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A Man Before His Time: The Unsung Story of Freydun Atouraya

A Man Before His Time: The Unsung Story of Freydun Atouraya




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Brand Alley brings logistics in-house with the help of Scurri

BrandAlley, an off-price premium and luxury brand e-tailer in the UK and France, has driven improved business performance by taking full control of its customer delivery proposition – from dispatch to customer notifications – in partnership with Scurri, the delivery management platform.




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ZigZag Survey proves that customers can come round to the idea of paid returns

Returns specialist ZigZag has published the results of a survey which indicates that one-off fees for returns are preferable to price rises on items among consumers.




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The Boycott Turkey Campaign

The Boycott Turkey Campaign



  • Armenian
  • Assyrian and Hellenic Genocide News

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CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients

CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients

In the first-ever (sanctioned) investigational use of multiple edits to the human genome, a study found that cells edited in three specific ways and then removed from patients and brought back into the lab setting were able to kill cancer months after their original manufacturing and infusion.

This is the first U.S. clinical trial to test the gene editing approach in humans, and the publication of this new data today follows on the initial report last year that researchers were able to use CRISPR/Cas9 technology to successfully edit three cancer patients' immune cells. The ongoing study is a cooperative between Tmunity Therapeutics, the Parker Institute for Cancer Immunotherapy, and the University of Pennsylvania. 

Patients on this trial were treated by Edward A. Stadtmauer, MD, section chief of Hematologic Malignancies at Penn, co-lead author on the study. The approach in this study is closely related to CAR T cell therapy, in which patient immune cells are engineered to fight cancer, but it has some key differences. Just like CAR T, researchers in this study began by collecting a patient's T cells from blood. However, instead of arming these cells with a receptor against a protein such as CD19, the team first used CRISPR/Cas9 editing to remove three genes. The first two edits removed a T cell's natural receptors so they can be reprogrammed to express a synthetic T cell receptor, allowing these cells to seek out and destroy tumors. The third edit removed PD-1, a natural checkpoint that sometimes blocks T cells from doing their job. 

Once the three genes are knocked out, a fourth genetic modification was accomplished using a lentivirus to insert the cancer-specific synthetic T cell receptor, which tells the edited T cells to target an antigen called NY-ESO-1. Previously published data show these cells typically survive for less than a week, but this new analysis shows the edited cells used in this study persisted, with the longest follow up at nine months. 

Several months after the infusion, researchers drew more blood and isolated the CRISPR-edited cells for study. When brought back into the lab setting, the cells were still able to kill tumors. 

The CRISPR-edited T cells used in this study are not active on their own like CAR T cells. Instead, they require the cooperation of a molecule known as HLA-A*02:01, which is only expressed in a subset of patients. This means that patients had to be screened ahead of time to make sure they were a match for the approach. Participants who met the requirements received other clinically-indicated therapy as needed while they waited for their cells to be manufactured. Once that process was completed, all three patients received the gene-edited cells in a single infusion after a short course of chemotherapy. Analysis of blood samples revealed that all three participants had the CRISPR-edited T cells take root and thrive in the patients. While none responded to the therapy, there were no treatment-related serious adverse events. 

CRISPR technology has not previously been tested in humans in the U.S. so the research team had to move through a comprehensive and rigorous series of institutional and federal regulatory approval steps, including approval by the National Institutes of Health's Recombinant DNA Research Advisory Committee and review by the U.S. Food and Drug Administration, as well as Penn's institutional review board and institutional biosafety committee. The entire process required more than two years.

 Researchers say these new data will open the door to later stage studies to investigate and extend this approach to a broader field beyond cancer, several of which are already planned at Penn.

sb admin Thu, 02/06/2020 - 14:52
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Caves Valley to host new LPGA international event in 2014

Caves Valley Country Club in Owings Mills, Md. will be the host of a first-of-its-kind event next year on the LPGA Tour. On Friday the tour announced it will establish the International Crown, a biennial, global match-play competition.




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Locals Freed, Katz win IJGT event in Hershey

Evan Katz, 14, of the District won his first International Junior Golf Tour event, last weekend in Hershey, Pa. / Courtesy photo




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Desperate parents turn to magnetic therapy to help kids with autism. They have little evidence to go on

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Wildfires can release more energy than an atomic bomb. No wonder they look apocalyptic

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Study finds Central Valley residents continually exposed to 'toxic soup' of pesticides

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Valley fever is a growing risk in Central California; few visitors ever get a warning

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As bird flu outbreaks rise, piles of dead cattle become shocking Central Valley tableau

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Key takeaways from our investigation into the science behind an alternative autism therapy

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Berkeley startup wins government award to develop radiation and lead poisoning treatment

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Bradley Beal, Cartier Martin have face-to-face collision in practice

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Bradley Beal crisp in return after six-game absence

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Bradley Beal proud of rookie season despite injuries

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Bradley Beal finishes third in NBA rookie of the year race

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Trump to host screening of Sound of Freedom at his New Jersey golf club

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Many California voters get their info from social media, even if they don't trust it, poll shows

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Why some Silicon Valley investors are backing the Trump-Vance campaign

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This controversial California AI bill was amended to quell Silicon Valley fears. Here's what changed

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Opinion: Silicon Valley is maximizing profit at everyone's expense. It doesn't have to be this way

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Gov. Gavin Newsom vetoes AI safety bill opposed by Silicon Valley

Gov. Gavin Newsom vetoed AI safety bill SB-1047, which was opposed by tech companies including ChatGPT maker OpenAI and Facebook parent company Meta.




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Opinion: The risks of sharing your DNA with online companies aren't a future concern. They're here now

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AI startup funding hit a record in the L.A. area last quarter. Here's who got the most money

L.A.-area startups received $1.8 billion in the third quarter, the highest quarterly amount for the region, according to CB Insights. Most of it went to a single company.




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eBooks: Key Tools for Scientific Advancement

Serving as a bridge between traditional textbooks and peer-reviewed journal articles, ebooks allow scientists to efficiently learn about new findings or fields.



  • Research Products Blog

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'Honey Badger' Tyrann Mathieu leaving a sour taste to some

The Redskins will have a chance to draft LSU corner Tyrann Mathieu. Two years ago, that would have been an exciting possibility. Now? After missing last season because he was kicked off the team, reportedly for multiple positive drug tests? It's far from a no-brainer and, really, it depends on your philosophy.




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New Jersey politician refuses to resign after alleged hit-and-run

A Jersey City councilwoman refused to step down from office Wednesday night amid outcry over an alleged hit-and-run last month.




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Greyhound bus accident leaves more than a dozen injured: Police

More than a dozen people sustained injuries in an incident involving a Greyhound bus in Georgia, which local authorities said flipped on its side when one of the vehicle's tires blew out.




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New Jersey trains delayed due to loose bull on the tracks

Commuters in Newark, New Jersey, were subject to delays Thursday morning after a bull got loose on the tracks of Newark Penn Station.




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How to Identify Long Tail Keywords for SEO Success

Long tail keywords have taken on a greater importance in organic search, especially with the ever-increasing momentum of mobile users. Whether driving traffic to your website, or promoting a PPC ad campaign, the value of long tail keywords create better targeted action for your marketing and sales funnels. Google’s Hummingbird engine has a conversational search […]




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Should I stay away from highly competitive keywords?

If you’ve used Google’s Keyword Tool, you’ve probably seen the column called “Competitiveness,” with levels low, medium, and high. The low. medium, and high are based on the competitiveness of a keyword among paid search advertisers. The more advertisers are bidding on a keyword, the higher the competitiveness. By itself, paid search competitiveness tells you […]




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Futuro Women`s Beyond Support Pantyhose Reinforced Toe.

Futuro women medical pantyhose. Firm compression 20-30mmHg (class 2). Improve circulation and reduce discomfort from leg fatigue, ankle swelling and other venous insufficiencies. For post surgical patients. Full-cut panty with control top for firming and shaping. Reinforced toe and heel (RHT). Comfort waistband. Manufacturer guarantee. Sizes S,M,L. See Sizechart. Price: USD49.29




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Futuro Women`s Beyond Support Pantyhose French Cut.

Futuro women medical pantyhose, mild compression 8-15mmHg (class 1). Improve circulation and reduce discomfort from leg fatigue, ankle swelling and other venous insufficiencies. Enhanced toe with run gaurd. Ultra sheer. Soft and silky. French cut lace panty design. Comfort waistband. Manufacturer guarantee. Sizes S,M,L. See Sizechart. Price: USD35.40




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Futuro Women`s Beyond Support Knee Highs.

Futuro women medical kneehigh. Improve circulation and reduce discomfort from leg fatigue, ankle swelling and other venous insufficiencies. Mild (light) compression (8-15mmHg). Ultra sheer, soft, silky, comfortable material. Enhanced toe with run guard and reinforced heel. Comfort band. With manufacturer guarantee. Sizes S,M,L. See Sizechart. Price: USD18.02




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OEM Oval Cat Eye Fashion Bracelet.

Eleven white oval-shaped cat eye gemstones forming fashion bracelet. Shiny silver-plated chain and clips. Known to ward off evils and avoid catastrophe. Size: 6.50 inches in length. Non-detachable hinge-joint. White color only. Price: USD15.09




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Delivery Of Guitars and Keyboards

We have had two "Give Away" parties. We are so happy we have been able to raise over $10,000 to purchase instruments. We have some funds left over that we will be hosting some weekend music workshops. If there are any of you that want to come and donate us a day, please let us know. We now have instruments in our hands and in our homes. So we are now ready to play.




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New collection: Oval Cat Eye Fashion Bracelet

Eleven white oval-shaped cat eye gemstones forming fashion bracelet. Shiny silver-plated chain and clips.

Known to ward off evils and avoid catastrophe.

Size: 6.50 inches in length.




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Oro Valley Fall Foodie & Art Festival

The Southern Arizona Arts & Cultural Alliance in partnership with Tucson Foodie, hosted the first Oro Valley Fall Foodie & Art Festival on Oct. 26 and Oct. 27 at the Oro Valley Marketplace. The event featured arts, food and fall festivities…



  • Arts & Culture/Arts: Feature

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Where to Shop: Boo Radley's

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A narrower Sprague Avenue now connects Spokane Valley City Hall and Balfour Park

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Spokane rental units are required to be registered, but not everyone knows that; now they might have to pay the fee

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Don't stay glued to your porch this summer, visit the honey bucket with the Melvins

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  • Music/Music News

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Burke, Idaho: Wedged between mountains, the Silver Valley mine town's history of rich resources still echoes down the canyon

Crammed in a narrow canyon of North Idaho's Silver Valley, in perhaps one of the most inconvenient but also beautiful places for a hub of human habitation, are the rusted remains of a once-lively mountain mine town…



  • Arts & Culture

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Gen Heywood's photography exhibition at Gonzaga University Urban Art Center explores the potency of two American icons

It's a scary time of year, but not because of Halloween…



  • Arts & Culture

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Spokane artist Chris Bovey opens Vintage Print + Neon storefront, studio and workshop in the Garland District

Chris Bovey's new shop on Garland Avenue isn't technically open on Tuesday, but it's too enjoyably warm and sunny on a late September afternoon to keep the roll-up door along the sidewalk closed…



  • Culture/Arts & Culture

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We asked more than 65 local politicians if they were vaccinated for COVID-19. Here's what they said

Before we start, let's get this out of the way: No, it is not a HIPAA violation to ask someone if they've been vaccinated for COVID-19…



  • News/Local News