b

Regioselective electrochemical cascade C–H sulfonylation–bromination of indolizines to access difunctionalized indolizines

Org. Chem. Front., 2024, 11,2306-2312
DOI: 10.1039/D4QO00035H, Research Article
Wenxuan Jiang, Xiang Liu, Chuanying Zhu, Meiyi Chen, Weidan Li, Hua Cao
Regioselective electrochemical C–H sulfonylation–bromination between indolizines, sodium sulfinates, and KBr has been established in an undivided cell, in which KBr serves as both the brominating agent and electrolyte.
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b

Nickel/photoredox-catalyzed carbonylative transformations of α-phosphorus-, α-sulfur-, and α-boron-substituted alkyl halides

Org. Chem. Front., 2024, 11,2297-2305
DOI: 10.1039/D4QO00167B, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Le-Cheng Wang, Xiao-Feng Wu
A novel dual nickel/photoredox catalyzed direct amino- and alkoxycarbonylation of α-heteroatom substituted organohalides has been developed.
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b

Prins cyclization of 1,3-dioxinone: synthesis of 11-epi-badkhysin

Org. Chem. Front., 2024, 11,2332-2338
DOI: 10.1039/D4QO00162A, Research Article
Xiaoliang Xu, Ping Hua, Yiren Xu, Baoqing He, Jingfeng Zhao, Liang Li, Wen Chen, Hongbin Zhang
The asymmetric synthesis of highly functional 11-epi-badkhysin has been accomplished using a structure-unit based approach.
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b

Advancement in the C–H bond alkylation of (hetero)arenes catalyzed by the most abundant transition metal–iron

Org. Chem. Front., 2024, 11,2397-2417
DOI: 10.1039/D4QO00063C, Review Article
Chandini Pradhan, Benudhar Punji
Advancement in the direct C–H bond alkylation of arenes and heteroarenes using the catalysts based on the most abundant transition metal, iron, is summarized.
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b

Contributors to the Organic Chemistry Frontiers Emerging Investigator Series 2022–2023

Org. Chem. Front., 2024, 11,2149-2154
DOI: 10.1039/D4QO90025A, Profile

This profile article showcases researchers who have contributed an article to the Organic Chemistry Frontiers Emerging Investigator Series.
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b

Correction: Cu-catalyzed arylation of S-tosyl peptides with arylboronic acids

Org. Chem. Front., 2024, 11,2418-2418
DOI: 10.1039/D4QO90029D, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Junjie Ying, Jingrong Huang, Chenguang Liu, Fa-Jie Chen, Chunfa Xu, Fen-Er Chen
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b

Assembly of ionic supramolecular polymers using a decacationic pillar[5]arene to noncovalently crosslink hyaluronic acid for short DNA delivery

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00447G, Research Article
Qian Li, Danying Ma, Yue-Yang Liu, Hui Wang, Wei Zhou, Dan-Wei Zhang, Zhan-Ting Li
A multicationic pillar[5]arene noncovalently crosslinks hyaluronic acid to afford ionic supramolecular polymers for intramolecular delivery of short DNA.
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b

Selective deletion of one carbon atom from C60 through benzylamine mediated reactions

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00449C, Research Article
Yaqiong Wang, Yiran Wu, Yuming Yu, Jie Su, Yi Qiu, Liangbing Gan
Benzylamine selectively adds to one of the two carbonyl groups on the 9-membered orifice to form an N,O-aminal moiety. Subsequent oxidation and hydrogen atom transfer lead to a decarboxylation process and formation of a nor [59]fullerene derivative.
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b

Aculeatones A and B, epimeric lovastatin derivatives with a 6/6/3-tricyclic carbon skeleton from Aspergillus aculeatus and their chemical transformation

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00351A, Research Article
Fei Liu, Fengqing Wang, Qin Li, Bingbing Dai, Weiguang Sun, Jianguo Li, Chunmei Chen, Yonghui Zhang, Hucheng Zhu
Lovastatin derivatives aculeatones A–F (1–6) with lipid-lowering activity were isolated from Aspergillus aculeatus. 1 and 2 represent the first examples with a 6/6/3-tricyclic scaffold and the biomimetic formation of 1 was achieved starting from 3.
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b

Cr-mediated Photocatalytic Decarboxylative Coupling of alpha-Oxo Acids with Benzylic Pyridinium Salts

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO00475B, Research Article
Jia Cao, Yan Liu, Zhixiang Wang, Le Liu
Herein, we report the chromium/photoredox dual catalytic synthesis of ketones using α-oxo acids with benzylic pyridinium salts. This reaction proceeded by photocatalytic generation of acyl radical from α-oxo acids and...
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b

Visible-light Induced [1, 3]-Brook Rearrangements of α-Ketoacylsilanes and Its Subsequent Trapping in a Tandem Annulation with 1, 3, 5-Triazinanes and Azomethine Imines

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO00463A, Research Article
Zhong Zhang, Sirui Wu, Yuqiao Zhou, Bao-Lin Li, Siyue Xiao, Xiaohu Zhao, Zhipeng Yu
An unusual visible light-induced [1, 3]-Brook rearrangement of α-ketoacylsilanes for cascade cyclization with 1,3,5-triazinanes and C,N-cyclic azomethine imines has been developed under catalyst-free and mild reaction conditions. The strategy offers...
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b

Cobalt-catalysed Csp3–Csp3 cross-coupling of benzyl Katritzky pyridinium salts with Callyl–O electrophiles

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00402G, Research Article
Mengyu Gao, Corinne Gosmini
Different allylbenzyl derivatives are synthesized by Co-catalyzed reductive cross-coupling from functionalized benzyl Katritzky pyridinium salts and various allylic acetates, ethers or carbonates in moderate to good yields under mild conditions.
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b

NBN/BNB-doped phenalenyl homo- and heterodyads: structural uniformity but optoelectronic diversity

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00468J, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Alexander S. Scholz, Thomas Froitzheim, Michael Bolte, Hans-Wolfram Lerner, Jan-M. Mewes, Matthias Wagner
Phenylene-bridged homo- and heterodyads of NBN- and BNB-phenalenyls were synthesized. The heterodyads show ambipolar redox character and aggregation-induced emission in the solid state.
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b

Copper-catalyzed oxidative sulfenylation and alkylation of indolin-2-ones for direct construction of sulfur-substituted quaternary carbons

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00491D, Research Article
Yun-Hao Zhang, Yi-Nuo Wang, Zi-Yu Liu, Si-Han Zheng, Guang-Lin Li, Dexin Feng, Da-Zhen Xu
A rapid and green one-pot access to S-substituted quaternary carbon centers from commercially available feedstock chemicals has been established, providing complex molecules with high chemoselectivity by the use of air as the terminal oxidant.
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b

Base- and metal-free visible-light driven site-selective α-C(sp3)–H functionalization reaction of glycine derivatives with hydroxamic acid derivatives

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00425F, Research Article
Shiyun He, Hongying Fan, Xue Zhang, Meiling Ye, Jian Chen, Jinyu Hou, Tianle Huang, Li Guo, Guanghui Lv, Yong Wu
A visible-light-mediated radical–radical cross-coupling reaction between hydroxamic acid and N-phenyl glycine derivatives under base and metal free conditions is reported. A series of unnatural amino acids and peptides were obtained in good to excellent yields with good chemo-selectivity.
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b

A retro-Mannich mediated transformation of Morita–Baylis–Hillman ketones to saturated imidazo[1,2-a]pyridines

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00352G, Research Article
Sachin Sharma, Ajit Kumar Jha, Srinivasan Easwar
Two fruits felled with one stone! – a proof of mechanism and a synthetic method that delivers a privileged heterocyclic motif.
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b

Development of a photoenzymatic one-pot hybrid system for the direct synthesis of 3,3-disubstituted indole-2-ketones from N-methyl indoles

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00371C, Research Article
Yao Yao, Yuan Yu, Ming-Liang Shi, Xin-Yue Fan, Ru-De Lin, Kun Li, Wen-Dian Li, Fei-Yan Tao, Na Wang
The effective combination of photocatalysis and enzyme catalysis has been widely utilized for the synthesis of high-value-added products.
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b

Efficient Synthesis of Benzophosphole Oxides by Ag-Promoted Radical Cycloisomerization

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO00552J, Research Article
Open Access
Liyao Ma, Sonia Mallet-Ladeira, Julien MONOT, Blanca Maria MARTIN VACA, Didier Bourissou
Cycloisomerization reactions involving C–P bond formation have been overlooked to prepare P-heterocycles. We discovered here a simple, efficient and versatile route to benzophosphole oxides by reacting ortho-alkynyl secondary phosphine oxides...
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b

Photochemical [2 + 2 + 1] annulation of 2-vinyloxy arylalkynes with bromomalonates via energy transfer

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00249K, Research Article
Shuo Tang, Jiupeng Liu, Min Zhang, Dan Wang, Yong Wang, Jingjing Zhao, Pan Li
A transition-metal-free, oxidant-free and base-free photochemical [2 + 2 + 1] radical annulation of 2-vinyloxy arylalkynes with bromomalonates has been developed.
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b

Substituent-controlled divergent cyclization reactions of benzo[c][1,2]dithiol-3-ones and hexahydro-1,3,5-triazines

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00356J, Research Article
Bohao Zhang, Sifan He, Na Dong, Antong Zhu, Haojie Duan, Dunjia Wang, Yao Zhou
An unprecedented metal-free divergent cyclization reaction of benzo[c][1,2]dithiol-3-ones with hexahydro-1,3,5-triazines to assemble six- and eight-membered N-containing heterocycles has been developed.
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b

Halogen-Bond-Promoted Direct Cross-Coupling of Ethyl 3-bromo-3-alkyl-2,2-difluoropropanoate with Coumarins/Quinolinones

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO00484A, Research Article
Guoliang Pu, Shi-Yuan Song, Jian Yang, Peng Guo, Jia Jia, Peijun Liu, Xuefei Li, Ping Liu, Chun-Yang He
Herein, we developed a practical method for the direct cross-coupling of ethyl 3-bromo-3-alkyl-2,2-difluoropropanoate with coumarins/quinolinones, leveraging a halogen bond as the pivotal non-covalent interaction. Employing this protocol, a library of...
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b

NHC-Catalyzed Stereoselective Synthesis of Spirooxindole Lactones by in situ Generated Oxindole-embedded o-Quinone Methides and Aldehydes

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO00347K, Research Article
Zhengqiang Cao, Fang Hu, Yunpeng Chu, Jiaxue Pei, Xin-Ping Hui
A novel N-heterocyclic carbene-catalyzed asymmetric [4 + 2] annulation of in situ generated oxindole-embedded o-quinone methides with aldehydes has been developed for the assembly of complicated spirooxindoles. The methodology provides...
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b

Palladium-catalyzed and ligand-controlled divergent cycloadditions of vinylidenecyclopropane-diesters with para-quinone methides enabled by zwitterionic π-propargyl palladium species

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00368C, Research Article
Jia-Hao Shen, Yong-Jie Long, Min Shi, Yin Wei
A palladium-catalyzed and ligand-controlled divergent synthesis of spiro-cyclohexadienones from p-quinone methides and VDCP-diesters was realized via zwitterionic π-propargyl palladium species and the mechanism was clarified by DFT calculations.
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b

Expedient deaminative phosphorylation and sulfonylation of benzylic tertiary amines enabled by difluorocarbene

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00412D, Research Article
Chengbo Li, Yu Guo, Jianke Su, Xinyuan Hu, Qingqing Xuan, Qiuling Song
A deaminative functionalization of aliphatic tertiary amines via the cleavage of C(sp3)–N bonds under transition metal-free conditions was disclosed, which goes through SN2 reaction with various phosphorus and sulfur nucleophiles.
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b

Diverting the Mannich reaction to access 2,2-disubstituted indolin-3-ones by merging 1,2-aryl migration and copper-catalyzed aerobic oxidation

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00481G, Research Article
Jia-Chen Xiang, Yu-Die Wang, Peng Yuan, Hui-Min Zhu, Tong Lei, An-Xin Wu, Zhixin Liao
Three typical substrates for the Mannich reaction, p-anisidine, aldehyde, and a nucleophile, did not afford the predictable linear Mannich base under an aerobic copper oxidation condition, but rendering a 2,2-disubstituted indolin-3-one product.
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b

Iridium-catalyzed asymmetric hydrogenation of 5-hydroxypicolinate pyridinium salts under batch and flow: stereodefined access to cis-configurated hydroxypiperidine esters

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00322E, Research Article
Zhi Yang, Shangxian Luan, Linxi Wan, Jingxi Chen, Xiaofang Wei, Pei Tang, Fen-Er Chen
An iridium-catalyzed asymmetric hydrogenation of 2-esteryl-5-hydroxypyridinium salts is reported, providing chiral cis-5-hydroxypiperidine-2-carboxylates in excellent yields with high levels of enantioselectivities and diastereoselectivities.
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b

A Hierarchical Surrogate Approach to Biomass Ethanolysis Reaction Kinetic Modelling

React. Chem. Eng., 2024, Accepted Manuscript
DOI: 10.1039/D4RE00378K, Paper
Ailís O'Shea, Conall McNamara, Prajwal Rao, Mícheál Séamus Howard, Mohammad Reza Ghaani, Stephen Dooley
The reaction mechanism and kinetics of the sulfuric acid catalysed ethanolysis of glucose, cellulose, xylan, and corncob was investigated using a combination of experiments and empirical reaction mechanism modelling. The...
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b

A self-adsorption molecule passivated interface enables efficient and stable lithium metal batteries

Energy Environ. Sci., 2024, Advance Article
DOI: 10.1039/D4EE02903H, Paper
Gongxun Lu, Xinru Wu, Miaofei Huang, Mengtian Zhang, Zhihong Piao, Xiongwei Zhong, Chuang Li, Yanze Song, Chengshuai Chang, Kuang Yu, Guangmin Zhou
Self-adsorbing molecules stabilize electrode interfaces and inhibit solvent decomposition to ensure high-voltage stability of lithium metal batteries.
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b

Scalable electrified cementitious materials production and recycling

Energy Environ. Sci., 2024, Advance Article
DOI: 10.1039/D4EE03529A, Paper
Open Access
Xiao Kun Lu, Wenxin Zhang, Brianna N. Ruggiero, Linsey C. Seitz, Jiaqi Li
Our electrochemical production uses carbon-free rocks, water electrolysis, and CO2 capture/circulation for carbon-neutral/negative cement and green H2, turning cement from the second-largest industrial CO2 emitter to a gigaton-scale CCUS enabler.
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b

Multifunctional zeolite film enables stable high-voltage operation of LiCoO2 cathode

Energy Environ. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4EE04370G, Paper
Zezhou Lin, Yiran Ying, Zhihang Xu, Gao Chen, Xi Gong, Zehua Wang, Daqin Guan, Leqi Zhao, Mingyang Yang, Ke Fan, Tiancheng Liu, Hao LI, Honglei Zhang, Huangxu Li, Xi Zhang, Ye Zhu, Zhou-Guang Lu, Zongping Shao, Peiyu Hou, Haitao Huang
Increasing upper cut-off voltage is a useful way for enhancing specific capacity of LiCoO2 (LCO) cathode and the energy density of corresponding lithium-ion batteries (LIBs), while the main challenge is...
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b

Contribution of an instructional module incorporating PhET simulations to Rwandan students' knowledge of chemical reactions, acids, and bases through social interactions

Chem. Educ. Res. Pract., 2024, Advance Article
DOI: 10.1039/D4RP00105B, Paper
Jean-Baptiste Ndagijimana, Jeannette Musengimana, Henriette Mushimiyimana, Evode Mukama, Olivier Habimana, Paulin Manirakiza, Jean Claude Dushimimana, Jean Pierre Alpha Munyaruhengeri, Samia Khan, Elizabeth Lakin
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b

New treatment option for young women with hormone-sensitive breast cancer

A drug used for treating breast cancer, known as exemestane, is more effective than a common breast cancer prevention drug, tamoxifen, in preventing breast cancer recurrence in young women who also receive post-surgical treatment to suppress ovarian function. The combined results of the Tamoxifen and Exemestane Trial and Suppression of Ovarian Function Trial were presented at the 2014 ASCO Annual Meeting in Chicago.




b

Germany opens doors to skilled Indians amid global visa cuts

The number of skilled Indian workers in Germany has increased to 1.3 lakh from 23,000 a decade ago




b

Stocks that will see action today: November 14, 2024

Buzzing stocks: Tata Power, India Glycols, Hero MotoCorp, BDL, Firstcry, Mamaearth, MTNL, HAL, Nazara Tech, Sobha, Glenmark Pharma, GVK Power, Medi Assist, Grasim, PNB Housing Fin, Samhi Hotels, Inox Green Energy, Varun Beverages, Piccadilly Agro, 




b

IIT Kharagpur-led study says tropical rainforests could survive global warming

The study, published online in the Elsevier journal, was conducted on records of rainforests in sediments from Gujarat’s Vastan coal mines deposited in coastal lagoons around 56 million years ago




b

Row over CPI(M) leader E.P. Jayarajan’s yet to be published autobiography

Jayarajan clarifies that though he is working on an autobiography, it remains unfinished, and no one has been authorised to publish or distribute it




b

CPI(M) Kerala secretary M.V. Govindan backs E.P. Jayarajan amid autobiography controversy

Govindan says CPI(M) does not require members to seek prior permission to write a book, though he emphasised that consultation with the party should occur before publication




b

Centre releases ₹266.8 crore under 15th Finance Commission grants for rural local bodies in Kerala

Allocation represents second instalment of untied grants for 2024-25, and is meant for all eligible district panchayats, block panchayats and gram panchayats in Kerala




b

E.P. Jayarajan’s ‘autobiography’ row: publishing house remains tight lipped, refuses to clear the air

Jayarajan claims that circulating excerpts from his ‘autobiography’ are baseless nonsense and asserts that he had not granted publishing rights for his autobiography to any establishment




b

Wayanad bypoll turns out to be a reunion for landslides survivors

Their tearful reunion touches many, as they witness the heartbreak of lost connections. We celebrated the previous election, but many who participated then are no longer with us, says a survivor. District administration designated three polling stations for the survivors, two at Neelicappu and one at Meppadi




b

Meenachil river basin project in for revival




b

Swami AI chatbot to improve Sabarimala pilgrimage experience




b

KFON to depend on Supplyco database to provide Internet connection to BPL families




b

Waqf Board can initiate criminal proceedings in post-2013 Waqf land encroachment cases

A Single Judge of the Kerala High Court quashed the proceedings against two people in an alleged pre-2013 land encroachment case on Tuesday by noting that such acts were made punishable only through an amendment to the Waqf Act in 2013, the accused were in possession of the property even before the introduction of the amendment, and no penal acts could be given retrospective operation




b

KHTC looking to resume boating in Anayirankal dam

Agency, in an affidavit submitted in the Kerala High Court, outlines plans to make boating facility more eco-friendly




b

Chelakkara records 72.77% turnout in bypoll




b

PDA will defeat BJP in bypolls, says Akhilesh

Welcoming the Supreme Court’s direction on bulldozer ‘justice’, the SP chief says from now onwards, the bulldozer will remain parked in garage forever




b

One-fourth of people living with diabetes in India, Lancet study estimates

Of the 82.8 crore, India's share formed over a quarter (21.2 crore). Another 14.8 crore were in China, while 4.2 crore, 3.6 crore and 2.2 crore lived in the US, Pakistan and Brazil, respectively, the researchers found




b

Rate cut unlikely even in February, inflation to dip January onwards: SBI research

The report adds that inflation is likely to average around 4.8 per cent to 4.9 per cent for financial year 2025, higher than the RBI target of 4.5 per cent




b

Tata Power Renewable Energy unveils 126 MW Omkareshwar floating solar project, setting new global standards

With this project, TPREL’s total renewable capacity reaches 10.9 GW, reinforcing its position in India’s journey towards a greener energy future.