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Light enhanced cytotoxicity and antitumoral effect of a ruthenium-based photosensitizer inspired from natural alkaloids

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00600C, Research Article
Open Access
Gennaro Sanità, Maria Laura Alfieri, Barbara Carrese, Serena Damian, Vincenza Mele, Gaetano Calì, Brigida Silvestri, Sebastiano Marra, Susan Mohammadi, Giuseppina Luciani, Paola Manini, Annalisa Lamberti
Biological assays carried out on melanoma and breast cancer cells highlighted the role of light in boosting the cytotoxic effect of a ruthenium complex featuring a dihydroisoquinoline ligand suggesting applications in photodynamic therapy.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Property-based optimisation of PROTACs

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00769G, Opinion
James Scott, Iacovos Michaelides, Markus Schade
PROTACs are an emerging therapeutic approach towards targeted protein degradation. This article examines the leading examples of this modality that are in clinical development through the prism of their physicochemical...
The content of this RSS Feed (c) The Royal Society of Chemistry




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A practical guide for the assay-dependent characterisation of irreversible inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00707G, Review Article
Lavleen K. Mader, Jessica E. Borean, Jeffrey W. Keillor
Kinetic evaluations for assay dependent characterization of irreversible inhibitors.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis and antifungal evaluation of new azole derivatives containing 1,2,3-triazole

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00724G, Research Article
Zhengxiao Huang, Hongjie Chen, Xiao Zhang, Ruirui Wang, Chunyan Hu, Zewei Mao
A series of novel azole derivatives containing 1,2,3-triazole have been synthesized with good antifungal effects on sensitive and drug-resistant C. albicans.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Changes in train services notified due to demolition of old bridge near Tiruchi junction




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Heavy weed growth at Kasi Viswanathar Temple tank prevents replenishing of underground water table, say Tiruchi residents




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Duo arrested for possession of banned tobacco products worth ₹3 lakh in Tiruchi




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Ensure time-bound implementation of development schemes, says Thirumavalavan




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Deputy CM releases commemorative flag of Bharat Scouts and Guides




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Farmers demand withdrawal of Tamil Nadu Land Consolidation Act

The Coordination Committee of All Farmers’ Associations of Tamil Nadu says the State government has created a situation where industries can acquire fertile lands




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Power shutdown in parts of Tiruchi on November 9




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EPS’s dream of AIADMK staging a comeback in 2026 election will not materialise: Law Minister Regupathy




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Tiruchi Corporation office expansion plan witnesses more delay




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IECD holds graduation ceremony of SUITS

As many as 93,435 students from Grade V to Grade IX in 358 schools across the State appeared for 2023-2024 BDU examinations




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Students and agriculture officials grapple with logistical, technical issues during digital crop survey




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Lack of signboards indicating bus timings at Chathiram Bus Stand in Tiruchi irks passengers

Passengers also say some buses leave earlier than scheduled or don’t pass certain rural areas, leading to schoolchildren not being able to board on time




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549: Ben Ubois of Feedbin

Ben Ubois is the founder of Feedbin, the RSS reader of choice for Dave and Chris. What influenced the creation of Feedbin, the state of RSS in 2023, curating your RSS feed, and subscribing to newsletters in Feedbin.




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555: React Documentary, Front of the Front End, Fast Fallacy, and Best Practices

Reacting to the React.js documentary, is there still jobs for front of the front end anymore? The fast fallacy in frameworks, best practices, dealing with too much or too little isolation, and AI test generation.




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559: Fidget Apps, Coding with AI, Dialog Element Navs, Getting Rid of CSS

Is there still any value in specializing in front-of-the-frontend dev? Would you ever use the dialog element for a mobile navigation? Why did CodePen decide to use Go for its GraphQL server?




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580: Chen Hui Jing and the State of CSS Survey for 2023

We're talking the State of CSS Survey, 2023 Edition, with Chen Hui Jing. What was it like helping develop the survey? A bit of follow up on regions, the benefits of being able to tell the browser what you want, language issues in developing and understanding CSS, the struggle for non-majority users, CSS frameworks, and more.




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581: DevRel, Musical Mics, Social Sharing, and 100 Years of WordPress

Dave calls a quick Luro branding meeting, some thoughts on DevRel, Chris tries to figure out musical instrument mics, follow up on WordPress from a previous episode, Chris' journey through the social graph options, 100 year hosting with WordPress, and the introduction of a new segment: Happy Project Share Time.




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594: Wiping Your Laptop, UX of Password Codes, and :Has Tips and Tricks

In this episode we're discussing making tech videos, website tinkering, :has tricks, SVG path commands, and the complexities of CSS & JavaScript logic.




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596: The Year of AI, Arc, and Being Mad About the Right Thing

Looking back at the year of AI, using Arc on macOS and now Windows, dreaming of subscriptions, and knowing how to be mad about the right thing.




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608: Can WordPress Kill Your Resume, Fav Parts of Web Dev, Exploring HTMX, and more!

We're opening up the ShopTalk mailbag and answering your questions, including does WordPress on your resume kill your job chances, what are our fav and least fav parts of web dev, our thoughts on HTMX, and what is it like to use pnpm instead of npm.




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622: Website Rendering, Updating Software, and Edge Gets Faster

We're talking website rendering, server side rendering, Astro's server islands, perf hits for navigation elements, updating software because the docs aren't available for older versions, and a new Microsoft Edge was released.




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625: CarTalk, Ownership of A Book Apart, and URL Shorteners

Dave's putting together a platform for his presidential bid and workshops his policies, discussing vehicle options for a family in 2024, Chris and other authors get ownership of their A Book Apart books back, and the ramifications and reasoning behind Google killing a URL shortener.




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640: Navigating the Pros and Cons of Web Components

Riffing off a Dave Rupert blog post, Chris and Dave talk through the pros and cons of web components, when to use them, when it's a bad idea to use them, what would it take to make the Next.js of web components, and how long until we don't need anymore frameworks?




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It’s good ‘office times’ for Bengaluru

The buoyant office market of Bangalore quite makes up for the lukewarm residential segment, according to findings.




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Improve quality of indoor air

Outdoor air pollutants are impacting the indoor environment and builders have to take remedial measures, says M.A. Siraj




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The ABC of composting

A quick primer on how to manage all that rich organic waste your home generates




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Beware of excess cement

Cement deteriorates with age, and has an inherent weakness of cracking.




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In times of distress

It is only through community action can we tackle water shortage.




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The commodification of water

Water purification systems in cities and villages may look attractive but do they actually benefit the needy?




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The monsoon of 2015

We will have to brace ourselves for a likely water deficient scenario from June to September this year.




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Unsuccessful malls on the verge of closure

Poor management practices have resulted in many malls across the country becoming unviable spaces.




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The art of dispensing water

Water-ATMs are becoming the rage all over the country. A look at the mechanism.




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Architecture of the senses

A building should have greenery, sound of water flowing, feel of natural stone under the feet, the smell of trees, flowers and fresh mud, and a charming yet sensitive design, feels architect Mona Doctor Pingel. A look by Nandhini Sundar.




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The management of sludge

There is a need for building bye-laws to insist on a range of on-plot sanitation as mandatory, depending on the location and the groundwater table.




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The price of growth

K. Sukumaran writes on how we could reduce pollution at construction sites




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Make full use of wastewater

In many small and medium towns, domestic wastewater is already being put to use by farmers. A look by S. Vishwanath




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Rammed earth on the roof

There is no dearth of ideas in construction, only of implementation, says Sathya Prakash Varanashi




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Green power, officially

The cumulative effects of changing the way government builds can have a lasting impact on the country’s carbon footprint




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The four Rs of urban living

Each one of us has a role to play in combating drought and we should adopt the mantra of reject, reduce, reuse and recycle, says S. Vishwanath




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F1: Verstappen pulls off stunning win

Red Bull's Max Verstappen dealt Lando Norris a shattering blow in their Formula One title battle by winning a wet and chaotic Sao Paulo Grand Prix from 17th on the grid.




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Gunning for a slice of billion-dollar defence contracts 

How a college project birthed a bootstrapped manufacturer of components for the armed forces 




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The pros and cons of spouses teaming up as co-founders

How do married co-founders navigate the personal and professional ties at work




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Balrampur Chini hopes success of polylactic acid plant will be sweet

In conversation with Avantika Saraogi, ED, and Stefan Barot, President, Chemicals Division, Balrampur Chini Mills




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Soft skills are most in demand

Why headhunters go for traits like leadership, communication, and emotional intelligence




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Carbon credits to boost incomes of Jharkhand village farmers 

The Birsa Harit Gram project serves as a potential model for agro-forestry, which is gaining ground because the buyers of carbon credits prefer — pay a premium — for credits based on Nature Based Solution, as opposed to offsetting projects like renewable energy or projects like carbon capture.




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New venture Zerofifty from ad veterans wants to simplify the agency model

ZeroFifty Mediaworks, set up by three ad veterans, wants to bring in Bandra vibes into the agency model