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Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety

RSC Med. Chem., 2024, 15,3837-3852
DOI: 10.1039/D4MD00426D, Research Article
Abdrrahman Shemsu Surur, Chin Fung Chan, Frieda-Marie Bartz, Iris L. K. Wong, Van T. D. Nguyen, Lukas Schulig, Andreas Link, Tak Hang Chan, Larry M. C. Chow, Patrick J. Bednarski
Structure-guided optimization of fexinidazole led to analog (S)-51, a promising lead compound with superior activity, improved metabolic stability, and enhanced hERG safety
The content of this RSS Feed (c) The Royal Society of Chemistry




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Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators

RSC Med. Chem., 2024, 15,3800-3816
DOI: 10.1039/D4MD00585F, Research Article
Marwa Abdel-Motaal, Dalal Ali Aldakhili, Ayman B. Farag, Ayman Abo Elmaaty, Marwa Sharaky, Nadia A. Mohamed, Saad Shaaban, Abdullah Yahya Abdullah Alzahrani, Ahmed A. Al-Karmalawy
Novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Prediction of synergistic gemcitabine-based combination treatment through a novel tumor stemness biomarker NANOG in pancreatic cancer

RSC Med. Chem., 2024, 15,3853-3861
DOI: 10.1039/D4MD00165F, Research Article
Jiongjia Cheng, Ting Zhu, Shaoxian Liu, Jiayu Zhou, Xiaofeng Wang, Guangxiang Liu
The synergistic effect observed in gemcitabine-based combination therapies targeting pancreatic cancer stem cells was correlated with the inhibiting effect on the expression of stemness-related gene NANOG.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling

RSC Med. Chem., 2024, 15,3746-3758
DOI: 10.1039/D4MD00122B, Research Article
Open Access
Shadid U. Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong Li
We designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway

RSC Med. Chem., 2024, 15,3817-3836
DOI: 10.1039/D4MD00477A, Research Article
Maha Saad, Walaa Ibrahim, Amany Helmy Hasanin, Aya Magdy Elyamany, Marwa Matboli
ZBiotics administration in the NASH model downregulated the RNA panel (MAPK3, EDN1, TNF, miR-6888-5p, lncRNA RABGAP1L-DT-206), restored intestinal barrier integrity, reduced hepatic inflammation, and improved lipid profiles and liver enzymes.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors

RSC Med. Chem., 2024, 15,3862-3879
DOI: 10.1039/D4MD00313F, Research Article
Daniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro Accetta
This study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Hydrophobic CPP/HDO conjugates: a new frontier in oligonucleotide-warheaded PROTAC delivery

RSC Med. Chem., 2024, 15,3695-3703
DOI: 10.1039/D4MD00546E, Research Article
Miyako Naganuma, Nobumichi Ohoka, Motoharu Hirano, Daishi Watanabe, Genichiro Tsuji, Takao Inoue, Yosuke Demizu
A novel hydrophobic cell-penetrating peptide (CPP) and heteroduplex oligonucleotide (HDO)-conjugated PROTAC, CPP/HDO-PROTAC, was designed to enhance its intracellular delivery and degradation efficiency.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy

RSC Med. Chem., 2024, 15,3912-3912
DOI: 10.1039/D4MD90040E, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex Joseph
The content of this RSS Feed (c) The Royal Society of Chemistry




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Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00610K, Research Article
Open Access
Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina Marzano
In this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....
The content of this RSS Feed (c) The Royal Society of Chemistry




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Advances in Detecting Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Using Molecular Receptors and Nanostructured Assemblies

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00661E, Review Article
Avijit Kumar Das
The detection and quantification of non-steroidal anti-inflammatory drugs (NSAIDs) are crucial due to their widespread use and potential impact on human health and the environment. This review provides a comprehensive...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Supreme Court stays order for CBI probe into sexual assault of minor in Chennai

Calls for a list of five to seven direct recruit IPS officers, including three women, who hail from other States but are now serving in Tamil Nadu cadre




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Amaran is a film about a soldier’s life, nothing more: Seeman




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AIADMK will not form an alliance with BJP in 2026 polls, reiterates Palaniswami

“During the Lok Sabha election, it was said at the party headquarters and in press bytes that the AIADMK will not have alliance with the BJP in the [2026] Assembly election,” he said




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Tamil Nadu CM Stalin to launch Phase II of nutritional intervention programme for malnourished children, mothers

Mothers of over 76,700 babies in the age group of zero to six months, identified as malnourished, would be covered under Phase II of the programme




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T.N. govt. to take a call on verifying criminal antecedents before appointing schoolteachers

It also assures Madras High Court of putting in place an effective complaint redressal mechanism in the interest of school students




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IIT-M students develop robot for O.P. Jindal university’s Constitution Museum

It is trained to respond to questions from visitors in Hindi and English, IIT-M professor says




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Leaders of various parties condemn attack on govt. doctor




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Southern Railway refuses to share inquiry report of Perumon train tragedy

105 people had died in after several coaches of the Island Express fell into the Ashtamudi Lake in 1988




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Four Swedish companies, including IKEA, looking to set up base in Tamil Nadu: Swedish Ambassador to India

There are 70 Swedish companies in Tamil Nadu, employing about 25,000 people. But we want to do more, says Jan Thesleff




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Delhi AQI drops to 361 in ‘very poor’ category as smog engulfs national capital

Delhi recorded its first dense fog of the season on Wednesday as visibility dropped to 0 metres at 8 a.m.




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Delhi airport sees seven flight diversions owing to bad weather

The IMD reported that very dense fog began forming at around 5.30 a.m., resulting in a thick haze over various parts of Delhi




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Delhi’s air quality turns ‘severe’ for first time this season: CPCB

According to Central Pollution Control Board data, Delhi’s air quality reaches ‘severe’ levels with AQI of 418




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SBI, HDFC Bank, ICICI Bank figure in RBI’s 2024 list of Domestic Systemically Important Banks (D-SIBs)

Higher D-SIB surcharge fixed for SBI and HDFC Bank, will be applicable from April 01, 2025




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Argentine monthly inflation falls to three-year low




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Arvinder Singh Sahney is new chairman of Indian Oil 




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Developed nations need to triple their contribution to make climate finance credible: Avinash Persaud

Currently, developed nations are expected to pay $100 billion a year but they haven’t stuck to agreed targets, and this system ends next year.




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Vodafone Idea narrows Q2 loss to ₹7,176 crore




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Sensex, Nifty hit a five-month low

Fifth straight losing session at the bourses; shares in the midcap, small cap segments plunged harder than large companies’ stocks in what some called ‘correction mode’




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Godrej Industries Q2 net profit surges over three fold to ₹288 crore




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SKDRDP provides desks and benches worth ₹2.75 crore to 507 government primary schools in four districts of Karnataka

Rajya Sabha MP Veerendra Heggade urges parents to get their wards admitted to government schools as they now have better facilities




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Mangaluru Junction - CSMT Superfast Express to get LHB coaches in March 2025

Train No. 12133 Mumbai CSMT-Mangaluru Junction Superfast Express will get an LHB rake from March 1 while its pairing service, Train No. 12134 Mangaluru Junction-Mumbai CSMT Superfast Express, will get an LHB rake from March 2




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Free and fair inquiry sought into death of snakebite victim in Srikakulam district

Son of the victim alleges that local medical and health officials misleading higher-ups regarding the incident




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Fervour marks ‘Kaisika Dwadasi’ at Tirumala




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New counters opened at Tirumala for issuing Srivani darshan tickets

Decision to open new counters taken following reports of devotees experiencing discomfort in queue at the previous counter, particularly during inclement weather, says TTD Additional EO




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Target is to to make 30,000 MT of sand available every day in East Godavari district, says Collector

P. Prasanthi warns boatmen associations of stringent action if they attempt to prevent vehicles transporting sand from the sand reaches




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SEIL Energy bags seven awards from QCFI




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All set for Urus festival at Pedda Dargah in Kadapa

Thousands of devotees from across Andhra Pradesh, Tamil Nadu, Karnataka and Maharashtra expected to converge at the famous Sufi shrine for the week-long event starting on November 16




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Centre’s nod sought for Vizag Metro, MA&UD Minister informs A.P. Assembly

The revised cost estimate stands at ₹17,232 crore; the project is initially proposed to come up in two phases with four corridors spanning a total length of 76 km




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Water supply from Pampa Reservoir to be paused this rabi

IAB makes decision to allow reservoir gate repairs and aqueduct construction works; water to affected lands to be supplied from the Eastern Godavari Delta, Pithapuram Branch Canal and Yeleru Reservoir instead




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Andhra Pradesh Budget reflects aspirations of all sections of people, say legislators

It has given impetus to the developmental goals outlined in the NDA’s election manifesto, say MLAs on the first day of discussion




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New road proposed from IIT-Tirupati campus to Rachagunneri

Rachagunneri is home to the massive 400/220/132kV electrical substation and also a private steel plant




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PAG report points out Andhra Pradesh govt.’s failure to disclose quantum of off-budget borrowings in Budget

Principal amount outstanding in 2019-20 was ₹67,171 crore, and it touched ₹1,54,797 crore in 2023-24, says the PAG report released by the I&PR Department




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Devotees offer special prayers at Sri Kalyana Venkateswara Swamy temple in Srikakulam




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RLDA invites bids for commercial land use in Tirupati railway station

The station is being developed on a massive scale, providing commuting area on the southern side, in view of the crammed locality on the northern side




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117 applications received at Kuppam’s first ‘Praja Darbar’




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Andhra Pradesh govt. reaffirms commitment to ‘irrigating every acre of farmland’ in State through river-interlinking projects




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Jagan dares govt. to arrest him, says will continue to ‘expose failures’




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Police book Sri Reddy for posting ‘defamatory content’ against Chandrababu Naidu, Pawan Kalyan




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Varun Hospitality announces eco-friendly mixed-use project to replace The Gateway Hotel in Visakhapatnam




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Andhra Pradesh High Court strikes down PIL seeking to restrain police from taking action on ‘abusive content on social media’