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Retrospective analysis of laboratory testing in 54 patients with severe- or critical-type 2019 novel coronavirus pneumonia




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Brightfield multiplex immunohistochemistry with multispectral imaging




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The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability




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Molecular signatures of tumor progression in myxoid liposarcoma identified by <i>N</i>-glycan mass spectrometry imaging




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Vasoinhibin reduces joint inflammation, bone loss, and the angiogenesis and vasopermeability of the pannus in murine antigen-induced arthritis




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Nuclear receptor binding factor 2 (NRBF2) is required for learning and memory




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A soluble endoplasmic reticulum factor as regenerative therapy for Wolfram syndrome




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Blocking thrombospondin-1 signaling via CD47 mitigates renal interstitial fibrosis




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Laboratory Investigation




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Igniting autophagy through the regulation of phase separation




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Immune dysfunction leads to mortality and organ injury in patients with COVID-19 in China: insights from ERS-COVID-19 study




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MCU-induced mitochondrial calcium uptake promotes mitochondrial biogenesis and colorectal cancer growth




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Liquid phase condensation directs nucleosome epigenetic modifications




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Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis




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Novel targeted drugs approved by the NMPA and FDA in 2019




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Therapeutic efficacy of Pudilan Xiaoyan Oral Liquid (PDL) for COVID-19 in vitro and in vivo




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Designing of improved drugs for COVID-19: Crystal structure of SARS-CoV-2 main protease M<sup>pro</sup>




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Signal Transduction and Targeted Therapy




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The chromosome-scale genome reveals the evolution and diversification after the recent tetraploidization event in tea plant




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Cadmium isotope fractionation reveals genetic variation in Cd uptake and translocation by <i>Theobroma cacao</i> and role of natural resistance-associated macrophage protein 5 and heavy metal ATPase-family transporters




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The <i>RhHB1</i>/<i>RhLOX4</i> module affects the dehydration tolerance of rose flowers (<i>Rosa hybrida</i>) by fine-tuning jasmonic acid levels




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MdMYB6 regulates anthocyanin formation in apple both through direct inhibition of the biosynthesis pathway and through substrate removal




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Chromosome-scale assembly of the <i>Kandelia obovata</i> genome




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A high-quality reference genome of wild <i>Cannabis sativa</i>




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Correction to: A universal pipeline for mobile mRNA detection and insights into heterografting advantages under chilling stress




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A pentaploid-based linkage map of the ancestral octoploid strawberry <i>Fragaria virginiana</i> reveals instances of sporadic hyper-recombination




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Concurrent germline and somatic pathogenic BAP1 variants in a patient with metastatic bladder cancer




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MACROD2 deficiency promotes hepatocellular carcinoma growth and metastasis by activating GSK-3β/β-catenin signaling




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<i>ATP7B</i> variant c.1934T &gt; G p.Met645Arg causes Wilson disease by promoting exon 6 skipping




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19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis




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Erlotinib sensitivity of <i>MAPK1</i>p.D321N mutation in head and neck squamous cell carcinoma




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Genes and genomes and unnecessary complexity in precision medicine




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Challenges in returning results in a genomic medicine implementation study: the Return of Actionable Variants Empirical (RAVE) study




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Clinical utility of 24-h rapid trio-exome sequencing for critically ill infants




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Kirigami/origami: unfolding the new regime of advanced 3D microfabrication/nanofabrication with “folding”




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Phase imaging with an untrained neural network




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Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo




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Controlling angular dispersions in optical metasurfaces




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Digital synthesis of histological stains using micro-structured and multiplexed virtual staining of label-free tissue




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Ultrafast optical response and ablation mechanisms of molybdenum disulfide under intense femtosecond laser irradiation




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Endo-microscopy beyond the Abbe and Nyquist limits




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Nonlinear interference in crystal superlattices




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Light: Science & Applications




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Author Correction: Particle physics at accelerators in the United States and Asia




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Philip Warren Anderson (1923–2020)




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Author Correction: Quantum metasurfaces with atom arrays




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The role of single-cell mechanical behaviour and polarity in driving collective cell migration