ter Gestational Diabetes Mellitus Can Be Prevented by Lifestyle Intervention: The Finnish Gestational Diabetes Prevention Study (RADIEL): A Randomized Controlled Trial By care.diabetesjournals.org Published On :: 2016-01-01 Saila B. KoivusaloJan 1, 2016; 39:24-30Considerations in the Management of Gestational Diabetes Mellitus Full Article
ter Diabetes Prevention in the Real World: Effectiveness of Pragmatic Lifestyle Interventions for the Prevention of Type 2 Diabetes and of the Impact of Adherence to Guideline Recommendations: A Systematic Review and Meta-analysis By care.diabetesjournals.org Published On :: 2014-04-01 Alison J. DunkleyApr 1, 2014; 37:922-933Current Concepts of Type 2 Diabetes Prevention Full Article
ter Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations By care.diabetesjournals.org Published On :: 2016-06-01 Francesco RubinoJun 1, 2016; 39:861-877Metabolic Surgery and the Changing Landscape for Diabetes Care Full Article
ter The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: Overview By care.diabetesjournals.org Published On :: 2014-01-01 David M. NathanJan 1, 2014; 37:9-16DCCT/EDIC 30th Anniversary Summary Findings Full Article
ter Prevalence and Determinants of Glucose Intolerance in a Dutch Caucasian Population: The Hoorn Study By care.diabetesjournals.org Published On :: 1995-09-01 Johanna M MooySep 1, 1995; 18:1270-1273Short Report Full Article
ter International Consensus on Use of Continuous Glucose Monitoring By care.diabetesjournals.org Published On :: 2017-12-01 Thomas DanneDec 1, 2017; 40:1631-1640Continuous Glucose Monitoring and Risk of Hypoglycemia Full Article
ter Former intelligence chief Mustafa al-Kadhini named Iraqi prime minister By www.upi.com Published On :: Thu, 07 May 2020 10:36:35 -0400 Former intelligence chief Mustafa al-Kadhini was named prime minister of Iraq on Thursday, after five months of political instability in the Middle Eastern nation. Full Article
ter South Korea sees new cluster of COVID-19 cases tied to nightclubs By www.upi.com Published On :: Fri, 08 May 2020 07:16:30 -0400 Just days after South Korea loosened its social distancing guidelines, a new COVID-19 cluster of infections has sprung up in the capital city of Seoul tied to several nightclubs. Full Article
ter More than 70 dead in Rwanda after floods, landslides By www.upi.com Published On :: Fri, 08 May 2020 11:29:22 -0400 Heavy rains, flash flooding and landslides have led to the deaths of more than 70 people in Rwanda, officials said Friday. Full Article
ter Northrop Grumman, Raytheon partner for Next Generation Interceptor bid By www.upi.com Published On :: Mon, 04 May 2020 13:19:43 -0400 Northrop Grumman Corp. and Raytheon Missiles and Defense will partner to develop the Defense Department's next missile interceptor, they announced on Monday. Full Article
ter Gestational Diabetes Mellitus and Diet: A Systematic Review and Meta-analysis of Randomized Controlled Trials Examining the Impact of Modified Dietary Interventions on Maternal Glucose Control and Neonatal Birth Weight By care.diabetesjournals.org Published On :: 2018-07-01 Jennifer M. YamamotoJul 1, 2018; 41:1346-1361Reconsidering Pregnancy With Diabetes Full Article
ter Table 1--Systeme International (SI) units for plasma, serum, or blood concentrations By care.diabetesjournals.org Published On :: 1994-04-01 Apr 1, 1994; 17:360-361Syst[egrave]me International (SI) Units Full Article
ter Effect of a Lifestyle Intervention Program With Energy-Restricted Mediterranean Diet and Exercise on Weight Loss and Cardiovascular Risk Factors: One-Year Results of the PREDIMED-Plus Trial By care.diabetesjournals.org Published On :: 2019-05-01 Jordi Salas-SalvadóMay 1, 2019; 42:777-788Continuing Evolution of Nutritional Therapy for Diabetes Full Article
ter Table 1--Systeme International (SI) units for plasma, serum, or blood concentrations By care.diabetesjournals.org Published On :: 1995-11-01 Nov 1, 1995; 18:1524-1525Syst[egrave]me International (SI) Units Full Article
ter Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations By care.diabetesjournals.org Published On :: 2016-06-01 Francesco RubinoJun 1, 2016; 39:861-877Metabolic Surgery and the Changing Landscape for Diabetes Care Full Article
ter Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study By care.diabetesjournals.org Published On :: 2016-10-01 Khalid A. JadoonOct 1, 2016; 39:1777-1786Emerging Technologies and Therapeutics Full Article
ter The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: Overview By care.diabetesjournals.org Published On :: 2014-01-01 David M. NathanJan 1, 2014; 37:9-16DCCT/EDIC 30th Anniversary Summary Findings Full Article
ter Glucose Management Indicator (GMI): A New Term for Estimating A1C From Continuous Glucose Monitoring By care.diabetesjournals.org Published On :: 2018-11-01 Richard M. BergenstalNov 1, 2018; 41:2275-2280Perspectives in Care Full Article
ter International Consensus on Use of Continuous Glucose Monitoring By care.diabetesjournals.org Published On :: 2017-12-01 Thomas DanneDec 1, 2017; 40:1631-1640Continuous Glucose Monitoring and Risk of Hypoglycemia Full Article
ter Table 1-Systeme International (SI) units for plasma, serum, or blood concentrations By care.diabetesjournals.org Published On :: 1995-08-01 Aug 1, 1995; 18:1223-1224Syst[egrave]me International (SI) Units Full Article
ter Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range By care.diabetesjournals.org Published On :: 2019-08-01 Tadej BattelinoAug 1, 2019; 42:1593-1603International Consensus Report Full Article
ter Steroid Metabolomic Signature of Insulin Resistance in Childhood Obesity By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE On the basis of urinary steroidal gas chromatography-mass spectrometry (GC-MS), we previously defined a novel concept of a disease-specific "steroid metabolomic signature" and reclassified childhood obesity into five groups with distinctive signatures. The objective of the current study was to delineate the steroidal signature of insulin resistance (IR) in obese children. RESEARCH DESIGN AND METHODS Urinary samples of 87 children (44 girls) aged 8.5–17.9 years with obesity (BMI >97th percentile) were quantified for 31 steroid metabolites by GC-MS. Defined as HOMA-IR >95th percentile and fasting glucose-to-insulin ratio >0.3, IR was diagnosed in 20 (of 87 [23%]) of the examined patients. The steroidal fingerprints of subjects with IR were compared with those of obese children without IR (non-IR). The steroidal signature of IR was created from the product of IR – non-IR for each of the 31 steroids. RESULTS IR and non-IR groups of children had comparable mean age (13.7 ± 1.9 and 14.6 ± 2.4 years, respectively) and z score BMI (2.7 ± 0.5 and 2.7 ± 0.5, respectively). The steroidal signature of IR was characterized by high adrenal androgens, glucocorticoids, and mineralocorticoid metabolites; higher 5α-reductase (An/Et) (P = 0.007) and 21-hydroxylase [(THE + THF + αTHF)/PT] activity (P = 0.006); and lower 11βHSD1 [(THF + αTHF)/THE] activity (P = 0.012). CONCLUSIONS The steroidal metabolomic signature of IR in obese children is characterized by enhanced secretion of steroids from all three adrenal pathways. As only the fasciculata and reticularis are stimulated by ACTH, these findings suggest that IR directly affects the adrenals. We suggest a vicious cycle model, whereby glucocorticoids induce IR, which could further stimulate steroidogenesis, even directly. We do not know whether obese children with IR and the new signature may benefit from amelioration of their hyperadrenalism. Full Article
ter Vasodilatory Actions of Glucagon-Like Peptide 1 Are Preserved in Skeletal and Cardiac Muscle Microvasculature but Not in Conduit Artery in Obese Humans With Vascular Insulin Resistance By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE Obesity is associated with microvascular insulin resistance, which is characterized by impaired insulin-mediated microvascular recruitment. Glucagon-like peptide 1 (GLP-1) recruits skeletal and cardiac muscle microvasculature, and this action is preserved in insulin-resistant rodents. We aimed to examine whether GLP-1 recruits microvasculature and improves the action of insulin in obese humans. RESEARCH DESIGN AND METHODS Fifteen obese adults received intravenous infusion of either saline or GLP-1 (1.2 pmol/kg/min) for 150 min with or without a euglycemic insulin clamp (1 mU/kg/min) superimposed over the last 120 min. Skeletal and cardiac muscle microvascular blood volume (MBV), flow velocity and blood flow, brachial artery diameter and blood flow, and pulse wave velocity (PWV) were determined. RESULTS Insulin failed to change MBV or flow in either skeletal or cardiac muscle, confirming the presence of microvascular insulin resistance. GLP-1 infusion alone increased MBV by ~30% and ~40% in skeletal and cardiac muscle, respectively, with no change in flow velocity, leading to a significant increase in microvascular blood flow in both skeletal and cardiac muscle. Superimposition of insulin to GLP-1 infusion did not further increase MBV or flow in either skeletal or cardiac muscle but raised the steady-state glucose infusion rate by ~20%. Insulin, GLP-1, and GLP-1 + insulin infusion did not alter brachial artery diameter and blood flow or PWV. The vasodilatory actions of GLP-1 are preserved in both skeletal and cardiac muscle microvasculature, which may contribute to improving metabolic insulin responses and cardiovascular outcomes. CONCLUSIONS In obese humans with microvascular insulin resistance, GLP-1’s vasodilatory actions are preserved in both skeletal and cardiac muscle microvasculature, which may contribute to improving metabolic insulin responses and cardiovascular outcomes. Full Article
ter A Multinational, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Efficacy of Cyclical Topical Wound Oxygen (TWO2) Therapy in the Treatment of Chronic Diabetic Foot Ulcers: The TWO2 Study By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE Topical oxygen has been used for the treatment of chronic wounds for more than 50 years. Its effectiveness remains disputed due to the limited number of robust high-quality investigations. The aim of this study was to assess the efficacy of multimodality cyclical pressure Topical Wound Oxygen (TWO2) home care therapy in healing refractory diabetic foot ulcers (DFUs) that had failed to heal with standard of care (SOC) alone. RESEARCH DESIGN AND METHODS Patients with diabetes and chronic DFUs were randomized (double-blind) to either active TWO2 therapy or sham control therapy—both in addition to optimal SOC. The primary outcome was the percentage of ulcers in each group achieving 100% healing at 12 weeks. A group sequential design was used for the study with three predetermined analyses and hard stopping rules once 73, 146, and ultimately 220 patients completed the 12-week treatment phase. RESULTS At the first analysis point, the active TWO2 arm was found to be superior to the sham arm, with a closure rate of 41.7% compared with 13.5%. This difference in outcome produced an odds ratio (OR) of 4.57 (97.8% CI 1.19, 17.57), P = 0.010. After adjustment for University of Texas Classification (UTC) ulcer grade, the OR increased to 6.00 (97.8% CI 1.44, 24.93), P = 0.004. Cox proportional hazards modeling, also after adjustment for UTC grade, demonstrated >4.5 times the likelihood to heal DFUs over 12 weeks compared with the sham arm with a hazard ratio of 4.66 (97.8% CI 1.36, 15.98), P = 0.004. At 12 months postenrollment, 56% of active arm ulcers were closed compared with 27% of the sham arm ulcers (P = 0.013). CONCLUSIONS This sham-controlled, double-blind randomized controlled trial demonstrates that, at both 12 weeks and 12 months, adjunctive cyclical pressurized TWO2 therapy was superior in healing chronic DFUs compared with optimal SOC alone. Full Article
ter Time Course of Normalization of Functional {beta}-Cell Capacity in the Diabetes Remission Clinical Trial After Weight Loss in Type 2 Diabetes By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To assess functional β-cell capacity in type 2 diabetes during 2 years of remission induced by dietary weight loss. RESEARCH DESIGN AND METHODS A Stepped Insulin Secretion Test with Arginine was used to quantify functional β-cell capacity by hyperglycemia and arginine stimulation. Thirty-nine of 57 participants initially achieved remission (HbA1c <6.5% [<48 mmol/mol] and fasting plasma glucose <7 mmol/L on no antidiabetic drug therapy) with a 16.4 ± 7.7 kg weight loss and were followed up with supportive advice on avoidance of weight regain. At 2 years, 20 participants remained in remission in the study. A nondiabetic control (NDC) group, matched for age, sex, and weight after weight loss with the intervention group, was studied once. RESULTS During remission, median (interquartile range) maximal rate of insulin secretion increased from 581 (480–811) pmol/min/m2 at baseline to 736 (542–998) pmol/min/m2 at 5 months, 942 (565–1,240) pmol/min/m2 at 12 months (P = 0.028 from baseline), and 936 (635–1,435) pmol/min/m2 at 24 months (P = 0.023 from baseline; n = 20 of 39 of those initially in remission). This was comparable to the NDC group (1,016 [857–1,507] pmol/min/m2) by 12 (P = 0.064) and 24 (P = 0.244) months. Median first-phase insulin response increased from baseline to 5 months (42 [4–67] to 107 [59–163] pmol/min/m2; P < 0.0001) and then remained stable at 12 and 24 months (110 [59–201] and 125 [65–166] pmol/min/m2, respectively; P < 0.0001 vs. baseline) but lower than that of the NDC group (250 [226–429] pmol/min/m2; P < 0.0001). CONCLUSIONS A gradual increase in assessed functional β-cell capacity occurred after weight loss, becoming similar to that of NDC group participants by 12 months. This result was unchanged at 2 years with continuing remission of type 2 diabetes. Full Article
ter Immigrant Veterans in the United States By www.migrationpolicy.org Published On :: Mon, 13 May 2019 10:05:34 -0400 Approximately 530,000 foreign-born veterans of the U.S. armed forces resided in the United States in 2018, accounting for 3 percent of the 18.6 million veterans nationwide. Immigrant veterans tend to have higher education levels and household incomes compared to native-born veterans, and the vast majority are naturalized citizens, as this data-rich article explores. Full Article
ter International Experience Suggests Safe Third-Country Agreement Would Not Solve the U.S.-Mexico Border Crisis By www.migrationpolicy.org Published On :: Mon, 24 Jun 2019 10:44:06 -0400 While safe third-country agreements appear to hold the potential of deterring new asylum claims, experience suggests this may be a false promise. As the Trump administration explores the possibility of such agreements with Mexico and Guatemala, this commentary examines the evidence of safe third-country arrangements in Europe, finding them difficult to enforce and playing little role in deterring new claims. Full Article
ter Interlocking Set of Trump Administration Policies at the U.S.-Mexico Border Bars Virtually All from Asylum By www.migrationpolicy.org Published On :: Wed, 26 Feb 2020 17:23:32 -0500 Through a set of interlocking policies, the Trump administration has walled off the asylum system at the U.S.-Mexico border, guaranteeing that only a miniscule few can successfully gain protection. While the Migrant Protection Protocols, more commonly known as Remain in Mexico, have been a key part of throttling asylum applications, two newer, far less visible programs hold the potential to complete the job, as this article explores. Full Article
ter A New Migration Policy for A New Era: A Conversation with Mexico's Interior Secretary Olga Sánchez Cordero By www.migrationpolicy.org Published On :: Thu, 28 Feb 2019 14:38:21 -0500 On her first official trip to Washington, DC, Secretary of the Interior Olga Sánchez Cordero offered a public address on Mexico’s new approach to migration policy at MPI. Her remarks and the event discussion were mostly conducted in Spanish, and this recording is of the simultaneous English interpretation. Full Article
ter Ally or Exploiter? The Smuggler-Migrant Relationship Is a Complex One By www.migrationpolicy.org Published On :: Tue, 04 Feb 2020 15:13:48 -0500 As highly industrialized countries ramp up their border controls, human smugglers are playing a central role in moving migrants through key migration corridors around the world. Despite the illicit nature of their work and being cast as villains in the public eye, smugglers have complex, multifaceted relationships with their clients. At times, the relationship can be mutually beneficial or even lifesaving; at others, it can be predatory and dangerous, as this article explores. Full Article
ter Stony Brook University opens Center for Implant and Digital Technology By www.ada.org Published On :: Thu, 02 Jan 2020 15:06:00 -0600 Stony Brook School of Dental Medicine opened Dec. 5 its Center for Implant and Digital Technology, which will serve as a state-of-the-art space for digital dentistry-focused education, patient care and research. Full Article
ter ADA CERP collaboration focuses on dentistry’s role in interprofessional education By www.ada.org Published On :: Thu, 09 Jan 2020 12:06:00 -0600 The ADA’s Continuing Education Recognition Program, or ADA CERP, announced in December that it is collaborating with Joint Accreditation for Interprofessional Continuing Education, in an effort to offer dentists more opportunities to participate in interprofessional education. Full Article
ter Anniversary of community water fluoridation arrives By www.ada.org Published On :: Tue, 14 Jan 2020 07:39:00 -0600 The ADA National Fluoridation Advisory Committee is inviting dentists and others who promote the adoption and continuation of adding an optimal amount of fluoride to water to celebrate this year. Full Article
ter ADA standards committees invite interested parties to upcoming meetings By www.ada.org Published On :: Thu, 16 Jan 2020 12:03:00 -0600 Those interested in developing dental standards that ensure product safety and efficacy and offer useful information on new and emerging technologies can attend upcoming meetings of the American Dental Association's standards committees. Full Article
ter Dental schools, industry team up to create innovation centers By www.ada.org Published On :: Fri, 17 Jan 2020 10:44:00 -0600 The Center for Research & Education in Technology is encouraging dental schools to find out how to participate in its program and learn about the benefits to the school and its students. Full Article
ter ADA standard on treating biofilm in waterlines available for comment By www.ada.org Published On :: Fri, 17 Jan 2020 12:35:00 -0600 The American Dental Association Standards Committee on Dental Products has approved the document for circulation and comment. Full Article
ter Alliance of the ADA offers education, entertainment at Conference 2020 By www.ada.org Published On :: Tue, 21 Jan 2020 10:14:00 -0600 From courses on burnout, vaping and more to golf and a low-country boil, the Alliance of the American Dental Association's upcoming Conference 2020 in Charleston, South Carolina, will offer a variety of educational and entertainment opportunities. Full Article
ter ‘It’s very rewarding when dentists can treat veterans’ By www.ada.org Published On :: Mon, 27 Jan 2020 13:45:00 -0600 “Our nation’s veterans deserve the best.” Those were the words of ADA President Chad P. Gehani following his Jan. 7 visit to the Orlando VA Healthcare System’s dental clinic. Full Article
ter Tufts University program provides homeless veterans with advanced dental care By www.ada.org Published On :: Tue, 28 Jan 2020 11:29:00 -0600 Service With A Smile was among 10 programs from nine universities to receive funding this year through the ADA Foundation’s E. “Bud” Tarrson Dental School Student Community Leadership Awards. Full Article
ter National Children’s Dental Health Month highlights optimally fluoridated water By www.ada.org Published On :: Wed, 29 Jan 2020 09:30:00 -0600 This year the February observance of National Children’s Dental Health Month honors the 75th anniversary of community water fluoridation with its theme, “Fluoride in water prevents cavities! Get it from the tap!” Full Article
ter ADA unveils dental licensure interactive map By www.ada.org Published On :: Wed, 05 Feb 2020 11:17:00 -0600 The ADA Council on Dental Education and Licensure launched in December an interactive map in an effort to assist dentists with keeping track of current initial licensure requirements by state. Full Article
ter After 3 years, Find-a-Dentist initiative a ‘success’ By www.ada.org Published On :: Mon, 10 Feb 2020 15:06:00 -0600 Of the more than 3 million profile views, the program found that 17% resulted in action, which include potential patients visiting a dentist’s website, calling or emailing the practice and sharing their profile. Industry average for similar sites is only 1-4%, so patients are nearly six times more likely to contact an ADA dentist through Find-a-Dentist. Full Article
ter Organized dentistry supports oral health literacy By www.ada.org Published On :: Wed, 04 Mar 2020 13:59:00 -0600 The Organized Dentistry Coalition is applauding Congress for introducing legislation aimed at improving oral health literacy. Full Article
ter DEA Call Center suspends phone operations By www.ada.org Published On :: Mon, 23 Mar 2020 12:54:00 -0500 Springfield, Virginia — The Drug Enforcement Administration announced that effective March 23, the DEA Call Center has temporarily suspended phone operations due to COVID-19 pandemic. Full Article
ter HRSA updates FAQs for health centers during COVID-19 By www.ada.org Published On :: Tue, 24 Mar 2020 15:31:00 -0500 The Health Resources and Services Administration says it is working to keep health centers and health center program partners updated on the latest information regarding COVID-19. Full Article
ter University of Minnesota dental school appoints Dr. Keith A. Mays as interim dean By www.ada.org Published On :: Fri, 27 Mar 2020 14:54:00 -0500 The University of Minnesota School of Dentistry announced March 19 that it named Dr. Keith A. Mays, Ph.D, as its interim dean for two years beginning May 15. Full Article
ter ADA releases interim guidance on minimizing COVID-19 transmission risk when treating dental emergencies By www.ada.org Published On :: Wed, 01 Apr 2020 20:20:00 -0500 The American Dental Association has released interim guidance for dentists on how to minimize the risk of COVID-19 transmission before, during and after treating dental emergencies. Full Article
ter ADA urges dentists to heed April 30 interim postponement recommendation By www.ada.org Published On :: Wed, 01 Apr 2020 20:48:00 -0500 In a statement issued April 1, the ADA issued an interim recommendation that “dentists keep their offices closed to all but urgent and emergency procedures until April 30 at the earliest.” Full Article
ter Harvard dental student recipient of health literacy essay contest By www.ada.org Published On :: Thu, 02 Apr 2020 10:49:00 -0500 An essay on community water fluoridation yielded a Harvard University dental student a first-place win in the annual American Dental Association’s Health Literacy in Dentistry essay contest. Full Article
ter ADA asks Treasury Department, Small Business Administration to clarify intent of interim rule By www.ada.org Published On :: Sun, 05 Apr 2020 11:09:00 -0500 The Association continues to wait for clear guidance from the U.S. Department of Treasury and Small Business Administration on the best way to help dentists considering applying for Paycheck Protection Program 7(a) loans and Economic Injury Disaster Loans. Full Article
