep concentration gradient for simultaneously developing vasculogenic vessels and a tumor. It enables vessel–tumor interaction to develop a tumor model with angiogenic vessels.
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Development of a self-contained microfluidic chip and an internet-of-things-based point-of-care device for automated identification of respiratory viruses

Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC00933E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Huynh Quoc Nguyen, Van Dan Nguyen, Vu Minh Phan, Tae Seok Seo
The COVID-19 pandemic greatly impacted the in vitro diagnostic market, leading to the development of new technologies such as point-of-care testing (POCT), multiplex testing, and digital health platforms.
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Microfluidic Particle Counter Visualizing Mucosal Antibody Levels against SARS-CoV-2 in the Upper Respiratory Tract for Rapid Evaluation of Immune Protection

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00118D, Paper
Open Access
Jiaheng Li, Lok Ting CHU, Hogi Hartanto, Guihuan Guo, Lu LIU, Jianpeng WU, Minghui Wu, Chenyu Cui, Gaobo Wang, Wengang LIU, Hoi Kwan Kwong, Siying WU, Ting-Hsuan Chen
Mucosal antibodies at the upper respiratory tract are the earliest and most critical responders to prevent respiratory infections, providing an indication to rapidly evaluate immune protection. Here, we report a...
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Evaluating thrombosis risk and patient-specific treatment strategy using an atherothrombosis-on-chip model

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00131A, Paper
Fahima Akther, Hedieh Fallahi, Jun Zhang, Nam-Trung Nguyen, Hang Thu Ta
An atherothrombosis-on-chip model to evaluate thrombosis risk and patient-specific treatment strategy.
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High-throughput viscoelastic characterization of cells in hyperbolic microchannels

Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC01061A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Felix Reichel, Ruchi Goswami, Salvatore Girardo, Jochen Guck
We use hyperbolic microchannels to create a flow field with linearly increasing velocity, leading to a constant tensile stress to probe the viscoelastic properties of cells. We verify our approach on oil droplets and polyacrylamide beads.
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Piezoelectric and microfluidic tuning of an infrared cavity for vibrational polariton studies

Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC01101A, Paper
Wei Wang, Jaime de la Fuente Diez, Nicolas Delsuc, Juan Peng, Riccardo Spezia, Rodolphe Vuilleumier, Yong Chen
A new method uses piezoelectric and microfluidic tuning to study vibrational polaritons in liquids under flow. This enables modifying cavity length adjustments and flexibility in experimental setups.
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Operando scanning electron microscopy platform for in situ imaging of fluid evolution in nanoporous shale

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D3LC01066J, Paper
Open Access
Artur Davletshin, Wen Song
Fluid-solid interactions in nanoporous materials underlie processes fundamental to nature and the engineered environment, including the thermochemical transformation of argillaceous materials during high-level nuclear waste disposal. Operando fluid-solid resolution at...
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Screening for Urothelial Carcinoma Cells in Urine Based on Digital Holographic Flow Cytometry through Machine Learning and Deep Learning Method

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D3LC00854A, Paper
Lu Xin, Xi Xiao, Wen Xiao, Ran Peng, Hao Wang, Feng Pan
The incidence of urothelial carcinoma continue to rise annually, particularly among the elderly. Prompt diagnosis and treatment can significantly enhance patient survival and quality of life. Urine cytology remains a...
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Dielectrophoretic characterization and selection of non-spherical flagellate algae in parallel channels with right-angle bipolar electrodes

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00165F, Paper
Xiaoming Chen, Shun Liu, Mo Shen, Jishun Shi, Chungang Wu, Zhipeng Song, Yong Zhao
We develop a microfluidic device with closed right-angle bipolar electrodes to realize dielectrophoretic characterization and selection of non-spherical flagellate algae.
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An economical in-class sticker microfluidic activity develops student expertise in microscale physics and device manufacturing

Lab Chip, 2024, 24,2176-2192
DOI: 10.1039/D3LC00912B, Paper
Open Access
Priscilla Delgado, C. Alessandra Luna, Anjana Dissanayaka, Oluwamayokun Oshinowo, Jesse J. Waggoner, Sara Schley, Todd Fernandez, David R. Myers
This activity enables students to construct geometrically complex microfluidics at their desk with no specialized equipment. It can be easily transported, and helped students significantly improve their understanding of miniaturization science.
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Thermal segment microwell plate control for automated liquid handling setups

Lab Chip, 2024, 24,2224-2236
DOI: 10.1039/D3LC00714F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Simon Seidel, Katja F. Winkler, Anke Kurreck, Mariano Nicolas Cruz-Bournazou, Katharina Paulick, Sebastian Groß, Peter Neubauer
This publication introduces a thermal segment microwell plate control device, integrating smart sensor technology and standardized well-plate geometry for automated biolab setups. It is tested in a high-throughput enzymatic activity assay.
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Deep learning-enabled detection of rare circulating tumor cell clusters in whole blood using label-free, flow cytometry

Lab Chip, 2024, 24,2237-2252
DOI: 10.1039/D3LC00694H, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Nilay Vora, Prashant Shekar, Taras Hanulia, Michael Esmail, Abani Patra, Irene Georgakoudi
We present a deep-learning enabled, label-free flow cytometry platform for identifying circulating tumor cell clusters in whole blood based on the endogenous scattering detected at three wavelengths. The method has potential for in vivo translation.
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Effect of in-plane and out-of-plane bifurcated microfluidic channels on the flow of aggregating red blood cells

Lab Chip, 2024, 24,2317-2326
DOI: 10.1039/D4LC00151F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Amirreza Gholivand, Olivera Korculanin, Knut Dahlhoff, Mehrnaz Babaki, Timo Dickscheid, Minne Paul Lettinga
Taking microfluidics to the third dimension causes scrambling of memory effects in blood flow due to out-of-plane vessel structures.
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Opto-combinatorial indexing enables high-content transcriptomics by linking cell images and transcriptomes

Lab Chip, 2024, 24,2287-2297
DOI: 10.1039/D3LC00866E, Paper
Arata Tsuchida, Taikopaul Kaneko, Kaori Nishikawa, Mayu Kawasaki, Ryuji Yokokawa, Hirofumi Shintaku
We introduce a simple integrated analysis method that links cellular phenotypic behaviour with single-cell RNA sequencing by utilizing a combination of optical indices from cells and hydrogel beads.
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A microfluidic model to study the effects of arrhythmic flows on endothelial cells

Lab Chip, 2024, 24,2347-2357
DOI: 10.1039/D3LC00834G, Paper
Austin Lai, Adam Hawke, Mokhaled Mohammed, Peter Thurgood, Gianmarco Concilia, Karlheinz Peter, Khashayar Khoshmanesh, Sara Baratchi
We created a versatile microfluidic system for studying the effect of arrhythmic flow patterns on endothelial cells in vitro. This system provides unique opportunities to identify the molecular machineries that control endothelial biology in response to arrhythmia.
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Designing and prototyping a novel biosensor based on a volumetric bar-chart chip for urea detection

Lab Chip, 2024, 24,2298-2305
DOI: 10.1039/D3LC00730H, Paper
Mahdi Samadi Khezri, Mohammad Reza Housaindokht, Mojtaba Firouzi
A volumetric bar-chart chip (V-chip) is a microfluidic device based on distance-based quantitative measurement that visualizes analyte concentration without the need for apparatus or data processing.
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Development of wafer-scale multifunctional nanophotonic neural probes for brain activity mapping

Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC00931A, Perspective
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Fu Der Chen, Ankita Sharma, David A. Roszko, Tianyuan Xue, Xin Mu, Xianshu Luo, Hongyao Chua, Patrick Guo-Qiang Lo, Wesley D. Sacher, Joyce K. S. Poon
We explore the development of multifunctional nanophotonic neural probes, integrating microelectrodes, optical emitters, and microfluidic channels for multimodal brain mapping.
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A novel ratiometric design of microfluidic paper-based analytical device for the simultaneous detection of Cu2+ and Fe3+ in drinking water using a fluorescent MOF@tetracycline nanocomposite

Lab Chip, 2024, 24,2306-2316
DOI: 10.1039/D3LC01045G, Paper
Sabah H. Al-Jaf, Sameera Sh. Mohammed Ameen, Khalid M. Omer
On-site monitoring of ions in drinking water is essential for safeguarding public health, ensuring high water quality, and preserving the ecological balance of aquatic ecosystems.
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Vascularized tissue on mesh-assisted platform (VT-MAP): a novel approach for diverse organoid size culture and tailored cancer drug response analysis

Lab Chip, 2024, 24,2208-2223
DOI: 10.1039/D3LC01055D, Paper
Open Access
Jungseub Lee, Sangmin Jung, Hye Kyoung Hong, Hyeonsu Jo, Stephen Rhee, Ye-Lin Jeong, Jihoon Ko, Yong Beom Cho, Noo Li Jeon
VT-MAP, a novel in vitro platform, offers better physiological reflection through the vascularized organoid. This advancement supports drug assessment with deeper insights into cancer biology through correlation between morphology and drug effects.
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Brachytherapy on-a-chip: a clinically-relevant approach for radiotherapy testing in 3d biology

Lab Chip, 2024, 24,2335-2346
DOI: 10.1039/D4LC00032C, Paper
Rodin Chermat, Elena Refet-Mollof, Yuji Kamio, Jean-François Carrier, Philip Wong, Thomas Gervais
We introduce the first brachytherapy-on-chip device for in vitro testing of brachytherapy on naturally hypoxic tumor spheroids, for translational research and drug development.
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A microfluidic-based gut-on-a-chip model containing the gut microbiota of patients with depression reveals physiological characteristics similar to depression

Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC01052J, Paper
Wenxin Wang, Yiyuan Liu, Zhikai Yao, Dengbo Chen, Yue Tang, Jingwei Cui, Jiangjiang Zhang, Hong Liu, Zikai Hao
A depression-on-gut-chip (DoGC) is prepared and enables extended co-culture of aerobic human intestinal epithelial cells and anaerobic gut microbiota, and allows direct study of interactions between human gut microbiota and depression.
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Study on the hemodynamic effects of different pulsatile working modes of a rotary blood pump using a microfluidic platform that realizes in vitro cell culture effectively

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00159A, Paper
Lixue Liang, Xueying Wang, Dong Chen, Palaniappan Sethu, Guruprasad A. Giridharan, Yanxia Wang, Yu Wang, Kai-Rong Qin
The best pulsation frequency mode of the RBP would be one that changes every 2–3 times of the cardiac cycle. The proposed in vitro microfluidic model could provide an effective platform to select the best working mode of the RBP for heart failure.
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