This invention publicizes a chronic renal disease diagnostic kit, comprised of FGF23 monoclonal antibody, biotin labeling reagent Sulfo-NHS-LC-Biotin, PBS buffer solution (pH7.0, 0.1M), casein saline solution, streptomycin avidin and substrate TMB. The labeling condition is the weight ratio of FGF23 antibody and Sulfo-NHS-LC-Biotin, which is 1:5-1:12. The dilution ratio of streptomycin avidin is 1:3000. The lowest testing threshold limit value of FGF23 kit is 10 pg/ml, whose sensitivity is 10 times higher than that of common monoclonal antibody, which is very significant for early diagnose of chronic renal disease.

The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.

The present invention relates to an in vitro method of diagnosing chronic myelomonocytic leukemia (CMML) in a subject, said method comprising the steps of: a) Detecting a monocyte population in a biological sample from said subject; b) Quantifying the CD14+/CD16− monocytes in said biological sample; c) Comparing the value of step b) to a reference value; and d) Diagnosing CMML based on said comparison. Preferably, said detecting step a) is performed by an exclusion gating strategy by flow cytometry.

A method to detect prostate cancer comprising contacting a sample of prostate cells from the patient with a set of detectably labeled probes under hybridization conditions and determining the presence of chromosomal abnormalities in prostate tumor tissue, PIN (intra-epithelial neoplasia), histologically benign tissue and benign prostatic hyperplasia (BPH); a method to combine immunofluorescence and FISH (IF-FISH) to facilitate the assessment of chromosomal abnormalities; a set of probes; and a kit comprising the set of probes and instructions for diagnosing prostate cancer in a patient.

We have discovered a protein in humans, herein referred to as collagen like gene (CLG) product (SEQ ID NOS: 12 and 13), that is expressed in human prostate cancer and breast cancer cell lines but not in normal adult, placenta, lung, liver, skeletal muscle, kidney or pancreas tissues. We have also discovered that the level of CLG mRNA expression correlates positively with the metastatic potential of the cancer cell lines tested.

In sporadic Alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been developed recently that detect tau in biological specimens, thus providing a means for pre-mortem diagnosis of Alzheimer's disease, which has remained elusive. These assays have been improved by the analysis of relevant post-translational modifications, such as phosphorylation, however opportunity for improvement remains. The present invention addresses this issue by disclosing synthetic methylated peptides derived from the tau protein of paired helical filaments and non-diseased control brain. Alzheimer's disease specificity is provided by the presence or absence of methyl moieties on lysine residues and differences between mono-, di-, and tri-methylation. The methylated peptide is useful as an antigen and a binding partner for identifying compounds that interact with the peptide and the methylated tau protein, including antibodies that can distinguish non-diseased brain from that affected by Alzheimer's disease. The resulting antibodies are useful diagnostically and therapeutically. The compounds that specifically bind to methylated tau proteins are useful for eliminating abnormally methylated tau.

A population of bright and stable nanocrystals is provided. The nanocrystals include a semiconductor core and a thick semiconductor shell and can exhibit high extinction coefficients, high quantum yields, and limited or no detectable blinking.

Just in time to celebrate its ten-year anniversary, popular Filipino-fusion food truck Señor Sisig has established a long-term location in Oakland.

The brand-new spot is at 3331 Fruitvale Ave. in the Dimond District.…

It takes some balls to say weed doubles the risk of stroke, and to not control the study for tobacco or alcohol use. New Zealand professor of clinical neurology Alan Barber: You sir, have some balls.…

The city's 911 system can leave callers waiting for more than 120 seconds before an operator ever answers. Seconds of delay in an emergency can lead to death. As a result, 911 calls are supposed to be answered quickly.…

The present invention relates to a process for producing an electrolytic capacitor, the process comprising process steps i) ii): i) providing a capacitor body (1) that comprises an electrode body (2) of an electrode material,a dielectric (3) which at least partially covers the surface of this electrode material, anda solid electrolyte (4) at least comprising an electrically conductive material which at least partially covers the dielectric surface; ii) applying a primer solution e) to the capacitor body (1), followed by an application of a solution or dispersion a) comprising a conjugated polymer b) and a solvent or dispersant d), followed by an at least partial removal of the solvent or dispersant d) for the formation of the polymeric outer layer (5) that is formed onto the capacitor body (1); wherein the primer solution e) comprises at least one monofunctional amine and at least one carboxylic acid.

More rose-tinted views of the EU: the EU not falling apart?

As we predicted earlier this year, a new Rekordbox version has been released. Rekordbox 6 has a new functionality, Cloud Library Sync, which allows the ability to upload tracks and playlists to Dropbox and sync them across multiple devices. Cloud Library Sync: Tracks, playlists, and track metadata are able to be synced across four different […]

The post Rekordbox 6: Now With Cloud Library Syncing appeared first on DJ TechTools.

On Facebook, live streaming just got taken things a step further: with monetization. Many suspected monetizing virtual events was coming, and it seems to be rapidly arriving on the largest social network. Facebook has come forward with new updates to assert its dominance in this COVID-19 era of online entertainment and relationships. New Facebook Tools […]

The post Facebook Now Lets You Charge Entry To Livestream Events appeared first on DJ TechTools.

The new AMC series Dispatches From Elsewhere was inspired by a massive art project created by the Oaklandish founder. Before it premiered last Sunday, months of promotional teasers for the AMC series Dispatches From Elsewhere intrigued viewers with scintillating visuals emerging from mundane settings, while only hinting at the show's quixotic premise. AMC describes its 10-hour series as the story of four people "brought together by chance — or perhaps it's by design — when they stumble onto a puzzle hiding just behind the veil of everyday life."…

A compound represented by the following formula (1):

A product for use in a turbocharger system. A turbine housing may define a center core that is circular in shape with a circumference. The turbine housing may define a first volute that extends for a length around only a part of the circumference of the center core, and a second volute that may be positioned radially outside the first volute and that may extend entirely around the circumference of the center core. The first volute and the second volute may define first and second exhaust gas passages through the turbine housing that may be asymmetric. All points of the second volute may be radially outside the first volute from the center core over the entire length of the first volute.

A fuel nozzle assembly includes a premix chamber, an air flow divider extending radially and axially within the premix chamber between an inner wall and an outer wall and a plurality of guide vanes disposed within the premix chamber. One or more of the guide vanes includes a fuel port in fluid communication with the flow divider. The fuel nozzle assembly further includes a premix plate that extends radially between the inner and outer walls and circumferentially between first and second side walls downstream from the fuel ports. The premix plate includes an upstream side axially spaced from a downstream side and a plurality of passages that provide for fluid flow from the premix chamber through the premix plate.

An injection assembly for a combustor of a gas turbine has an outer body provided with inlet passages for comburent air, a conical tubular portion housed inside the outer body and delimiting partly an inner duct and an outer annular duct; a first and a second supply means for supplying a liquid fuel into the inner duct and, respectively, into the outer annular duct; at least one circumferential annular seat formed being carried by one of the tubular portion and the outer body, so as to collect a mass of liquid fuel advancing in the outer annular duct and make uniform the flow of liquid flowing out of the circumferential annular seat.

The present invention relates to an optical clear resin and a method for producing a liquid optical clear photo-curable adhesive.

A bituminous composition is used as an adhesive binder. The bituminous composition has at least one acidic additive of general formula (I): R—(COOH)z in which R is a linear or branched, saturated or unsaturated hydrocarbon-based chain having from 4 to 68 carbon atoms, preferably from 4 to 54 carbon atoms, more preferentially from 4 to 36 carbon atoms and z is an integer ranging from 1 to 4, preferably from 2 to 4.

There is described a sonotrode for sealing an opening device onto a hole of a packaging material destined to from a sealed package, comprising: a sealing surface adapted to cooperate with a said packaging material in order to seal the opening device to the packaging material; a cavity bounded by an opening of sealing surface and adapted to receive the opening device; and a ring made in an elastomeric material, partially protruding inside the cavity, and adapted to center a first axis of the opening device on a second axis of the sonotrode.

The disclosed apparatus cools a drinking liquid utilizing the Peltier effect, and optionally includes a system of gasification for gasifying the drinking liquid, once cooled. The cooling system in turn includes: a first cooling circuit, in which an operating fluid circulates, associated with a hot side of a Peltier cell; and a second cooling circuit, in which the drinking liquid circulates, associated with a cold side of the Peltier cell. The Peltier cell is integrated in a cooling unit exhibiting a special sandwich structure which integrates, as well as the Peltier cell, a first and a second heat exchanger, apt respectively to exchange directly the heat between the operating fluid which circulates in the first cooling circuit and the hot side of the Peltier cell and between the drinking liquid which circulates in the second cooling circuit and the cold side of the Peltier cell to cool the drinking liquid.

Wiltshire becomes a metaphor for today's Britain in Barney Norris' retelling of Lorca's Blood Wedding at Salisbury Playhouse. The blood feud of the original is replaced by laddish drunkenness and Mediterranean passion by English reticence in which ‘Sorry’ is the most used word.

Despite a surge in support for independence in the last few weeks, the Better Together campaign came through with a majority sufficient to put to bed the question of independence for Scotland, at least for now.

The end to the fluoride saga in the Southampton city region will put a big hole in the correspondence bag for this paper’s daily letters page.

IT had seemed a simple plan: to drive from Basingstoke to Ringwood, leaving the function I was attending around 10pm.

It is interesting that the Greek Prime Minister, Alexis Tsipras, summons the very real fact his nation invented democracy to bolster his government’s argument for a favourable solution to the debt crisis wracking its citizens.

Cain Manor is an exquisite Elizabethan oak-framed manor house near Farnham. It is set in 30 acres of landscaped grounds and woodland with wonderful views over Surrey’s Golden Valley. The whole venue has been discerningly renovated and furnished in a tasteful, contemporary style.

News you don't want to miss for April 8:

1. Schools in Alameda County, and five other Bay Area counties, will not re-open this academic year, the San Francisco Chronicle reports.…

News you don't want to miss for May 4:

1. Businesses such as bookstores, florists, clothing retailers, among others, can begin to reopen on Friday, Gov. Gavin Newsom announced, according to the Associated Press.…

Having a baby was complicated even before the coronavirus pandemic added a new set of issues to the equation By Amani Hamed Every morning, Shanell Qualls, 26, leaves her two toddlers with her husband and travels to the hospital where she gave birth to their third child on March 9.…

The present invention provides color-coded accessories such as wristbands, bibs, and other patient wearables, color-coded pillows and pillow cases, and a universal chart wherein the color code is associated with a specific medical diagnosis. These accessories alert healthcare providers to the medical diagnosis of the patient and enhance patient safety by reducing medical errors during administration of treatments and medicines to the patients. These accessories also provide protection to healthcare providers assisting them to identify diagnostic categories and alerting them to take proper precautions with patients, for example those with infectious diseases, thereby decreasing or preventing transmission of infectious diseases.

The mood music for savers isn’t good. The world economic outlook is gloomy and there’s huge uncertainty here in the UK, so the City’s long-term interest rates have plummeted. And it’s these that many fixed savings rates are based on – so they’re dropping too. On top of that, the two top easy-access savings accounts cut their rates within days of each other.

Mis-sold Wonga customers have been legally robbed.

The invention relates to a product for pilgrims performing the rites of Haj and Umrah. Used to reduce the crushes resulting from pilgrims colliding because, for example, pilgrims places their shoes close to the gate from which they entered thinking that it will be easy to return to the same place once they have performed the rites of circumambulation (tawaf) and running (sa'ay). However, in reality the pilgrims must walk against the flow, causing collisions and severe crushes, or he is forced to leave his shoes behind, which is a burden for cleaning staff, looks untidy and is a nuisance for pilgrims, the main figures for the inventions are FIG. 7 before wearing the shoes and FIGS. 8,9,10 and 11 after wearing it.

A footwear effects toning of the leg muscles. It includes two soles and a redress mechanism contained within each of the soles for redressing the positions of the soles, in order to adjust corresponding feet positions by toning the leg muscles. A shock absorbing pebble for use within the soles, includes an elastic membrane that deforms under pressure, and that defines two chambers that are connected by means of a gas permeable membrane. In a balanced position, the first chamber is filled with a mixture of gas along with fluid, and the second chamber is filled with gas. As an external force is applied to the membrane, gas molecules are forced into the second chamber, inflating it until equilibrium is achieved, thus dampening the external force.

POLICE are appealing for information after a 'suspicious' 4X4 was seen pulling onto someone's drive with the number plates covered up.

IT was the perfectly scripted Hollywood ending for a distinctly familiar cinema audience.

IT'S the perfect antidote to cold winter afternoons - and this year it's bigger than ever.

Matthew Hoggard thinks his former team-mate Kevin Pietersen has no chance of playing for England again and believes incoming chairman Colin Graves was ''careless'' to suggest otherwise.

View pictures of Saints thumping Norwich 3-0.

HARRY Redknapp has “no doubt” Cherries will steer clear of trouble – and the club’s former boss says he admires Eddie Howe’s refusal to sacrifice his footballing principles as the survival battle hots up.

NEW Forest carp farmers Heather Fisheries were delighted to be asked to provide a memorial fish for the Stone family to put into Christchurch Angling Club’s Hucklesbrook Lake.

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AMBULANCE crews rushed to the scene of a football match in Hythe after a player was knocked unconscious.

Southampton's Gabi Taylor is in the Surbiton Trophy quarter-finals after a stunning win against GB teammate Heather Watson - and another victory today.

Gabi Taylor pushed defending champion Donna Vekic all the way before losing her first-round match at the Nottingham Open.

IT SEEMS very un- Saintslike, almost unnatural, to go into the last day of the season with nothing to play for.

A COUNCIL has announced schools across Hampshire will continue to support children throughout the Easter holidays in a bid to tackle the coronavirus crisis.