Peptides having a structure characterized by the presence of two loops constrained in cyclic structure by the presence of covalent bonds between amino acid side chains, the amino acid sequences of the first and the second loop being substantially homologues to that of loop 1 (residues 29-38) and of loop 4 (residues 92-97) of NGF, respectively, displaying nerve growth factor (NGF) agonist or partial agonist activity.

Mono-pegylated arginase conjugate and method producing thereof. The mono-pegylated arginase is homogeneous in molecular weight and shows therapeutic effect for treating cancers and viral infections. The method of producing such arginase conjugate has a main step of genetically modifying the gene encoding an arginase so that the PEG moiety can attach to the enzyme at a predetermined, specific intended site. This is achieved by removing the PEG attaching amino acid residues at undesirable sites while keeping (or adding, if necessary) the one at the desirable site of the enzyme. Two exemplary mono-pegylated arginase conjugates so produced are human arginase I (HAI) where a polyethylene glycol (PEG) moiety is site-specific covalently bonded to Cys45 of the enzyme and Bacillus caldovelox arginase (BCA) where a polyethylene glycol (PEG) moiety is site-specific covalently bonded to Cys161 of the enzyme.

Disclosed are compositions and methods related to the isolation and identification of the primate T-lymphotropic viruses, HTLV-3 and HTLV-4. The diversity of HTLVs was investigated among central Africans reporting contact with NHP blood and body fluids through hunting, butchering, and keeping primate pets. Herein it is shown that this population is infected with a variety of HTLVs, including two retroviruses; HTLV-4 is the first member of a novel phylogenetic lineage that is distinct from all known HTLVs and STLVs; HTLV-3 falls within the genetic diversity of STLV-3, a group that has not previously been seen in humans. The present disclosure also relates to vectors and vaccines for use in humans against infection and disease. The disclosure further relates to a variety of bioassays and kits for the detection and diagnosis of infection with and diseases caused by HTLV-3 and HTLV-4 and related viruses.

Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.

The present invention relates to novel compounds having a function of a peptide in the amylin family, related nucleic acids, expression constructs, host cells, and processes production of the compounds. The compounds of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent metabolic disorders such as obesity, diabetes, and increased cardiovascular risk.

The present invention relates to treating a tissue in a mammal from the effects of reperfusion using flagellin.

Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.

The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve ganglia and/or trunks for the morphofunctional restoration of peripheral nerves in painful sensory-motor neuropathy as well as manifestations of ischemic neuritis. The invention also includes a composition containing EGF which can be formulated together with anesthetics or analgesics or encapsulated in microspheres and to the use thereof for the morphofunctional restoration of peripheral nerves in painful sensitive-motor-type diabetic neuropathy and the manifestations of ischemic neuritis.

Disclosed are polypeptides, nucleic acids, and related compositions that render plants resistant to bacterial pathogens. Also disclosed are transgenic plants having the nucleic acids and resistant to bacterial pathogens.

IL4/IL13-binding proteins comprise binding domains, which inhibit IL4/IL13 binding to IL4Ralpaha and common gamma chain complexes (Type 1) and inhibit IL4 binding to IL4Ralpha and IL13Ralpha1 complexes (Type 2), and IL13 binding to IL13Ralpha1 and/or IL13Ralpha2, are useful in the treatment of cancer, inflammatory, and other pathological conditions, such as allergic or fibrotic conditions, especially pulmonary conditions.

A method of treating cancer through use of guanosine 3',5'-cyclic monophosphate (cyclic GMP). Cyclic GMP decreases the number of human breast cancer and prostate adenocarcinoma as well as small-cell and squamous lung cells in culture by 30% (1 μM), 84% (1 mM), 31% (1 μM), and 30% (1 μM), respectively. Cyclic GMP decreases DNA synthesis in human pancreatic, breast, and prostate adenocarcinomas as well as small-cell and squamous cell carcinomas of the lung at its 1 μM concentration by 51%, 54%, 56%, 50% and 52%, respectively. Cyclic GMP when infused for one week decreases the tumor volume of human pancreatic adenocarcinomas in athymic mice 95% compared to untreated animals with human pancreatic adenocarcinomas.

The present invention relates to muscle repair promoters for local application that contain a colony-stimulating factor (CSF) as an active ingredient. The muscle repair promoters of the present invention exhibit their effect at low doses, particularly when they are administered intramuscularly.

The present invention provides variable mass labeling reagents, a set of the variable mass labeling reagents, and a multiplexed set of variable mass labeling reagents.

The present invention provides for a bio-mimetic polymer capable of catalyzing CO2 into a carbonate.

The present invention provides processes for the manufacturing of polypeptide conjugates. In particular, the invention provides methods for the purification of polypeptide conjugates, which include at least one polymeric modifying groups, such as a poly(alkylene oxide) moiety. Exemplary poly(alkylene oxide) moieties include poly(ethylene glycol) (PEG) and poly(propylene glycol). In an exemplary process, hydrophobic interaction chromatography (HIC) is used to resolve different glycoforms of glycoPEGylated polypeptides.

The present invention is relevant to human medicine, and, in particular, to the use of Epidermal Growth Factor (EGF) in a pharmaceutical composition, said composition is administered through infiltration at the periphery of nerve trunks and/or ganglia, for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as ischemic neuritis. It is also relevant to an EGF containing composition, where this molecule can be formulated together with anesthetic or analgesic drugs, or encapsulated in microspheres, and their use for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as in ischemic neuritis.

A disc drive unit is configured with a plurality of disc drives as one unit. At least one of a pair of opposed disc drives arranged on an identical horizontal plane is provided with a tray support member for supporting a front end of a tray of the other disc drive when the tray is ejected. The tray support member is capable of protruding from the one disc drive and withdrawing into the same.

A cartridge drive apparatus includes a holder, a lock plate, and a drive unit. The holder is configured to hold a cartridge inserted therein. The lock plate is attached with respect to the holder to be movable in one of an insertion direction and a discharge direction of the cartridge and includes a locking mechanism configured to lock the cartridge. The drive unit is configured to drive the holder and the lock plate in one of the insertion direction and the discharge direction of the cartridge.

The disk-shaped information recording medium having an outer diameter and an inner diameter comprises a substrate having a predetermined thickness, a first side that is one side of the substrate, a second side that is the other side of the substrate, a cylindrical portion forming a through hole formed at a center of the substrate, and a thin portion formed so as to surround an outer diameter of the cylindrical portion. The thin portion is thinner than the predetermined thickness and includes a non-inclined surface and an inclined surface formed on an outer diameter side of the non-inclined surface. The inclined surface is inclined at a predetermined angle to the non-inclined surface and is larger than the non-inclined surface in the thin portion.

An apparatus for rotating disc is provided, the apparatus according to an exemplary embodiment is characterized in that an anti-slip torque that is applied to the upper face of the disc by using the clamp unit and the elastic member is stronger than a rotation torque that is generated by the turn table to inhibit slipping of the optical disc from the turn table.

A wobble determining apparatus is provided with: a calculating device for calculating (i) a first time required until reaching a number of revolutions of a motor which allows a predetermined linear velocity, and (ii) a second time required to move an optical head to a position which allows the predetermined linear velocity, on the basis of the number of revolutions of the motor and the position of the optical head; a judging device for judging whether to keep the optical head in accordance with the calculated first time and the calculated second time; and a controlling device for controlling a moving device not to move the optical head if it is judged to keep the optical head, and for controlling the moving device to move the optical head to the position which allows the predetermined linear velocity if it is judged not to keep the optical head.

A holding portion includes at least three pressing members which are operable to press an inner peripheral of a hole formed on the medium. The pressing members are movable between first positions where the pressing members do not come in contact with the inner peripheral and second positions where the pressing members come in contact with and press the inner peripheral. Each of the pressing members is adapted to interlockingly move with each other when moving toward the first positions and to press the inner peripheral independently from the other members when positioning the second positions.

A disc drive that includes: a housing configured to receive a tray, a pickup mounted on the tray; a connector installed on the housing for outputting signals obtained from the optical pickup; a ribbon cable that includes a first end which is connected to the connector, including a plurality of wire layers, and a part installed adjacent to a side of a body of the housing; and at least one penetration hole formed in a side of the body of the housing so as to reduce a capacitive coupling between the ribbon cable and the body of the housing.

A holding mechanism is operable to hold a top medium from a plurality of plate-shaped media accommodated in a stacker in a stacked manner. A transport arm supports the holding mechanism. When the lift mechanism lifts down the transport arm, one of a first elastic pressing force and a second elastic pressing force greater than the first elastic pressing force is selectively applied from the holding mechanism to an upper surface of the top medium.

The disk-shaped information recording medium having an outer diameter and an inner diameter comprises a substrate having a predetermined thickness, a first side that is one side of the substrate, a second side that is the other side of the substrate, a cylindrical portion forming a through hole formed at a center of the substrate, and a thin portion formed so as to surround an outer diameter of the cylindrical portion. The thin portion is thinner than the predetermined thickness and includes a non-inclined surface and an inclined surface formed on an outer diameter side of the non-inclined surface. The inclined surface is inclined at an angle greater than or equal to 25 degrees and less than or equal to 35 degrees with respect to the non-inclined surface.

Provided are apparatuses for grounding the objective lens driving unit of an optical pickup device. An optical pickup device includes an objective lens driving unit and a base that supports the objective lens driving unit, and wherein the objective lens driving unit includes a moving structure including an objective lens and a plurality of drive coils; a static structure comprising magnets corresponding to the plurality of drive coils, a yoke that supports the magnets, and a wire holder that has a plurality of wiring layers including a ground wiring layer; a plurality of suspension wires that connect the plurality of drive coils to the plurality of wiring layers; a supporting portion connected to the yoke and fixed to the wire holder; a projection extending from the supporting portion and disposed adjacent to the ground wiring layer; and conductive bonding material connects the ground wiring layer with the projection.

A machine which provides for both leaf stripping and grading can be used to process plants, such as burley tobacco plants, by continuously moving the plants in a first direction while simultaneously varying the position of the plants in a second direction relative to a defoliating apparatus. The plants may be moved horizontally through a machine by a transporter engaging the plant stalks while the vertical distance between the transporter (and thus the plants) is varied relative to the defoliating apparatus. The transporter and defoliating apparatus may be positioned at an angle to one another. Due to the changing amount of vertical distance, leaves from different sections of the plants, such as leaves at different stalk heights, can be contacted and removed at different corresponding horizontal locations in the machine. Accordingly, leaves can be graded based on the location(s) from which they are retrieved after removal.

A cob conveying and cleaning system for use with a corn harvester, incorporating air induction in cooperation with an air flow from the harvester, for cleaning and separating lighter crop residue to be returned to the field from a mixed flow of the residue and cobs, such that the cleaned cobs can be collected, and the lighter residue optionally spread on the field. The air flow and induction are combined to cooperatively lift or draw the lighter residue from the mixed flow, and to optionally spread the removed lighter residue over a field. The induction apparatus can be located on the harvester, and used as a residue spreader when cobs are not collected.

The present disclosure is a handheld harvester apparatus including a threshing drum configured to rotate. The harvester may further include a plurality of teeth connected to the threshing drum and configured to strip seeds from a head of a plant. The harvester also includes a screening assembly coupled to the threshing drum. The screening assembly is configured to receive seeds and plant material from the threshing drum and to eject the plant material from the harvester and direct the seeds downward. The harvester further includes a first screen configured to receive the seeds from the screening assembly and to allow seeds sized below a predetermined threshold to pass through the first screen and to prevent plant material exceeding the predetermined threshold to pass through the first screen. The harvester may further include a collection chamber coupled to the first screen and configured to receive the seeds.

A granular material stirring apparatus for breaking up clumps of a granular material in an interior of a storage bin comprises a base assembly for resting on a floor of the bin, an agitation rotor rotatably mounted on the base assembly, and a rotation device connected to the rotatable agitation rotor to cause the agitation rotor to rotate with respect to the base assembly. The agitation rotor may include a central member rotatable about a substantially horizontal axis and a plurality of stirrer members extending substantially radially outwardly from the central member to rotate about the substantially horizontal axis.

A depth adjustable crop transport vane, crop transport vane assembly, and agricultural combine threshing chambers employing such adjustable crop transport vanes are disclosed.

A grain bin located atop a harvester includes upstanding walls having a substantially continuous upper edge defining an opening. A grain bin extension is deployable between extended and retracted positions to expand the capacity of the grain bin. The extension includes extension panels and a cap overlaying the opening. The cap is supported by a cap frame that is also deployable between extended and retracted positions. An extension deployment apparatus raises and lowers the extension panels. Extension deployment mechanisms located at opposing corners of the grain bin control the deployment of adjacent extension panels. Each extension deployment mechanism has a first rack and a trunnion to drive extension panels in a vertical direction and pivot the panels in an outward direction and a second rack mounted to the trunnion to drive the cap frame in a vertical direction, and a drive gear between the first and second racks.

A combine harvester comprises a separating apparatus arranged to receive a threshed crop stream and convey rearwardly. The separating apparatus comprises a grate for allowing grain and chaff to fall onto an underlying separator pan, the separator pan being driven in an oscillating manner to convey a grain/chaff stream forwardly for delivery to a cleaning unit. The separator pan comprises a first portion and a second portion disposed forwardly of the first portion. A rear edge of the second portion is releasably attached to a front edge of the first portion, the second portion being pivotable around a forward mounting around a transverse axis between an operating position in which the second portion is attached to the first portion forming a continuous pan surface, and a lowered position in which the second portion is detached from the first portion giving maintenance access to the underside of the separating apparatus.

A biomass feed system includes a device to propel an airborne flow of the biomass along a trajectory within a collection device. At least one air flow port is disposed and operable in cooperation with at least one fan for discharging a flow of air for creating a blanket of pressurized air within the interior cavity beneath the trajectory for supporting and extending a distance of travel of the biomass within the collection device. The collection device can include an air flow outlet adjacent to a terminal end of the trajectory, to and through which the pressurized air will flow, in a manner for lifting and carrying at least some of the airborne biomass farther into the interior cavity. And, vanes or other elements can be provided to used to achieve better sideward distribution.

Method and apparatus are provided for mechanically processing an organ or organs taken out from slaughtered poultry in a processing device or processing line, which organ or organs form part of an organ package and wherein the organ or organs are separated from the organ package. The organ package is spatially oriented by the processing device without notably breaking tissue connections in the package, and in a preselected order so as to cause the harvesting of organs from the package to occur in a preselected sequence that depends on the location of the organ package in the processing device or processing line.

A method for filling sausages with a paste-like substance by means of a filling machine and to a filling machine for performing this method, including a sensor unit capable of determining at least one parameter that varies differently for different paste-like substances as a function of time. Depending on the at least one determined parameter, a controller determines whether a measure to be implemented on one or more wearing parts is necessary, the wearing parts wearing out at different times depending on the different paste-like substances.

A poultry front half processing module is shown and described. The module includes a rotatable wing bracket for securely engaging the wings of the front half to allow more accurate processing and easier deboning and transfer operations.

The meat cutting cabinet provides an apparatus for automatically cutting and slicing meat using laser beams. The cabinet includes a motor disposed in the interior top thereof. The motor is connected to a winch or spool that pays out or reels in a steel cable. A steel hanger adapted for holding meat is suspended from the steel cable. Interior sidewalls of the cabinet have elongate standards extending from the upper portion to a lower portion proximate the cutting area of the cabinet. The steel hanger is slidably attached to the elongate members via channels formed in the standards. A laser carrier is disposed along an interior periphery of the cabinet and holds laser heads that can move via translation inside the carrier. This laser arrangement forms the cutting area through which the suspended meat can travel under control of a control panel connected to the spool motor.

A work hanging apparatus includes a hanger line continuously conveying hangers each having a hook, a robot that has a hand with which a work having a hole is held and transfers the held work to a hanging location set in the hanger line, a controller controlling a movement of the hand to catch the hook of one of the hangers with the hole of the held work at the hanging location, a hole deviation detector that detects a positional deviation of the hole of the work, an attitude deviation detector that detects an attitudinal deviation of the hanger, and a corrector that corrects the movement of the hand according to the positional and attitudinal deviations.

A method for processing poultry suspended by the feet from a conveyor hook is provided. The method and apparatus allow the quality of the poultry to be classified and graded in a simpler and more effective manner to realize higher yields or an extra added value. In one exemplary embodiment, a processing apparatus for a foot of the poultry is provided that includes a foot pad inspection apparatus.

The invention relates to a poultry defeathering apparatus and to a picking row for use in such an apparatus. The picking row comprises an elongate support part with a front side surface, a back side surface, a two interconnecting side surfaces interconnecting the front and back side surfaces. Said side surfaces extends in parallel to a length axis of the support part and a plurality of picking heads are arranged on the front side surface. At least one of the interconnecting side surfaces is convex, preferably being curved with a radius of curvature corresponding to half the height of the support part. In the apparatus, two or more picking rows are arranged side-by-side with the picking heads facing in substantially the same direction such that interconnecting side surfaces of neighboring picking rows face each other. In such a pair of interconnecting surfaces, at least one of them is convex.

A method and apparatus for removing fat from one face of a meat cut, where a knife tool cuts a layer of fat and possibly skin from the face. The knife tool is adapted to cut across the entire width of said meat cut along a desired trimming interface. The knife tool includes at least two controllable blade parts, each having a cutting edge, the blade parts extending between the first face and a fat-to-lean interface without intersecting said first face. The position of said cutting edges and the angle of the blade parts are continuously adapted, by controlling the at least two controllable blade parts, to cut following the desired trimming interface, whereby the fat and possible skin is trimmed from the lean in one single piece of fat.

A processing apparatus for poultry is provided. In an exemplary embodiment, the apparatus includes one or more transfer units placed intermediate of, conveying poultry from, a first line to a subsequent second line, wherein both the first line and the second line are selected from the group including a slaughtering line, an evisceration line, a chilling line, a sorting line and a cutup line. Each transfer unit is embodied with a circulating support that includes material that is magnetically conductive and transfer devices are provided with at least one magnet so as to induce eddy currents in the circulating support that counteracts relative motion between the transfer devices and the circulating support.

A knife having a hook incorporated into the blade for skinning, wherein the hook is a belly hook that is positioned on the belly side or under side of the knife opposite a finger guard area. Methods of the using the knife include steps for using the cutting edge to cut and using the hook to cut by pressure applied away from the user's body.

Method and apparatus are provided for mechanically processing an organ or organs taken out from slaughtered poultry in a processing device or processing line, which organ or organs form part of an organ package and wherein said organ or organs are separated from the organ package. The organ package is spatially oriented by the processing device without notably breaking tissue connections in the package, and in a preselected order so as to cause harvesting of organs from the package to occur in a preselected sequence that depends on the location of the organ package in the processing device or processing line.

A vacuum apparatus and method for recovering poultry breast sub-tenders or other trim products from poultry or meat carcass shells, or for recovering other materials. The apparatus has a cover which can be lowered on to a base to form a vacuum chamber. One or more vacuum hoses extend from the apparatus for suctioning the product into the vacuum chamber. A product container is removably positioned in the vacuum chamber such that the product suctioned into the vacuum chamber will fall into the product container by gravity.

A method for stunning poultry in a slaughterhouse by means of supplying a stunning gas into a closed chamber wherein the poultry is advanced through a plurality of successive ambients between an inlet, wherein the stunning gas concentration is at a minimum, and an outlet, at which the stunning gas concentration is at a maximum. The stunning gas concentration increases progressively from each ambient to the successive ambient, initially with a minimum increase rate and thereafter with a higher increase rate up to the maximum concentration.

A conveying apparatus has a conveying path to supply a plurality of products for consumption having soft parts and intended for processing to a processing device. A conveying intermediate space has conveying surfaces that face one another and receive the products for consumption between them while applying pressure thereto. A first conveying surface comprises a flexible surface-deformable conveying cover and a row arrangement of pressure elements that are arranged next to one another in a row extending transverse to the conveying direction, each having a pressure-applying transverse profile extending transverse to the conveying direction, and are held to be displaceable in the height dimension direction of the conveying intermediate space against a restoring force such that each pressure element co-operates with the surface-deformable conveying cover during the passage of the products for consumption through the conveying path in order to form a variable conveyor cross-section.

Positive electrode active material particles for lithium ion secondary batteries include: a core particle including a first olivine-structured, lithium-containing phosphate compound which includes Fe and/or Mn and Li; and a shell layer attached to the surface of the core particle. The shell layer includes a second olivine-structured, lithium-containing phosphate compound which includes Fe and/or Mn and Li. At least the core particle includes a phosphorous compound represented by the formula (1): MemPnOp, where Me is Fe and/or Mn, 0

Electrode protection in electrochemical cells, and more specifically, electrode protection in both aqueous and non-aqueous electrochemical cells, including rechargeable lithium batteries, are presented. In one embodiment, an electrochemical cell includes an anode comprising lithium and a multi-layered structure positioned between the anode and an electrolyte of the cell. A multi-layered structure can include at least a first single-ion conductive material layer, and at least a first polymeric layer positioned between the anode and the single-ion conductive material. The invention also can provide an electrode stabilization layer positioned within the electrode to control depletion and re-plating of electrode material upon charge and discharge of a battery. Advantageously, electrochemical cells comprising combinations of structures described herein are not only compatible with environments that are typically unsuitable for lithium, but the cells may be also capable of displaying long cycle life, high lithium cycling efficiency, and high energy density.