da Watch: Large flock of migrating birds shows up on Florida weather radar By www.upi.com Published On :: Wed, 06 May 2020 13:36:16 -0400 A Florida TV station's weather radar detected a large mass between the state and Cuba that turned out to be something other than an unseasonable storm -- it was a flock of migrating birds. Full Article
da Look: Dangling raccoon rescued from under California highway on-ramp By www.upi.com Published On :: Fri, 08 May 2020 15:08:05 -0400 Animal rescuers in California said they reached over the side of a freeway on-ramp to rescue a raccoon seen dangling from a metal beam under the ramp. Full Article
da Despite Flurry of Actions, Trump Administration Faces Constraints in Achieving Its Immigration Agenda By www.migrationpolicy.org Published On :: Wed, 24 Apr 2019 10:39:18 -0400 Though it has achieved success in some areas, the Trump administration’s many efforts to stiffen immigration enforcement in the U.S. interior and at the Southwest border are being consistently stymied by court injunctions, existing laws and settlements, state and local resistance, congressional pushback, and migration pressures that are beyond the government’s ability to swiftly address, as this article explores. Full Article
da Migration, Development, and Global Governance: From Crisis toward Consolidation By www.migrationpolicy.org Published On :: Tue, 25 Jun 2019 18:12:58 -0400 Migration and development policy discussions have edged closer to each other on the international stage. The adoption of the Global Compact for Migration in December 2018 marks an important milestone. As all eyes turn toward the compact’s implementation, this brief examines some of the key topics states have pledged to work more closely on—from labor migration and migrants’ rights, to returns and reintegration. Full Article
da Democrats Under Pressure: Political Calendar Exposes Ideological Differences on Immigration By www.migrationpolicy.org Published On :: Wed, 24 Jul 2019 17:39:12 -0400 Ideological differences in the Democratic Party over immigration that were once masked by unity against President Trump’s border wall and immigration agenda are now being exposed as Democratic presidential candidates seek to stand out in a crowded field and amid controversy over an emergency border spending bill. As the 2020 electoral calendar accelerates, how the party navigates the gulf between its most liberal and conservative wings will become a greater challenge for its leaders. Full Article
da Drug may curb dangerous urges in pedophiles, study says By www.upi.com Published On :: Sat, 09 May 2020 01:31:06 -0400 A testosterone-lowering drug can reduce male pedophiles' risk of sexually abusing children, according to a new Swedish study. Full Article
da FDA approves first at-home saliva test for COVID-19 By www.upi.com Published On :: Sat, 09 May 2020 03:37:06 -0400 The first COVID-19 test using saliva samples that patients collect at home has been approved by the U.S. Food and Drug Administration. Full Article
da Evidence-Informed Clinical Practice Recommendations for Treatment of Type 1 Diabetes Complicated by Problematic Hypoglycemia By care.diabetesjournals.org Published On :: 2015-06-01 Pratik ChoudharyJun 1, 2015; 38:1016-1029Type 1 Diabetes at a Crossroads Full Article
da Lipid and Inflammatory Cardiovascular Risk Worsens Over 3 Years in Youth With Type 2 Diabetes: The TODAY clinical trial By care.diabetesjournals.org Published On :: 2013-06-01 TODAY Study GroupJun 1, 2013; 36:1758-1764TODAY Study Full Article
da Day and Night Home Closed-Loop Insulin Delivery in Adults With Type 1 Diabetes: Three-Center Randomized Crossover Study By care.diabetesjournals.org Published On :: 2014-07-01 Lalantha LeelarathnaJul 1, 2014; 37:1931-1937Emerging Technologies and Therapeutics Full Article
da National Standards for Diabetes Self-Management Education and Support By care.diabetesjournals.org Published On :: 2014-01-01 Linda HaasJan 1, 2014; 37:S144-S153National Standards Full Article
da Characterization of Renal Glucose Reabsorption in Response to Dapagliflozin in Healthy Subjects and Subjects With Type 2 Diabetes By care.diabetesjournals.org Published On :: 2013-10-01 Ralph A. DeFronzoOct 1, 2013; 36:3169-3176Emerging Technologies and Therapeutics Full Article
da Exploring the Potential of the SGLT2 Inhibitor Dapagliflozin in Type 1 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Pilot Study By care.diabetesjournals.org Published On :: 2015-03-01 Robert R. HenryMar 1, 2015; 38:412-419Evolving Tactics With Inhibition of Sodium-Glucose Cotransporters Full Article
da Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range By care.diabetesjournals.org Published On :: 2019-08-01 Tadej BattelinoAug 1, 2019; 42:1593-1603International Consensus Report Full Article
da Update on Cardiovascular Outcomes at 30 Years of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study By care.diabetesjournals.org Published On :: 2014-01-01 John M. LachinJan 1, 2014; 37:39-43DCCT/EDIC 30th Anniversary Summary Findings Full Article
da Rapid Rise in Hypertension and Nephropathy in Youth With Type 2 Diabetes: The TODAY clinical trial By care.diabetesjournals.org Published On :: 2013-06-01 TODAY Study GroupJun 1, 2013; 36:1735-1741TODAY Study Full Article
da Dietary Sugar and Body Weight: Have We Reached a Crisis in the Epidemic of Obesity and Diabetes?: Health Be Damned! Pour on the Sugar By care.diabetesjournals.org Published On :: 2014-04-01 George A. BrayApr 1, 2014; 37:950-956Current Concepts of Type 2 Diabetes Prevention Full Article
da Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence: A Scientific Statement From the American Heart Association and the American Diabetes Association By care.diabetesjournals.org Published On :: 2015-09-01 Caroline S. FoxSep 1, 2015; 38:1777-1803Scientific Statement Full Article
da Standardizing Clinically Meaningful Outcome Measures Beyond HbA1c for Type 1 Diabetes: A Consensus Report of the American Association of Clinical Endocrinologists, the American Association of Diabetes Educators, the American Diabetes Association, the Endo By care.diabetesjournals.org Published On :: 2017-12-01 Gina AgiostratidouDec 1, 2017; 40:1622-1630Continuous Glucose Monitoring and Risk of Hypoglycemia Full Article
da Effects of Metformin, Metformin Plus Rosiglitazone, and Metformin Plus Lifestyle on Insulin Sensitivity and {beta}-Cell Function in TODAY By care.diabetesjournals.org Published On :: 2013-06-01 TODAY Study GroupJun 1, 2013; 36:1749-1757TODAY Study Full Article
da Diabetes Prevention in the Real World: Effectiveness of Pragmatic Lifestyle Interventions for the Prevention of Type 2 Diabetes and of the Impact of Adherence to Guideline Recommendations: A Systematic Review and Meta-analysis By care.diabetesjournals.org Published On :: 2014-04-01 Alison J. DunkleyApr 1, 2014; 37:922-933Current Concepts of Type 2 Diabetes Prevention Full Article
da Consensus Development Conference on the Diagnosis of Coronary Heart Disease in People With Diabetes: 10-11 February 1998, Miami, Florida By care.diabetesjournals.org Published On :: 1998-09-01 American Diabetes AssociationSep 1, 1998; 21:1551-1559Consensus Development Conference Report Full Article
da Current State of Type 1 Diabetes Treatment in the U.S.: Updated Data From the T1D Exchange Clinic Registry By care.diabetesjournals.org Published On :: 2015-06-01 Kellee M. MillerJun 1, 2015; 38:971-978Type 1 Diabetes at a Crossroads Full Article
da Chinese exports up in April, Beijing’s data show By www.upi.com Published On :: Thu, 07 May 2020 12:45:49 -0400 China's exports rebounded in April, growing 3.5 percent, according to the latest data from Beijing's General Administration of Customs on Thursday. Full Article
da Subdued ceremonies in Europe mark 75th anniversary of VE Day By www.upi.com Published On :: Fri, 08 May 2020 07:28:15 -0400 French President Emanuel Macron led a series of events in Europe Friday that commemorate the 75th anniversary of Victory in Europe Day, with a small ceremony in Paris. Full Article
da More than 70 dead in Rwanda after floods, landslides By www.upi.com Published On :: Fri, 08 May 2020 11:29:22 -0400 Heavy rains, flash flooding and landslides have led to the deaths of more than 70 people in Rwanda, officials said Friday. Full Article
da Blue Angels to fly over Dallas, Houston, New Orleans on Wednesday By www.upi.com Published On :: Tue, 05 May 2020 13:47:57 -0400 The U.S. Navy Flight Demonstration Squadron, also known as the Blue Angels, will fly over Dallas/Fort Worth, Houston and New Orleans Wednesday to honor frontline workers fighting the COVID-19 pandemic. Full Article
da Blue Angels to fly over Jacksonville, Miami on Friday By www.upi.com Published On :: Thu, 07 May 2020 15:45:25 -0400 The U.S. Navy Flight Demonstration Squadron, the Blue Angels, will fly over Jacksonville and Miami, Fla., Friday as part of a nationwide tour to show appreciation for healthcare workers and frontline responders. Full Article
da Dalcetrapib Reduces Risk of New-Onset Diabetes in Patients With Coronary Heart Disease By care.diabetesjournals.org Published On :: 2020-05-01 Gregory G. SchwartzMay 1, 2020; 43:1077-1084Emerging Therapies: Drugs and Regimens Full Article
da Professional Practice Committee: Standards of Medical Care in Diabetes--2019 By care.diabetesjournals.org Published On :: 2019-01-01 Jan 1, 2019; 42:S3-S3Professional Practice Committee Full Article
da Disclosures: Standards of Medical Care in Diabetes--2020 By care.diabetesjournals.org Published On :: 2020-01-01 Jan 1, 2020; 43:S205-S206Disclosures Full Article
da Dietary Sugar and Body Weight: Have We Reached a Crisis in the Epidemic of Obesity and Diabetes?: Health Be Damned! Pour on the Sugar By care.diabetesjournals.org Published On :: 2014-04-01 George A. BrayApr 1, 2014; 37:950-956Current Concepts of Type 2 Diabetes Prevention Full Article
da Diabetes Technology Update: Use of Insulin Pumps and Continuous Glucose Monitoring in the Hospital By care.diabetesjournals.org Published On :: 2018-08-01 Guillermo E. UmpierrezAug 1, 2018; 41:1579-1589Diabetes Care Symposium Full Article
da 2017 National Standards for Diabetes Self-Management Education and Support By care.diabetesjournals.org Published On :: 2017-10-01 Joni BeckOct 1, 2017; 40:1409-1419National Standards Full Article
da Treatment of Type 2 Diabetes: From "Guidelines" to "Position Statements" and Back: Recommendations of the Israel National Diabetes Council By care.diabetesjournals.org Published On :: 2016-08-01 Ofri MosenzonAug 1, 2016; 39:S146-S153II. Diabetes Treatment Options Full Article
da Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range By care.diabetesjournals.org Published On :: 2019-08-01 Tadej BattelinoAug 1, 2019; 42:1593-1603International Consensus Report Full Article
da 2019 Update to: Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) By care.diabetesjournals.org Published On :: 2020-02-01 John B. BuseFeb 1, 2020; 43:487-493Consensus Report Update Full Article
da Professional Practice Committee: Standards of Medical Care in Diabetes--2020 By care.diabetesjournals.org Published On :: 2020-01-01 Jan 1, 2020; 43:S3-S3Professional Practice Committee Full Article
da Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE The MHC region harbors the strongest loci for latent autoimmune diabetes in adults (LADA); however, the strength of association is likely attenuated compared with that for childhood-onset type 1 diabetes. In this study, we recapitulate independent effects in the MHC class I region in a population with type 1 diabetes and then determine whether such conditioning in LADA yields potential genetic discriminators between the two subtypes within this region. RESEARCH DESIGN AND METHODS Chromosome 6 was imputed using SNP2HLA, with conditional analysis performed in type 1 diabetes case subjects (n = 1,985) and control subjects (n = 2,219). The same approach was applied to a LADA cohort (n = 1,428) using population-based control subjects (n = 2,850) and in a separate replication cohort (656 type 1 diabetes case, 823 LADA case, and 3,218 control subjects). RESULTS The strongest associations in the MHC class II region (rs3957146, β [SE] = 1.44 [0.05]), as well as the independent effect of MHC class I genes, on type 1 diabetes risk, particularly HLA-B*39 (β [SE] = 1.36 [0.17]), were confirmed. The conditional analysis in LADA versus control subjects showed significant association in the MHC class II region (rs3957146, β [SE] = 1.14 [0.06]); however, we did not observe significant independent effects of MHC class I alleles in LADA. CONCLUSIONS In LADA, the independent effects of MHC class I observed in type 1 diabetes were not observed after conditioning on the leading MHC class II associations, suggesting that the MHC class I association may be a genetic discriminator between LADA and childhood-onset type 1 diabetes. Full Article
da Redefining Hypoglycemia in Clinical Trials: Validation of Definitions Recently Adopted by the American Diabetes Association/European Association for the Study of Diabetes By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE To determine if the International Hypoglycaemia Study Group (IHSG) level 2 low glucose definition can identify clinically relevant hypoglycemia in clinical trials and offer value as an end point for future trials. RESEARCH DESIGN AND METHODS A post hoc analysis was performed of the SWITCH (SWITCH 1: n = 501, type 1 diabetes; SWITCH 2: n = 721, type 2 diabetes) and DEVOTE (n = 7,637, type 2 diabetes) trials utilizing the IHSG low glucose definitions. Patients in all trials were randomized to either insulin degludec or insulin glargine 100 units/mL. In the main analysis, the following definitions were compared: 1) American Diabetes Association (ADA) 2005 (plasma glucose [PG] confirmed ≤3.9 mmol/L with symptoms); and 2) IHSG level 2 (PG confirmed <3.0 mmol/L, independent of symptoms). RESULTS In SWITCH 2, the estimated rate ratios of hypoglycemic events indicated increasing differences between treatments with decreasing PG levels until 3.0 mmol/L, following which no additional treatment differences were observed. Similar results were observed for the SWITCH 1 trial. In SWITCH 2, the IHSG level 2 definition produced a rate ratio that was lower than the ADA 2005 definition. CONCLUSIONS The IHSG level 2 definition was validated in a series of clinical trials, demonstrating its ability to discriminate between basal insulins. This definition is therefore recommended to be uniformly adopted by regulatory bodies and used in future clinical trials. Full Article
da Leukocyte Telomere Length, DNA Oxidation, and Risk of Lower-Extremity Amputation in Patients With Long-standing Type 1 Diabetes By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE Telomere shortening and DNA oxidation are associated with premature vascular aging, which may be involved in lower-extremity amputation (LEA). We sought to investigate whether leukocyte telomere length (LTL) and plasma 8-hydroxy-2'-deoxyguanosine (8-OHdG), a biomarker of DNA oxidation, were associated with LEA in subjects with type 1 diabetes at high vascular risk. RESEARCH DESIGN AND METHODS LTL (quantitative PCR) and plasma 8-OHdG concentrations (immunoassay method) were assessed at baseline in the GENEDIAB (Génétique de la Néphropathie Diabétique) type 1 diabetes cohort. Logistic and Cox proportional hazards regression models were fitted to estimate odds ratio (OR) (at baseline) and hazard ratio (HR) (during follow-up), with related 95% CI, by increasing biomarker tertiles (T1, T2, T3). RESULTS Among 478 participants (56% male, mean ± SD age 45 ± 12 years and diabetes duration 29 ± 10 years), 84 patients had LEA at baseline. Baseline history of LEA was associated with shorter LTL (OR for T2 vs. T1 0.62 [95% CI 0.32–1.22] and for T3 vs. T1 0.41 [0.20–0.84]) but not with plasma 8-OHdG (1.16 [0.56–2.39] and 1.24 [0.61–2.55], respectively). New cases of LEA occurred in 34 (12.3%) participants during the 10-year follow-up. LTL were shorter (HR T2 vs. T1 0.25 [95% CI 0.08–0.67] and T3 vs. T1 0.29 [0.10–0.77]) and plasma 8-OHdG higher (2.20 [0.76–7.35] and 3.11 [1.07–10.32]) in participants who developed LEA during follow-up compared with others. No significant interaction was observed between biomarkers on their association with LEA. CONCLUSIONS We report the first independent association between LTL shortening and excess risk of LEA in type 1 diabetes. High plasma 8-OHdG was also associated with incident LEA but partly dependent on cofounding variables. Full Article
da Respective Contributions of Glycemic Variability and Mean Daily Glucose as Predictors of Hypoglycemia in Type 1 Diabetes: Are They Equivalent? By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To evaluate the respective contributions of short-term glycemic variability and mean daily glucose (MDG) concentration to the risk of hypoglycemia in type 1 diabetes. RESEARCH DESIGN AND METHODS People with type 1 diabetes (n = 100) investigated at the University Hospital of Montpellier (France) underwent continuous glucose monitoring (CGM) on two consecutive days, providing a total of 200 24-h glycemic profiles. The following parameters were computed: MDG concentration, within-day glycemic variability (coefficient of variation for glucose [%CV]), and risk of hypoglycemia (presented as the percentage of time spent below three glycemic thresholds: 3.9, 3.45, and 3.0 mmol/L). RESULTS MDG was significantly higher, and %CV significantly lower (both P < 0.001), when comparing the 24-h glycemic profiles according to whether no time or a certain duration of time was spent below the thresholds. Univariate regression analyses showed that MDG and %CV were the two explanatory variables that entered the model with the outcome variable (time spent below the thresholds). The classification and regression tree procedure indicated that the predominant predictor for hypoglycemia was %CV when the threshold was 3.0 mmol/L. In people with mean glucose ≤7.8 mmol/L, the time spent below 3.0 mmol/L was shortest (P < 0.001) when %CV was below 34%. CONCLUSIONS In type 1 diabetes, short-term glycemic variability relative to mean glucose (i.e., %CV) explains more hypoglycemia than does mean glucose alone when the glucose threshold is 3.0 mmol/L. Minimizing the risk of hypoglycemia requires a %CV below 34%. Full Article
da Invertir en el Vecindario: Cambios en los Patrones de Migración Entre México y Estados Unidos y Oportunidades para una Cooperación Sostenible By www.migrationpolicy.org Published On :: Fri, 20 Sep 2019 11:31:12 -0400 Presentación del reporte que refleja el contenido de encuentros del grupo de estudio sobre la migración México-Estados Unidos convocado por El Colegio de México y el Migration Policy Institute (MPI). Full Article
da Will Supreme Court Ruling on DACA Finally Force Congress to Break the Ice on Immigration Reform? By www.migrationpolicy.org Published On :: Tue, 19 Nov 2019 12:36:19 -0500 The fate of the Deferred Action for Childhood Arrivals (DACA) program has ping ponged between all three branches of government. But with the Supreme Court poised to decide DACA's future in spring 2020, Congress may finally be forced to act to resolve the status of DREAMers after nearly two decades of considering various DREAM Act bills. Could this break the long stalemate Congress has had on passing substantive immigration legislation, and pave the way for other actions? Full Article
da ADA supports proposed rules to update federal Anti-Kickback Statute, Stark Law By www.ada.org Published On :: Mon, 06 Jan 2020 14:32:00 -0600 The American Dental Association supports a new safe harbor for cybersecurity technology and services and modifying the existing safe harbor for electronic health records to add protections for cybersecurity. This was in response to the Office of the Inspector General and Centers for Medicare & Medicaid Services’ proposed changes to the federal Anti-Kickback Statute and Stark Law exceptions. Full Article
da New ADA standard, technical report available for comment by Feb. 17 By www.ada.org Published On :: Wed, 08 Jan 2020 07:00:00 -0600 The American Dental Association Standards Committee on Dental Informatics has approved two documents for circulation and comment. Full Article
da ADA Member Advantage ends two endorsements By www.ada.org Published On :: Thu, 09 Jan 2020 09:55:00 -0600 ADA Member Advantage announced Jan. 8 the end of its endorsement relationship with two companies. Full Article
da ADA CERP collaboration focuses on dentistry’s role in interprofessional education By www.ada.org Published On :: Thu, 09 Jan 2020 12:06:00 -0600 The ADA’s Continuing Education Recognition Program, or ADA CERP, announced in December that it is collaborating with Joint Accreditation for Interprofessional Continuing Education, in an effort to offer dentists more opportunities to participate in interprofessional education. Full Article
da ADA asks Congress to pass Ensuring Lasting Smiles Act By www.ada.org Published On :: Thu, 09 Jan 2020 14:16:00 -0600 The American Dental Association is asking Congress to pass the Ensuring Lasting Smiles Act — legislation that would require all private group and individual health plans to cover medically necessary services that repair or restore congenital anomalies. Full Article
da Former ADA vice president dies at 87 By www.ada.org Published On :: Thu, 09 Jan 2020 20:00:00 -0600 Dr. Chauncey Cross, who served as vice president of the American Dental Association from 1997-98, died Sept. 5, 2019, on his 87th birthday. Full Article
