pro Driving Force to Detect Alzheimer's Disease Biomarkers: The Application Of A Thioflavine T@Er-MOF Ratiometric Fluorescent Sensor for Smart Detection of Presenilin 1, amyloid β-protein and Acetyl Choline By feeds.rsc.org Published On :: Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00440E, PaperXing Ze Wang, jing du, Nannan Xiao, Yan Zhang, Ling Fei, Jed D. LaCoste, Zhuo Huang, Qian wang, Xin Rui Wang, Bin DingCurrently, the highly sensitive detection of Alzheimer's Disease (AD) biomarkers, namely presenilin 1, amyloid β-protein (Aβ), and acetylcholine (ACh), are vital to helping us prevent and diagnose AD. In this...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pro [ASAP] <italic toggle="yes">In Vivo</italic> Production of Five Crocins in the Engineered <italic toggle="yes">Escherichia coli</italic> By feedproxy.google.com Published On :: Tue, 07 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00039 Full Article
pro [ASAP] A Modular Method for Directing Protein Self-Assembly By feedproxy.google.com Published On :: Thu, 09 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00504 Full Article
pro [ASAP] Efficient and Reproducible Multigene Expression after Single-Step Transfection Using Improved BAC Transgenesis and Engineering Toolkit By feedproxy.google.com Published On :: Mon, 13 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00457 Full Article
pro [ASAP] A Novel Biosynthetic Pathway for the Production of Acrylic Acid through ß-Alanine Route in <italic toggle="yes">Escherichia coli</italic> By feedproxy.google.com Published On :: Wed, 15 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00019 Full Article
pro [ASAP] Engineering Prokaryotic Transcriptional Activator XylR as a Xylose-Inducible Biosensor for Transcription Activation in Yeast By feedproxy.google.com Published On :: Fri, 17 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00122 Full Article
pro [ASAP] Genome-Wide CRISPRi-Based Identification of Targets for Decoupling Growth from Production By feedproxy.google.com Published On :: Tue, 21 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00143 Full Article
pro [ASAP] Engineering Stable <italic toggle="yes">Pseudomonas putida</italic> S12 by CRISPR for 2,5-Furandicarboxylic Acid (FDCA) Production By feedproxy.google.com Published On :: Tue, 28 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00006 Full Article
pro [ASAP] Facilitating Protein Expression with Portable 5'-UTR Secondary Structures in <italic toggle="yes">Bacillus licheniformis</italic> By feedproxy.google.com Published On :: Wed, 29 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00355 Full Article
pro [ASAP] Truncating the Structure of Lipopolysaccharide in <italic toggle="yes">Escherichia coli</italic> Can Effectively Improve Poly-3-hydroxybutyrate Production By feedproxy.google.com Published On :: Thu, 30 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00071 Full Article
pro [ASAP] A Chemical Switch System to Modulate Chimeric Antigen Receptor T Cell Activity through Proteolysis-Targeting Chimaera Technology By feedproxy.google.com Published On :: Thu, 30 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00476 Full Article
pro [ASAP] Analyzing and Engineering the Product Selectivity of a 2-Methylenebornane Synthase By feedproxy.google.com Published On :: Mon, 04 May 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00432 Full Article
pro [ASAP] Translation Related Factors Improve the Productivity of a <italic toggle="yes">Streptomyces</italic>-Based Cell-Free Protein Synthesis System By feedproxy.google.com Published On :: Wed, 06 May 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00140 Full Article
pro [ASAP] Bacteriophage Inspired Growth-Decoupled Recombinant Protein Production in <italic toggle="yes">Escherichia coli</italic> By feedproxy.google.com Published On :: Thu, 07 May 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00028 Full Article
pro [ASAP] MymA Bioactivated Thioalkylbenzoxazole Prodrug Family Active against <italic toggle="yes">Mycobacterium tuberculosis</italic> By feedproxy.google.com Published On :: Sun, 19 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00003 Full Article
pro [ASAP] A Selective Modulator of Peroxisome Proliferator-Activated Receptor ? with an Unprecedented Binding Mode By feedproxy.google.com Published On :: Mon, 20 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01786 Full Article
pro [ASAP] Molecule Property Analyses of Active Compounds for <italic toggle="yes">Mycobacterium tuberculosis</italic> By feedproxy.google.com Published On :: Mon, 20 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02075 Full Article
pro [ASAP] Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties By feedproxy.google.com Published On :: Wed, 22 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00117 Full Article
pro [ASAP] Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands By feedproxy.google.com Published On :: Thu, 23 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01835 Full Article
pro [ASAP] Discovery of Peptide Boronate Derivatives as Histone Deacetylase and Proteasome Dual Inhibitors for Overcoming Bortezomib Resistance of Multiple Myeloma By feedproxy.google.com Published On :: Thu, 23 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02161 Full Article
pro [ASAP] Molecular Interactions of Pyrazine-Based Compounds to Proteins By feedproxy.google.com Published On :: Fri, 24 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02021 Full Article
pro [ASAP] Correction to Photoactivatable Prolyl Hydroxylase 2 Inhibitors for Stabilizing the Hypoxia-Inducible Factor with Light By feedproxy.google.com Published On :: Tue, 28 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00599 Full Article
pro [ASAP] Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies By feedproxy.google.com Published On :: Wed, 29 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00202 Full Article
pro [ASAP] Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities By feedproxy.google.com Published On :: Wed, 29 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00015 Full Article
pro [ASAP] Triazolo-Peptidomimetics: Novel Radiolabeled Minigastrin Analogs for Improved Tumor Targeting By feedproxy.google.com Published On :: Thu, 30 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01936 Full Article
pro [ASAP] Degradation versus Inhibition: Development of Proteolysis-Targeting Chimeras for Overcoming Statin-Induced Compensatory Upregulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase By feedproxy.google.com Published On :: Mon, 04 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00339 Full Article
pro [ASAP] Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma By feedproxy.google.com Published On :: Tue, 05 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00395 Full Article
pro [ASAP] Discovery of Potent Inhibitors against P-Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2-(4-(Pyridin-2-yl)phenoxy)pyridine Analogue By feedproxy.google.com Published On :: Thu, 07 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00337 Full Article
pro [ASAP] Progress in the Field of Aldehyde Dehydrogenase Inhibitors: Novel Imidazo[1,2-<italic toggle="yes">a</italic>]pyridines against the 1A Family By feedproxy.google.com Published On :: Tue, 31 Mar 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00686 Full Article
pro [ASAP] Peptoid NPhe<sup>4</sup> in AGRP-Based c[Pro<sup>1</sup>-Arg<sup>2</sup>-Phe<sup>3</sup>-Phe<sup>4</sup>-Xxx<sup>5</sup>-Ala<sup>6</sup>-Phe<sup>7</sup> By feedproxy.google.com Published On :: Wed, 01 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00641 Full Article
pro [ASAP] Novel HIV-1 Protease Inhibitors with Morpholine as the P2 Ligand to Enhance Activity against DRV-Resistant Variants By feedproxy.google.com Published On :: Thu, 02 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00043 Full Article
pro [ASAP] Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction By feedproxy.google.com Published On :: Fri, 10 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00594 Full Article
pro [ASAP] Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents By feedproxy.google.com Published On :: Fri, 10 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00129 Full Article
pro [ASAP] Discovery of a Potent Dual Inhibitor of Wild-Type and Mutant Respiratory Syncytial Virus Fusion Proteins By feedproxy.google.com Published On :: Wed, 15 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00008 Full Article
pro [ASAP] PROTAC Compounds Targeting a-Synuclein Protein for Treating Neurogenerative Disorders: Alzheimer’s and Parkinson’s Diseases By feedproxy.google.com Published On :: Tue, 28 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00192 Full Article
pro [ASAP] Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors By feedproxy.google.com Published On :: Fri, 01 May 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00025 Full Article
pro [ASAP] Development of a Raltegravir-based Photoaffinity-Labeled Probe for Human Immunodeficiency Virus-1 Integrase Capture By feedproxy.google.com Published On :: Tue, 05 May 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00009 Full Article
pro Construction has started on the largest solar project in Nepal By latestsolarnews.com Published On :: Tue, 01 May 2018 18:55:50 +0000 The reports say that the constructions of a 25MW largest solar PV project in Nepal has begun. The foundation stone was laid last week at Devighat in Nuwakot by Minister for Energy, Water Resources and Irrigation, Barsha Man Pun. The government plans to finish the construction of the project in a year. As stated by … The post Construction has started on the largest solar project in Nepal appeared first on LatestSolarNews. Full Article News
pro India is planning to achieve 50 GW of prodction from renewbale energy by 2028 By latestsolarnews.com Published On :: Tue, 08 Jan 2019 10:08:19 +0000 India is planning to achieve 50 gigawatt (GW) of production from renewable energy by 2028, in order to get to its goal of 40 per cent of electricity generation from non-fossil fuels by 2030, Ministry of New and Renewable Energy secretary, Anand Kumar said at the India-Norway Business Summit 2019 in New Delhi. Of this … The post India is planning to achieve 50 GW of prodction from renewbale energy by 2028 appeared first on LatestSolarNews. Full Article News india solar energy india
pro Contextual styling with custom properties By simurai.com Published On :: Sun, 01 Apr 2018 00:00:00 +0000 Something I’ve been wanting for a long time, define different regions like a footer section, or side bar and not have to deal with all the contextual styling hassle. A.k.a. “Now that this button is used on a dark background, the button needs to change its colors too. Where should the styles live?”. Here an old post about struggling with contextual styling. So then the other day I was doing some experiments with using custom properties for Atom’s UI. Turns out, using custom properties might make contextual styling a bit easier. For the rest of the post, let’s switch to a more simple example. A page where the main area is light, but then has a dark hero and footer section. Like this: In the past, I probably would’ve created variations like Button--dark or overwrote it with header .Button {…}. Depends a bit on the project. Here another approach: Create themes with a set of variables, then apply the theme to the different areas. 1. Default theme First let’s define our default theme with a bunch of variables. [data-theme="default"] { --fg: hsl(0,0%,25%); --border: hsl(0,0%,75%); --bg: hsl(0,0%,95%); --button-bg: hsl(0,0%,99%); --input-bg: hsl(0,0%,90%); } Then we create some components where we use the variables defined above. [data-theme] { color: var(--fg); background-color: var(--bg); } .Button { color: var(--fg); border: 1px solid var(--border); background-color: var(--button-bg); } .Input { color: var(--fg); border: 1px solid var(--border); background-color: var(--input-bg); } And lastly we add the [data-theme="default"] attribute on the body so that our components will pick up the variables. <body data-theme="default"> If you wonder why use data-theme attributes over classes? Well, no specific reason. Maybe with attributes, it’s a hint that only one theme should be used per element and is more separated from your other classes. At this point we get this: See the Pen Contextual styling with custom properties (1/3) by simurai (@simurai) on CodePen. 2. Dark theme But our designer wants the hero and footer to be dark. Alright, let’s define another theme region. [data-theme="dark"] { --fg: hsl(0,10%,70%); --border: hsl(0,10%,10%); --bg: hsl(0,0%,20%); --button-bg: hsl(0,0%,25%); --input-bg: hsl(0,0%,15%); } And add the theme attribute to the header and footer. <header data-theme="dark"> <footer data-theme="dark"> Which gives us this: See the Pen Contextual styling with custom properties (2/3) by simurai (@simurai) on CodePen. The reason why this works is that custom properties cascade and can be overridden on nested elements, just like normal properties. 3. Hero theme A few months pass and our designer comes back with a redesigned hero section. “To make it look fresh” with a splash of color. No problem! Just like with the dark theme, we define a new “hero” theme. [data-theme="hero"] { --fg: hsl(240,50%,90%); --border: hsl(240,50%,10%); --bg: hsl(240,33%,30%); --button-bg: hsl(240,33%,40%); --input-bg: hsl(240,33%,20%); } <header data-theme="hero"> And here is that fresh hero: See the Pen Contextual styling with custom properties (3/3) by simurai (@simurai) on CodePen. It’s also not limited to colors only, could be used for sizes, fonts or anything that makes sense to define as variables. Benefits Using these theme “regions” lets your components stay context un-aware and you can use them in multiple themes. Even on the same page. Developers can add components, move components around, without having to know about in what context (theme) they live. The markup for the components stays the same. Design systems authors can create new components without worrying about where they get used, the variables used in components stay the same. Designers can define new theme regions, or change existing ones, without having to make changes to a component’s HTML or CSS, it stays the same. Less time to talk about who, how and where, more time to talk about the weather. ☔️???? Concerns Yeah, right. The big question: But does it scale? Can this be used for all use cases. Ok, I’m pretty sure it doesn’t fit all situations. There are just too many to find a single solution for them all. And I’m actually not sure how well it scales. I guess it works great in these simple demos, but I have yet to find a larger project to test it on. So if you have used (or plan to use) this approach, I’m curious to know how it went. A concern I can imagine is that the list of variables might grow quickly if themes have totally different characteristics. Like not just a bit darker or lighter backgrounds. Then you might need to have foreground and border colors for each component (or group of components) and can’t just use the general --fg and --border variables. Naming these variables is probably the hardest part. Update I @giuseppegurgone made an interesting comment: in suitcss projects I used to define component level custom props, theme variables and then create themes by mapping the former to the latter suitcss-toolkit So if I understood it correctly, by mapping theme variables to component variables, you could avoid your theme variables from growing too much and you can decide for each component how to use these theme variables. Update II If it’s too early to use custom properties in your project, @szalonna posted an example how to do something similar in SCSS. Full Article
pro Inventing Boston: design, production, and consumption / Edward S. Cooke, Jr By library.mit.edu Published On :: Sun, 23 Feb 2020 06:00:02 EST Rotch Library - NK838.B67 C66 2019 Full Article
pro Neuer Norden Zürich: ein Kunstprojekt im öffentlichen Raum, 9. Juni-2. September 2018 = New north Zurich: a public art project, 9th of June-2nd of September 2018 / herausgegeben von Christoph Doswald ; fotografiert von Pierluigi Macor ; Übe By library.mit.edu Published On :: Sun, 23 Feb 2020 06:00:02 EST Rotch Library - N6496.3.S9 Z876 2018 Full Article
pro Animal: exploring the zoological world / project editor, Lucy Kingett By library.mit.edu Published On :: Sun, 23 Feb 2020 06:00:02 EST Hayden Library - N7660.A653 2018 Full Article
pro Picture industry: a provisional history of the technical image 1844-2018 / edited, with an introduction by Walead Beshty ; foreword by Maja Hoffmann, Tom Eccles By library.mit.edu Published On :: Sun, 23 Feb 2020 06:00:02 EST Rotch Library - TR350.P53 2018 Full Article
pro New approaches to spatial planning and design: planning, design, applications / Murat Özyavuz By library.mit.edu Published On :: Sun, 22 Mar 2020 06:00:01 EDT Rotch Library - NK1520.O99 2019 Full Article
pro À l'orientale: collecting, displaying and appropriating Islamic art and architecture in the 19th and early 20th centuries / edited by Francine Giese, Mercedes Volait, Ariane Varela Braga By library.mit.edu Published On :: Sun, 12 Apr 2020 06:00:01 EDT Rotch Library - N6260.A12 2020 Full Article
pro This baby doll will be a junkie / Ulrike Montmann ; Kunst und Forschung: Projektbericht uber Abhangigkeiten und Gewaltraume By library.mit.edu Published On :: Sun, 19 Apr 2020 06:00:02 EDT Rotch Library - N6498.C66 T45 2018 Full Article
pro Paul Rand: inspiration and process in design / introduction and selection by Steve Heller ; edited by Eugenia Bell By library.mit.edu Published On :: Sun, 26 Apr 2020 06:00:01 EDT Rotch Library - NC999.4.R36 A4 2020 Full Article
pro Medieval art in motion: the inventory and gift giving of Queen Clémence de Hongrie / Mariah Proctor-Tiffany By library.mit.edu Published On :: Sun, 26 Apr 2020 06:00:01 EDT Rotch Library - N5262.C56 P76 2019 Full Article
pro Proceedings of the 2nd International and Interdisciplinary Conference on Image and Imagination: IMG 2019 / Enrico Cicalò, editor By library.mit.edu Published On :: Sun, 26 Apr 2020 06:00:01 EDT Online Resource Full Article
