Charles Max Wood talks to Filipa Lacerda in this week's My JavaScript Story. Filipa has been working as a front end engineer since 2011 and she currently works at GitLab.

Filipa originally wanted to study Economy but when she got to university she decided to major in Communications thinking it would be a lot more about communication and not as much about coding. At first she really didn't like the coding aspect of it but then as time went by she actually started to enjoy coding.

When she first started working she started out on the User Experience side, but then she wanted to switch to building stuff with code because she wanted to see results really fast and enjoyed that aspect of coding.

Charles asks why she stuck with that degree instead of switching it and Filipa explains that at first because she didn't want to go back and re - take the exams and also decided that this degree offered many job opportunities in many different industries and now she can't imagine herself doing anything else.

Filipa then talks about why she is working with Vue and all the different kind of projects she has done using Vue as well as what working for GitLab looks like on a day to day basis.

Host: Charles Max Wood

Joined by Special Guest:  Filipa Lacerda

Links

• https://devchat.tv/views-on-vue/vov-025-gitlabs-journey-with-vue-with-filipa-lacerda-and-jacob-schatz/

• https://devchat.tv/views-on-vue/vov-009-building-modal-component-with-filipa-lacerda/

• https://filipa.gitlab.io/

• https://twitter.com/FilipaLacerda

Sponsors

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Picks

Filipa Lacerda:

• Why We Sleep by Walker PhD, Matthew

Charles Max Wood:

• RxJS Live: Conference

• Nikon D5600 Camera

• RØDE Microphones

Gant Laborde is the Chief Innovation Officer of Infinite Red who is working on a course for beginners on machine learning. There is a lot of gatekeeping with machine learning, and this attitude that only people with PhDs should touch it. In spite of this, Gant thinks that in the next 5 years everyone will be using machine learning, and that it will be pioneered by web developers. One of the strong points of the web is experimentation, and Gant contrasts this to the academic approach. 

They conversation turns to Gant’s course on machine learning and how it is structured. He stresses the importance of understanding unicode, assembly, and other higher concepts. In his course he gives you the resources to go deeper and talks about libraries and frameworks available that can get you started right away. His first lesson is a splashdown into the jargon of machine learning, which he maps over into developer terms. After a little JavaScript kung fu, he takes some tools that are already out there and converts it into a website.

Chris and Gant discuss some different uses for machine learning and how it can improve development. One of the biggest applications they see is to train the computers to figure monotonous tasks out while the human beings focus on other projects, such as watching security camera footage and identifying images. Gant restates his belief that in the next 5 years, AI will be everywhere. People will grab the boring things first, then they will go for the exciting things. Gant talks about his creation NSFW.js, an open source train model to help you catch indecent content. He and Chris discuss different applications for this technology.

Next, the panel discusses where machine learning can be seen in everyday life, especially in big companies such as Google. They cite completing your sentences in an email for you as an example of machine learning. They talk about the ethics of machine learning, especially concerning security and personal data. They anticipate that the next problem is edge devices for AI, and this is where JavaScript really comes in, because security and privacy concerns require a developer mindset. They also believe that personal assistant devices, like those from Amazon and Google, will become even more personal through machine learning. They talk about some of the ways that personal assistant devices will improve through machine learning, such as recognizing your voice or understanding your accent. 

Their next topic of discussion is authenticity, and how computers are actually incredibly good at finding deep fakes. They discuss the practice of placing passed away people into movies as one of the applications of machine learning, and the ethics surrounding that. Since developers tend to be worried about inclusions, ethics, and the implications of things, Gant believes that these are the people he wants to have control over what AI is going to do to help build a more conscious data set. 

The show concludes with Gant talking about the resources to help you get started with machine learning. He is a panelist on upcoming DevChat show, Adventures in Machine Learning. He has worked with people with all kinds of skill sets and has found that it doesn’t matter how much you know, it matters how interested and passionate you are about learning. If you’re willing to put the pedal to the metal for at least a month, you can come out with a basic understanding. Chris and Gant talk about Tensorflow, which helps you take care of machine learning at a higher level for fast operations without calculus. Gant is working on putting together a course on Tensorflow. If you’re interested in machine learning, go to academy.infinite.red to sign up for Gant’s course. He also announces that they will be having a sale on Black Friday and Cyber Monday.

Panelists

• Christopher Buecheler

With special guest: Gant Laborde

Sponsors

• React Round Up

• Sentry use the code “devchat” for 2 months free on Sentry’s small plan

• Adventures in Angular

Links

• Machine Learning: How To go from Zero to Hero

• NSFW.js

• Tensorflow.js

• PyTorch

• Keras

• Academy.infinite.red

• Gantlaborde.com 

Follow DevChatTV on Facebook and Twitter

Picks

Christopher Buecheler:

• Next.js

• Big Wreck, But For The Sun

Gant Laborde: 

• Nicornot.com

Free 5 day mini course on academy.infinite.red

Chris is an independent consultant working with open source startups. He taught himself to program and started in open source. He talks about how he got into programming and how he learned to code.

Chris' first access to programming was writing index.hml files when he was younger and again when he was majoring in Arts in university he was introduced to ActionScript.

Host: Charles Max Wood

Joined by Special Guest:  Chris Biscardi

Sponsors

• Sentry use the code “devchat” for 2 months free on Sentry small plan

• iPhreaks

• Adventures in DevOps

• CacheFly

_______________________________________________________

"The MaxCoders Guide to Finding Your Dream Developer Job" by Charles Max Wood will be out on November 20th on Amazon. Get your copy on that date only for $2.99

_______________________________________________________

Links

• JSJ 386: Gatsby.js with Chris Biscardi

• Chris' LinkedIn

• Chris' Twitter

• https://www.twitch.tv/chrisbiscardi

Picks

Charles Max Wood:

• Follow Charles Max Wood on Instagram at CharlesMaxWood

• Follow Charles at https://devchat.tv/events/

• Suggest a topic/guests on podcast pages at https://devchat.tv

• Follow Devchat.tv on Instagram at devchat.tv

• Join us on Discord by going to https://discordapp.com/invite/z7RNTHR

• Go to Maxcoders.io to find out more about MaxCoders movement

Chris Biscardi:

• Follow Chris on Instagram at ChrisBiscardi

Douglas Crockford self-described as the person who discovered that JavaScript has good parts is on this week's My JavaScript Story. Charles and Douglas talk about how Douglas got introduced to programming. and how he specialized in JavaScript.

Douglas realized that there's going to be a convergence of TV and computing very early in his career. So a lot of his career has been bridging those two things, helping the evolution toward digital media. After working for Atari he went to work at Lucasfilm where he stayed for 8 years.

Charles asks Douglas what he is working on now, and what his plans are for the future. Douglas is planning to write more books one of which is Math for Programmers.

Host: Charles Max Wood

Joined by Special Guest:  Douglas Crockford

Sponsors

•  

• Sentry use the code “devchat” for 2 months free on Sentry small plan

• My Angular Story

• React Native Radio

• CacheFly

•  

________________________________________________________________________________________________

"The MaxCoders Guide to Finding Your Dream Developer Job" by Charles Max Wood will be out on November 20th on Amazon. Get your copy on that date only for $2.99

________________________________________________________________________________________________

Links

• JSJ 392: The Murky Past and Misty Future of JavaScript with Douglas Crockford

• JavaScript: The Good Parts

• How JavaScript Works by Douglas Crockford

• https://www.crockford.com

•  

Picks

Charles Max Wood:

• https://www.mypillow.com/

Sasson, Diane, 1946-

Konicek-Moran, Richard

Coward, Harold G

Betts, Dion E. (Dion Emile), 1963-

Schwedt, Rachel E., 1944-

Underdown, Angela

ʻAmr, Sāmī, 1924-1998

Ribbens McCarthy, Jane

Teixeira, Joe

Busse, Richard C

Edwards, Kenneth W., 1928-

Blumenthal, Noah, 1972-

Lakes, Richard D

Lahire, Nathalie

International Labour Conference (93rd : 2005 : Geneva, Switzerland)

Krzaklewska, Ewa , author

McKinney, Gordon B., 1943-

Jaffe, Irma B

Austin, James H., 1925-

Pickover, Clifford A

Aitken, Robert, 1917-2010

Rotenstreich, Nathan, 1914-1993

Bardin, Hillel

This cohort study assesses whether long-term variability and rate of change of blood pressure from young adulthood to midlife are associated with cardiovascular disease and all-cause mortality by middle age.

In this issue of JAMA Cardiology, Lim and colleagues report on cardiovascular functional reserve in people with end-stage renal disease before and after kidney transplant. They performed a 3-arm, prospective, concurrent cohort study to assess change in cardiovascular functional reserve after kidney transplant using state-of-the-art cardiopulmonary exercise testing (CPET). They also assessed left ventricular morphologic findings 1 year after transplant. They enrolled 81 participants with stage 5 chronic kidney disease (CKD) who underwent kidney transplant, 85 wait-listed participants with stage 5 CKD who had not undergone transplant, and 87 controls treated for hypertension only. The authors quantified cardiovascular functional reserve using CPET in parallel with transthoracic echocardiography. One year after transplant, a significant improvement in maximum oxygen consumption was found in the transplant group compared with the nontransplant group. Moreover, left ventricular function improved but not the body mass index.

To the Editor We read the recent article by Klauser et al with great interest. While the potential implications of the findings are exciting, we have several concerns. First, the authors do not explicitly state whether electrocardiogram gating was used in their study. This is an important detail because cardiac motion artifact is a source of artifactual coloration with dual-energy computed tomography (DECT), particularly with dual-source scanners given the approximately 80-millisecond temporal difference between the 2 radiography beams. Furthermore, beam hardening artifact from calcified atheromas and partial volume effect, known sources of artifacts in the 2-material decomposition algorithm of DECT, may largely explain the findings. While patients with gout had higher prevalence of coronary calcification (55 of 59 patients [93%]) and cardiovascular monosodium urate (MSU) deposition (51 of 59 patients [86%]) than controls, the authors do not report whether the 4 patients with gout without coronary calcifications exhibited MSU deposition nor the number of controls or cadaveric hearts with coronary calcification. The images from the article show areas of green pixelization occurring adjacent to calcified plaques on grayscale computed tomography images (eg, Figure 2A and D, left anterior descending artery [yellow arrowhead]), which would favor this artifact hypothesis without additional data.

In Reply We appreciate the valuable comments of Becce et al on our article. We applied prospective electrocardiography gating using a thin-slice cardiac protocol to ensure highest spatial resolution with minimal motion artifact. A noncontrast electrocardiography-gated computed tomography (CT) examination with standardized scan parameters was performed using a 128-slice dual-source CT (SOMATOM Definition Flash; Siemens) with a detector collimation of 2 × 64 × 0.6 mm, rotation time of 0.28 seconds, and prospective electrocardiography triggering for heart rates less than 65 beats per minute (diastolic padding, 70% of RR interval) and more than 65 beats per minute (systolic padding, 40% of RR interval). Axial images were reconstructed with 0.75-mm slice width, increment of 0.5, and a medium-smooth convolution kernel (B26f). When motion artifact was present, it was distinguished by visual analysis of an experienced observer and colorized pixels related to motion were excluded.

This cohort study assesses cardiovascular functional reserve before and after kidney transplant in patients with end-stage renal disease.

Lowering low-density lipoprotein cholesterol (LDL-C) levels remains a mainstay of cardiovascular disease prevention, but gaps in treatment remain, even in persons with hypercholesterolemia and greatly elevated LDL-C levels. Although well-described gene variants in the apolipoprotein B (APOB), low-density lipoprotein receptor (LDLR), and proprotein convertase subtilisin/kexin type 9 (PCSK9) genes explain small but important fractions of monogenic hypercholesterolemia, recent attention has turned to prognostication of cardiovascular disease using polygenic risk scores (PRS) that incorporate common genetic variants derived from large-scale genome-wide association studies of lipid subfractions. Earlier PRS considered only variants with genome-wide significance, and newer studies have focused on methods that better capture the variance conferred by millions of variants, suggesting an ability to identify risk equivalent to monogenic mutations. There remains a gap in evidence from prospective observational studies or treatment trials regarding the appropriate placement of PRS in risk assessment and lipid treatment decisions relative to information on rare monogenic gene variants, particularly in multiethnic populations.

This cohort study uses the UK Biobank cohort data to compare the association of monogenic vs polygenic hypercholesterolemia with the risk of atherosclerotic cardiovascular disease among individuals with comparable levels of low-density lipoprotein cholesterol.

This randomized clinical trial assesses the effectiveness of an implantable loop recorder plus 24-hour Holter electrocardiographic monitoring vs standard 24-hour Holter electrocardiographic monitoring alone for detecting arrhythmias in pregnant women with structural heart disease and/or symptoms suggestive of arrhythmias.

In the Editorial titled “Disproportionate Emphasis on Proportionate Mitral Regurgitation—Are There Better Measures of Regurgitant Severity?,” published online February 19, 2020, there was a wording error in the fifth paragraph. The sentence beginning “Rejection fraction is calculated….” should have been “Regurgitant fraction is calculated….” This article has been corrected online.

Mission Statement: JAMA Cardiology publishes exceptional original research, state-of-the-art reviews, and informative opinions that advance the science and practice of cardiology, enhance cardiovascular health, and inform health care policy. JAMA Cardiology is the definitive journal for clinical investigators, clinicians, and trainees in cardiovascular medicine worldwide. JAMA Cardiology focuses on all aspects of cardiovascular medicine, including epidemiology and prevention, diagnostic testing, interventional and pharmacologic therapeutics, translational research, health care policy and outcomes, and global health.

Lawyer and banker. Diaries, documenting Mitchell's July 3-August 31, 1914, automobile trip in France as World War I broke out.

Radio actor, writer, and producer from the 1930s-1950s. Scripts, financial records, correspondence, and visual materials primarily pertain to radio and television programming. Chiefly documented is the show Gang Busters from its conception to its iterations on television and film.

Dewey Library - PQ6653.E62 M6613 2020