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Free drug and ROS-responsive nanoparticle delivery of synergistic doxorubicin and olaparib combinations to triple negative breast cancer models

Biomater. Sci., 2024, 12,1822-1840
DOI: 10.1039/D3BM01931D, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Robert J. Cavanagh, Patrícia F. Monteiro, Cara Moloney, Alessandra Travanut, Fatemeh Mehradnia, Vincenzo Taresco, Ruman Rahman, Stewart G. Martin, Anna M. Grabowska, Marianne B. Ashford, Cameron Alexander
Combinations of the topoisomerase II inhibitor doxorubicin and the poly (ADP-ribose) polymerase inhibitor olaparib offer potential drug–drug synergy for treatment of triple negative breast cancers (TNBC) both in free drug form and when delivered by oxidation-responsive nanoparticles.
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Ferroptosis and ferroptosis-inducing nanomedicine as a promising weapon in combination therapy of prostate cancer

Biomater. Sci., 2024, 12,1617-1629
DOI: 10.1039/D3BM01894F, Review Article
Mengjun Huang, Qiliang Teng, Fei Cao, Jinsheng Huang, Jun Pang
Existing treatments could be sensitized by targeting the ferroptosis pathway in prostate cancer.
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Sorafenib and tetrakis (4-carboxyphenyl) porphyrin assembled nanoparticles for synergistic targeted chemotherapy and sonodynamic therapy of hepatocellular carcinoma

Biomater. Sci., 2024, 12,1864-1870
DOI: 10.1039/D3BM01994B, Paper
Yongzhi Chen, Qiuxia Tan, Yuanyu Tang, E. Pang, Rui Peng, Minhuan Lan, Dousheng Bai
Hepatocellular carcinoma (HCC) is characterized by a high degree of malignancy and mortality.
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Advanced postoperative tissue antiadhesive membranes enabled with electrospun nanofibers

Biomater. Sci., 2024, 12,1643-1661
DOI: 10.1039/D3BM02038J, Review Article
Yanting Zhu, Chenwei Zhang, Ying Liang, Jianyuan Shi, Qiuhao Yu, Shen Liu, Dengguang Yu, Hui Liu
Electrospun nanofibers with fascinating properties provide a versatile platform for postoperative tissue anti-adhesion.
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Dynamic monitoring of the fibrosis disease by a collagen targeting near infrared probe

Biomater. Sci., 2024, 12,1924-1931
DOI: 10.1039/D3BM01926H, Paper
Xiaoke Zhang, Qianwen Yang, Sensen Zhou, Cheng Li, Xiqun Jiang
A H2O2-sensitive macromolecular optical probe which can effectively bind to collagen was developed for real time noninvasive visualization of fibrotic tissues.
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Fibromodulin facilitates the osteogenic effect of Masquelet's induced membrane by inhibiting the TGF-β/SMAD signaling pathway

Biomater. Sci., 2024, 12,1898-1913
DOI: 10.1039/D3BM01665J, Paper
Kai Wang, Ming Zhou, Yuanshu Zhang, Yesheng Jin, Yuan Xue, Dong Mao, Yongjun Rui
Schematic illustration of the mechanism by which an IM promotes bone formation. FMOD secreted by the IM promotes osteogenesis of BMSCs and angiogenesis of HUVECs by inhibiting the TGF-β/SMAD signaling pathway, thus facilitating bone formation.
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Application of a meshed artificial dermal scaffold and negative-pressure wound therapy in the treatment of full-thickness skin defects: a prospective in vivo study

Biomater. Sci., 2024, 12,1914-1923
DOI: 10.1039/D3BM01675G, Paper
Open Access
Pei Wei, Lijiao Wu, Hongteng Xie, Zhaohong Chen, Rongwei Tan, Zhaorong Xu
A novel meshed ADS combined with NPWT can reduce the risk of scaffold-related complications, which helps to improve the quality of wound repair and promotes a broader range of applications.
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The unexplored role of alkali and alkaline earth elements (ALAEs) on the structure, processing, and biological effects of bioactive glasses

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D3BM01338C, Review Article
Open Access
Adam Shearer, Matthew Molinaro, Maziar Montazerian, Jessica J. Sly, Marta Miola, Francesco Baino, John C. Mauro
Alkali and alkaline earth elements play a crucial role in the structure, processing, and properties of bioactive glasses, widely used in medical applications since their inception in 1969.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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N-Halaminated spermidine-containing polymeric coating enables titanium to achieve dual functions of antibacterial and osseointegration

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00061G, Paper
Hang Ren, Peng Wang, Hanwen Huang, Junshen Huang, Yuheng Lu, Yanfeng Wu, Zhongyu Xie, Youchen Tang, Zhaopeng Cai, Huiyong Shen
Modified Ti with a porous N-halaminated spermidine-containing polymeric coating is constructed, and it has both excellent antibacterial and osteogenic abilities to enhance osseointegration, making it potentially applicable in orthopedics.
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Escape sites from the endo-lysosomal trafficking route manipulate exocytosis of nanoparticles in polar epithelium

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00174E, Paper
Lingling Wang, Yuting Li, Xi Liu, Liyun Xing, Ruinan Wu, Yuan Huang
MNPs escaping from early endosomes and late endosomes are prone to entering the ER/GA for efficient basolateral exocytosis. However, MNPs escaping from lysosomes are detained within cells by autophagosomes.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Bioactivity of cerium dioxide nanoparticles as a function of size and surface features

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D3BM01900D, Paper
Veronika Sarnatskaya, Yuliia Shlapa, Denis Kolesnik, Olexandra Lykhova, Dmytro Klymchuk, Serhii Solopan, Svitlana Lyubchyk, Iuliia Golovynska, Junle Qu, Yurii Stepanov, Anatolii Belous
Nano-dispersed cerium dioxide is promising for use in medicine due to its unique physicochemical properties, low toxicity, the safety of in vivo usage, active participation in different redox processes occurring in living cells, and its regenerative potential.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Correction: ECM-based bioadhesive hydrogel for sutureless repair of deep anterior corneal defects

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM90027H, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Safieh Boroumand, Faraz Sigaroodi, Seyed Mohsen Ahmadi Tafti, Keyvan Khoshmaram, Masoud Soleimani, Mohammad-Mehdi Khani
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Macrophage membrane-camouflaged nanoclusters of ultrasmall iron oxide nanoparticles for precision glioma theranostics

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00357H, Paper
Bin Zhang, Rui Yang, Hongwei Yu, Yamin Peng, Haoyu Huang, Meera Moydeen Abdul Hameed, Han Wang, Guixiang Zhang, Mohamed EL-Newehy, Mingwu Shen, Xiangyang Shi, Shaojun Peng
Macrophage membrane-camouflaged nanoclusters of ultrasmall iron oxide nanoparticles can be developed to cross the blood–brain barrier for magnetic resonance imaging and chemo/chemodynamic therapy.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Comparison study of surface-initiated hydrogel coatings with distinct side-chains for improving biocompatibility of polymeric heart valves

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00158C, Paper
Yiduo Chen, Yirong Guo, Xinyi Li, Yanchen Chen, Jiarong Wang, Honglin Qian, Jing Wang, Youxiang Wang, Xinyang Hu, Jian'an Wang, Jian Ji
Three surface-initiated hydrogel coatings (pMPC, pAMPS, pHEMA) are constructed on polymeric heart valves. The zwitterionic pMPC coating displays optimal performances, including durable anti-coagulation, anti-inflammation, and anti-calcification.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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ABCD of IA: A multi-scale agent-based model of T cell activation in inflammatory arthritis

Biomater. Sci., 2024, 12,2041-2056
DOI: 10.1039/D3BM01674A, Paper
David A. McBride, James S. Wang, Wade T. Johnson, Nunzio Bottini, Nisarg J. Shah
The study develops a computational framework to model factors that lead to the evolution of autoreactive T cells in inflammatory arthritis. The results provide a tool for planning immunomodulatory strategies focused on new disease-modifying agents.
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Liquid–liquid phase separation-inspired design of biomaterials

Biomater. Sci., 2024, 12,1943-1949
DOI: 10.1039/D3BM02008H, Minireview
Yang Song
Biological liquid–liquid phase separation (LLPS) provides novel insights for the assembly of biomaterials with tailored structure and intrinsic functionality.
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Nanotechnology-based delivery of therapeutics through the intranasal pathway and the blood–brain barrier for Alzheimer's disease treatment

Biomater. Sci., 2024, 12,2007-2018
DOI: 10.1039/D3BM02003G, Review Article
Mark-Jefferson Buer Boyetey, Yonghyun Choi, Hee-Young Lee, Jonghoon Choi
Drugs for Alzheimer's disease (AD) fail to exhibit efficacy in clinical trials for a number of reasons, a major one being blood–brain barrier (BBB) permeability.
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Enhancing antioxidant properties of CeO2 nanoparticles with Nd3+ doping: structural, biological, and machine learning insights

Biomater. Sci., 2024, 12,2108-2120
DOI: 10.1039/D3BM02107F, Paper
Oscar Ceballos-Sanchez, Diego E. Navarro-López, Jorge L. Mejía-Méndez, Gildardo Sanchez-Ante, Vicente Rodríguez-González, Angélica Lizeth Sánchez-López, Araceli Sanchez-Martinez, Sergio M. Duron-Torres, Karla Juarez-Moreno, Naveen Tiwari, Edgar R. López-Mena
The antioxidant capabilities of nanoparticles are contingent upon various factors, including their shape, size, and chemical composition.
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Transplantation of a bioengineered tissue patch promotes uterine repair in the sheep

Biomater. Sci., 2024, 12,2136-2148
DOI: 10.1039/D3BM01912H, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Edina Sehic, Lucía de Miguel Gómez, Hardis Rabe, Emy Thorén, Ingigerdur Gudmundsdottir, Mihai Oltean, Randa Akouri, Mats Brännström, Mats Hellström
Innovative bioengineering strategies utilizing extracellular matrix (ECM) based scaffolds derived from decellularized tissue offer new prospects for restoring damaged uterine tissue.
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Optimization of lipid assisted polymeric nanoparticles for siRNA delivery and cancer immunotherapy

Biomater. Sci., 2024, 12,2057-2066
DOI: 10.1039/D3BM02071A, Paper
Song Lin, Houjin Jing, Xiaojiao Du, Xianzhu Yang, Jun Wang
A siRNA delivery system was developed using clinically approved mPEG-b-PLGA, cationic lipid and ionizable lipid for siRNA delivery and cancer immunotherapy.
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Design, manufacturing and testing of a green non-isocyanate polyurethane prosthetic heart valve

Biomater. Sci., 2024, 12,2149-2164
DOI: 10.1039/D3BM01911J, Paper
Open Access
Sofia F. Melo, Alicia Nondonfaz, Abdelhafid Aqil, Anna Pierrard, Alexia Hulin, Céline Delierneux, Bartosz Ditkowski, Maxime Gustin, Maxime Legrand, Bibian M. E. Tullemans, Sanne L. N. Brouns, Alain Nchimi, Raoul Carrus, Astrid Dejosé, Johan W. M. Heemskerk, Marijke J. E. Kuijpers, Jan Ritter, Ulrich Steinseifer, Johanna C. Clauser, Christine Jérôme, Patrizio Lancellotti, Cécile Oury
Non-isocyanate polyurethanes (NIPUs) were developed and tested in vitro. Prosthetic heart valves made of NIPU were designed and manufactured. NIPUs showed low thrombogenicity and the produced valves performed well in terms of hydrodynamics.
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Retraction: Strontium-doped gelatin scaffolds promote M2 macrophage switch and angiogenesis through modulating the polarization of neutrophils

Biomater. Sci., 2024, 12,2167-2167
DOI: 10.1039/D4BM90023E, Retraction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Tao Li, Hongtao He, Zezheng Yang, Junjie Wang, Yuxin Zhang, Guangxu He, Jun Huang, Deye Song, Jiangdong Ni, Xiaojun Zhou, Junfeng Zhu, Muliang Ding
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Correction: A Y1 receptor ligand synergized with a P-glycoprotein inhibitor improves the therapeutic efficacy of multidrug resistant breast cancer

Biomater. Sci., 2024, 12,2165-2166
DOI: 10.1039/D4BM90022G, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Yinjie Wang, Zhenqi Jiang, Bo Yuan, Yuchen Tian, Lingchao Xiang, Yanying Li, Yong Yang, Juan Li, Aiguo Wu
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Cell-membrane engineering strategies for clinic-guided design of nanomedicine

Biomater. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D3BM02114A, Review Article
Di Huang, Xiaoyu Wang, Wentao Wang, Jiachen Li, Xiaomei Zhang, Bing Xia
Cells are the fundamental units of life. The cell membrane primarily composed of two layers of phospholipids (a bilayer) structurally defines the boundary of a cell, which can protect its...
The content of this RSS Feed (c) The Royal Society of Chemistry




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A universal strategy to enhance photothermal conversion efficiency by regulating the molecular aggregation states for safe photothermal therapy of bacterial infections

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00412D, Paper
Hao Fu, Yongxin Zhang, Cheng Wang, Zhencheng Sun, Shuyi Lv, Minghui Xiao, Kaiyu Wu, Linqi Shi, Chunlei Zhu
A universal strategy is developed to remarkably enhance the photothermal conversion efficiency of photothermal materials. This advancement enables effective treatment of drug-resistant bacterial infections through safe photothermal therapy.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Applications of hydrogels in tissue-engineered repairing of temporomandibular joint diseases

Biomater. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D3BM01687K, Review Article
Xuan Wang, Fushuang Liu, Tianyi Wang, Yikai He, Yongwen Guo
Epidemiological studies reveal that symptoms of TMD occur in 60-70% of adults. The inflammatory damage caused by TMD can easily lead to defects in the articular disc, condylar cartilage, subchondral...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: Hindering the unlimited proliferation of tumor cells synergizes with destroying tumor blood vessels for effective cancer treatment

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM90033B, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ya Liu, Yajun Xu, Ying Wang, Jianlin Lv, Kun Wang, Zhaohui Tang
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Towards a better understanding of the effect of protein conditioning layers on microbial adhesion: A focused investigation on Fibronectin and Bovine Serum Albumin layers on SiO2 surfaces

Biomater. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4BM00099D, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Maya Rima, Christina Villeneuve-Faure, Marvine Soumbo, Fatima El Garah, Ludovic Pilloux, Christine Roques, Kremena Makasheva
The interaction of foreign implants with its surrounding environment is significantly influenced by the adsorption of proteins on the biomaterial surfaces, playing role in the microbial adhesion. Therefore, understanding protein...
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Developing an in vitro model of haematoma for study of intracerebral haemorrhage

Biomater. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4BM00039K, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Siobhan Crilly, Victor Sebastian Tapia, Carlo Bawn, Annalisa Tirella
Intracerebral haemorrhage (ICH) is a devastating neurovascular attack with limited treatment options. Alternative, pre-clinical modelling approaches are required to identify and trial therapeutic drug compounds. In this study we have...
The content of this RSS Feed (c) The Royal Society of Chemistry




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An injectable fluorescent and iodinated hydrogel for preoperative localization and dual image-guided surgery of pulmonary nodules

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00035H, Paper
Open Access
Woojin Back, Jiyun Rho, Kyungsu Kim, Hwan Seok Yong, Ok Hwa Jeon, Byeong Hyeon Choi, Hyun Koo Kim, Ji-Ho Park
We report the development of an injectable hydrogel-based dual computed tomography (CT) and near-infrared (NIR) imaging marker for use in preoperative pulmonary localization and intraoperative dual-imaging of deep-seated nodules.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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RSS: The Amazing Profit Potential

The marketing and profit potential of RSS is, simply said, quite amazing. It's not just good for blogs, and it's certainly much more than »just another« way of getting your content to your readers. And it's just reaching the tipping point. There are still only »a few« RSS publishers and RSS usage is growing every day. This is your best chance to get on the wave... To get you started, here's a quick overview of what RSS can do for your internet business...

Complete Article - RSS : The Amazing Profit Potential




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RSS Meets the Needs of Direct Marketers

Contrary to general opinion, RSS meets the needs of even the most demanding direct marketer, actually providing most of what e-mail marketing does, except for the strong push factor.

Most direct marketing reasons against RSS are in fact the result of inadequate understanding of RSS by most marketers.

a] Scheduled and autoresponder messages
There are already a few services and software packages on the market that allow for scheduled and autoresponder messages via RSS feeds. Once your visitor subscribes to your special RSS feed, he can receive a pre-determined set of messages in a specific time frame, determined by you. Use these messages to welcome your new reader to your RSS feed; thank your new customer after the purchase, send him additional information about the ordered product and give him the opportunity to buy an additional product at a lower price tag a couple of days later, and so on.

Complete Article - RSS Meets the Needs of Direct Marketers




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Microsoft and Google Show It's Time for RSS Marketing

Many internet marketers are still wondering whether to start marketing with RSS or not. It seems that not even all the case studies, hard metrics and benefits available can’t convince them, or everyone would be jumping on the RSS wagon by now.

Microsoft and Google It Is Time for RSS




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The Full Circle of RSS Marketing Power

RSS is a many-in-one marketing & publishing tool, although unfortunatelly most marketers still fail to understand this powerful concept.

While RSS does provide a number of benefits when used for each individual marketing function, best results are achieved when it is fully integrated in your internet marketing strategy. In more simpler terms --- when you use it to power most of your marketing online.

The key point is that RSS makes various marketing functions work together, in order to generate the best possible end result.

Complete Article - The Full Circle RSS Marketing




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The Future of RSS is Not Blogs

Blogs vaulted RSS into the limelight but are unlikely to be the force that sustains RSS as a communication medium. The biggest opportunities for RSS are not in the blogosphere but as a corporate communication channel.

Even now, businesses that were initially reluctantly evaluating RSS are beginning to realize the power and benefit of the RSS information avenue. The inherent capacity for consumers to select the content they wish to receive will be the driving mechanism for keeping advertisements to a minimum and content quality consistent.

Complete Article




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Profiting from RSS Feeds

Publishers are evaluating options and determining how they can profit from RSS feeds. The two obvious contenders that publishers are considering to profit from their RSS feeds are: subscription RSS feeds and RSS feed advertisements.

Subscriptions.
Subscription feeds are designed so that subscription fees are charged for unique quality content. Publisher include teaser copy in the RSS feed and readers have to purchase a subscription to see the content in its entirety. The New York Times was the first to introduce the subscription model. Initially the NY Times faced some resentment from users who had become accustom to free RSS based content, but ultimately consumers realize that businesses must achieve profits in order to continue.

Profiting from RSS Feeds




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Create Professional RSS Feeds

More and more companies are using RSS as a means to communicate, so having an RSS feed that is professional and well polished will help differentiate your company from your competition. What makes an RSS feed professional? Follow these simple steps to polish your RSS feed and take it to the next level...

Create Professional RSS Feeds






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Sound Effects: Power of Audio

Sound effects are often used to compliment and enhance artistic presentations, whether they be podcasts, videos, or other audio/visual productions. Royalty-free sound effects are typically non-exclusive and can be used by anyone who purchases them. Professional sound effects can give a podcast or production a more professional sound. However, many new producers may not realize that sound effects have copyrights, and in many cases it is illegal to use a sound effect that you happen to find on the web without properly licensing it.

Most podcasters and producers do not have the time or equipment to go out and record all the sound effects they may want to incorporate into their production. Podcasters are better off using royalty-free sound effects. Royalty-free sound effects are purchased, and there is no recurring fee for the use of the effect. The purchaser may use the sound effect(s) as often as required within the license terms and conditions, without paying for the use of the sound effect each time the effect is used.

Sound Effects: The Power of Audio




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Pros and Cons of RSS Feeds

If you are struggling with the decision of whether to implement RSS feeds or not, consider the following pros and cons for webmasters who use RSS feeds as part of their content and communication plan...

Benefits (Pros Of Using RSS)
The benefits for a webmaster who opts to implement RSS feeds on their website are numerous:

1. Saves Time
RSS feeds save time. RSS subscribers can quickly scan RSS feeds, without having to visit each and every website. Subscribers can then click on any items they are interested in, to get additional information.

Pros and Cons of RSS Feeds




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POCO X6 Pro review: Performance prowess and a smudge of quirks 

The POCO X6 Pro delivers on multiple fronts which include great performance, a nice display and decent battery life. It makes for an interesting value-for-money choice for those looking for a gaming-forward device




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realme 12 Pro+ review: A touch of luxury on an affordable flagship

The new smartphone shines bright in places, literally and figuratively




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Lenovo has shifted focus to solution-oriented offerings: Tom Butler

In conversation with businessline at MWC 2024, Tom Butler, Executive Director, Worldwide Commercial Portfolio and Product Management at Lenovo, has shed light on successes, disappointments, transparent tech and much more




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I drank soup, sniffed some wine, and took a walk in the woods at MWC 2024. And none of it was real!

Here’s a firsthand account of ‘Feel Tech Bar’ in World Mobile Congress 2024, Barcelona




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Google Pixel 9 Pro XL review: Shines bright, with tonnes of AI might!

The premium flagship smartphone continues with its photography legacy and adds more AI goodies




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HP Elitebook Ultra G1q review: Keeping it professional!

The premium laptop offers a rather charming corporate companion, with a few quirks




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Redington brings much anticipated Call of Duty: Black Ops 6 to India

Redington Ltd has partnered with Microsoft and Activision to distribute the highly anticipated title, Call of Duty: Black Ops 6, in India.




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Lenovo launches a slew of CoPilot AI PCs  

Unveils additions to its Lenovo Yoga and Lenovo IdeaPad portfolios at Lenovo Innovation World 2024




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From vacuum cleaners to headphones, Dyson’s legacy of innovation continues

Mark Heard, engineering manager at Dyson on how and why the brand has journeyed from vacuum cleaners towards styling products and now headphones.