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Self-actuated microfluidic chiplet for two-stage multiplex nucleic acid amplification assay

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00752B, Paper
Open Access
Felix Ansah, Marziyeh Hajialyani, Fatemeh Ahmadi, Yuming Gu, Ergün Alperay Tarım, Michael G. Mauk, Gordon A. Awandare, Haim H. Bau
Self-actuated chiplet for Penn-RAMP assay.
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3D-printed microfluidic–microwave device for droplet network formation and characterisation

Lab Chip, 2024, 24,5101-5112
DOI: 10.1039/D4LC00387J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kai Silver, Jin Li, Adrian Porch, William David Jamieson, Oliver Castell, Pantelitsa Dimitriou, Colin Kallnik, David Barrow
A 3D-printed microwave–microfluidic device using a liquid metal resonator for droplet network formation and characterisation.
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Effect of base methylation on binding and mobility of bacterial protein Hfq on double-stranded DNA

Lab Chip, 2024, 24,5137-5144
DOI: 10.1039/D4LC00628C, Paper
Jijo Easo George, Rajib Basak, Indresh Yadav, Chuan Jie Tan, Jeroen A. van Kan, Frank Wien, Véronique Arluison, Johan R. C. van der Maarel
Using nanofluidics to probe protein mobility on DNA reveals how DNA base methylation impacts protein–DNA interactions.
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Real-time monitoring of a 3D blood–brain barrier model maturation and integrity with a sensorized microfluidic device

Lab Chip, 2024, 24,5085-5100
DOI: 10.1039/D4LC00633J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Maria Cristina Ceccarelli, Marie Celine Lefevre, Attilio Marino, Francesca Pignatelli, Katarzyna Krukiewicz, Matteo Battaglini, Gianni Ciofani
A new in vitro sensorized model of the blood–brain barrier has been developed and characterized.
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Real-time impedance-activated dielectrophoretic actuation for reconfigurable manipulation of single flowing particles

Lab Chip, 2024, 24,5145-5154
DOI: 10.1039/D4LC00622D, Paper
Alexis Lefevre, Cristian Brandi, Adele De Ninno, Filippo Ruggiero, Enrico Verona, Michaël Gauthier, Paolo Bisegna, Aude Bolopion, Federica Caselli
We present an original all-electrical platform that combines MIC-sensing and DEP-actuation for precise and selective trajectory control of single flowing particles.
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Integrated device for plasma separation and nucleic acid extraction from whole blood toward point-of-care detection of bloodborne pathogens

Lab Chip, 2024, 24,5124-5136
DOI: 10.1039/D4LC00571F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Abigail G. Ayers, Christia M. Victoriano, Samuel K. Sia
This work presents PRECISE, a device that integrates plasma separation and nucleic acid extraction, enabling streamlined sample preparation of whole blood for point-of-care diagnostics without external equipment or electricity.
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Optical tweezer-assisted cell pairing and fusion for somatic cell nuclear transfer within an open microchannel

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00561A, Paper
Yidi Zhang, Han Zhao, Zhenlin Chen, Zhen Liu, Hanjin Huang, Yun Qu, Yaowei Liu, Mingzhu Sun, Dong Sun, Xin Zhao
We developed a somatic cell nuclear transfer-electrofusion system for pairing and fusing oocytes and somatic cells with a thousand-fold volume difference. The system showed a 90.56% pairing efficiency, potentially boosting batch cloning efficiency.
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Discretised microfluidics for noninvasive health monitoring using sweat sensing

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00763H, Paper
Open Access
Emma J. M. Moonen, Walther Verberne, Eduard Pelssers, Jason Heikenfeld, Jaap M. J. den Toonder
We present the first wearable device with integrated electrowetting, which collects and transports sweat from single glands and measures sweat rate for extremely low sweat rate. This enables non-invasive biomarker monitoring of hospitalized patients.
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Microstring-engineered tension tissues: a novel platform for replicating tissue mechanics and advancing mechanobiology

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00753K, Paper
Zixing Zhou, Tingting Li, Wei Cai, Xiaobin Zhu, Zuoqi Zhang, Guoyou Huang
A simple, cost-effective approach for fabricating soft microstring chips that enables precise engineering of tension tissues (METTs), advancing research in mechanobiology and biomedical applications.
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SERS-based pump-free microfluidic chip sensor for highly sensitive competitive immunoassay of cortisol in human sweat

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00858H, Paper
Siyue Xiong, Chushu Zhu, Chengxuan Wang, Peitao Dong, Xuezhong Wu
Cortisol, known as the "stress hormone," is secreted by the adrenal cortex. Measuring cortisol levels in body fluids is essential for evaluating stress levels, adrenal function, hormone imbalances, and psychological...
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Man armed with machete creates tension in Aluva




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Man accused in 25 cases arrested for attempted theft at magistrate’s house in Ernakulam




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Multiple factors remain a hurdle in setting up centralised sewer networks, Kerala govt. informs NGT

Faecal sludge treatment plants proposed in a radius of 15 km on cluster basis in urban and rural local bodies




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KITE gives technological edge to coverage of State school sports meet




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Two youngsters from Kochi determined to smash their disabilities on the badminton court

Atul Krishna and Jyothish Kumar defy physical limitations to excel in badminton, inspiring with their determination and talent.




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ERCMPU set to become fully solar-powered dairy cooperative




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Police officer arraigned as accused in accident case




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Woman arrested on charge of job fraud




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Drenched in sweat, student volunteers have a bittersweet experience at sports meet in Kochi




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Over 12,000 dengue cases reported in Ernakulam since January

Sources include illegal waste dumping sites, vacant plots, and mosquito-breeding grounds like discarded containers, used tyres, and pots




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Thammanam-Pullepady Road development: joint site inspection planned

Landowners along the stretch seek adequate compensation for small tracts of additional land that will be acquired in keeping with the revised alignment




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Civic authorities racing against time to save Central funds for Edakochi STP

The deadline for the ₹18.6-crore project is December 31, and failure to complete it in time will lead to the Corporation losing the Central share of ₹7.75 crore




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Hema Committee report: Preliminary inquiry in cases to be completed by December-end, Kerala govt tells HC

Submission made in a progress report filed by Kerala govt in response to public interest litigation in High Court filed in connection with Hema Committee report




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Laugh in life: Kochi-based comedians Abhishek and Akshay on their latest show, their inspirations and more

The duo has been performing stand-up comedy for around three years now.




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Media rights cannot be restricted: Kerala High Court

Expression by the media of any definitive opinion regarding the guilt or innocence of a party in an ongoing criminal investigation will not get protection under Article 19(1)(a), observes an HC bench




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Hurdles abound for SilverLine as Railways seek revised DPR for project




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Two more held in alleged cooperative society fraud




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Boxing competition disrupted by man claiming to be YouTuber in Kerala




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Kerala man arrested with nitrazepam tablets




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Contempt case hearing against Kerala govt. adjourned in directive to take over Jacobite churches




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About 10 lakh tonnes of legacy waste awaiting scientific remediation




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Kerala, Tamil Nadu united to ensure that India belongs to everyone, says Kanimozhi

DMK MP Kanimozhi was addressing an event held at the Ernakulam Town Hall to felicitate Sr. Vinitha, director of St. Teresa’s College, for her contributions to higher education, social welfare, and culture.




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Man accused of raping a tribal Odisha woman engaged as domestic help surrenders before police

Former managing director surrenders after raping tribal woman, sparking protests; accused hospitalised; case under investigation




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State affected due to lack of support from Centre during disasters: Kerala CM

Union government’s attitude reflects a desire for Kerala to suffer, says Pinarayi Vijayan




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Perumbavoor Urban Cooperative Society to witness novel election as aggrieved investors set to field panel to seize control

Election for 11-member board set for November 24 after cooperative faces financial crisis due to alleged fraud in loan valuations and sanctions




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Union Minister inaugurates Milma’s fully solar-powered dairy

Milma Federation Chairman K.S. Mani handed over the keys of the Central Quality Control Lab to National Dairy Development Board Chairman Meenesh Shah.




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HC allows medical termination of pregnancy of minor rape survivor

Division Bench passed the order while allowing an appeal filed against a single judge’s order declining permission. Medical board said that termination of pregnancy was most appropriate




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Seaplane demo flight in Kochi draws mixed response




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1,000 consumer clubs to be formed on campuses, says Kerala Minister




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Action initiated against units lacking sewage treatment facilities, Environment dept. tells NGT




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Illegally mined sand, vehicles seized in Ernakulam




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Kerala School Sports & Games: Govt. determined to reclaim Kerala’s lost glory in sports, says CM Pinarayi Vijayan

‘Kerala could attract investments worth ₹5,050 crore to the sports sector by becoming the first State to hold a sports summit’




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Detailed probe launched into fire at commercial unit near Aluva




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Vyasa, Lockheed, Ravishing Form, Nyx and Eastern Gold please




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Chief Minister’s Trophy declared null and void due to false start




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Redefined upstages Santissimo to claim the HPSL Pune Derby




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Champions Way primed to deliver in the Governor’s Cup




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Sweet Legacy, Young Heart, Lebua and Dedicate impress




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Suresh Kumar elected




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Excellent Lass, Ashwa Vedha, Shamrock, Mandarino and The Leader shine