in Assam: Army celebrates 'National Education Day' with students in Tinsukia By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:08:01 +0530 Full Article
in UP: Devotees celebrate 'Tulsi Vivah' at Balua Ghat in Prayagraj, marking sacred union of Lord Vishnu, Vrinda By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:10:02 +0530 Full Article
in BRO rescues 20 vehicles stuck in snow in J-K's Bandipora By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:12:01 +0530 Full Article
in Defence Space Agency hosts first ever space exercise 'Antariksha Abhyas - 2024' in Delhi By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:14:02 +0530 Full Article
in There will be census in country but not based on caste: Union Minister Shobha Karandlaje By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:18:02 +0530 Full Article
in Rajnath Singh stresses on adaptive defence to cope with Age of Grey Zone, hybrid warfare By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:20:02 +0530 Full Article
in Union Education Minister Dharmendra Pradhan urges states to support exam reforms for zero-error entrance test By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:22:01 +0530 Full Article
in Indian Coast Guard evacuates critically ill fisherman off Diu coast By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:24:02 +0530 Full Article
in Akashteer: Transforming India's air defence with cutting-edge technology By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:26:02 +0530 Full Article
in Union Jal Shakti Minister CR Paatil chairs 13th high-powered review meeting of Brahmaputra Board By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:34:02 +0530 Full Article
in AI and hi-tech technologies will be used in CCTV arrangements: UP DGP Prashant Kumar on Mahakumbh 2025 preparations By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:40:02 +0530 Full Article
in Assam Governor attends Sainik school Goalpara's Diamond Jubilee celebrations By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:42:03 +0530 Full Article
in HC modifies the status quo order on maintaining constructions for Tent City in two islands of Lakshadweep By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:14:08 +0530 Full Article Kochi
in No gaps in management of biodegradable waste, Kerala tells NGT By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:23:47 +0530 Full Article Kerala
in HC quashes magistrate court’s directive to register FIR against police officers By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:36:51 +0530 Magistrate court’s order to file FIR against police officers, including IPS officer and former Malappuram Superintendent of Police Sujith Das, in connection with an alleged sexual assault case quashed Full Article Kerala
in Afghanistan attends U.N. climate talks for first time since Taliban return to power By www.thehindu.com Published On :: Wed, 13 Nov 2024 11:33:16 +0530 Afghanistan’s first delegation at United Nations climate talks since the Taliban’s return to power in 2021 has arrived in Baku, Azerbaijan Full Article Environment
in China's largest air show takes off with fighter jets, attack drones By www.thehindu.com Published On :: Wed, 13 Nov 2024 11:39:52 +0530 China has poured resources into modernising and expanding its aviation capabilities as it faces off against the United States and others around regional flashpoints like Taiwan. Full Article World
in Fifth storm in a month bears down on the Philippines By www.thehindu.com Published On :: Wed, 13 Nov 2024 11:49:22 +0530 The local government also reported knee-high floods across Santiago, a city of 1,50,000 people along an upper bank of the Cagayan river Full Article Environment
in Cold War-era H-6 bomber enhances China’s ability to strike U.S. bases By www.thehindu.com Published On :: Wed, 13 Nov 2024 12:14:26 +0530 The H-6 long-range bomber was used in China’s October war games around Taiwan; it flew close to the U.S. mainland for first time in June Full Article World
in Xi leaves China for APEC meeting in Peru: state media By www.thehindu.com Published On :: Wed, 13 Nov 2024 12:55:46 +0530 Chinese leader Xi Jinping travels to Peru for APEC summit amid trade tensions with U.S., inaugurates Chinese-funded port Full Article News
in COP29: India, other developing countries demand fair climate finance commitments By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:33:21 +0530 India, LMDCs advocate for equitable climate finance at COP29, pushing for transparency, fairness, and flexibility in financial commitments Full Article Environment
in Iran executes in public a serial rapist convicted in dozens of cases By www.thehindu.com Published On :: Wed, 13 Nov 2024 14:43:02 +0530 Iran’s state media say authorities have executed in public a man convicted of raping dozens of women over two decades Full Article World
in IndiGo, Air India cancel flights to Bali following volcanic eruption By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:23:06 +0530 The Mount Lewotobi Laki Laki volcano located in a remote island in East Nusa Tenggara province erupted earlier this month and has resulted in ash clouds Full Article India
in Senior Russian naval officer killed in car bombing claimed by Kyiv By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:28:48 +0530 Russia's state Investigative Committee said in a statement that an improvised explosive device had detonated in an act of terrorism, killing a serviceman whom it did not identify Full Article World
in Indonesia and Australia hold joint military drills after signing a new defense agreement By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:32:15 +0530 The Indonesian and Australian militaries are holding joint combat drills off Indonesia’s main island of Java with about 2,000 troops training in air, maritime, amphibious and land operations Full Article World
in Chemical synthetic approaches to mimic the TRAIL: promising cancer therapeutics By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3639-3651DOI: 10.1039/D4MD00183D, Review ArticleAbdullah-Al Masum, Shin Aoki, Md. Mahbubur Rahman, Yosuke HisamatsuTRAIL induced apoptosis signalling by death receptors (DR4/DR5).The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
in In vitro identification of oridonin hybrids as potential anti-TNBC agents inducing cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3674-3694DOI: 10.1039/D4MD00580E, Research ArticleJinhua Ning, Nini Zhan, Zhanpan Wu, Yuzhe Li, Die Zhang, Yadian Shi, Yingxun Zhou, Chuan-Huizi Chen, Wenbin JinOridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin in human plasma.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
in New ATP-competitive inhibitors of E. coli GyrB obtained from the mapping of the hydrophobic floor at the binding site: synthesis and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3759-3777DOI: 10.1039/D4MD00498A, Research ArticleLucas Gutierrez, Peter Peršolja, Rodrigo Tosso, Nace Zidar, Danijel Kikelj, Ricardo D. EnrizA diagram of the active site of E. coli gyrase B, highlighting the hydrophobic subsite, including key residues relevant to ligand binding.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
in Furoxan–piplartine hybrids as effective NO donors and ROS inducers in PC3 cancer cells: design, synthesis, and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3778-3794DOI: 10.1039/D4MD00281D, Research ArticleCarolyne Brustolin Braga, Julio Cesar Milan, Matheus Andrade Meirelles, Bruno Zavan, Guilherme Álvaro Ferreira-Silva, Ester Siqueira Caixeta, Marisa Ionta, Ronaldo A. PilliA novel hybrid integrating piplartine with a furoxan moiety exhibited a sub-micromolar IC50 and extraordinary selectivity for PC3 cells, which was associated with its capacity to release NO, generate ROS, induce DNA damage, and trigger apoptosis.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
in Preventing SARS-CoV-2 infection using Fv-antibodies targeting the proprotein convertase (PPC) cleavage site By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3704-3710DOI: 10.1039/D4MD00552J, Research ArticleJaeyong Jung, Jeong Soo Sung, Soonil Kwon, Hyung Eun Bae, Min-Jung Kang, Joachim Jose, Misu Lee, Jae-Chul PyunFv-antibodies targeting the PPC region of SARS-CoV-2 to prevent infection, screened from an Fv-antibody library (displayed on outer membrane of E. coli cell).The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
in Discovery of hybrid Glypromate conjugates with neuroprotective activity against paraquat-induced toxicity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3711-3727DOI: 10.1039/D4MD00584H, Research ArticleSara C. Silva-Reis, Vera M. Costa, Daniela Correia da Silva, David M. Pereira, Xavier Cruz Correia, Xerardo García-Mera, José E. Rodríguez-Borges, Ivo E. Sampaio-DiasA series of bicyclic-based Glypromate conjugates with reduction of protein aggregation elicited by Aβ25–35 and neuroprotective activity against paraquat-induced toxicity is reported, paving the way for the discovery of novel neurotherapeutics.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
in Stachydrine, a pyrrole alkaloid with promising therapeutic potential against metabolic syndrome and associated organ dysfunction By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3652-3673DOI: 10.1039/D4MD00425F, Review ArticleSemim Akhtar Ahmed, Prasenjit Manna, Jagat Chandra BorahMetabolic syndrome is a multifaceted condition marked by interconnected risk factors, significantly increasing the risk of serious diseases like cardiovascular disease, type 2 diabetes, and stroke.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
in A photoswitchable CENP-E inhibitor with single blue-green light to control chromosome positioning in mitotic cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3795-3799DOI: 10.1039/D4MD00458B, Research ArticleKazuya Matsuo, Takashi Kikukawa, Tomonori Waku, Akio Kobori, Nobuyuki TamaokiA photoswitchable centromere-associated protein E (CENP-E) inhibitor based on the 4-methylaminoazobenzene photoswitch is reported, which is characterized with cis–trans photoisomerization with blue-green light and fast thermal relaxation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
in Pyridinyl 4-(2-oxoalkylimidazolidin-1-yl)benzenesulfonates and their hydrochloride salts as novel water soluble antimitotic prodrugs bioactivated by cytochrome P450 1A1 in breast cancer cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3728-3745DOI: 10.1039/D4MD00476K, Research ArticleVincent Ouellette, Chahrazed Bouzriba, Atziri Corin Chavez Alvarez, Quentin Bruxelles, Geneviève Hamel-Côté, Sébastien FortinNew water soluble antimitotic CYP1A1-activated prodrugs named PYRAIB-SOs and their hydrochlorides targeting breast cancers.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
in Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3837-3852DOI: 10.1039/D4MD00426D, Research ArticleAbdrrahman Shemsu Surur, Chin Fung Chan, Frieda-Marie Bartz, Iris L. K. Wong, Van T. D. Nguyen, Lukas Schulig, Andreas Link, Tak Hang Chan, Larry M. C. Chow, Patrick J. BednarskiStructure-guided optimization of fexinidazole led to analog (S)-51, a promising lead compound with superior activity, improved metabolic stability, and enhanced hERG safetyThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
in Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3800-3816DOI: 10.1039/D4MD00585F, Research ArticleMarwa Abdel-Motaal, Dalal Ali Aldakhili, Ayman B. Farag, Ayman Abo Elmaaty, Marwa Sharaky, Nadia A. Mohamed, Saad Shaaban, Abdullah Yahya Abdullah Alzahrani, Ahmed A. Al-KarmalawyNovel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
in Asymmetric imidazole-4,5-dicarboxamide derivatives as SARS-CoV-2 main protease inhibitors: design, synthesis and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3880-3888DOI: 10.1039/D4MD00414K, Research ArticlePhuong Nguyen Hoai Huynh, Phatcharin Khamplong, Minh-Hoang Phan, Thanh-Phuc Nguyen, Phuong Ngoc Lan Vu, Quang-Vinh Tang, Phumin Chamsodsai, Supaphorn Seetaha, Truong Lam Tuong, Thien Y. Vu, Duc-Duy Vo, Kiattawee Choowongkomon, Cam-Van T. VoNovel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
in Prediction of synergistic gemcitabine-based combination treatment through a novel tumor stemness biomarker NANOG in pancreatic cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3853-3861DOI: 10.1039/D4MD00165F, Research ArticleJiongjia Cheng, Ting Zhu, Shaoxian Liu, Jiayu Zhou, Xiaofeng Wang, Guangxiang LiuThe synergistic effect observed in gemcitabine-based combination therapies targeting pancreatic cancer stem cells was correlated with the inhibiting effect on the expression of stemness-related gene NANOG.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
in Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3746-3758DOI: 10.1039/D4MD00122B, Research Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shadid U. Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong LiWe designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
in Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3817-3836DOI: 10.1039/D4MD00477A, Research ArticleMaha Saad, Walaa Ibrahim, Amany Helmy Hasanin, Aya Magdy Elyamany, Marwa MatboliZBiotics administration in the NASH model downregulated the RNA panel (MAPK3, EDN1, TNF, miR-6888-5p, lncRNA RABGAP1L-DT-206), restored intestinal barrier integrity, reduced hepatic inflammation, and improved lipid profiles and liver enzymes.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
in Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3862-3879DOI: 10.1039/D4MD00313F, Research ArticleDaniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro AccettaThis study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
in Hydrophobic CPP/HDO conjugates: a new frontier in oligonucleotide-warheaded PROTAC delivery By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3695-3703DOI: 10.1039/D4MD00546E, Research ArticleMiyako Naganuma, Nobumichi Ohoka, Motoharu Hirano, Daishi Watanabe, Genichiro Tsuji, Takao Inoue, Yosuke DemizuA novel hydrophobic cell-penetrating peptide (CPP) and heteroduplex oligonucleotide (HDO)-conjugated PROTAC, CPP/HDO-PROTAC, was designed to enhance its intracellular delivery and degradation efficiency.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
in Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3912-3912DOI: 10.1039/D4MD90040E, Correction Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex JosephThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
in Advances in Detecting Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Using Molecular Receptors and Nanostructured Assemblies By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00661E, Review ArticleAvijit Kumar DasThe detection and quantification of non-steroidal anti-inflammatory drugs (NSAIDs) are crucial due to their widespread use and potential impact on human health and the environment. This review provides a comprehensive...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
in Supreme Court stays order for CBI probe into sexual assault of minor in Chennai By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:07:47 +0530 Calls for a list of five to seven direct recruit IPS officers, including three women, who hail from other States but are now serving in Tamil Nadu cadre Full Article Tamil Nadu
in Amaran is a film about a soldier’s life, nothing more: Seeman By www.thehindu.com Published On :: Wed, 13 Nov 2024 14:55:42 +0530 Full Article Tamil Nadu
in AIADMK will not form an alliance with BJP in 2026 polls, reiterates Palaniswami By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:30:55 +0530 “During the Lok Sabha election, it was said at the party headquarters and in press bytes that the AIADMK will not have alliance with the BJP in the [2026] Assembly election,” he said Full Article Tamil Nadu
in Tamil Nadu CM Stalin to launch Phase II of nutritional intervention programme for malnourished children, mothers By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:23:48 +0530 Mothers of over 76,700 babies in the age group of zero to six months, identified as malnourished, would be covered under Phase II of the programme Full Article Tamil Nadu
in T.N. govt. to take a call on verifying criminal antecedents before appointing schoolteachers By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:15:58 +0530 It also assures Madras High Court of putting in place an effective complaint redressal mechanism in the interest of school students Full Article Tamil Nadu
in CM Stalin inaugurates 27 new projects at temples across T.N. By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:23:55 +0530 Full Article Tamil Nadu
