the

K2CO3-Mediated (3+3-1) Annulation of 1,3-Acetonedicarboxylates with 2-Fluoro-1-nitroarenes: Synthesis of Indoles

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00488D, Paper
Meng-Yang Chang, Chin-Huey Ho, Hsing-Yin Chen
The K2CO3-mediated one-pot reaction of 1,3-acetonedicarboxylates with 2 equiv. of substituted 2-fluoro-1-nitrobenzenes has been developed to synthesize various 2,3-dicarboxylate indoles via a tandem (3 + 3 − 1) annulation pathway....
The content of this RSS Feed (c) The Royal Society of Chemistry




the

DevTools Digest - Chrome 35: Updates to the Developer Tools in Chrome 35

Updates to the Chrome Developer Tools: CSS property quick search, memory stats for heap snapshots, CodeMirror upgrade and more.




the

The Hobbit Experience 2014: Adding WebRTC gameplay to the Hobbit Experience

Learn how North Kingdom built an immersive multimedia experience optimized for modern mobile browsers using Web RTC




the

Updates to the service worker cache API




the

The EME Logger extension




the

Empathy is the need of the hour

Demand for proactive customer services




the

A time when hijackings were dime-a-dozen in the US

Unthinkable in today’s hyper-security post-9/11 environment, forced diversions were commonplace in the ’60s




the

Piloting through the pandemic

How AirAsia India innovated with a distance-learning training programme for its cockpit crew




the

As the price of aviation turbine fuel soars, airlines’ finances spin out of control




the

Regional airlines fly into rough weather

From poor applicability of policy to lack of quality manpower and capital, problems plaguing them are manifold




the

‘The challenge was in getting the aircraft’s custom clearance’

Private jet operator JetSetGo’s CEO Kanika Tekriwal describes the intricacies of directly importing and leasing an aircraft




the

The making of ‘agile’ airlines

How adoption of AI, ML can empower flying




the

Air India sale: Who will bag the Maharaja's crown?

Financial bid winner for sale of the State-owned airlines to be declared in three weeks; sources say it may take longer




the

Pick the rear seats to fly safe

Passengers who pick a seat near the tail of an aeroplane are more likely to survive a crash




the

2022 holds promise for the airline sector

Omicron might dent growth, but the long-term outlook seems promising




the

Another tough year for airlines

Ukraine-Russia conflict to result in the steep escalation of aircraft leasing charges




the

In case the engine gives out

If an aircraft’s engine fails, the pilot has nearly half an hour to find a landing spot




the

UDAN flies high despite the odds

The scheme has made short commutes via flight accessible to over 92 lakh people




the

The art of avoiding accidents in air

Flying distance may vary based on flight phases, altitudes and regions




the

Blockchain: Piloting the future of aviation

Enables effective solutions that positively impact industry players and end consumers




the

5 things Indian airlines must do to break their way out of pandemic blues

Post pandemic, the airlines must revamp strategies and resort to long-term measures to recover from the crisis 




the

Why do planes leave a white trail behind them?




the

Why opening the emergency door mid-flight is not possible




the

Why do planes dump excess fuel in the sky?




the

Boeing bids farewell to ‘Queen of the skies’

The first Boeing 747 took off from New York on Jan 22, 1970 and now the final 747 freighter was delivered to Atlas Air on February 1, 2022.




the

Apple Intelligence launches the iPhone into the AI era

Apple has released a free software update that will inject its first dose of artificial intelligence into its iPhone 16 line-up as the trendsetting company tries to catch up with technology’s latest craze




the

Apple AirPods Pro’s new hearing aid feature could help people face a problem they’d rather ignore

Millions who could benefit from hearing aids have never tried them, but the Apple AirPods could change this




the

Meta builds AI search engine to cut Google, Bing reliance, the Information reports

The Facebook-owner currently relies on Google and Bing search engines to give users answers on news, stocks and sports




the

As Bitcoin nears all-time high, WazirX investors are in pain over their locked crypto funds

Bitcoin was inching towards its March 2024 all-time-high price of $73,750.07, but those whose crypto assets are locked with the WazirX exchange after a cyberattack are anxious about missing out




the

Google CEO confirms the next Gemini model coming soon

Gemini 1.5, their last iteration had been released in February this year




the

Google Maps adds AI features to help users explore and navigate the world around them

Google Maps is heading down a new road steered by artificial intelligence




the

Microsoft, Meta, Apple, Amazon, and the burden of expectations knock Wall Street sharply lower

Drops for Big Tech companies including Microsoft and Facebook’s parent company Meta Platforms led Wall Street lower




the

Should men be allowed into operation theatres when their wives are having a baby? Doctors weigh in after YouTuber’s video sparks controversy

YouTuber Irfan recently posted a video on social media that showed him cutting the umbilical cord of his newborn, in the operation theatre of a private hospital in Chennai; consent of the medical personnel involved to being videoed was another aspect doctors say needs discussion




the

Why did the Centre sanction a 50% hike in prices of commonly-used drugs?

According to the government the recent 50% hike in prices of eight drugs was sanctioned keeping in mind the larger public interest and to ensure continued availability of drugs




the

Air pollution: Centre warns of the rising ill-effects of deteriorating air quality

In a letter to States and UTs, the Director General of Health Services Atul Goel has said to discourage stubble and waste burning, and spread awareness among people about reducing firecrackers during festivities




the

Drugs regulator finds 49 samples not of standard quality, manufacturers asked to withdraw their products

Four spurious drugs were also found and action has been initiated against the makers, the DCGI said




the

Polio in Pakistan: Another vaccination campaign begins after worrying surge

Pakistan regularly launches such campaigns, but violence targeting the health workers and police assigned to escort them is common




the

What is stereotactic radiation therapy for prostate cancer? How does it compare to other treatments?

Stereotactic radiotherapy uses high doses of radiation to target and kill cancer cells; it uses newer machines that can deliver very focused radiation beams




the

Bridging the gap in mental healthcare services: NGOs launch dementia clinics in Hyderabad’s slums

India continues to grapple with a dearth of mental healthcare services, even as the number of persons with dementia is expected to rise over the next two decades




the

Tuberculosis infected 8 million people last year, the most WHO has ever tracked

The World Health Organization says more than 8 million people were diagnosed with tuberculosis last year




the

Telemedicine in India: is the government’s eSanjeevani platform living up to its potential?

While the eSanjeevani numbers are impressive, doctors and experts point out that unless a number of systemic issues -- including low doctor numbers on the platform are fixed -- telemedicine in the country will not be able to move past infancy




the

Third phase of polio vaccination campaign to resume in northern Gaza: WHO-UNICEF

“Despite the lack of access to all eligible children in northern Gaza, the Polio Technical Committee for Gaza has taken the decision to resume the campaign,” a joint statement by UNICEF and WHO said




the

Putting patients at the centre

At the heart of the recent controversy over the management of the Institute of Mental Health in Chennai, rests a deep desire to improve services for those in need of mental health care and support. Setting this situation in context, Serena Josephine M. tries to trace the progress of the mental health movement in the State, looking at State and non-State actors, and examines the crucial question of what more needs to be done.




the

ICMR announces ‘First in the World Challenge’ to encourage scientists to find innovative ideas to tackle health issues

The Council said that the scheme proposes to foster novel, out of the box, futuristic ideas, new knowledge generation, discovery / development of breakthrough health technologies




the

Understanding orphan drugs: what are they, how are they classified and what are their challenges in the Indian context

While orphan drugs are crucial to treating rare, sometimes debilitating conditions, the high cost of their research and development is a major barrier to their development in India




the

Glioblastoma: why immunotherapy may offer hope for brain cancer patients

Recent trials have shown that immunotherapy can safely be delivered through injections into the cerebrospinal fluid; scientists are now exploring how to adapt these methods to penetrate the tumour more effectively




the

Lassa fever: Understanding the risk, response and global threat

The Lassa virus causes Lassa fever, a zoonotic disease; humans usually contract the virus through contact with food or items contaminated by the the Mastomys rat’s urine or faeces.




the

Symposium stresses on the urgent need for integrated health strategies