no

DEVICE WITH MAGNET(S) FOR ENGAGING WITH ANOTHER DEVICE

In one aspect, a first device includes a housing, at least one system component housed by the housing, a connector coupled to the housing that engages with a second device for exchange, between the first device and the second device, of at least one of data and power, and a first magnet coupled to the housing. The first magnet is coupled to the housing so that a first pole of the first magnet faces away from the first device to repel a first pole of a second magnet coupled to the second device when the first device is juxtaposed next to the second device in a first orientation relative to the second device.




no

SEMICONDUCTOR DEVICE INCLUDING A PLURALITY OF CIRCUITS AND A BUS CONNECTING THE CIRCUITS TO ONE ANOTHER, AND METHOD OF OPERATING THE SEMICONDUCTOR DEVICE

A semiconductor device includes a plurality of circuits, a general bus configured to be connected to each of the plurality of circuits and to provide a general channel among the plurality of circuits, and a designated bus configured to be connected to a subgroup of circuits from among the plurality of circuits and to provide a designated channel among the subgroup of circuits.




no

METHOD FOR ASSIGNING ADDRESSES TO NODES OF A BUS SYSTEM, AND INSTALLATION

A method for assigning addresses to nodes of a bus system, and installation, bus nodes being furnished with an identical delivery address, where (i) an assigning entity, particularly a central computer, start-up computer or bus node sends information to the delivery address via the bus system, (ii) the information includes a first address, (iii) an action is performed whose effect is detected by a first bus node, (iv) the first bus node accepts the first address, (v) the first bus node sends a response to the assigning entity, and (vi) steps (i) through (v) are repeated, each time with a further address for a further bus node.




no

Technologies for automatic timing calibration in an inter-integrated circuit data bus

Technologies for controlling timing calibration of a dedicated inter-integrated circuit data bus by a primary microcontroller are disclosed. The primary microcontroller performs a data transfer with a secondary integrated circuit using the dedicated inter-integrated circuit data bus, and determines a duration of the data transfer. If the duration is outside of an acceptable range, the primary microcontroller updates one or more data transfer timing parameters so that the duration of future data transfers are closer to the acceptable range.




no

Solar collector based on carbon nanotubes and solar heating system using the same

A solar collector includes a substrate having a top surface and a bottom surface opposite to the upper surface, a sidewall, a transparent cover, and a heat-absorbing layer. The sidewall is arranged on the periphery of the top surface of the substrate. The transparent cover is disposed on the sidewall opposite to the substrate to form a sealed chamber. The heat-absorbing layer is disposed on the upper surface of the substrate and includes a carbon nanotube film having a plurality of carbon nanotubes. The carbon nanotubes in the carbon nanotube film are joined end-to-end.




no

Induced-draft low swirl burner for low NOx emissions

A burner for use with an induced draft furnace and which satisfies reduced nitrous oxide (NOx) emission standards is disclosed. The burner may employ a mechanical swirler that introduces a rotational vector to the emitted air and fuel mixed by the burner. By introducing the rotational vector, the resulting flame is more stable and sustainable even with the relatively low air flow afforded by an induced system. Such flame stability can be enhanced by positioning the burner directly within an inlet to a heat exchanger and manufacturing the inlet with reception surfaces that form a frusto-conically shaped flame expansion zone. In doing so, a secondary source of air is avoided and NOx emissions are reduced.




no

Nanoparticle-enhanced phase change materials (NEPCM) with improved thermal energy storage

Nanoparticle-enhanced phase change materials (NEPCM) including nanoparticles dispersed with a base phase change material and that exhibit enhanced thermal conductivity in comparison to the base phase change material.




no

Apparatus for treating air by using porous organic-inorganic hybrid materials as an absorbent

The present disclosure provides an apparatus for treating air by using porous organic-inorganic hybrid materials as an absorbent, which comprises an inlet passage for receiving air from outside; a dehumidifying part comprising porous organic-inorganic hybrid materials as an adsorbent for removing moisture from the air receiving through the inlet passage; a regenerating unit for regenerating the adsorbent of the dehumidifying part; and an outlet passage for discharging the dehumidified air to outside. Said apparatus preferably comprises two dehumidifying parts of two-bed switching type and two switch valves, wherein said two dehumidifying parts are alternatively operated for dehumidification and for regeneration by switching said switch valves to convert direction of air flow.




no

Composite nanoparticles and manufacturing method thereof

Metal nanoparticles having improved migration resistance are provided. The present invention relates to a method for manufacturing composite nanoparticles including obtaining composite nanoparticles containing at least silver and copper in a single particle by heat treating a mixture containing an organic silver compound and an organic copper compound at a temperature of 150° C. or more in a non-oxidative atmosphere in the presence of a tertiary amine compound represented by the general formula R1R2R3N (wherein R1 through R3 are optionally substituted alkyl groups or aryl groups that may be the same or different, R1 through R3 may be linked in a ring, and the number of carbon atoms in each of R1 through R3 is 5 through 18 and may be the same or different).




no

Electrically conductive compositions comprising non-eutectic solder alloys

Transient liquid phase sintering compositions comprising one or more high melting point metals and one or more low melting temperature alloys are known in the art as useful compositions for creating electrically and/or thermally conductive pathways in electronic applications. The present invention provides transient liquid phase sintering compositions that employ non-eutectic low melting temperature alloys for improved sintering and metal matrix properties.




no

Platinum-coated non-noble metal-noble metal core-shell electrocatalysts

Core-shell particles encapsulated by a thin film of a catalytically active metal are described. The particles are preferably nanoparticles comprising a non-noble core with a noble metal shell which preferably do not include Pt. The non-noble metal-noble metal core-shell nanoparticles are encapsulated by a catalytically active metal which is preferably Pt. The core-shell nanoparticles are preferably formed by prolonged elevated-temperature annealing of nanoparticle alloys in an inert environment. This causes the noble metal component to surface segregate and form an atomically thin shell. The Pt overlayer is formed by a process involving the underpotential deposition of a monolayer of a non-noble metal followed by immersion in a solution comprising a Pt salt. A thin Pt layer forms via the galvanic displacement of non-noble surface atoms by more noble Pt atoms in the salt. The overall process is a robust and cost-efficient method for forming Pt-coated non-noble metal-noble metal core-shell nanoparticles.




no

Methods for producing silver nanoparticles

An exemplary embodiment of the invention is a method for making silver nanoparticles, and includes steps of reacting a silver salt with a phosphene amino acid to make silver nanoparticles. Exemplary phosphene amino acids include trimers, with a particular example being a trimeric amino acid conjugate containing one phosphene group. In an exemplary method of the invention, the silver nanoparticles may be produced in timer periods of less than about 30 minutes, and at temperatures of less than about 40° C. Other methods of the invention are directed to methods for stabilizing silver nanoparticles.




no

Articles containing copper nanoparticles and methods for production and use thereof

Articles containing a matrix material and plurality of copper nanoparticles in the matrix material that have been at least partially fused together are described. The copper nanoparticles are less than about 20 nm in size. Copper nanoparticles of this size become fused together at temperatures and pressures that are much lower than that of bulk copper. In general, the fusion temperatures decrease with increasing applied pressure and lowering of the size of the copper nanoparticles. The size of the copper nanoparticles can be varied by adjusting reaction conditions including, for example, surfactant systems, addition rates, and temperatures. Copper nanoparticles that have been at least partially fused together can form a thermally conductive percolation pathway in the matrix material.




no

Method of generating hydrogen from the reaction of stabilized aluminum nanoparticles with water and method of forming stabilized aluminum nanoparticles

A method of generating hydrogen gas from the reaction of stabilized aluminum nanoparticles with water is provided. The stabilized aluminum nanoparticles are synthesized from decomposition of an alane precursor in the presence of a catalyst and an organic passivation agent, and exhibit stability in air and solvents but are reactive with water. The reaction of the aluminum nanoparticles with water produces a hydrogen yield of at least 85%.




no

Highly aromatic compounds and polymers as precursors to carbon nanotube and metal nanoparticle compositions in shaped solids

A method of making metal nanoparticles and carbon nanotubes is disclosed. A mixture of a transition metal compound and an aromatic polymer, a precursor of an aromatic polymer, or an aromatic monomer is heated to form a metal nanoparticle composition, optionally containing carbon nanotubes.




no

Nanowire preparation methods, compositions, and articles

Methods of preparing nanowires having small diameters and large lengths are disclosed. Such nanowires are useful in electronics applications.




no

Composition for the synthesis of bimetallic nanoparticles in an ionic liquid and associated method

The invention relates to a composition for synthesizing bimetallic nanoparticles, wherein the composition contains a first organometallic precursor and a second organometallic precursor having different decomposition rates and contained within an ionic liquid solution. The invention also relates to a method for synthesizing bimetallic nanoparticles, in which the composition is transformed under a hydrogen gas pressure between 0.1 and 10 MPa at a temperature between 0 and 150° C. until a suspension of bimetallic nanoparticles is obtained. The resulting nanoparticles are useful in diverse fields including the fields of catalysis and microelectronics.




no

Nanowire preparation methods, compositions, and articles

Nanomaterial preparation methods, compositions, and articles are disclosed and claimed. Such methods can provide nanomaterials with improved morphologies relative to previous methods. Such materials are useful in electronic applications.




no

Nanowire preparation methods, compositions, and articles

Nanomaterial preparation methods, compositions, and articles are disclosed and claimed. Such methods can provide nanomaterials with improved morphologies relative to previous methods. Such materials are useful in electronic applications.




no

Methods of producing nanoparticle reinforced metal matrix nanocomposites from master nanocomposites

Methods of forming metal matrix nanocomposites are provided. The methods include the steps of introducing a master metal matrix nanocomposite into a molten metal at a temperature above the melting temperature of the master metal matrix nanocomposite, allowing at least a portion of the master metal matrix nanocomposite to mix with the molten metal and, then, solidifying the molten metal to provide a second metal matrix nanocomposite.




no

Method for making metal-based nano-composite material

A method for making a metal-based nano-composite material is disclosed. In the method, a semi-solid state metal-based material is provided. The semi-solid state metal-based material is stirred and nano-sized reinforcements are added into the semi-solid state metal-based material to obtain a semi-solid state mixture. The semi-solid state mixture is heated to a temperature above a liquidus temperature of the metal-based material, to achieve a liquid-metal-nano-sized reinforcement mixture. The liquid-metal-nano-sized reinforcement mixture is ultrasonically processed at a temperature above the liquidus temperature by conducting ultrasonic vibrations to the liquid-metal-nano-sized reinforcement mixture along different directions at the same time.




no

Methods of manufacturing high aspect ratio silver nanowires

A process for manufacturing high aspect ratio silver nanowires is provided, wherein the recovered silver nanowires exhibit an average diameter of 25 to 80 nm and an average length of 10 to 100 μm; and, wherein the total glycol concentration is




no

Nanowire preparation methods, compositions, and articles

Nanomaterial preparation methods, compositions, and articles are disclosed and claimed. Such methods can provide nanomaterials with improved morphologies and reduced nitric oxide co-production relative to previous methods. Such materials are useful in electronic applications.




no

Method for surface inclusions detection, enhancement of endothelial and osteoblast cells adhesion and proliferation, sterilization of electropolished and magnetoelectropolished nitinol surfaces

The method for surface inclusions detection, enhancement of endothelial and osteoblast cells adhesion and proliferation and sterilization of electropolished and magnetoelectropolished Nitinol implantable medical device surfaces uses an aqueous solution of chemical compounds containing halogenous oxyanions as hypochlorite (ClO−) and hypobromite (BrO−) preferentially 6% sodium hypochlorite (NaClO).




no

Oxygen monolayer on a semiconductor

A Si or Ge semi-conductor substrate includes an oxygen monolayer on a surface thereof. The oxygen monolayer can be fractional or complete. A Si4+ or Ge4+ oxidation state of the surface of the Si or Ge substrate, respectively, resulting from the presence of the oxygen monolayer represents less than 50%, preferably less than 40% and more preferably less than 30% of the sum of Si1+, Si2+, Si3+ and Si4+ oxidation states or the sum of Ge1+, Ge2+, Ge3+ and Ge4+ oxidation states, respectively, as measured by XPS.




no

Preparation method of nanocrystalline titanium alloy at low strain

Provided is a method of preparing a nanocrystalline titanium alloy at low strain to have better strength. The present invention is characterized in that an initial microstructure is induced as martensites having a fine layered structure, and then a nanocrystalline titanium alloy is prepared at low strain by optimizing process variables through observation of the effects of strain, strain rate, and deformation temperature on the changes in the microstructure.




no

Electric induction heating of a rail head with non-uniform longitudinal temperature distribution

Apparatus and method are provided for making the longitudinal temperature distribution of the bulbous end of a longitudinally oriented workpiece, such as a rail's head, generally uniform when the head has a non-uniform longitudinal temperature distribution. A combination of crown and skirt electric inductors is used to achieve the generally uniform temperature distribution by modulating the magnetic field intensity produced by current flow through one or more of the combination of crown and skirt inductors as required for the non-uniformly heated regions of the rail's head.




no

Canopy for portable electrical device

A system and method are provided for the shielding of outdoor electrical equipment from inclement weather, the system comprising: a plurality of support brackets affixed to the outdoor electrical equipment; a support frame disposed in the support brackets; a waterproof cover disposed over the frame; an apron depending from the cover, configured to cover electrical connections on a side of the outdoor electrical equipment.




no

Inhibiting corrosion of aluminum on consumer ware washing product using phosphinosuccinic acid oligomers

A dishwashing detergent composition is provided for consumer use for in cleaning of alkaline sensitive metals such as aluminum or aluminum containing alloys. The compositions include alternatives to sodium tripolyphosphate and/or other phosphorus containing raw materials, while retaining cleaning performance and corrosion prevention. According to the invention, a phosphinosuccinic acid oligomer or mixture thereof is used as a corrosion inhibitor and can be included for aluminum protection in a number of different detergent compositions.




no

Nozzle and a substrate processing apparatus including the same

A nozzle of a nozzle device includes an arm pipe that extends in a horizontal direction and a downstream pipe formed so as to curve downward from one end of the arm pipe. In the nozzle, a metallic pipe is provided inside a second resin pipe. Moreover, a first resin pipe is provided inside the metallic pipe. A boss is attached to the tip of the metallic pipe between the first resin pipe and the second resin pipe. At the tip of the nozzle, an outer peripheral surface of the first resin pipe, an end surface of the second resin pipe and an end surface of the boss are welded by welding resin. In this way, the metallic pipe is reliably coated with the first resin pipe, the second resin pipe, the boss and the welding resin.




no

Corrosion and fouling mitigation using non-phosphorus based additives

Water treatment compositions are provided that are effective for mitigating corrosion or fouling of surfaces in contact with aqueous systems. The water treatment compositions can include one or more azole compounds, one or more transition metals, and one or more dispersants, in addition to various other additives. The water treatment compositions can exclude phosphorus and still be effective. Methods for mitigating corrosion or fouling of a surface in an aqueous system are also provided.




no

Low foam media cleaning detergent with nonionic surfactants

A detergent for cleaning media is provided. The detergent comprises deionized water, between about 1% and about 5% by weight of a nonionic surfactant having an hydrophile/lipophile balance (HLB) value between about 10 and about 20, and an ethoxylation level between about 5 and about 20, between about 1% and about 5% by weight of a dispersing agent, between about 3% and about 10% by weight of a chelating agent comprising phosphonic acid, and between about 2% and about 6% by weight of an inorganic salt.




no

Method and apparatus for multiple cutoff machining of rare earth magnet block, cutting fluid feed nozzle, and magnet block securing jig

In a method for multiple cutoff machining a rare earth magnet block, a cutting fluid feed nozzle having a plurality of slits is combined with a plurality of cutoff abrasive blades coaxially mounted on a rotating shaft, each said blade comprising a base disk and a peripheral cutting part. The slits in the feed nozzle into which the outer peripheral portions of cutoff abrasive blades are inserted serve to restrict any axial run-out of the cutoff abrasive blades during rotation. Cutting fluid is fed from the feed nozzle through slits to the rotating cutoff abrasive blades and eventually to points of cutoff machining on the magnet block.




no

Non-electroslag remelting type clean metal ingot mold

A non-electroslag remelting type clean metal ingot mold includes an ingot mold body and a insulating riser arranged on the ingot mold body; an insulated heating and heat preservation device is vertically arranged in the ingot mold body and divides the space in the ingot mold body into a plurality of independent cavity units; and the cavity units are distributed in two rows in the ingot mold body. Because the insulated heating and heat preservation device is arranged in the ingot mold body and divides the space in the ingot mold body into a plurality of independent cavity units, most of impurities and segregates in liquid metals are enriched in the part in contact with the isolation and heat insulation mechanism during the directional solidification and crystallization of the liquid metals and the enriched alloy segregates, and the impurities can be easily eliminated by utilizing flame or other processing methods.




no

Bituminous froth inline steam injection processing

An inline bitumen froth steam heater system including steam injection and static mixing devices is provided. The system heats and de-aerates input bitumen froth without creating downstream processing problems with the bitumen froth such as emulsification or live steam entrainment. The system is a multistage unit that injects and thoroughly mixes steam with bitumen resulting in output bitumen material having temperature of about 190° F. The system conditions a superheated steam supply to obtain saturated steam at about 300° F. The saturated steam is contacted with bitumen froth flow and mixed in a static mixer stage. The static mixers provide surface area and rotating action that allows the injected steam to condense and transfer its heat to the bitumen froth. The mixing action and increase in temperature of the bitumen froth results in reduction in bitumen viscosity and allows the release of entrapped air from the bitumen froth.




no

Method for manufacturing weaving material from nonwoven

The present invention provides a method for producing thread using nonwoven, which discloses that nonwoven having different materials is slit first to get a plurality of nonwoven threads and then the nonwoven threads are used for performing a twisting process to get a plurality of nonwoven yarns. In the twisting process, each of the nonwoven threads has different materials, so that the nonwoven yarns have good mechanical characteristic and can be added for producing textiles with various functionalities.




no

Knitted component for an article of footwear including a full monofilament upper

An article of footwear including a full monofilament upper is described. The full monofilament upper incorporates a knitted component including a monofilament knit element. The monofilament knit element is formed by knitting with a monofilament strand. The monofilament knit element is formed of unitary knit construction with the remaining portions of the knitted component, including peripheral portions that are knit using a natural or synthetic twisted fiber yarn. An inlaid tensile element can extend through the knitted component, including portions of the monofilament knit element. The monofilament knit element may be knitted with a monofilament strand according to a variety of knit structures.




no

Article of footwear including a monofilament knit element with peripheral knit portions

An article of footwear including a knitted component having a monofilament knit element with peripheral knit portions is described. The knitted component includes a monofilament knit element formed by knitting with a monofilament strand. The monofilament knit element is formed of unitary knit construction with the remaining portions of the knitted component, including peripheral portions that are knit using a natural or synthetic twisted fiber yarn. An inlaid tensile element can extend through the knitted component, including portions of the monofilament knit element. The monofilament knit element may be knitted with a monofilament strand according to a variety of knit structures.




no

Article of footwear including a monofilament knit element with a fusible strand

An article of footwear including a full monofilament upper is described. The full monofilament upper incorporates a knitted component including a monofilament knit element. The monofilament knit element is formed by knitting with a monofilament strand. The monofilament knit element is formed of unitary knit construction with the remaining portions of the knitted component, including peripheral portions that are knit using a natural or synthetic twisted fiber yarn. An inlaid tensile element can extend through the knitted component, including portions of the monofilament knit element. The monofilament knit element may be knitted with a monofilament strand according to a variety of knit structures. A fusible strand may be knit with the monofilament knit element. Upon heating, the fusible strand can combine and surround the monofilament strand within the monofilament knit element.




no

Article of footwear including a monofilament knit element with peripheral knit portions

An article of footwear including a knitted component having a monofilament knit element with peripheral knit portions is described. The knitted component includes a monofilament knit element formed by knitting with a monofilament strand. The monofilament knit element is formed of unitary knit construction with the remaining portions of the knitted component, including peripheral portions that are knit using a natural or synthetic twisted fiber yarn. An inlaid tensile element can extend through the knitted component, including portions of the monofilament knit element. The monofilament knit element may be knitted with a monofilament strand according to a variety of knit structures.




no

Novel method for preparing pH dependent Ultra Small Polymeric Nanoparticles for topical and/or Transdermal delivery

The invention provides a new method for preparing ultra-small polymeric-lipidic delivery nanoparticles (USDNs) that were synthesized by a nanoprecipitation method followed by a layer-by-layer nanodeposition. The USDNs particle size can be controlled between 5-25 mn and provides loading capacities of 22.12% to 72.08%. Moreover, the USDNs platform provides pH controlled drug release, within a terminal release ratio of 68% at pH 5.0 and almost no release to pH of 7.5. Furthermore, based on their small sizes (5-25 nm) and unique composition, the USDNs penetrates the skin strata efficiently, release the payload at the target site as topical or transdermal treatment of a variety of skin disorders. Additionally the USDNs system can be used to treat and diagnoses other crucial diseases (Cancer, Alzheimer, etc) can be combined with various micro-needles or needles free array technologies for special application.




no

EBOLA MONOCLONAL ANTIBODIES

The present disclosure provides antibodies, and antigen-binding fragments thereof that bind to EBOV glycoprotein. The present disclosure further provides hybridoma cell lines and methods for making and using the compositions provided herein.




no

IMMUNOPOTENTIATOR CONTAINING ANTI-ANG2 ANTIBODY

Provided is a method of potentiating immunity or preventing or treating an immune-related disease comprising administering an anti-Ang2 antibody or an antigen-binding fragment thereof to a subject in need thereof.




no

Immunological Targeting of Pathological Tau Proteins

The present invention relates to methods and compositions for treating, preventing, and diagnosing Alzheimer's Disease or other tauopathies in a subject by administering an immunogenic tau peptide or an antibody recognizing the immunogenic tau epitope under conditions effective to treat, prevent, or diagnose Alzheimer's Disease or other tauopathies. Also disclosed are methods of promoting clearance of aggregates from the brain of the subject and of slowing progression of tau-pathology related behavioral phenotype in a subject.




no

IMMUNE-STIMULATING MONOCLONAL ANTIBODIES AGAINST HUMAN INTERLEUKIN-2

The invention relates to a human Interleukin-2 (hIL-2) specific monoclonal antibody (mAb), or antigen binding fragment thereof, the binding of which to hIL-2 inhibits binding of hIL-2 to CD25 and the antibody is characterized by any of the parameters: the variable chain of the mAb comprises the amino acid sequence of SEQ ID NO 005 or SEQ ID NO 006; the binding to hIL-2 is characterized by a dissociation constant (KD)≦7.5 nmol/L; the binding to hIL-2 is characterized by an off-rate (Koff)≦1×10−4 s−1 and/or the antibody displays no measurable cross-reactivity to murine IL-2.




no

NOTCH1 RECEPTOR BINDING AGENTS AND METHODS OF USE THEREOF

The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor and inhibits tumor growth. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.




no

ANTIBODY SCAFFOLD FOR HOMOGENOUS CONJUGATION

Provided in some embodiments are antibodies comprising a heavy chain having no native interchain cysteine amino acids, a light chain having no native interchain cysteine amino acids, and having no native interchain disulphide linkages between the heavy chain and the light chain. Also provided in certain embodiments are antibodies comprising a heavy chain having no native interchain cysteine amino acids, a light chain having no native interchain cysteine amino acids, and having no native interchain disulphide linkages between the heavy chain and the light chain where the native interchain cysteine amino acids have been replaced by amino acids having no thiol moiety.




no

CD123 SPECIFIC CHIMERIC ANTIGEN RECEPTORS FOR CANCER IMMUNOTHERAPY

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a CD123 monoclonal antibody, conferring specific immunity against CD123 positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas and leukemia.




no

BCMA (CD269) SPECIFIC CHIMERIC ANTIGEN RECEPTORS FOR CANCER IMMUNOTHERAPY

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a BCMA monoclonal antibody, conferring specific immunity against BCMA positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas, multiple myeloma and leukemia.




no

Simian Adenoviruses SAdV-36, -42.1, -42.2, and -44 and Uses Thereof

A recombinant vector comprises simian adenovirus 36, simian adenovirus 42.1, simian adenovirus 42.2 and/or simian adenovirus 44 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-36, -42.1, -42.2 or -44 gene(s) is also described. Methods of using the vectors and cell lines are provided.