ot King Edward I, at the birth of his son Edward Prince of Wales, while the baby's mother Eleanor of Castile lies in bed. Mezzotint by V. Green, 1788, after J.G. Huck. By feedproxy.google.com Published On :: London (No. 29 Newman Street, Oxford Street) : Published ... by V. & R. Green, January 18th 1788 Full Article
ot Michigan Teachers Can Leave the Union at Any Time, Not Just in August, Court Rules By feedproxy.google.com Published On :: Mon, 26 Mar 2018 00:00:00 +0000 The Michigan ruling could be a signal of what's to come after the case on union fees that's currently being decided by the U.S. Supreme Court. Full Article Michigan
ot Open Carry Issue in Michigan Schools May Not Be Settled By feedproxy.google.com Published On :: Fri, 03 Aug 2018 00:00:00 +0000 Questions remain after the Michigan Supreme Court ruled that two school districts have the right to ban guns from their schools. Full Article Michigan
ot 2020 NHL draft profile: William Wallinder looks a lot like Flyers prospect Egor Zamula By sports.yahoo.com Published On :: Wed, 06 May 2020 17:27:47 GMT The next Egor Zamula? A package of size and skill could be there for the Flyers in the 2020 NHL draft with William Wallinder. By Jordan Hall Full Article article Sports
ot The Latest: China's football association to cut pay By sports.yahoo.com Published On :: Thu, 07 May 2020 08:32:17 GMT In a video posted along with the schedule, the Seahawks gave season tickets to 12 workers who had been nominated for consideration. The 12 were told of receiving season tickets in video calls with Seahawks players Shaquill and Shaquem Griffin, DK Metcalf, Tyler Lockett, Will Dissly and coach Pete Carroll. The Royal St. John’s Regatta in Canada has been canceled because of the COVID-19 pandemic. Full Article article Sports
ot Caps Stanley Cup run lookback: Re-living Kuzy's OT goal against the Penguins By sports.yahoo.com Published On :: Thu, 07 May 2020 16:41:37 GMT It's been two years since Kuzy sent the Caps to the Eastern Conference Final with a legendary goal in overtime. Full Article article Sports
ot A 24-team Stanley Cup Playoffs? Latest NHL buzz and a hypothetical Flyers matchup By sports.yahoo.com Published On :: Thu, 07 May 2020 20:15:48 GMT A 24-team Stanley Cup Playoffs? Here's a look at the latest NHL buzz and a hypothetical Flyers matchup. By Jordan Hall Full Article article Sports
ot Roundtable: What is your favorite hockey photo of all-time? By sports.yahoo.com Published On :: Fri, 08 May 2020 15:00:23 GMT There have been so many great hockey images taken by photographers. We choose our top three shots ranging from Stanley Cup celebations to iconic moments. Full Article article Sports
ot 2020 NHL draft profile: Ridly Greig, son of Flyers scout Mark Greig, is a center with 200-foot bite By sports.yahoo.com Published On :: Fri, 08 May 2020 15:56:48 GMT Ridly Greig, son of Flyers scout Mark Greig, is a center with 200-foot bite and should be available for the club in the first round of the 2020 NHL draft. By Jordan Hall Full Article article Sports
ot This Date in Bruins History: B's earn thrilling OT wins vs. Leafs, Canadiens By sports.yahoo.com Published On :: Fri, 08 May 2020 16:55:04 GMT Few things in sports are better than overtime in the Stanley Cup Playoffs, and May 8 has seen the Boston Bruins play in a couple memorable games that required bonus hockey. Full Article article Sports
ot 'Slap Shot' still iconic in hockey despite sport's changes By sports.yahoo.com Published On :: Fri, 08 May 2020 18:32:06 GMT A few nights after one of their players was injured by a dirty hit, the Johnstown Jets plotted to exact some revenge on Buffalo's Greg Neeld. An all-out brawl broke out during warmups and the North American Hockey League game was postponed, much to the dismay of ownership and presumably the fans at a sold-out War Memorial Arena. It just so happened that director George Roy Hill was in the arena that night, cameras rolling. Full Article article Sports
ot High Court Declines Missouri District's Appeal Over At-Large Board Voting By feedproxy.google.com Published On :: Mon, 07 Jan 2019 00:00:00 +0000 The justices declined to hear the appeal of the Ferguson-Florissant district over its at-large board elections, which lower courts invalidated as violating the Voting Rights Act. Full Article Missouri
ot After Protracted Political Spat, Missouri Rehires Fired State Schools Chief By feedproxy.google.com Published On :: Tue, 27 Nov 2018 00:00:00 +0000 Former Republican Missouri Gov. Eric Greitens appointed enough board members to have Commissioner Margie Vandeven fired last year, but now that he's gone, the state board decided to hire her back. Full Article Missouri
ot The English provincial printer 1700-1800 : exhibition notes / British Library. By search.wellcomelibrary.org Published On :: London : British Library, [1983] Full Article
ot III. Ueber "Systemerkrankungen" im Rückenmark : 4. Artikel / P. Flechsig By search.wellcomelibrary.org Published On :: [Place of publication not identified] : [publisher not identified], [18--?] Full Article
ot Parce que, travestis et transgenres, notre regard sur le mode et les autres se veut teinté de respect et de douceur / Hommefleur. By search.wellcomelibrary.org Published On :: Châtillon, France : Association Hommefleur, [date of publication not identified] Full Article
ot Taking Herbal Baths | a zine about using herbs for bathing | relax rejuvenate soothing personal care | natural health bath spa | hand drawn By search.wellcomelibrary.org Published On :: 2019 Full Article
ot Zine: The Sweetness Of Doing Nothing (ArtBooklet) By search.wellcomelibrary.org Published On :: Full Article
ot Big brother to an angel / written by Holly Hunt ; illustrated by Jenny Duda. By search.wellcomelibrary.org Published On :: Howe Island, Canada : Pier 44 Press, [2017] Full Article
ot Das Apothekenwesen in Baden von 1945 bis 1960 / Ilse Denninger ; mit einem Geleitwort von Christoph Friedrich. By search.wellcomelibrary.org Published On :: Stuttgart : In Kommission: Wissenschaftliche Verlagsgesellschaft mbH, 2019. Full Article
ot Aminergic hypotheses of behavior : reality or cliché? / edited by Bruce Kenneth Bernard. By search.wellcomelibrary.org Published On :: Rockville, Maryland : National Institute on Drug Abuse, 1975. Full Article
ot Narcotic antagonists, the search for long-acting preparations / editor, Robert Willette. By search.wellcomelibrary.org Published On :: Rockville, Maryland : National Institute on Drug Abuse, 1976. Full Article
ot Narcotic antagonists : naltrexone : progress report / editors, Demetrios Julius, Pierre Renault. By search.wellcomelibrary.org Published On :: Rockville, Maryland : U.S. Dept. of Health, Education, and Welfare, Public Health Service, Alcohol, Drug Abuse and Mental Health Administration, 1976. Full Article
ot Drug dependence in pregnancy : clinical management of mother and child / [editor, Lorreta P. Finnegan]. By search.wellcomelibrary.org Published On :: Rockville, Maryland : National Institute on Drug Abuse, 1979. Full Article
ot An evaluation of the California civil addict program / by William H. McGlothlin, M. Douglas Anglin, Bruce D. Wilson. By search.wellcomelibrary.org Published On :: Rockville, Maryland : National Institute on Drug Abuse, 1977. Full Article
ot Evil eye : to protect use red thread : images of eyes being attacked. By search.wellcomelibrary.org Published On :: [London] : [publisher not identified], [2019] Full Article
ot Your thoughts are not facts. By search.wellcomelibrary.org Published On :: [London] : [publisher not identified], [2019] Full Article
ot Co-ordinating drugs services : the role of regional and district drug advisory committees : a preliminary study for the Department of Health / by Peter Baker and Dorothy Runnicles. By search.wellcomelibrary.org Published On :: London : London Research Centre, 1991. Full Article
ot Monitoring and evaluation : alcoholism and other drug dependence services. By search.wellcomelibrary.org Published On :: Chicago, Ill. : Joint Commission on Accreditation of Healthcare Organizations, 1987. Full Article
ot Development of tolerance and cross-tolerance to psychomotor effects of benzodiazepines in man / by Kari Aranko. By search.wellcomelibrary.org Published On :: Helsinki : Department of Pharmacology and Toxicology, University of Helsinki, 1985. Full Article
ot Evaluation of the 'progress' pilot projects "from recovery into work" / by Stephen Burniston, Jo Cutter, Neil Shaw, Michael Dodd. By search.wellcomelibrary.org Published On :: York : York Consulting, 2001. Full Article
ot Wedding photographs of William Thomas Cadell and Anne Macansh set in Harriet Scott graphic By feedproxy.google.com Published On :: 9/10/2015 12:00:00 AM Full Article
ot Top three Satou Sabally moments: Sharpshooter's 33-point game in Pullman was unforgettable By sports.yahoo.com Published On :: Fri, 03 Apr 2020 19:40:06 GMT Since the day she stepped on campus, Satou Sabally's game has turned heads — and for good reason. She's had many memorable moments in a Duck uniform, including a standout performance against the USA Women in Nov. 2019, a monster game against Cal in Jan. 2020 and a career performance in Pullman in Jan. 2019. Full Article video News
ot Notre Dame's Muffet McGraw retires; won 2 national titles By sports.yahoo.com Published On :: Thu, 23 Apr 2020 02:36:25 GMT Just two years removed from the euphoria of winning her second national championship, Muffet McGraw knew it was time. The Hall of Fame coach retired Wednesday with a resume that includes two national championships in 33 seasons at the school, a surprising decision to many of the countless players and coaches she has influenced on and off the court as a mentor and advocate for women. ''I am proud of what we have accomplished and I can turn the page to the next chapter in my life with no regrets, knowing that I gave it my best every day,'' said McGraw, a four-time winner of the AP women's basketball Coach of the Year. Full Article article Sports
ot Ivey introduced as new Notre Dame coach, succeeding McGraw By sports.yahoo.com Published On :: Thu, 23 Apr 2020 17:21:29 GMT Niele Ivey is coming home. Full Article article Sports
ot Natalie Chou breaks through stereotypes, inspires young Asian American girls on 'Our Stories' quick look By sports.yahoo.com Published On :: Thu, 07 May 2020 17:34:41 GMT Watch the debut of "Our Stories - Natalie Chou" on Sunday, May 10 at 12:30 p.m. PT/ 1:30 p.m. MT on Pac-12 Network. Full Article video Sports
ot Pac-12 women's basketball student-athletes reflect on the influence of their moms ahead of Mother's Day By sports.yahoo.com Published On :: Fri, 08 May 2020 21:24:08 GMT Pac-12 student-athletes give shout-outs to their moms ahead of Mother's Day on May 10th, 2020 including UCLA's Michaela Onyenwere, Oregon's Sabrina Ionescu and Satou Sabally, Arizona's Aari McDonald, Cate Reese, and Lacie Hull, Stanford's Kiana Williams, USC's Endyia Rogers, and Aliyah Jeune, and Utah's Brynna Maxwell. Full Article video Sports
ot The limiting behavior of isotonic and convex regression estimators when the model is misspecified By projecteuclid.org Published On :: Tue, 05 May 2020 22:00 EDT Eunji Lim. Source: Electronic Journal of Statistics, Volume 14, Number 1, 2053--2097.Abstract: We study the asymptotic behavior of the least squares estimators when the model is possibly misspecified. We consider the setting where we wish to estimate an unknown function $f_{*}:(0,1)^{d} ightarrow mathbb{R}$ from observations $(X,Y),(X_{1},Y_{1}),cdots ,(X_{n},Y_{n})$; our estimator $hat{g}_{n}$ is the minimizer of $sum _{i=1}^{n}(Y_{i}-g(X_{i}))^{2}/n$ over $gin mathcal{G}$ for some set of functions $mathcal{G}$. We provide sufficient conditions on the metric entropy of $mathcal{G}$, under which $hat{g}_{n}$ converges to $g_{*}$ as $n ightarrow infty $, where $g_{*}$ is the minimizer of $|g-f_{*}| riangleq mathbb{E}(g(X)-f_{*}(X))^{2}$ over $gin mathcal{G}$. As corollaries of our theorem, we establish $|hat{g}_{n}-g_{*}| ightarrow 0$ as $n ightarrow infty $ when $mathcal{G}$ is the set of monotone functions or the set of convex functions. We also make a connection between the convergence rate of $|hat{g}_{n}-g_{*}|$ and the metric entropy of $mathcal{G}$. As special cases of our finding, we compute the convergence rate of $|hat{g}_{n}-g_{*}|^{2}$ when $mathcal{G}$ is the set of bounded monotone functions or the set of bounded convex functions. Full Article
ot Asymptotic properties of the maximum likelihood and cross validation estimators for transformed Gaussian processes By projecteuclid.org Published On :: Mon, 27 Apr 2020 22:02 EDT François Bachoc, José Betancourt, Reinhard Furrer, Thierry Klein. Source: Electronic Journal of Statistics, Volume 14, Number 1, 1962--2008.Abstract: The asymptotic analysis of covariance parameter estimation of Gaussian processes has been subject to intensive investigation. However, this asymptotic analysis is very scarce for non-Gaussian processes. In this paper, we study a class of non-Gaussian processes obtained by regular non-linear transformations of Gaussian processes. We provide the increasing-domain asymptotic properties of the (Gaussian) maximum likelihood and cross validation estimators of the covariance parameters of a non-Gaussian process of this class. We show that these estimators are consistent and asymptotically normal, although they are defined as if the process was Gaussian. They do not need to model or estimate the non-linear transformation. Our results can thus be interpreted as a robustness of (Gaussian) maximum likelihood and cross validation towards non-Gaussianity. Our proofs rely on two technical results that are of independent interest for the increasing-domain asymptotic literature of spatial processes. First, we show that, under mild assumptions, coefficients of inverses of large covariance matrices decay at an inverse polynomial rate as a function of the corresponding observation location distances. Second, we provide a general central limit theorem for quadratic forms obtained from transformed Gaussian processes. Finally, our asymptotic results are illustrated by numerical simulations. Full Article
ot Asymptotics and optimal bandwidth for nonparametric estimation of density level sets By projecteuclid.org Published On :: Mon, 27 Apr 2020 22:02 EDT Wanli Qiao. Source: Electronic Journal of Statistics, Volume 14, Number 1, 302--344.Abstract: Bandwidth selection is crucial in the kernel estimation of density level sets. A risk based on the symmetric difference between the estimated and true level sets is usually used to measure their proximity. In this paper we provide an asymptotic $L^{p}$ approximation to this risk, where $p$ is characterized by the weight function in the risk. In particular the excess risk corresponds to an $L^{2}$ type of risk, and is adopted to derive an optimal bandwidth for nonparametric level set estimation of $d$-dimensional density functions ($dgeq 1$). A direct plug-in bandwidth selector is developed for kernel density level set estimation and its efficacy is verified in numerical studies. Full Article
ot Monotone least squares and isotonic quantiles By projecteuclid.org Published On :: Wed, 22 Apr 2020 04:02 EDT Alexandre Mösching, Lutz Dümbgen. Source: Electronic Journal of Statistics, Volume 14, Number 1, 24--49.Abstract: We consider bivariate observations $(X_{1},Y_{1}),ldots,(X_{n},Y_{n})$ such that, conditional on the $X_{i}$, the $Y_{i}$ are independent random variables. Precisely, the conditional distribution function of $Y_{i}$ equals $F_{X_{i}}$, where $(F_{x})_{x}$ is an unknown family of distribution functions. Under the sole assumption that $xmapsto F_{x}$ is isotonic with respect to stochastic order, one can estimate $(F_{x})_{x}$ in two ways: (i) For any fixed $y$ one estimates the antitonic function $xmapsto F_{x}(y)$ via nonparametric monotone least squares, replacing the responses $Y_{i}$ with the indicators $1_{[Y_{i}le y]}$. (ii) For any fixed $eta in (0,1)$ one estimates the isotonic quantile function $xmapsto F_{x}^{-1}(eta)$ via a nonparametric version of regression quantiles. We show that these two approaches are closely related, with (i) being more flexible than (ii). Then, under mild regularity conditions, we establish rates of convergence for the resulting estimators $hat{F}_{x}(y)$ and $hat{F}_{x}^{-1}(eta)$, uniformly over $(x,y)$ and $(x,eta)$ in certain rectangles as well as uniformly in $y$ or $eta$ for a fixed $x$. Full Article
ot On the predictive potential of kernel principal components By projecteuclid.org Published On :: Wed, 15 Apr 2020 04:02 EDT Ben Jones, Andreas Artemiou, Bing Li. Source: Electronic Journal of Statistics, Volume 14, Number 1, 1--23.Abstract: We give a probabilistic analysis of a phenomenon in statistics which, until recently, has not received a convincing explanation. This phenomenon is that the leading principal components tend to possess more predictive power for a response variable than lower-ranking ones despite the procedure being unsupervised. Our result, in its most general form, shows that the phenomenon goes far beyond the context of linear regression and classical principal components — if an arbitrary distribution for the predictor $X$ and an arbitrary conditional distribution for $Yvert X$ are chosen then any measureable function $g(Y)$, subject to a mild condition, tends to be more correlated with the higher-ranking kernel principal components than with the lower-ranking ones. The “arbitrariness” is formulated in terms of unitary invariance then the tendency is explicitly quantified by exploring how unitary invariance relates to the Cauchy distribution. The most general results, for technical reasons, are shown for the case where the kernel space is finite dimensional. The occurency of this tendency in real world databases is also investigated to show that our results are consistent with observation. Full Article
ot Asymptotic seed bias in respondent-driven sampling By projecteuclid.org Published On :: Wed, 08 Apr 2020 22:01 EDT Yuling Yan, Bret Hanlon, Sebastien Roch, Karl Rohe. Source: Electronic Journal of Statistics, Volume 14, Number 1, 1577--1610.Abstract: Respondent-driven sampling (RDS) collects a sample of individuals in a networked population by incentivizing the sampled individuals to refer their contacts into the sample. This iterative process is initialized from some seed node(s). Sometimes, this selection creates a large amount of seed bias. Other times, the seed bias is small. This paper gains a deeper understanding of this bias by characterizing its effect on the limiting distribution of various RDS estimators. Using classical tools and results from multi-type branching processes [12], we show that the seed bias is negligible for the Generalized Least Squares (GLS) estimator and non-negligible for both the inverse probability weighted and Volz-Heckathorn (VH) estimators. In particular, we show that (i) above a critical threshold, VH converge to a non-trivial mixture distribution, where the mixture component depends on the seed node, and the mixture distribution is possibly multi-modal. Moreover, (ii) GLS converges to a Gaussian distribution independent of the seed node, under a certain condition on the Markov process. Numerical experiments with both simulated data and empirical social networks suggest that these results appear to hold beyond the Markov conditions of the theorems. Full Article
ot Estimating piecewise monotone signals By projecteuclid.org Published On :: Wed, 08 Apr 2020 22:01 EDT Kentaro Minami. Source: Electronic Journal of Statistics, Volume 14, Number 1, 1508--1576.Abstract: We study the problem of estimating piecewise monotone vectors. This problem can be seen as a generalization of the isotonic regression that allows a small number of order-violating changepoints. We focus mainly on the performance of the nearly-isotonic regression proposed by Tibshirani et al. (2011). We derive risk bounds for the nearly-isotonic regression estimators that are adaptive to piecewise monotone signals. The estimator achieves a near minimax convergence rate over certain classes of piecewise monotone signals under a weak assumption. Furthermore, we present an algorithm that can be applied to the nearly-isotonic type estimators on general weighted graphs. The simulation results suggest that the nearly-isotonic regression performs as well as the ideal estimator that knows the true positions of changepoints. Full Article
ot Consistency and asymptotic normality of Latent Block Model estimators By projecteuclid.org Published On :: Mon, 23 Mar 2020 22:02 EDT Vincent Brault, Christine Keribin, Mahendra Mariadassou. Source: Electronic Journal of Statistics, Volume 14, Number 1, 1234--1268.Abstract: The Latent Block Model (LBM) is a model-based method to cluster simultaneously the $d$ columns and $n$ rows of a data matrix. Parameter estimation in LBM is a difficult and multifaceted problem. Although various estimation strategies have been proposed and are now well understood empirically, theoretical guarantees about their asymptotic behavior is rather sparse and most results are limited to the binary setting. We prove here theoretical guarantees in the valued settings. We show that under some mild conditions on the parameter space, and in an asymptotic regime where $log (d)/n$ and $log (n)/d$ tend to $0$ when $n$ and $d$ tend to infinity, (1) the maximum-likelihood estimate of the complete model (with known labels) is consistent and (2) the log-likelihood ratios are equivalent under the complete and observed (with unknown labels) models. This equivalence allows us to transfer the asymptotic consistency, and under mild conditions, asymptotic normality, to the maximum likelihood estimate under the observed model. Moreover, the variational estimator is also consistent and, under the same conditions, asymptotically normal. Full Article
ot Modal clustering asymptotics with applications to bandwidth selection By projecteuclid.org Published On :: Fri, 07 Feb 2020 22:03 EST Alessandro Casa, José E. Chacón, Giovanna Menardi. Source: Electronic Journal of Statistics, Volume 14, Number 1, 835--856.Abstract: Density-based clustering relies on the idea of linking groups to some specific features of the probability distribution underlying the data. The reference to a true, yet unknown, population structure allows framing the clustering problem in a standard inferential setting, where the concept of ideal population clustering is defined as the partition induced by the true density function. The nonparametric formulation of this approach, known as modal clustering, draws a correspondence between the groups and the domains of attraction of the density modes. Operationally, a nonparametric density estimate is required and a proper selection of the amount of smoothing, governing the shape of the density and hence possibly the modal structure, is crucial to identify the final partition. In this work, we address the issue of density estimation for modal clustering from an asymptotic perspective. A natural and easy to interpret metric to measure the distance between density-based partitions is discussed, its asymptotic approximation explored, and employed to study the problem of bandwidth selection for nonparametric modal clustering. Full Article
ot The bias of isotonic regression By projecteuclid.org Published On :: Tue, 04 Feb 2020 22:03 EST Ran Dai, Hyebin Song, Rina Foygel Barber, Garvesh Raskutti. Source: Electronic Journal of Statistics, Volume 14, Number 1, 801--834.Abstract: We study the bias of the isotonic regression estimator. While there is extensive work characterizing the mean squared error of the isotonic regression estimator, relatively little is known about the bias. In this paper, we provide a sharp characterization, proving that the bias scales as $O(n^{-eta /3})$ up to log factors, where $1leq eta leq 2$ is the exponent corresponding to Hölder smoothness of the underlying mean. Importantly, this result only requires a strictly monotone mean and that the noise distribution has subexponential tails, without relying on symmetric noise or other restrictive assumptions. Full Article
ot Provably robust estimation of modulo 1 samples of a smooth function with applications to phase unwrapping By Published On :: 2020 Consider an unknown smooth function $f: [0,1]^d ightarrow mathbb{R}$, and assume we are given $n$ noisy mod 1 samples of $f$, i.e., $y_i = (f(x_i) + eta_i) mod 1$, for $x_i in [0,1]^d$, where $eta_i$ denotes the noise. Given the samples $(x_i,y_i)_{i=1}^{n}$, our goal is to recover smooth, robust estimates of the clean samples $f(x_i) mod 1$. We formulate a natural approach for solving this problem, which works with angular embeddings of the noisy mod 1 samples over the unit circle, inspired by the angular synchronization framework. This amounts to solving a smoothness regularized least-squares problem -- a quadratically constrained quadratic program (QCQP) -- where the variables are constrained to lie on the unit circle. Our proposed approach is based on solving its relaxation, which is a trust-region sub-problem and hence solvable efficiently. We provide theoretical guarantees demonstrating its robustness to noise for adversarial, as well as random Gaussian and Bernoulli noise models. To the best of our knowledge, these are the first such theoretical results for this problem. We demonstrate the robustness and efficiency of our proposed approach via extensive numerical simulations on synthetic data, along with a simple least-squares based solution for the unwrapping stage, that recovers the original samples of $f$ (up to a global shift). It is shown to perform well at high levels of noise, when taking as input the denoised modulo $1$ samples. Finally, we also consider two other approaches for denoising the modulo 1 samples that leverage tools from Riemannian optimization on manifolds, including a Burer-Monteiro approach for a semidefinite programming relaxation of our formulation. For the two-dimensional version of the problem, which has applications in synthetic aperture radar interferometry (InSAR), we are able to solve instances of real-world data with a million sample points in under 10 seconds, on a personal laptop. Full Article
ot Noise Accumulation in High Dimensional Classification and Total Signal Index By Published On :: 2020 Great attention has been paid to Big Data in recent years. Such data hold promise for scientific discoveries but also pose challenges to analyses. One potential challenge is noise accumulation. In this paper, we explore noise accumulation in high dimensional two-group classification. First, we revisit a previous assessment of noise accumulation with principal component analyses, which yields a different threshold for discriminative ability than originally identified. Then we extend our scope to its impact on classifiers developed with three common machine learning approaches---random forest, support vector machine, and boosted classification trees. We simulate four scenarios with differing amounts of signal strength to evaluate each method. After determining noise accumulation may affect the performance of these classifiers, we assess factors that impact it. We conduct simulations by varying sample size, signal strength, signal strength proportional to the number predictors, and signal magnitude with random forest classifiers. These simulations suggest that noise accumulation affects the discriminative ability of high-dimensional classifiers developed using common machine learning methods, which can be modified by sample size, signal strength, and signal magnitude. We developed the measure total signal index (TSI) to track the trends of total signal and noise accumulation. Full Article