ic 3-Halo-5,6-dihydro-4H-1,2-oxazine N-oxides as synthetic equivalents of unsaturated nitrile oxides in the [3 + 2]-cycloaddition with arynes: synthesis of substituted 3-vinyl-1,2-benzisoxazoles By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00391H, CommunicationAlexander A. Lukoyanov, Svetlana A. Aksenova, Andrey A. Tabolin, Alexey Yu. Sukhorukov3-Halo-1,2-oxazine N-oxide derivatives act as surrogates of vinyl nitrile oxides in tandem [3 + 2]-cycloaddition/[3 + 2]-cyclofragmentation with arynes leading to benzisoxazoles.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Dess–Martin periodinane-mediated oxidation of the primary alcohol of cytidine into a carboxylic acid By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00240G, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Alexandra R. E. Serre, Vibhu Jha, Adèle Rivault, Leif A. Eriksson, Goreti Ribeiro Morais, Robert A. FalconerHerein we describe the first example of the conversion of the primary alcohol of cytidine into a carboxylic acid by use of the Dess–Martin periodinane oxidising agent.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Revisiting Biginelli-like Reactions: Solvent Effects, Mechanisms, Biological Applications and Correction of Several Literature Reports By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00272E, PaperBrenno A. D. Neto, Pedro Beck, Arthur Leitão, Yasmin Santana, Jose R. Correa, Carime Vitória da Silva Rodrigues, Daniel Machado, Guilherme Matos, Luciana Machado Ramos, Claudia Cristina Gatto, Carlos Kleber Z. Andrade, Sarah CaldasThis study critically reevaluates reported Biginelli-like reactions using a Kamlet-Abboud-Taft-based solvent effect model. Surprisingly, structural misassignments were discovered in certain multicomponent reactions, leading to the identification of pseudo three-component derivatives...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Design, synthesis, biological evaluation and molecular docking studies of quinoline-anthranilic acid hybrids as potent anti-inflammatory drugs By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00040D, PaperSidra Siddique, Khalid Hussain, Naureen Shehzadi, Muhammad Arshad, Muhammad Nadeem Arshad, Sadaf Iftikhar, Farhat Saghir, Ayisha Shaukat, Muhammad Sarfraz, Nisar AhmedDespite the high global prevalence, rheumatoid arthritis lacks a satisfactory treatment.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Discovery of selective monosaccharide receptors via dynamic combinatorial chemistry By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00015C, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Miguel Alena-Rodriguez, Marcos Fernandez-Villamarin, Ignacio Alfonso, Paula M. MendesAn effective workflow to discover selective saccharide receptors by combining dynamic combinatorial chemistry with isothermal titration calorimetry and NMR.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Recent developments in the enzymatic modifications of steroid scaffolds By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00327F, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Huibin Wang, Ikuro AbeThis review highlights the recent advancements in the enzymatic modifications of steroid scaffolds, emphasizing enzymatic hydroxylation, ketoreduction, dehydrogenation, enzymatic cascade reactions, and other modifications.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Isothiocyanates: Happy-Go-Lucky Reagents in Organic Synthesis By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00281D, Review ArticleBubul Das, Anjali Dahiya, Bhisma K Patel: Owing to their unique structural features, isothiocyanates (ITCs) are a class of highly useful and inimitable reagents as the N=C=S group serves both as electrophile and nucleophile in organic...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Natural products from human microbiome: an emergent frontier in organic synthesis and drug discovery By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00236A, Review ArticleGoverdhan Mehta, Saumitra Sengupta, Srihari PabbarajaOften referred to as “second genome”, human microbiome is at the epicenter of a complex inter-habitat biochemical network, such as the “gut-brain axis”, which have emerged as significant determinant of...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Design, synthesis, and biological application of A–D–A-type boranil fluorescent dyes By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00297K, PaperWei Luo, Yiling Li, Liang Wang, Yanhua Qin, Qiao Cheng, Guochang Hu, Chaoyi Yao, Xiangzhi SongAcceptor–donor–acceptor boranil fluorescent dyes, CSU-BF-R (R = H, CH3, and OCH3), were developed with strong red fluorescence and large Stokes shifts. CSU-BF-OCH3 could selectively sense intracellular hypochlorous acid in living cells and zebrafish.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Facile synthesis of tetrahydroquinoline containing dithiocarbamate derivatives via one-pot sequential multicomponent reaction By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00490F, CommunicationSIDDHARTHA KUMAR SENAPATI, Anit Pal, Animesh DasAn efficient sequential multi-component method for the synthesis of tertrahydroquinoline containing dithiocarbamate has been developed. This reaction involved a boronic acid-catalyzed reduction of quinoline to tertrahydroquinoline, followed by nucleophilic addition...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic A Highly Diastereoselective One-Pot Ugi/Radical Spirocyclization/Aza-Michael Addition Sequence By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00610K, CommunicationChandra Volla, Salman Khan, Abhradeep Chatterjee, Akshay Murali NairWe hereby report a highly diastereoselective synthesis of chalcogenated azaspirotricycles via a one-pot Ugi/spirocyclization/ aza-Michael addition sequence. The reaction proceeded via a key visible light mediated spirocyclization step under mild,...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic N-Functionalization of beta-aminophosphonates; Cytotoxic effect of the new derivatives By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00243A, PaperGyörgy Keglevich, Petra Regina Varga, Emőke Dinnyési, Zsuzsanna Szalai, Szilvia Bősze, Rita Oláhné Szabó, Laszlo Drahos, Konstantin KaraghiosoffBeta-Aminophosponates obtained by the Michael addition of primary amines to the double bond of diethyl vinylphosphonate proved to be suitable starting materials (amine components) in the Kabachnik–Fields reaction with formaldehyde...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Sustainable preparation of 2-acylbenzothiazoles under the cooperation of ionic liquids and microwave irradiation By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00315B, PaperShoushun Wang, Mengjie Liu, Yiyuan Yue, Xiude Hu, Yalin Zhang, Guodong Shen, Ruiguo Dong, Lilong Shi, Bing Yu, Xianqiang HuangA series of 2-acylbenzothiazole derivatives were sustainably synthesized for the first time under the cooperation of ionic liquids and microwave irradiation, metal- and extra-additives-free conditions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Tetrabutylammonium decatungstate (TBADT), a compelling and trailblazing catalyst for visible-light-induced organic photocatalysis By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00171K, Review ArticleBor-Cherng Hong, Ranadheer Reddy IndurmuddamThis review summarizes recent developments in visible-light or near-visible-light photocatalysis reactions enabled by the TBADT catalyst.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Efficient synthesis of SCF3-containing 3-alkenylquinoxalinones via three-component radical cascade reaction By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00363B, PaperSi-Yu Wang, Chu Liu, Wei Yang, Zhong-Ying Tian, Lin Yuan, Long-Yong XieA three-component cascade reaction of quinoxalinones, alkynes and AgSCF3 toward complete E-selective SCF3-containing 3-alkenylquinoxalinones was developed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Base- and sulfur-promoted oxidative lactonization of chalcone-acetate Michael adducts: access to pyran-2-ones By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00479E, CommunicationCao Nguyen Nguyen, Duc Toan Nguyen, Ha An Tran, Dinh Hung Mac, Thi Thu Tram Nguyen, Pascal Retailleau, Thanh Binh NguyenA cost-effective, practical, straightforward and scalable synthesis of α-pyrones via base- and sulfur-promoted annulation of phenylacetates and chalcones is reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Visible light-driven photocatalytic sulfonative oxidation of benzyl secondary amines By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00348A, PaperYong-Xiang Lü, Xinqian Wang, Ying-Ming Pan, Keyume AblajanA method for the α-oxidation and sulfonation of benzyl secondary amines was developed utilizing Ir(III) or Eosin Y as the photocatalyst in the presence of O2 as a green oxidant....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic K2CO3-Mediated (3+3-1) Annulation of 1,3-Acetonedicarboxylates with 2-Fluoro-1-nitroarenes: Synthesis of Indoles By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00488D, PaperMeng-Yang Chang, Chin-Huey Ho, Hsing-Yin ChenThe K2CO3-mediated one-pot reaction of 1,3-acetonedicarboxylates with 2 equiv. of substituted 2-fluoro-1-nitrobenzenes has been developed to synthesize various 2,3-dicarboxylate indoles via a tandem (3 + 3 − 1) annulation pathway....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Introduction to Service Worker: How to use Service Worker By www.html5rocks.com Published On :: Mon, 01 Dec 2014 00:00:00 +0000 Service Worker will revolutionize the way we build for the web. Learn about what it is, why it is important and how to use it. Full Article
ic Rolling out Public Key Pinning with HPKP Reporting By developers.google.com Published On :: Tue, 01 Sep 2015 00:00:00 +0000 Full Article
ic Updates to the service worker cache API By developers.google.com Published On :: Thu, 03 Sep 2015 00:00:00 +0000 Full Article
ic Tickets to safe flying By www.thehindubusinessline.com Published On :: Sun, 11 Jul 2021 19:09:20 +0530 A list of the top Covid-19-compliant airlines Full Article Logistics
ic Piloting through the pandemic By www.thehindubusinessline.com Published On :: Sun, 11 Jul 2021 19:23:15 +0530 How AirAsia India innovated with a distance-learning training programme for its cockpit crew Full Article Logistics
ic As the price of aviation turbine fuel soars, airlines’ finances spin out of control By www.thehindubusinessline.com Published On :: Sun, 25 Jul 2021 16:35:44 +0530 Full Article Flight Plan
ic Gearing up to fly twice as fast as sound By www.thehindubusinessline.com Published On :: Sun, 05 Sep 2021 17:14:22 +0530 The US-based start-up Boom Supersonic is putting together an aircraft that can fly at a maximum speed of Mach 2.2 Full Article Flight Plan
ic Domestic air travel leads airline recovery: Boeing By www.thehindubusinessline.com Published On :: Sun, 19 Sep 2021 15:39:11 +0530 Low-cost carriers aid market with point-to-point structure and affordable rates Full Article Logistics
ic Pandemic: Contactless technology on an overdrive By www.thehindubusinessline.com Published On :: Sun, 19 Sep 2021 15:50:25 +0530 As demand for travel rises, industry must meet it while ensuring passenger safety Full Article Logistics
ic Pick the rear seats to fly safe By www.thehindubusinessline.com Published On :: Sun, 14 Nov 2021 20:02:19 +0530 Passengers who pick a seat near the tail of an aeroplane are more likely to survive a crash Full Article Logistics
ic Omicron: Airlines on a wing and prayer By www.thehindubusinessline.com Published On :: Sun, 26 Dec 2021 18:03:30 +0530 Over 3,000 flights were cancelled on the eve of Christmas and cancellations are expected to double as New Year approaches Full Article Flight Plan
ic Those magnificent flying machines By www.thehindubusinessline.com Published On :: Sun, 26 Dec 2021 18:12:38 +0530 The aviation industry’s roller-coaster ride Full Article Flight Plan
ic Profits offer hope of soft landing to Spicejet By www.thehindubusinessline.com Published On :: Sun, 20 Feb 2022 22:00:00 +0530 Apart from swift settlement with former owners, the airline urgently needs an immediate infusion of cash Full Article Flight Plan
ic From geopolitics strife to a war of words between two aviation giants By www.thehindubusinessline.com Published On :: Sun, 20 Feb 2022 22:00:00 +0530 Qatar Airways and Airbus lock horns over safety concerns Full Article Flight Plan
ic Unmanned Flying Objects, at your service By www.thehindubusinessline.com Published On :: Sun, 06 Mar 2022 22:00:00 +0530 From capturing candid shots at in a wedding, to spraying pesticides to surveillance of places where access is difficult for humans, drones as a service (DaaS) is the next big thing Full Article Flight Plan
ic Domestic airline industry may face a rejig By www.thehindubusinessline.com Published On :: Sun, 17 Apr 2022 20:18:03 +0530 The pandemic laid bare fault-lines within India’s airlines Full Article Flight Plan
ic Electric aircraft set to transform urban mobility By www.thehindubusinessline.com Published On :: Sun, 15 May 2022 19:20:02 +0530 Investors are pouring in billions of dollars into eVTOL project (electric vertical take offs and landing aircraft) to ferry passengers Full Article Flight Plan
ic Yoke vs. sidestick: Jury still out on what works best for pilots By www.thehindubusinessline.com Published On :: Sun, 24 Jul 2022 21:00:00 +0530 Why do Airbus commercial aircraft have sidesticks and Boeing have yokes as control units? Full Article Logistics
ic Chicken gun test: Saving jets from bird strikes By www.thehindubusinessline.com Published On :: Sun, 07 Aug 2022 20:30:00 +0530 According to ICAO, at least 34 bird strikes happen every day, causing around $1 billion worth damages every year Full Article Flight Plan
ic 5 things Indian airlines must do to break their way out of pandemic blues By www.thehindubusinessline.com Published On :: Sun, 21 Aug 2022 21:00:00 +0530 Post pandemic, the airlines must revamp strategies and resort to long-term measures to recover from the crisis Full Article News
ic Airlines’ performance metrics may need an overhaul By www.thehindubusinessline.com Published On :: Sun, 04 Sep 2022 22:00:00 +0530 It may be time to revisit RASK, CASK metrics; benchmarking based on cost drivers can boost an airline’s performance Full Article Flight Plan
ic Embraer expects capacity dynamics to tilt demand in its favour By www.thehindubusinessline.com Published On :: Sun, 18 Sep 2022 21:00:00 +0530 The plane maker’s current foray attempts to shed the tentativeness that overshadowed its earlier endeavours Full Article Flight Plan
ic Post-pandemic, OTAs are coming of age By www.thehindubusinessline.com Published On :: Sun, 18 Sep 2022 21:00:00 +0530 Are they finally paying up or paying off? Full Article Flight Plan
ic Air India’s roadmap can be tricky to pull off By www.thehindubusinessline.com Published On :: Sun, 02 Oct 2022 21:00:00 +0530 The airline has to work hard to drastically grow its network and fleet while improving reliability as well Full Article Flight Plan
ic Sarvam AI launches Sarvam 1 for Indic languages By www.thehindu.com Published On :: Mon, 28 Oct 2024 14:47:54 +0530 The custom training corpus, Sarvam-2T comprised of 20 percent datasets in Hindi as well as English and programming languages so the AI model can perform multilingual tasks Full Article Technology
ic Microsoft Teams to launch threaded conversations, combined chats and channels features By www.thehindu.com Published On :: Tue, 29 Oct 2024 11:28:42 +0530 The app has also added other changes in the interface so users can organise their chats better Full Article Technology
ic Crypto firm Consensys to cut 20% of workforce amid macroeconomic, regulatory headwinds By www.thehindu.com Published On :: Wed, 30 Oct 2024 11:42:41 +0530 The crypto firm added that elevated interest rates, inflationary pressures, and tightening liquidity have created a more “cautious macroeconomic environment” Full Article Technology
ic Microsoft, Meta, Apple, Amazon, and the burden of expectations knock Wall Street sharply lower By www.thehindu.com Published On :: Fri, 01 Nov 2024 09:27:41 +0530 Drops for Big Tech companies including Microsoft and Facebook’s parent company Meta Platforms led Wall Street lower Full Article Technology
ic Karnataka government plans to start 11 medical colleges under contentious PPP model By www.thehindu.com Published On :: Sun, 20 Oct 2024 21:20:19 +0530 As of now, the State has 22 government medical colleges in 22 districts while 11 others have no government medical colleges; the PPP model however has been criticised by some experts Full Article Health
ic WHO to evacuate 1,000 Gazan women, children for urgent medical care By www.thehindu.com Published On :: Mon, 21 Oct 2024 16:02:57 +0530 Last week, U.N. investigators said Israel was deliberately targeting health facilities in Gaza, and killing and torturing medical personnel there, accusing the country of "crimes against humanity". Full Article Health
ic Dietary restriction or good genes: new study tries to unpack which has greater impact on lifespan By www.thehindu.com Published On :: Mon, 21 Oct 2024 16:50:20 +0530 If we know that genetics and lifestyle affect how long you live, which one is more important? And how do they interact? Full Article Health
ic High cataract rate among elderly in Mucherla, Meerkhanpet of Rangareddy district, says survey By www.thehindu.com Published On :: Tue, 22 Oct 2024 10:05:07 +0530 HHF’s screening of 200 patients in Mucherla and Meerkhanpet found that 21% had senile cataracts, 18% had immature cataracts, and 15% had refractive errors Full Article Telangana