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DHL Supply Chain: this is a significant step towards decarbonising Tesco’s fleet in Ireland 

 As part of its ongoing partnership with DHL Supply Chain, Tesco Ireland has taken delivery of 50 state-of-the-art biomethane fuelled trucks which will operate across its country-wide distribution network.  




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Wincanton and Co-op join forces for another five-years

Wincanton, a supply chain partner for UK business, has been awarded a five-year contract extension by convenience retailer, Co-op, building on over three decades of successful collaboration between the two companies. 




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ZigZag partnership “a significant step forward in providing a seamless and sustainable solution for brands”

 ZigZag, a provider of technology-driven retail returns solutions, has partnered with Portless, a  supply chain company specialising in fulfilling DTC orders directly from China and Vietnam with a domestic experience.




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Wincanton extends contract with Valero

Wincanton has renewed its contract with Valero, the world's largest independent petroleum refiner and producer of low-carbon transportation fuels, for a further five years.




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Wincanton: UK businesses aren’t making enough headway when it comes to reducing emissions in their supply chain operations

 New research from Wincanton reveals that two thirds (66%) of UK organisations say they are under pressure to hit their net-zero targets, with logistics seen as key to achieving their goals in this area, according to 83%.  




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ZigZag Survey proves that customers can come round to the idea of paid returns

Returns specialist ZigZag has published the results of a survey which indicates that one-off fees for returns are preferable to price rises on items among consumers.




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Driver dies after crashing on hurricane-damaged highway in North Carolina




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China reveals Mach 7 hypersonic weapon design that can deploy missiles, drones




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Miss Universe contestant expelled from competition over ‘personal’ scandal as rumors swirl




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Man escapes from SUV after driving into Canandaigua Lake from City Pier




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Voxist: Visual voicemail you can read

Description: 

Voxist is an intelligent voicemail that replaces your carrier’s inefficient voicemail. Impress callers with customized greetings and save time by reading transcribed voicemail messages. Access messages on your phone or via email, so you never miss out.

Voxist is a free voicemail app that’s really simple to navigate, so you can manage all of your business and personal voicemail efficiently. In a meeting? On the train? With another client? Read your voicemail instead of listening to it!

- FEATURES -

*VISUAL VOICEMAIL*
Get all your voicemail in one screen, and in...

Free Or Paid: 

Free With In App Purchases

Other Comments: 

A couple of features make this voicemail app stand above the rest. There is a play button next to each message, so there is no need to open a message to listen to it. Also, although voicemail greetings can be voice recordings, it is also possible to write the text of your voicemail greeting, which will be played for callers using a synthetic voice. This text can include name or phone number information from your contacts, so that everyone who is in your contact list can for example be greeted by name. This is not a call blocking app, nor does it do conferencing, voice chat or unified messaging. It is just a simple no-frills visual voicemail app that does its job well.

Developer's Twitter Username: 

@voxist

Category: 




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In a cancel culture, anonymity must be a civil right

Anonymity, in ordinary times, is a tough topic to wrestle with. These days, however, it’s easy: Dissent, and thus democracy, will only survive in today’s culture if anonymity is preserved.




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CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients

CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients

In the first-ever (sanctioned) investigational use of multiple edits to the human genome, a study found that cells edited in three specific ways and then removed from patients and brought back into the lab setting were able to kill cancer months after their original manufacturing and infusion.

This is the first U.S. clinical trial to test the gene editing approach in humans, and the publication of this new data today follows on the initial report last year that researchers were able to use CRISPR/Cas9 technology to successfully edit three cancer patients' immune cells. The ongoing study is a cooperative between Tmunity Therapeutics, the Parker Institute for Cancer Immunotherapy, and the University of Pennsylvania. 

Patients on this trial were treated by Edward A. Stadtmauer, MD, section chief of Hematologic Malignancies at Penn, co-lead author on the study. The approach in this study is closely related to CAR T cell therapy, in which patient immune cells are engineered to fight cancer, but it has some key differences. Just like CAR T, researchers in this study began by collecting a patient's T cells from blood. However, instead of arming these cells with a receptor against a protein such as CD19, the team first used CRISPR/Cas9 editing to remove three genes. The first two edits removed a T cell's natural receptors so they can be reprogrammed to express a synthetic T cell receptor, allowing these cells to seek out and destroy tumors. The third edit removed PD-1, a natural checkpoint that sometimes blocks T cells from doing their job. 

Once the three genes are knocked out, a fourth genetic modification was accomplished using a lentivirus to insert the cancer-specific synthetic T cell receptor, which tells the edited T cells to target an antigen called NY-ESO-1. Previously published data show these cells typically survive for less than a week, but this new analysis shows the edited cells used in this study persisted, with the longest follow up at nine months. 

Several months after the infusion, researchers drew more blood and isolated the CRISPR-edited cells for study. When brought back into the lab setting, the cells were still able to kill tumors. 

The CRISPR-edited T cells used in this study are not active on their own like CAR T cells. Instead, they require the cooperation of a molecule known as HLA-A*02:01, which is only expressed in a subset of patients. This means that patients had to be screened ahead of time to make sure they were a match for the approach. Participants who met the requirements received other clinically-indicated therapy as needed while they waited for their cells to be manufactured. Once that process was completed, all three patients received the gene-edited cells in a single infusion after a short course of chemotherapy. Analysis of blood samples revealed that all three participants had the CRISPR-edited T cells take root and thrive in the patients. While none responded to the therapy, there were no treatment-related serious adverse events. 

CRISPR technology has not previously been tested in humans in the U.S. so the research team had to move through a comprehensive and rigorous series of institutional and federal regulatory approval steps, including approval by the National Institutes of Health's Recombinant DNA Research Advisory Committee and review by the U.S. Food and Drug Administration, as well as Penn's institutional review board and institutional biosafety committee. The entire process required more than two years.

 Researchers say these new data will open the door to later stage studies to investigate and extend this approach to a broader field beyond cancer, several of which are already planned at Penn.

sb admin Thu, 02/06/2020 - 14:52
Categories




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Summer break is ending. Here are 10 ways parents can help their kids get back into school mode

With summer break ending, The Times spoke with psychologists about how parents can help their students embrace a back-to-school mindset. Here's their advice.




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What Elmo — and his human friends — learned by asking Americans about their mental health

Mental and emotional health is on a par with physical health and financial security when it comes to negative impacts on overall well-being, researchers say.




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Fast, wet and furious: How the North American monsoon floods the California desert

The North American monsoon plays an important role in the climate of the Four Corners states, bringing crucial moisture to areas that would otherwise be dry.




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Growing need. Glaring gaps. Why mental health care can be a struggle for autistic youth

Autistic people and their families say they can't find adequate help in their communities before they reach a crisis point.




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How parents and caregivers can evaluate the research on MERT and other potential treatments

For parents considering autism interventions for their children, evaluating treatments can be daunting. Experts talked to The Times about what to watch for.




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'Grief into action.' Philanthropists give historic $150 million donation to City of Hope for pancreatic cancer research

Entrepreneur Emmet Stephenson and his daughter are giving $150 million to City of Hope to fund an award for innovation research in pancreatic cancer. It's the largest single gift the center has received.




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Wildfires can release more energy than an atomic bomb. No wonder they look apocalyptic

Uncontrolled wildfires can be powerful enough to generate their own weather.




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Funny, it isn't hard to make a comedy show that autistic adults can enjoy too

"Let It Out," a stand-up show hosted at the Laugh Factory, aimed to demonstrate that making comedy shows inclusive for neurodivergent people could be easy.




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Virus that can cause paralysis in children is on the rise in California: A few safeguards

Enterovirus D68, which in rare cases can cause polio-like paralysis in children, is on the rise in California and across the nation, analyses show.




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Half a pound of this powder can remove as much CO₂ from the air as a tree, scientists say

Berkeley chemists have created a reusable material that pulls carbon dioxide from the air and holds onto it until it can be stored.




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Opinion: Too many older Americans are getting tested for Alzheimer's

Diagnosing 'Stage One Alzheimer's Disease' based solely on biomarkers is potentially dangerous to patients.




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Jim Williams: John McEnroe breaks down challenges of French Open, looks at who can beat Rafael Nadal on clay

As a player, John McEnroe was not a fan of the French Open. He has few fond memories of the dark red clay on the courts of Roland Garros. As brilliant a career as McEnroe had, he was never able to win a French Open title. He spoke with me by phone from Paris, where he is preparing for his job as a television analyst for the Tennis Channel. We talked about the 2013 French Open and the red clay at Roland Garros.




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House Republicans learn from Trump’s first-term mistakes to be ‘ready on day one’

House Republican leaders are learning from their mistakes during President-elect Donald Trump’s first term to be “ready on day one” to implement their aggressive agenda plans filled with policy changes during the first 100 days of Trump’s presidency.  House leaders have been in conversations with Trump for nearly a year to discuss policy proposals and […]




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How AI might help researchers make esophageal cancer less deadly

To improve survival for esophageal cancer patients, researchers are using artificial intelligence to improve screening for the disease.




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FTC adopts 'click to cancel' rule to make it easier to end subscriptions, mirroring California law

A divided FTC adopted a powerful rule that requires companies to make it just as easy to cancel a subscription as it is to sign up for one.




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L.A. Times, Washington Post see subscription cancellations over not endorsing in presidential race

The Washington Post has lost about 8% of its readers and the L.A. Times 1.8%. But some argue to stay with the newspapers for their roles in reality checking Donald Trump.




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Apple is trying to sell loyal iPhone users on AI tools. Here's what Apple Intelligence can do

Apple customers starting on Wednesday can go to Apple stores for sessions on Apple Intelligence — the company's suite of AI tools.




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Data by the Dozen: Consortium Cancer Maps Provide a 3D View of Tumor Evolution

New 3D blueprints that highlight tumor complexity reveal several new discoveries, some of which challenge existing theories of cancer progression.




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How a Moldy Cantaloupe Took Fleming’s Penicillin from Discovery to Mass Production

Alexander Fleming’s 1928 discovery of a mold with antibacterial properties was only the first serendipitous event on the long road to penicillin as a life-saving drug.



  • News
  • News & Opinion

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How Can Fungi Address the Global Food Waste Problem?

Scientists are reimagining the food system, turning to fungal fermentation as a sustainable method for transforming food byproducts into tasty treats.



  • News
  • News & Opinion

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Newsbabes join forces for breast cancer

The Newsbabes -- those pink-clad broads of broadcasting -- are back again this year with their annual breast cancer fundraising, this year raising money for the Howard University Cancer Center. The event, in its fifth year, will be taking place June 27 from 7 to 9 p.m. at the Hamilton in downtown D.C. Tickets cost $75. The host committee consists of WJLA's Rebecca Cooper, NBC4's Angie Goff, CNN's Brianna Keilar and more.




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Driverless cars in California can get out of almost any ticket: Report

California will ticket a driver for violating the rules of the road, but for driverless vehicles, there is reportedly no mechanism to ticket the person responsible because of a loophole in some jurisdictions.




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'It takes away from the Native Americans': Son of Redskins logo designer denounces rebranding

The Washington Redskins branding change isn’t sitting well with everyone.




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'Hail to the No-Names' — how to lose to cancel culture without surrendering

The first thing any reader needs to know is that the vast, vast majority of Native Americans were never offended by the Washington Redskins' mascot or logo. Certainly, there are offensive ways of representing Native Americans in sports and in other areas — Chief Wahoo comes to mind, as do mocking versions of native dances and rituals. But the Redskins did not engage in those, and people noticed.




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Native American organization wants to make ‘Redskins’ name great again

Left-wing activists may have fueled the movement to change the name of Washington’s NFL franchise. However, an indigenous organization known as the Native American Guardian’s Association is trying to resurrect its former moniker and make Washington’s football team the “Redskins” again. Now known as the Commanders, the team changed its name in 2020 to appease a fanatical mob of social justice warriors and white guilt apologists who claimed the name and logo were racist.




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Native American group files lawsuit against Washington Commanders over 'fake' group claims

A Native American group filed a lawsuit against the Washington Commanders after the team alleged the group, which is advocating that the team revert to its "Redskins" title, was "fake."




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Cancer Research Takes a Leap Thanks to Nobel-Winning MicroRNA Discovery

The Nobel Prize-winning discovery of microRNA has reshaped our understanding of gene regulation. Learn what these tiny molecules mean for cancer research.




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Eric Cantor was defeated for breaking one old rule and two newer ones

It’s not often that something almost universally unexpected happens in American politics. Frequent public opinion polls and a variety of political media usually give political junkies a good idea of what to expect next.




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You Can Still Vote!

Tomorrow marks yet another “most important election of our lifetimes.” And to be fair, it is pretty important. We get to pick a Governor between the Democrat’s heir apparent and the guy who definitely did not solve the Green River killer case. We have the chance to tell Council appointee Tanya Woo “no” for the second time. We could vote away hundreds of millions in education funding if enough people fall for Let’s Go Washington’s phony populist schtick, and this might be the last time you ever vote for President! Want to get in on the action? Turn in your ballot by 8pm Tuesday, November 5! by Hannah Krieg

Tomorrow marks yet another “most important election of our lifetimes.” And to be fair, it is pretty important. We get to pick a Governor between the Democrat’s heir apparent and the guy who definitely did not solve the Green River killer case. We have the chance to tell Council appointee Tanya Woo “no” for the second time. We could vote away hundreds of millions in education funding if enough people fall for Let’s Go Washington’s phony populist schtick, and this might be the last time you ever vote for President! Want to get in on the action? Turn in your ballot by 8pm Tuesday, November 5!

According to King County Elections’ (KCE) ballot return statistics, many of you already turned yours in. As of 9am Monday, 50% of King County’s 1.4 million registered voters cast a ballot. That’s a much higher engagement rate than in typical odd-year elections, where less than half of registered voters usually participate. However, turnout still falls short of the nearly 86% we saw in 2020.

Young people need to pick up the slack. About 21% of registered voters are 65 or older, but with a whopping 71% of those voters turning in a ballot, they make up 30% of the returned ballots. As for voters under 35, they account for 28% of all registered voters, but make up only about 19% of the returned ballots. Young people: You tend to vote better than old people. Sorry, not sorry. Please get to the ballot box!

First step, you need to register. You can check here to see if you already are. 

If you’re not registered, it is unfortunately too late to register to vote by mail. However, you can still register and vote at one of seven voting centers in the county, which are all open today until 6pm and then 8:30am to 8pm on election day. Remember to bring your Washington State driver's license, and a state ID, or memorize the last four digits of your social security number when you go. 

If you’re already registered to vote, awesome. The ballot should be in your mailbox unless you took it out and put it somewhere weird. I can’t help you find it in your own home. Well, maybe if you send me a nice email I would. 

But if you really can’t find it, you can print out a new one, or go vote in person at a King County voting center.

Once you have your ballot in hand, you can check out our endorsements to figure out who you should vote for if you’re even a centimeter left of center. If you’re in a hurry — I know some of you are reading this at 7:30pm — you can read this cheat sheet. 

Then, put the ballot in the envelope, give it a lil lick, seal it, sign it, and then I recommend going to a drop box rather than banking on the USPS post marking it in time. You can find your nearest drop box here. 

Login here to track your ballot and make sure it gets counted. If election counters “challenge” your signature, you can correct it here. 

Last, I’d suggest buying yourself a lil drink. You’re gonna need it. 

 




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How a Blog Can Transform Your Brand

Blogging is fast becoming an essential for businesses across a diverse range of sectors. Retail, I.T, travel, food & drink and entertainment brands have all done their fair share of dabbling in this commonly overlooked activity, and while some might be quick to rubbish the idea, it’s an undeniable fact that blogging has the potential […]




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4 Powerful Ways You Can Automate Your Marketing

Marketing once used to be about carefully debated messages that were packaged in the most appealing ways by people who looked like Jon Hamm for people who looked like you and I to buy more. No more. And that’s not a comment on the impending demise of an iconic series. But why marketing automation, you […]





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Cannabinoid Spotlight: CBC

While there are technically six major cannabinoids, not all are collectively understood, or even paid attention to…



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Good Vibez at MSA Annex: The Third Annual Cultura x Chicano Vibez Festival is on the horizon

It wasn’t that long ago that the land occupied by the MSA Annex was vacant…



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Up in Smoke: Halloweed is immersed in cannabis

Count on a varied, immersive scene Saturday when Tucson Doobie presents Halloweed at Generation Cool…



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Study: Cannabis use and prenatal impacts

A study published in JAMA Pediatrics found cohesive links between prenatal cannabis use and poor thinking skills, lack of impulse control, issues with planning and paying attention and an increase in aggressive behavior among preschool-aged children…



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Kamala Harris throws support behind federal cannabis legalization

Vice President Kamala Harris announced last week her intention, if elected president, to "legalize marijuana at the federal level."…