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Dess–Martin periodinane-mediated oxidation of the primary alcohol of cytidine into a carboxylic acid

By pubs.rsc.org
Published On ::

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00240G, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Alexandra R. E. Serre, Vibhu Jha, Adèle Rivault, Leif A. Eriksson, Goreti Ribeiro Morais, Robert A. Falconer
Herein we describe the first example of the conversion of the primary alcohol of cytidine into a carboxylic acid by use of the Dess–Martin periodinane oxidising agent.
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Electro-oxidative three-component cascade coupling of isocyanides with elemental sulfur and amines for the synthesis of 2-aminobenzothiazoles

By pubs.rsc.org
Published On ::

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00432A, Paper
Peng-Fei Huang, Jia-Le Fu, Ying Peng, Jian-Hong Fan, Long-Jin Zhong, Kewen Tang, Yu Liu
2-Aminobenzothiazoles are commonly encountered in various functional compounds. Herein, we disclose an electro-oxidative three-component reaction for the effective synthesis of 2-aminobenzothiazoles under mild conditions, utilizing non-toxic and abundant elemental sulfur...
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Revisiting Biginelli-like Reactions: Solvent Effects, Mechanisms, Biological Applications and Correction of Several Literature Reports

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Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00272E, Paper
Brenno A. D. Neto, Pedro Beck, Arthur Leitão, Yasmin Santana, Jose R. Correa, Carime Vitória da Silva Rodrigues, Daniel Machado, Guilherme Matos, Luciana Machado Ramos, Claudia Cristina Gatto, Carlos Kleber Z. Andrade, Sarah Caldas
This study critically reevaluates reported Biginelli-like reactions using a Kamlet-Abboud-Taft-based solvent effect model. Surprisingly, structural misassignments were discovered in certain multicomponent reactions, leading to the identification of pseudo three-component derivatives...
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Photoproperties of Favipiravir and their 6-Substituted Analogues: Fluorescence Controlled through Halogen Substitution and Tautomerism

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Published On ::

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00397G, Paper
Angel H Romero, Marcos Couto, Ivan E Romero, German Fuentes, Matías N. Möller
Herein, we showed the photophysical properties of the favipiravir and their 6-substituted analogues. Also, we interpreted the origin of the fluorescence of the favipiravir and their 6-substituted analogues as function...
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Design, synthesis, biological evaluation and molecular docking studies of quinoline-anthranilic acid hybrids as potent anti-inflammatory drugs

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Published On ::

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00040D, Paper
Sidra Siddique, Khalid Hussain, Naureen Shehzadi, Muhammad Arshad, Muhammad Nadeem Arshad, Sadaf Iftikhar, Farhat Saghir, Ayisha Shaukat, Muhammad Sarfraz, Nisar Ahmed
Despite the high global prevalence, rheumatoid arthritis lacks a satisfactory treatment.
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Discovery of selective monosaccharide receptors via dynamic combinatorial chemistry

By pubs.rsc.org
Published On ::

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00015C, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Miguel Alena-Rodriguez, Marcos Fernandez-Villamarin, Ignacio Alfonso, Paula M. Mendes
An effective workflow to discover selective saccharide receptors by combining dynamic combinatorial chemistry with isothermal titration calorimetry and NMR.
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Recent developments in the enzymatic modifications of steroid scaffolds

By pubs.rsc.org
Published On ::

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00327F, Review Article
Open Access
Huibin Wang, Ikuro Abe
This review highlights the recent advancements in the enzymatic modifications of steroid scaffolds, emphasizing enzymatic hydroxylation, ketoreduction, dehydrogenation, enzymatic cascade reactions, and other modifications.
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Synthesis of Deuteriodifluoromethylthiolated Isocoumarins-1- imines and Isocoumarins Enabled by Multi-Component Reagents System (MCRS)

By pubs.rsc.org
Published On ::

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00328D, Communication
Xuemin Li, Haofeng Shi, Jiaxin He, Jialiang Wu, Fengxia Sun, Yunfei Du
The combining use of BnSCF2D, mCPBA and Tf2O serves as an efficient multi-component reagents system (MCRS) for the synthesis of deuteriodifluoromethylthiolated isocoumarins-1-imines/isocoumarins via intramolecular cyclization/ deuteriodifluoromethylthiolation of 2-alkynylbenzamide/2-alkynylbenzoates. The approach...
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TEMPO/PhI(OAc)2 promotes the α-aminophosphinoylation of alcohols with amines and H-phosphine oxides in aqueous medium

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Published On ::

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00302K, Communication
Qiang Huang, Xin Jin, Lvjia Wu, Jiangdong Li, Qianlu Xing, Xianheng Wang, Changkuo Zhao
The aminophosphinoylation of alcohols with amines and H-phosphine oxides provides an efficient and mild approach to access various α-aminoalkylphosphine oxides in good yields with good tolerance of functional groups using H2O as a clean solvent.
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An FeCl3-catalyzed three-component reaction for the synthesis of β-(1,2,3-triazolyl)-ketones using DMF as a one-carbon source

By pubs.rsc.org
Published On ::

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00207E, Communication
Ruilin Fang, Lei Zheng, Xuyang Chen, Can Wang, Yunfeng Chen
FeCl3-catalyzed oxidative condensation of NH-1,2,3-triazoles and aryl methyl ketones and DMF has been reported.
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Design, synthesis, and biological application of A–D–A-type boranil fluorescent dyes

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00297K, Paper
Wei Luo, Yiling Li, Liang Wang, Yanhua Qin, Qiao Cheng, Guochang Hu, Chaoyi Yao, Xiangzhi Song
Acceptor–donor–acceptor boranil fluorescent dyes, CSU-BF-R (R = H, CH3, and OCH3), were developed with strong red fluorescence and large Stokes shifts. CSU-BF-OCH3 could selectively sense intracellular hypochlorous acid in living cells and zebrafish.
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Facile synthesis of tetrahydroquinoline containing dithiocarbamate derivatives via one-pot sequential multicomponent reaction

By pubs.rsc.org
Published On ::

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00490F, Communication
SIDDHARTHA KUMAR SENAPATI, Anit Pal, Animesh Das
An efficient sequential multi-component method for the synthesis of tertrahydroquinoline containing dithiocarbamate has been developed. This reaction involved a boronic acid-catalyzed reduction of quinoline to tertrahydroquinoline, followed by nucleophilic addition...
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New Generation of Highly Reactive Allylborating Agents For Cu(I)-Catalyzed Allylation of Chiral Sulfinylimines

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Published On ::

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00291A, Paper
Michael S. Alexeev, Tatyana V. Strelkova, Michail M. Ilyin, Jr., Yulia V. Nelyubina, Ivan A. Bespalov, Michael Medvedev, Victor N Khrustalev, Nikolai Kuznetsov
The implementation of selective catalytic processes with highly active reagents is an attractive strategy that meets modern principles of sustainable development of chemistry. In the current study, we for the...
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N-Functionalization of beta-aminophosphonates; Cytotoxic effect of the new derivatives

By pubs.rsc.org
Published On ::

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00243A, Paper
György Keglevich, Petra Regina Varga, Emőke Dinnyési, Zsuzsanna Szalai, Szilvia Bősze, Rita Oláhné Szabó, Laszlo Drahos, Konstantin Karaghiosoff
Beta-Aminophosponates obtained by the Michael addition of primary amines to the double bond of diethyl vinylphosphonate proved to be suitable starting materials (amine components) in the Kabachnik–Fields reaction with formaldehyde...
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Sustainable preparation of 2-acylbenzothiazoles under the cooperation of ionic liquids and microwave irradiation

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Published On ::

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00315B, Paper
Shoushun Wang, Mengjie Liu, Yiyuan Yue, Xiude Hu, Yalin Zhang, Guodong Shen, Ruiguo Dong, Lilong Shi, Bing Yu, Xianqiang Huang
A series of 2-acylbenzothiazole derivatives were sustainably synthesized for the first time under the cooperation of ionic liquids and microwave irradiation, metal- and extra-additives-free conditions.
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Regioselective synthesis of 4-arylamino-1,2-naphthoquinones in eutectogel as a confined reaction medium using LED light

By pubs.rsc.org
Published On ::

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00140K, Communication
R. Vara Prasad, Yogendra Kumar, R. Arun Kumar, Tohira Banoo, Subbiah Nagarajan
The use of a simple carbohydrate-derived eutectogel facilitating a LED-light-induced regioselective synthesis of 4-arylamino-1,2-naphthoquinones in good yields is reported.
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Efficient synthesis of SCF3-containing 3-alkenylquinoxalinones via three-component radical cascade reaction

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Published On ::

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00363B, Paper
Si-Yu Wang, Chu Liu, Wei Yang, Zhong-Ying Tian, Lin Yuan, Long-Yong Xie
A three-component cascade reaction of quinoxalinones, alkynes and AgSCF3 toward complete E-selective SCF3-containing 3-alkenylquinoxalinones was developed.
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Base- and sulfur-promoted oxidative lactonization of chalcone-acetate Michael adducts: access to pyran-2-ones

By pubs.rsc.org
Published On ::

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00479E, Communication
Cao Nguyen Nguyen, Duc Toan Nguyen, Ha An Tran, Dinh Hung Mac, Thi Thu Tram Nguyen, Pascal Retailleau, Thanh Binh Nguyen
A cost-effective, practical, straightforward and scalable synthesis of α-pyrones via base- and sulfur-promoted annulation of phenylacetates and chalcones is reported.
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Visible light-driven photocatalytic sulfonative oxidation of benzyl secondary amines

By pubs.rsc.org
Published On ::

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00348A, Paper
Yong-Xiang Lü, Xinqian Wang, Ying-Ming Pan, Keyume Ablajan
A method for the α-oxidation and sulfonation of benzyl secondary amines was developed utilizing Ir(III) or Eosin Y as the photocatalyst in the presence of O2 as a green oxidant....
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K2CO3-Mediated (3+3-1) Annulation of 1,3-Acetonedicarboxylates with 2-Fluoro-1-nitroarenes: Synthesis of Indoles

By pubs.rsc.org
Published On ::

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00488D, Paper
Meng-Yang Chang, Chin-Huey Ho, Hsing-Yin Chen
The K2CO3-mediated one-pot reaction of 1,3-acetonedicarboxylates with 2 equiv. of substituted 2-fluoro-1-nitrobenzenes has been developed to synthesize various 2,3-dicarboxylate indoles via a tandem (3 + 3 − 1) annulation pathway....
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Empathy is the need of the hour

By www.thehindubusinessline.com
Published On :: Sun, 30 May 2021 15:02:26 +0530

Demand for proactive customer services


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As the price of aviation turbine fuel soars, airlines’ finances spin out of control

By www.thehindubusinessline.com
Published On :: Sun, 25 Jul 2021 16:35:44 +0530


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The making of ‘agile’ airlines

By www.thehindubusinessline.com
Published On :: Sun, 22 Aug 2021 16:13:04 +0530

How adoption of AI, ML can empower flying


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Reskilling of airline workforce needed

By www.thehindubusinessline.com
Published On :: Sun, 28 Nov 2021 18:14:11 +0530

Industry grapples with skilling/reskilling employees right from pilots to ground handling staff whose skills may be redundant


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Tech adoption will not lead to loss of jobs

By www.thehindubusinessline.com
Published On :: Sun, 28 Nov 2021 18:17:53 +0530

Every half per cent increase in GDP requires 10 per cent growth in travel


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As India builds its newest airports, it needs robust, fail-proof SOPs

By www.thehindubusinessline.com
Published On :: Mon, 24 Jan 2022 10:23:59 +0530

A near air mishap on Bengaluru skies that put the lives of 430 people in danger shows safety risk norms require constant refresh


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Next order of business for Tata Sons

By www.thehindubusinessline.com
Published On :: Sun, 06 Feb 2022 16:53:48 +0530

How will Tata Sons turn around all the airlines under its fold, except maybe the Kochi-based Air India Express?


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Profits offer hope of soft landing to Spicejet

By www.thehindubusinessline.com
Published On :: Sun, 20 Feb 2022 22:00:00 +0530

Apart from swift settlement with former owners, the airline urgently needs an immediate infusion of cash


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From geopolitics strife to a war of words between two aviation giants

By www.thehindubusinessline.com
Published On :: Sun, 20 Feb 2022 22:00:00 +0530

Qatar Airways and Airbus lock horns over safety concerns


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Insolvency of aircraft operator: default remedies.

By www.thehindubusinessline.com
Published On :: Sun, 17 Apr 2022 20:19:27 +0530

India should adopt Cape Town Convention as part of the domestic legal framework.


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Evolution of security in aviation

By www.thehindubusinessline.com
Published On :: Sun, 01 May 2022 18:56:29 +0530

Data and technology need to be adopted


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The art of avoiding accidents in air

By www.thehindubusinessline.com
Published On :: Sun, 10 Jul 2022 16:52:28 +0530

Flying distance may vary based on flight phases, altitudes and regions


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Will Akasa Air’s contra bet on Boeing 737 Max instead of Airbus pay off?

By www.thehindubusinessline.com
Published On :: Sun, 07 Aug 2022 20:00:00 +0530

Rakesh Jhunjhunwala’s Akasa airline has gone against the tide, placing its bets on Boeing aircrafts; it now needs to carve out a niche for itself 


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Blockchain: Piloting the future of aviation

By www.thehindubusinessline.com
Published On :: Sun, 07 Aug 2022 22:30:00 +0530

Enables effective solutions that positively impact industry players and end consumers


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5 things Indian airlines must do to break their way out of pandemic blues

By www.thehindubusinessline.com
Published On :: Sun, 21 Aug 2022 21:00:00 +0530

Post pandemic, the airlines must revamp strategies and resort to long-term measures to recover from the crisis 


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Hope you never get into a ‘coffin corner’ while flying

By www.thehindubusinessline.com
Published On :: Sun, 21 Aug 2022 21:00:00 +0530

This situation occurs when the aircraft’s low-speed stall and high-speed buffet meet


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Air infrastructure plans should be future-proof

By www.thehindubusinessline.com
Published On :: Sun, 04 Sep 2022 22:00:00 +0530

India’s aviation story is full of delayed, untapped and under-utilised potential


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Post-pandemic, OTAs are coming of age

By www.thehindubusinessline.com
Published On :: Sun, 18 Sep 2022 21:00:00 +0530

Are they finally paying up or paying off?


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Air India’s roadmap can be tricky to pull off

By www.thehindubusinessline.com
Published On :: Sun, 02 Oct 2022 21:00:00 +0530

The airline has to work hard to drastically grow its network and fleet while improving reliability as well


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Boeing bids farewell to ‘Queen of the skies’

By www.thehindubusinessline.com
Published On :: Sun, 05 Feb 2023 21:00:00 +0530

The first Boeing 747 took off from New York on Jan 22, 1970 and now the final 747 freighter was delivered to Atlas Air on February 1, 2022.


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Microsoft Teams to launch threaded conversations, combined chats and channels features

By www.thehindu.com
Published On :: Tue, 29 Oct 2024 11:28:42 +0530

The app has also added other changes in the interface so users can organise their chats better


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 Instagram downgrades quality of less popular videos

By www.thehindu.com
Published On :: Tue, 29 Oct 2024 11:38:32 +0530

Last year, Meta had admitted in a blog to having separate encoding configurations for different videos based on how popular they were


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Jio’s Diwali Dhamaka plan offers year-long prepaid plan for ₹3,599

By www.thehindu.com
Published On :: Tue, 29 Oct 2024 13:14:07 +0530

Jio is offering a prepaid plan of 2.5 GB of data per day for an entire year, priced at₹3,599, as part of a Diwali offer


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Google’s moneymaking machine still pumping out massive profits despite multiple threats

By www.thehindu.com
Published On :: Wed, 30 Oct 2024 08:18:51 +0530

Google is still thriving while the company navigates through a pivotal shift to artificial intelligence and battles regulators trying to topple its internet empire


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Google ad change could affect millions of small businesses

By www.thehindu.com
Published On :: Wed, 30 Oct 2024 09:22:43 +0530

Google is changing the way its Google Local Services ads work, which could affect millions of small businesses


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Crypto firm Consensys to cut 20% of workforce amid macroeconomic, regulatory headwinds

By www.thehindu.com
Published On :: Wed, 30 Oct 2024 11:42:41 +0530

The crypto firm added that elevated interest rates, inflationary pressures, and tightening liquidity have created a more “cautious macroeconomic environment”


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Microsoft, Meta, Apple, Amazon, and the burden of expectations knock Wall Street sharply lower

By www.thehindu.com
Published On :: Fri, 01 Nov 2024 09:27:41 +0530

Drops for Big Tech companies including Microsoft and Facebook’s parent company Meta Platforms led Wall Street lower


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Chinese researchers develop AI model for military use on back of Meta's Llama

By www.thehindu.com
Published On :: Fri, 01 Nov 2024 09:59:35 +0530

ChatBIT was fine-tuned and "optimised for dialogue and question-answering tasks in the military field", the paper said


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Amazon's improving retail sales boost third-quarter profit, revenue beats estimates

By www.thehindu.com
Published On :: Fri, 01 Nov 2024 10:16:16 +0530

Like its tech peers, Amazon said it expected higher capital expenditures for the foreseeable future to help develop artificial intelligence software


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Indonesia bans sales of Google phones days after blocking Apple's iPhone 16

By www.thehindu.com
Published On :: Fri, 01 Nov 2024 13:36:42 +0530

Indonesia said it has banned sales of smartphones made by Alphabet's Google due to rules requiring the use of locally manufactured components


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