The Food and Drug Administration published a concept paper in early January that describes a preliminary proposal for how the agency will ensure that companies developing antibiotics for administration to animals establish defined, evidence-based durations of use for all medically important antibiotics.

GLP-1 receptor agonists, used to treat Type 2 diabetes and now widely prescribed for weight loss, have seen […]

 We introduced a Topics tab in the online documentation a few releases ago, and there are corresponding pages in our focus area that briefly describe the topic areas and the procedures that perform analyses for those areas.

Johnson & Johnson must pay US$15 million (S$19.6 million) to a Connecticut man who alleges that he developed mesothelioma, a rare form of cancer, as a result of using the company's talc powder for decades, a jury found on Tuesday (Oct 15). Plaintiff Evan Plotkin sued the company in 2021 soon after his diagnosis, saying he was sickened by inhaling J&J's baby powder. The jury in Fairfield County, Connecticut Superior Court also found that the company should pay additional punitive damages, which will be determined later by the judge overseeing the case. "Evan Plotkin and his trial team are thrilled that a jury once again decided to hold Johnson & Johnson accountable for their marketing and sale of a baby powder product that they knew contained asbestos," Ben Braly, a lawyer for Plotkin, said in an email. Erik Haas, J&J's worldwide vice president of litigation, said in a statement that the company would appeal "erroneous" rulings by the trial judge that kept the jury from hearing critical facts about the case.

To mark Breast Cancer Awareness Month, we speak to inspiring Singaporeans about their journey in battling and overcoming cancer.  Warda Ismail gets anxious about things easily, especially when it comes to her health.  So much so that her doctor once told her that she is a "borderline hypochondriac", she shared with AsiaOne in an interview.  For the uninitiated, hypochondria is a condition where a person is excessively and unduly worried about having a serious illness. To keep her mind at ease, the 44-year-old preschool educator has the habit of going for regular medical checkups.  Though she was vigilant, her worst nightmare came true — she was diagnosed with breast cancer on May 8 this year.  And in the midst of her recovery journey, she got more terrible news — her mother, who had been caring for her, was diagnosed with stage-three gall bladder cancer.  Despite the string of unfortunate events, Warda persevered and tried to have a more positive outlook on life and her health. 

LONDON — The world's biggest food and beverage companies on average sell products in low-income countries that are less healthy than what they sell in high-income countries, according to a new report. Products sold by companies including Nestle, Pepsico and Unilever were assessed as part of a global index published by the Access to Nutrition Initiative (ATNI), its first since 2021. The non-profit group found that across 30 companies, the products sold in low-income countries scored lower on a star rating system developed in Australia and New Zealand than those sold in high-income countries. In the Health Star Rating system, products are ranked out of five on their healthiness, with five the best, and a score above 3.5 considered to be a healthier choice.

OTTAWA - Canada has detected its first presumptive case of H5 bird flu in a person, a teenager in the western province of British Columbia, health officials said on Saturday (Nov 9). The teenager likely caught the virus from a bird or animal and was receiving care at a children's hospital, the province said in a statement. The province said it was investigating the source of exposure and identifying the teenager's contacts. The risk to the public remains low, Canada's Health Minister Mark Holland said in posting on X. "This is a rare event," British Columbia Health Officer Bonnie Henry said in a statement. "We are conducting a thorough investigation to fully understand the source of exposure here in B.C." H5 bird flu is widespread in wild birds worldwide and is causing outbreaks in poultry and US dairy cows, with several recent human cases in US dairy and poultry workers. There has been no evidence of person-to-person spread so far. But if that were to happen, a pandemic could unfold, scientists have said.

My Chemical Romance teased a new project on social media. The Welcome to the Black Parade rockers — who broke up in 2013 before releasing new song The Foundations of Decay nine years later — have largely kept things quiet since their reunion tour ended in March 2023, besides a headline slot at When We Were Young Festival last month. On Monday (Nov 11), the band's official Instagram shared an image of a hazy skyline and confetti alongside Russian letters which translate to "TPK". The cryptic post was captioned: "If you could be anything, what would you be?" https://www.instagram.com/p/DCPw84izQkN/?utm_source=ig_web_copy_link&igsh=MzRlODBiNWFlZA== While there are no further hints about the message and what it could mean, fans have suggested it may refer to MCR's scrapped record The Paper Kingdom, which was ditched in 2013 and would have been their fifth album.

The quest for realism in Thai drama The Empress of Ayodhaya went too far when a cat was reportedly drugged in a poisoning scene. In episode five of the show, the character Indravedi (Fern Nopjira Lerkkajornnamkul) suspects her drink has been drugged, so she asks nanny Thongdee (Ja Molywon Phantara) to test it out on the black feline. The cat can be seen convulsing and retching, and the camera moves to show Indravedi looking concerned, while Thongdee declares that it is dead. The scene caused public outrage with fears that the cat had actually been killed, and calls to ban the period drama were trending on X. On Nov 7, a now-deleted X account reportedly belonging to Ja posted: "The cat didn't actually die. We put it under anaesthesia, but while filming, the cat retched and seized." She and Fern initially thought the cat had actually died while filming and their faces "turned pale", she added.

Armie Hammer's mom got him a vasectomy for his birthday. The Call Me by Your Name actor — who has two children, Harper, nine, and Ford, seven, with his ex-wife Elizabeth Chambers — has revealed the bizarre gift Dru Hammer got him for his 38th birthday in August. Speaking to his mom on the second episode of a two-part chat on his new podcast Armie HammerTime Podcast, she said: "Let's talk about what I gave you for your birthday this year." She continued: "I call Armie, and I go, 'What would you like for your birthday this year?' He was like, 'I don't know. Maybe money. Whatever.' And I was like, 'I believe I'm going to give you a vasectomy.'"

TORONTO — A teenager is in critical condition in a British Columbia children's hospital, sick with Canada's first presumptive human case of avian influenza. "This was a healthy teenager prior to this, so no underlying conditions," said provincial health officer Bonnie Henry in a news conference on Tuesday (Nov 12). "It just reminds us that in young people this is a virus that can progress and cause quite severe illness and the deterioration that I mentioned was quite rapid." British Columbia health officials said on Saturday the province had detected Canada's first human case of H5 bird flu in a teenager.

LONDON - Kate, UK's Princess of Wales, will make her most prominent return to royal engagements since having treatment for cancer next month when she hosts an annual Christmas carol service at London's Westminster Abbey. Kate, the wife of heir to the throne Prince William, has only made a handful of public appearances after having major abdominal surgery in January, and then undergoing a course of preventative chemotherapy when subsequent tests revealed the presence of cancer. Last weekend, she attended two high-profile Remembrance events to commemorate those who lost their lives in conflict as part of her gradual return to official duties, but the carol service — ​​​​​the fourth she has organised, will be the first major royal event she has hosted herself. "This year's service provides a moment to reflect upon the importance of love and empathy, and how much we need each other, especially in the most difficult times of our lives," her office, Kensington Palace, said in a statement.

The Public Service has expressed its commitment to implementing flexible work arrangements (FWAs) for its employees, taking into account the workforce's changing needs. In a written answer to a Parliamentary question posed by Choa Chu Kang GRC MP Zhulkarnain Abdul Rahim on Monday (Nov 11), Minister-in-charge of the Public Service Chan Chun Sing said the Government recognises the growing need for FWAs, given Singapore's demographic changes and its ever-changing demands on Singaporeans. Zhulkarnain had asked whether the Civil Service will continue to support flexible working arrangements despite some companies in the private sector requiring employees to work from the office five days a week. Grab Singapore, for example, said it will enforce its five-day return-to-office mandate starting Dec 2, reported CNA. Referencing the Tripartite Guidelines on FWA Requests (TG-FWAR), which will be enforced starting Dec 1, Chan stressed the importance of such arrangements in supporting working caregivers, encouraging workforce re-entry, sustaining labour force participation, and attracting and retaining talent.

The Community Disputes Resolution Tribunals (CDRT) will be able to mandate mental health treatment for those who cause unreasonable interferences in the community if a bill to amend the Community Disputes Resolution Act (CDRA) goes through.  The bill was proposed in Parliament by Minister for Community, Culture and Youth Edwin Tong on Tuesday (Nov 12). The CDRT currently hears disputes under CDRA between neighbours involving acts of unreasonable interference with the enjoyment or use of places of residence. Under the bill, the tribunal will be able to issue Mandatory Treatment Orders (MTO) should there be a belief that the acts of disturbance stem from an underlying psychiatric condition. "In those cases, the issue therefore is not just a disamenity one," Minister Tong said. "Hence, the MTO is intended to address the root cause of certain acts that a resident may engage in." Tong added that their priority remains in persuading the resident to go for treatment voluntarily, and that the CDRT-issued MTO is a measure of last resort. There are also criteria that must be met for the MTO to be issued.

JAKARTA — Indonesia said on Monday (Nov 11) it does not recognise China's claims over the South China Sea despite signing a joint maritime development deal with Beijing, as some analysts warned the agreement risked compromising the country's sovereign rights. Beijing has long clashed with its Southeast Asian neighbours over territory in the South China Sea, which it claims sovereignty over in almost its entirety via a "nine-dash line" on its maps that cuts into the exclusive economic zones (EEZ) of several countries. Joint agreements with China in the strategic waterway have for years been sensitive, with some claimant states wary of entering into deals they fear could be interpreted as legitimising Beijing's vast claims. An arbitral tribunal in 2016 said the Chinese claim, based on its old maps, has no basis under international law, a decision China refuses to recognise. A joint statement issued at the weekend during Indonesian President Prabowo Subianto's visit to Beijing mentioned the two countries had "reached important common understanding on joint development in areas of overlapping claims".

TAIPEI — Taiwanese businessman Robert Tsao said on Nov 11 that he would sue in a Taiwan court senior Chinese officials over sanctions they had placed on him, saying he was seeking to counter China's intimidation of lawful activity. China, which claims Taiwan as its own territory, said in October it would punish and sanction Tsao, the retired founder of chipmaker United Microelectronics Corp (UMC), for alleged criminal and pro-Taiwan independence activities. China's Taiwan Affairs Office said the "Black Bear Academy" that Tsao has helped fund was seeking to incite separatism that would endanger cross-strait ties. Tsao, one of Taiwan's richest men who has pledged to provide millions to two civilian defence training programmes, told a press conference that China was threatening the lawful holding of political views in Taiwan and his personal safety. The lawsuit will be lodged in a Taipei court against Song Tao, head of China's Taiwan Affairs Office, and also the office's spokesman Chen Binhua. Taiwan courts have no jurisdiction in China and senior Chinese officials do not visit the island.

CANBERRA — China is putting ever-greater pressure on the Philippines to cede its sovereign rights in the South China Sea, Secretary of National Defence Gilberto Teodoro said on Nov 12 after a meeting with his Australian counterpart in Canberra. "What we see is an increasing demand by Beijing for us to concede our sovereign rights in the area," he said, adding that the Philippines was a "victim of Chinese aggression". China and the Philippines have sparred repeatedly this year over disputed areas of the South China Sea, including the Scarborough Shoal, one of Asia's most contested features. Teodoro's meeting with his Australian counterpart Richard Marles, their fifth since August 2023, reflects growing security ties between the countries, both of whom have expressed concern about Chinese activity in areas of the South China Sea claimed by the Philippines and other Southeast Asian nations. The two nations signed a strategic partnership in September 2023 and held their first joint sea and air patrols in the South China Sea several months later. The Philippines also joined war games in Australia this year for the first time.

ISLAMABAD — Beijing is pushing Pakistan to allow its own security staff to provide protection to thousands of Chinese citizens working in the South Asian nation, during talks after a car bombing in Karachi that was seen as a major security breach, sources said. Last month's airport bombing in the southern port city that killed two Chinese engineers returning to work on a project after a holiday in Thailand was the latest in a string of attacks on Beijing's interests in Pakistan. The attacks, and Islamabad's failure to deter them, have angered China, which has pushed Pakistan to begin formal negotiations for a joint security management system. Reuters spoke to five Pakistani security and government sources with direct knowledge of the previously unreported negotiations and demands on condition of anonymity, as the talks are sensitive, and reviewed a written proposal sent by Beijing to Islamabad. "They (Chinese) want to bring in their own security," said one official, who sat in on a recent meeting, adding that Pakistan had not so far agreed to such a step.

Dec 5, 2023

David W. Kearn argues that deployment of nuclear weapons cannot rectify a perceived imbalance in conventional forces in the western Pacific.

Dec 15, 2023

Mariana Budjeryn writes: War never stops at the border, especially on a continent like Europe. The European Union absorbed millions of Ukrainian war refugees and poured billions of euros into Ukraine's defenses and economic survival. The war permanently reshaped Europe: its demographics, political economy, and energy architecture are shifting in ways that will have irreversible long-term consequences. All of this is because in a very real sense Ukraine already is inextricably woven into the fabric of Europe: Ukraine’s pain is Europe’s pain and Ukraine’s gain will inevitably be Europe's gain, too.

Feb 20, 2024

Mariana Budjeryn reflects on the tenth anniversary of her native Ukraine's Revolution of Dignity.

Feb 9, 2023

In the first comprehensive post-mortem analysis of the Noel Kempff Mercado Climate Action Project (NKMCAP), Reine Rambert and Amanda Sardonis examine how NKMCAP failed to live up to its potential, by focusing on three different dimensions of partnership effectiveness: 1) the sustainability of the partnership, 2) the effectiveness of the collaboration process itself, and 3) the achievement of the planned objectives. Rambert and Sardonis extract several transferable lessons from the challenges faced by NKMCAP that are highly consequential to partnership effectiveness.

The Indian socialist tradition is now moribund, but there was a time when it had a profound and mostly salutary influence on politics and society. Yet few people now know of its past vigour and dynamism. The Congress, the Communists, the regional parties, the Ambedkarites, and (especially in recent years) the Jana Sangh and the [...]

An Indian I greatly admire is the social worker and pioneer of the Chipko movement, Chandi Prasad Bhatt. My first meeting with him, when I was in my early twenties, had an transformative impact on my life. I have met him many times since; each encounter providing fresh insights into the moral, political and environmental [...]

In a June 11 meeting, Prime Minister Singh assured Under Secretary Burns of his strong personal commitment to strengthening further India's ties to the United States.

In a wide-ranging meeting with CODEL McCaskill February 17, National Security Advisor Shivshankar Menon touched on several regional security and trade-related issues.

Benazir Bhutto claimed that the Sindh Government had informed her that if she goes to Larkhana (her ancestral home), she would be attacked.

Embassy strongly recommends against providing a U.S. Government evaluation, saying it will inevitably expose performance gaps that would not meet American standards of training and equipment.

Even with support from the government, serious threats against Bhutto will persist.

It was made clear to the PPP representatives that certain dangers were inherent in the return of Bhutto to Karachi, mostly directed by elements from the northern areas.

During recent trips to southern Punjab, Principal Officer was repeatedly told that a sophisticated jihadi recruitment network had been developed in the Multan, Bahawalpur, and Dera Ghazi Khan Divisions.

Admitting that they are "facing a tough time in the courts," Asif related that the LHC has asked for the evidence that the Home Department used to extend the detention. "There has never been a case against them," he noted, "and we have no criminal record of these gentlemen."

Pakistan concern that freedom of expression be balanced with respect for religion as "we are not as advanced as you are" in terms of respect for freedom of religion and could not always control the reactions of sometimes ignorant crowds.

U.S. Mission in New York raised concerns about Pakistan's voting on key issues such as counterterrorism and human rights

You will find an Indian government that is more committed than ever to building a durable and wide ranging USG-GOI relationship after Prime Minister Singh's Washington visit in November.

In a surprise development, the GOI has told us that it would welcome US participation as an Observer to SAARC.

Cable reveals the conditions brokered by a Pakistan court between him and the government for his freedom

S.M. Zafar, Khan's prominent and highly respected lawyer, had pledged to the government that the meeting with the press would be Khan's "first and last" such encounter.

Benazir Bhutto's public comments that she would grant the IAEA access to Khan were highly controversial in Pakistan. Zardari's options for delivering on Benazir's promise is limited.

UAEG officials pledged their cooperation on cases of mutual interest, but Central Bank Governor Sultan Nasser al-Suweidi noted his frustration with the USG over the frozen assets of A.Q. Khan's daughter, Dina Khan.

Cutting off the flow of funds to terrorist organizations and achieving stability in Af/Pak are top U.S. priorities.

Chinese officials had approached the Indian government for more information but had since been reportedly told by the Indian government that the information presented was sufficient to justify the listing.

Deputy Director Shen acknowledged the message but offered no further comment.

While each side adhered to familiar positions, the chemistry between the principals was good and the dialogue was cordial and frank.

The Indian civil nuclear bureaucracy understands it is "essential" to advance cooperation with the U.S., but claims progress is stymied by the inability of U.S. firms to share sensitive technical information pending the authorizations required under U.S. licensing regulations.