With regulations urging residents statewide to wear masks when in public, here is how Southern Utahsn have fared following the recommended guidelines

مجموعه‌ای از عکس‌های برگزیده خبری در هفته گذشته (۲-۸ می ۲۰۲۰) که در نقاط مختلف دنیا منتشر شده‌اند.

Purdue Boilermakers play seven games in West Lafayette during the 2018 season, including their first four

Tight end who scored 16 touchdowns for the Boilermakers is picked by the Los Angeles Rams in the fourth round.

After leaning on their defense in 2017, the Boilermakers will need more from their offense in coach Jeff Brohm's second season

Purdue's athletic department had its best finish in the Learfield Directors Cup standings in nearly a decade but more is expected in 2018-19

Markus Bailey missed most of his senior season with a knee injury but he started 40 games for the Boilermakers.

Purdue coach Matt Painter and staff will explore the July evaluation period over the next three weeks. But the recruiting foundation for 2019 is set.

Games involving Notre Dame, Purdue and Indiana could have a lot at stake this season.

A look at where locals land on new national lists

From Notre Dame to the Monon Bell. We rank Indiana's top 50 college football games in 2018.

Tracking the Boilermakers throughout the offseason

Decision makers at Penske Entertainment are beginning to chart the course for a historic summer of racing at the Indianapolis Motor Speedway.

Canadian Felicia (Feenom) Spencer's on-again off-again title challenge against UFC featherweight champion Amanda (Lioness) Nunes has been confirmed for UFC 250.

Deaths and hospitalizations related to COVID-19 could increase dramatically in Montreal if social distancing measures are lifted, according to a new study.

Police Federation calls for anyone using coronavirus as a weapon automatically to be remanded in custody.

The Most Useful Websites - self published using Amazon KDP.

Bollywood Movies on Zero Dollar Movies

Mail Merge for Gmail to help you send personalized emails.

There have been 1,644 total lab-confirmed cases of COVID-19 since the first case was confirmed March 11.

As millions of people have their salaries cut, will mortgage providers lend based on reduced salary?

How coping with OCD prepared one man for the challenges of the coronavirus pandemic.

Around 50,000 coronavirus test samples had to be sent to the US due to "operational issues" in the UK, it has been revealed.

Filed under: Internet Tools, News

Continue reading Facebook, Instagram Release Top Checked-in Locations of 2013

Facebook, Instagram Release Top Checked-in Locations of 2013 originally appeared on Gadling on Fri, 13 Dec 2013 14:23:00 EST. Please see our terms for use of feeds.

Filed under: North America, United States

Continue reading MapQuest Unveils 10 Top Destinations of 2013

MapQuest Unveils 10 Top Destinations of 2013 originally appeared on Gadling on Mon, 23 Dec 2013 10:29:00 EST. Please see our terms for use of feeds.

Filed under: History, Blogs

A recently-released program called Mosaic was revolutionizing what might be possible on the World Wide Web. "What we hope you'll do," the editor [at O'Reilly Media] said, "is write columns for us - from the road. We'll publish them live, on the GNN [Global Network Navigator, O'Reilly's website], where people can read them as you travel." The Travelers' Center, he told me, would include a feature that sounded miraculous: A map would be displayed on their website, with dots showing the locations from where I'd sent back posts. People would simply click on those dots - and see the story I'd written from that location!

Continue reading Travel Blogging Turns 20 Today

Travel Blogging Turns 20 Today originally appeared on Gadling on Mon, 06 Jan 2014 17:31:00 EST. Please see our terms for use of feeds.

Filed under: Business, Europe, North America, Denmark, Iceland, Belize, United States

Continue reading Top 5 Family Travel Destinations for 2014 (and Possibly Beyond)

Top 5 Family Travel Destinations for 2014 (and Possibly Beyond) originally appeared on Gadling on Thu, 09 Jan 2014 13:09:00 EST. Please see our terms for use of feeds.

Many companies use the term artificial intelligence, or AI, as a way to generate excitement for their products and to present themselves as on the cutting edge of tech development.

But what exactly is artificial intelligence? What does it involve? And how will it help the development of future generations?

Find out the answers to these questions and more in AI 101, a brand new FREE report from Business Insider Intelligence, Business Insider's premium research service, that describes how AI works and looks at its present and potential future applications.

To get your copy of the FREE slide deck, simply click here.

Join the conversation about this story »

John Hillman - the 101-year-old Second World War veteran who has been walking laps around the courtyard of his Oak Bay retirement home in hopes of raising $101,000 for charity - has surpassed his goal.

A department store that served Vancouver's Gastown and Downtown Eastside neighbourhoods for decades is closing, along with four other Army and Navy locations, because of the COVID-19 pandemic.

The following article, NYC Nurse Steals Credit Card From 70-Yr-Old Dying COVID-19 Patient On Ventilator, was first published on 100PercentFedUp.com.

"She is a despicable human being"

Continue reading: NYC Nurse Steals Credit Card From 70-Yr-Old Dying COVID-19 Patient On Ventilator ...

7 October 2014

12 November 2014 , Volume 90, Number 6

Mary Wardell posted a photo:

This old lighthouse keeper stared out into the storm to see if there were any ships out there caught in the wnds and waves .

Webtraverser posted a photo:

Tyrannosaurus silhouette

"I think it's always important to think about suicide as individual vulnerabilities and context," Eric Caine said.

Lethal infections by strains of the highly-pathogenic avian influenza virus (HPAIV) H5N1 pose serious threats to both the poultry industry and public health worldwide. A lack of confirmed HPAIV epitopes recognized by cytotoxic T lymphocytes (CTLs) has hindered the utilization of CD8+ T-cell–mediated immunity and has precluded the development of effectively diversified epitope-based vaccination approaches. In particular, an HPAIV H5N1 CTL-recognized epitope based on the peptide MHC-I–β2m (pMHC-I) complex has not yet been designed. Here, screening a collection of selected peptides of several HPAIV strains against a specific pathogen-free pMHC-I (pBF2*1501), we identified a highly-conserved HPAIV H5N1 CTL epitope, named HPAIV–PA123–130. We determined the structure of the BF2*1501–PA123–130 complex at 2.1 Å resolution to elucidate the molecular mechanisms of a preferential presentation of the highly-conserved PA123–130 epitope in the chicken B15 lineage. Conformational characteristics of the PA123–130 epitope with a protruding Tyr-7 residue indicated that this epitope has great potential to be recognized by specific TCRs. Moreover, significantly increased numbers of CD8+ T cells specific for the HPAIV–PA123–130 epitope in peptide-immunized chickens indicated that a repertoire of CD8+ T cells can specifically respond to this epitope. We anticipate that the identification and structural characterization of the PA123–130 epitope reported here could enable further studies of CTL immunity against HPAIV H5N1. Such studies may aid in the development of vaccine development strategies using well-conserved internal viral antigens in chickens.

Contact between inflammatory cells and endothelial cells (ECs) is a crucial step in vascular inflammation. Recently, we demonstrated that the cell-surface level of endomucin (EMCN), a heavily O-glycosylated single-transmembrane sialomucin, interferes with the interactions between inflammatory cells and ECs. We have also shown that, in response to an inflammatory stimulus, EMCN is cleared from the cell surface by an unknown mechanism. In this study, using adenovirus-mediated overexpression of a tagged EMCN in human umbilical vein ECs, we found that treatment with tumor necrosis factor α (TNF-α) or the strong oxidant pervanadate leads to loss of cell-surface EMCN and increases the levels of the C-terminal fragment of EMCN 3- to 4-fold. Furthermore, treatment with the broad-spectrum matrix metalloproteinase inhibitor batimastat (BB94) or inhibition of ADAM metallopeptidase domain 10 (ADAM10) and ADAM17 with two small-molecule inhibitors, GW280264X and GI254023X, or with siRNA significantly reduced basal and TNFα-induced cell-surface EMCN cleavage. Release of the C-terminal fragment of EMCN by TNF-α treatment was blocked by chemical inhibition of ADAM10 alone or in combination with ADAM17. These results indicate that cell-surface EMCN undergoes constitutive cleavage and that TNF-α treatment dramatically increases this cleavage, which is mediated predominantly by ADAM10 and ADAM17. As endothelial cell-surface EMCN attenuates leukocyte–EC interactions during inflammation, we propose that EMCN is a potential therapeutic target to manage vascular inflammation.