Meropenem/vaborbactam resistance in Klebsiella pneumoniae is associated with loss of function mutations in the OmpK35 and OmpK36 porins. Here we identify two previously unknown loss of function mutations that confer cefuroxime resistance in K. pneumoniae. The proteins lost were NlpD and KvrA; the latter is a transcriptional repressor controlling capsule production. We demonstrate that KvrA loss reduces OmpK35 and OmpK36 porin production, which confers reduced susceptibility to meropenem/vaborbactam in a KPC-3 producing K. pneumoniae isolate.

Security researchers are demonstrating how you can use the Windows 10 flaw, CVE-2020-0601, to spoof the trusted digital certificates for official website domains on Google's Chrome browser. These same certificates can warn you about hacking attempts.

'As CEO of Avast, I feel personally responsible and I would like to apologize to all concerned,' wrote Ondrej Vlcek following a PCMag-Motherboard investigation into the privacy risks around the data harvesting.

"The entire energy market is still on a knife edge," says an economist.

The local bourse inched higher on Wednesday as global stocks took a breather following consecutive sessions of weakness.

Stock markets plunged on Thursday after economic growth data confirmed fears of Covid-19's bruising impact on the world economy.

Deep losses were recorded across most European benchmarks except the FTSE 100 which managed to trade relatively flat on the day.

A new paper sketches out the landscape and tensions in civic education as philanthropies look for ways to support the field.

In number 10 in our countdown, I tried to offer a few thoughts to funders as they embraced new agendas and looked to avoid repeating yesterday's missteps.

BACKGROUND:

Pediatricians are less frequently sued than other physicians. When suits are successful, however, the average payout is higher. Little is known about changes in the risk of litigation over time. We sought to characterize malpractice lawsuit trends for pediatricians over time.

Timing, preparation and control are essential to getting paid fairly. This infographic by Adzuna is guide on how you can navigate your way to a salary increase.

The onus is on you to uncover any defects before you buy, writes Angelique Ruzicka.

SIM-swap fraud complaints seem to be on the rise with a growing number of victims coming forward to share their dreadful experiences. Vodacom offers some helpful tips.

Your smooth-talking builder may promise you the world, but you could end up in a world of pain, writes Angelique Ruzicka.

New research has found that inequality in SA has increased, with wealth becoming ever more concentrated among the rich.

Reducing indebtedness and improving savings in South Africa is a major socio-economic challenge, warns an industry expert.

For bank account holders who have been victims of debit order fraud, the big four banks share their remedies.

With credit card fraud rising at an alarming rate in the first quarter of the year, the Ombudsman for Banking Services has provided 10 tips to avoid becoming a victim of scammers.

If you want to get healthy, a fitness tracker can help. Here at PCMag, we put them through vigorous testing to see which ones are up to the challenge.

Are you sure you know what the "insurance speak" in your policy means?

Geopolitical factors and economic uncertainty make some investors shift away from equities into what they perceive to be the safety of higher-quality bonds.

When starting your savings journey, contribute the maximum tax-free allocation and then explore further options that suit your risk appetite and profile, says an expert.

There's more than one way to invest in the yellow metal: either by buying it in its physical form, or investing in shares linked to gold. Fin24 asked the experts how to get started.

Don't wait until you have a large amount of money to invest: the key to building wealth is just starting somewhere and letting your returns generate over time, says Ebrahim Moola of Bobats Wealth Solutions.

As shootings break out at high school athletic events, districts must grapple with major questions about their role in keeping venues safe.

Serbia and Hungary secured narrow wins in the first legs of their play-offs while debut-chasing France and Georgia both found themselves pegged back. The second legs are on 26 September.

The official UEFA Futsal EURO 2018 programme, featuring all you need to know about the teams plus interviews with the likes of Wissam Ben Yedder, is out now and available to download for free.

UEFA Futsal EURO 2018 runs until 10 February in Ljubljana with 12 teams aiming for the title: we give you the key pointers to following a tournament full of skill and passion.

Holders Spain face neighbours Portugal for the second time in a UEFA Futsal EURO final, putting their title on the line in Ljubljana on Saturday: read the full lowdown, including where to watch.

It's vital that school boards make it clear that leaving students without access to meaningful instruction for 4-6 months is unacceptable, says national school board guru AJ Crabill.

Many resources are available to help engage all students in STEM learning and help them persist in STEM careers.

It's only a matter of time before your Windows 10 PC begins to run slowly. You can kick the operating system back into high gear with these useful tips. And they won't cost you a penny.

If you're running out of room on your Apple Watch, get rid of specific apps and content you no longer need. Here's how to free up space from the Watch app and the device.

With iOS 13.1 and iPadOS, Apple adds an Audio Sharing feature that lets you share with a friend what you're listening to on your Apple AirPods or select Beats headphones.

Getting ready for the big game? There are plenty of options, even if you're abroad. Here's how to watch in the states or bypass region blocking with a VPN to watch the Super Bowl.

Want to contribute to Apple's health research studies? You can sign up for programs on women's health, your heart and movement, and hearing using the Research app.

There are plenty of ways to transfer large files between Windows, Mac, iOS, and Android devices, including AirDrop, Google Photos, Bluetooth transfer, and third-party programs.

Loading and running Windows 10 from a USB drive is a handy option when you're using a computer saddled with an older version of Windows.

Computer fans can get pretty noisy, but there are a few things you can do to reduce the din. Here's how to quiet disruptive PC equipment.

The Windows 10 search feature seems pretty simple, but it can be even more effective. Here are some ways to control your searches and find things faster.

Apple's Shortcuts app can quickly and easily run a host of tasks on your Apple Watch or iOS or iPadOS device. Here's how to create and use shortcuts for Siri.

Is your favorite music missing on your iPhone or iPad? Maybe you inadvertently turned off syncing or accidentally deleted those tunes. All is not lost; here's how to recover your music.

If you’re having trouble sleeping, you may want to monitor your sleep cycle. Apple Watch makes it easy with these apps.

Don’t like to wait for programs to boot up when you’re looking for a specific document? With the right tools, you can preview a variety of files in Windows 10 without opening their applications.

Not sure which sources to trust when you're online? These browser plug-ins and online tools can help you figure out how to detect fake news sites.

The big difference between Spotify and Amazon Music Unlimited is Amazon offers an affordable tier of service available on just one Echo device. Here's how else they differ.

CyberPower's Gamer Xtreme midtower packs fluid 1080p gaming performance into a quality package, although it's not quite the top value in its class.

Some are bare-bones kits. Others are ready to go out of the box, complete with an OS, RAM, and memory installed. Whatever the form, these top Windows micro desktops all deliver surprising features, value, and pep for their size.

With the best scanning and OCR apps, you can save whiteboard text, business cards, and important documents so that you can not only read them, but also edit them.

Superheroics. Crime capers. Historical fiction. Conspiracies. Put a world of wonderful stories in your pocket with these 10 excellent digital comics.