Given all we know about facial recognition tech, it is literally jaw-dropping that anyone could make this claim… especially without being vetted independently.

A group of Harrisburg University professors and a PhD student have developed an automated computer facial recognition software capable of predicting whether someone is likely to be a criminal.

The software is able to predict if someone is a criminal with 80% accuracy and with no racial bias. The prediction is calculated solely based on a picture of their face.

There's a whole lot of "what even the fuck" in CBS 21's reprint of a press release, but let's start with the claim about "no racial bias." That's a lot to swallow when the underlying research hasn't been released yet. Let's see what the National Institute of Standards and Technology has to say on the subject. This is the result of the NIST's examination of 189 facial recognition AI programs -- all far more established than whatever it is Harrisburg researchers have cooked up.

Asian and African American people were up to 100 times more likely to be misidentified than white men, depending on the particular algorithm and type of search. Native Americans had the highest false-positive rate of all ethnicities, according to the study, which found that systems varied widely in their accuracy.

The faces of African American women were falsely identified more often in the kinds of searches used by police investigators where an image is compared to thousands or millions of others in hopes of identifying a suspect.

Why is this acceptable? The report inadvertently supplies the answer:

Middle-aged white men generally benefited from the highest accuracy rates.

Yep. And guess who's making laws or running police departments or marketing AI to cops or telling people on Twitter not to break the law or etc. etc. etc.

To craft a terrible pun, the researchers' claim of "no racial bias" is absurd on its face. Per se stupid af to use legal terminology.

Moving on from that, there's the 80% accuracy, which is apparently good enough since it will only threaten the life and liberty of 20% of the people it's inflicted on. I guess if it's the FBI's gold standard, it's good enough for everyone.

Maybe this is just bad reporting. Maybe something got copy-pasted wrong from the spammed press release. Let's go to the source… one that somehow still doesn't include a link to any underlying research documents.

What does any of this mean? Are we ready to embrace a bit of pre-crime eugenics? Or is this just the most hamfisted phrasing Harrisburg researchers could come up with?

A group of Harrisburg University professors and a Ph.D. student have developed automated computer facial recognition software capable of predicting whether someone is likely going to be a criminal.

The most charitable interpretation of this statement is that the wrong-20%-of-the-time AI is going to be applied to the super-sketchy "predictive policing" field. Predictive policing -- a theory that says it's ok to treat people like criminals if they live and work in an area where criminals live -- is its own biased mess, relying on garbage data generated by biased policing to turn racist policing into an AI-blessed "work smarter not harder" LEO equivalent.

The question about "likely" is answered in the next paragraph, somewhat assuring readers the AI won't be applied to ultrasound images.

With 80 percent accuracy and with no racial bias, the software can predict if someone is a criminal based solely on a picture of their face. The software is intended to help law enforcement prevent crime.

There's a big difference between "going to be" and "is," and researchers using actual science should know better than to use both phrases to describe their AI efforts. One means scanning someone's face to determine whether they might eventually engage in criminal acts. The other means matching faces to images of known criminals. They are far from interchangeable terms.

If you think the above quotes are, at best, disjointed, brace yourself for this jargon-fest which clarifies nothing and suggests the AI itself wrote the pullquote:

“We already know machine learning techniques can outperform humans on a variety of tasks related to facial recognition and emotion detection,” Sadeghian said. “This research indicates just how powerful these tools are by showing they can extract minute features in an image that are highly predictive of criminality.”

"Minute features in an image that are highly predictive of criminality." And what, pray tell, are those "minute features?" Skin tone? "I AM A CRIMINAL IN THE MAKING" forehead tattoos? Bullshit on top of bullshit? Come on. This is word salad, but a salad pretending to be a law enforcement tool with actual utility. Nothing about this suggests Harrisburg has come up with anything better than the shitty "tools" already being inflicted on us by law enforcement's early adopters.

I wish we could dig deeper into this but we'll all have to wait until this excitable group of clueless researchers decide to publish their findings. According to this site, the research is being sealed inside a "research book," which means it will take a lot of money to actually prove this isn't any better than anything that's been offered before. This could be the next Clearview, but we won't know if it is until the research is published. If we're lucky, it will be before Harrisburg patents this awful product and starts selling it to all and sundry. Don't hold your breath.

I'm lucky enough to own a decades old Nintendo 64 and a handful of games, including the classic Mario 64. My kids love that game. Still, the first thing they asked when I showed it to them the first time is why the screen was letterboxed, why the characters looked like they were made of lego blocks, and why I needed weird cords to plug it all into the flat screen television. The answer to these spoiled monsters' questions, of course, is that the game is super old and wasn't meant to be played on modern televisions. It's the story of a lot of older games, though many PC games at least have a healthy modding community that will take classics and get them working on present day hardware. Consoles don't have that luxury.

Well, usually, that is. It turns out that enough folks were interested in modernizing Mario 64 that a group of fans managed to pull off porting it to PC. And, because this is a port and not emulation, they managed to update it to run in 4k graphics and added a ton of modern visual effects.

Last year, Super Mario 64's N64 code was reverse-engineered by fans, allowing for all kinds of new and exciting things to be done with Nintendo’s 1996 classic. Like building a completely new PC port of the game, which can run in 4K and ultra-wide resolutions.

This is a very new and cool thing! Previously, if you were playing Super Mario 64 on PC, you were playing via emulation, as your PC ran code pretending to be an N64. This game is made specifically for the PC, built from the ground up, meaning it not only runs like a dream, but even supports mod stuff like ReShade, allowing for graphical tweaks (like the distance blur seen here).

As you'll see, the video the Kotaku post is referencing can't be embedded here because Nintendo already took it down. Instead, I'll use another video that hasn't been taken down at the time of this writing, so you can see just how great this looks.

In addition to videos of the project, Nintendo has also been busy firing off legal salvos to get download links for the PC port of the game taken down from wherever it can find them. Now, while Nintendo's reputation for IP protectionism is such that it would almost certainly take this fan project down under virtually any circumstances, it is also worth noting that the company has a planned re-release of Mario 64 for its latest Nintendo console. That likely only supercharged the speed with which it is trying to disappear this labor of love from fans of an antiquated game that have since moved on to gaming on their PCs.

But why should the company do this? Nintendo consoles are known for many things, including user-friendly gaming and colorful games geared generally towards younger audiences. You know, exactly not the people who would take it on themselves to get an old Mario game working on their PC instead of a Nintendo console. What threat does this PC port from fans represent to Nintendo revenue? It's hard to imagine that threat is anything substantial.

And, yet, here we are anyway. Nintendo, after all, doesn't seem to be able to help itself.

A few weeks ago, the US telecom industry began pushing a bullshit narrative through its usual allies. In short, the claim revolves around the argument that the only reason the US internet still works during a pandemic was because the Trump FCC ignored the public, ignored most objective experts, and gutted itself at the behest of telecom industry lobbyists. The argument first popped up over at AEI, then the Trump FCC, then the pages of the Wall Street Journal, and has since been seen in numerous op-eds nationwide. I'd wager that's not a coincidence, and I'd also wager we'll be seeing a lot more of them.

All of the pieces try to argue that the only reason the US internet works during a pandemic is because the FCC gutted its authority over telecom as part of its "restoring internet freedom" net neutrality repeal. This repeal, the story goes, drove significant investment in US broadband networks (not remotely true), resulting in telecom Utopia (also not true). The argument also posits that in Europe, where regulators have generally taken a more active role in policing things like industry consolidation and telecom monopolies, the internet all but fell apart (guess what: not true).

Usually, like in this op-ed, there's ample insistence that the US broadband sector is largely wonderful while the EU has gone to hell:

"Unlike here, European networks are more heavily regulated. This has led to less investment and worse performance for consumers for years. American consumers are being generally well served by the private sector."

Anybody who has spent five minutes talking to Comcast customer support -- or tried to get scandal-plagued ISP like Frontier Communications to upgrade rotten DSL lines -- knows this is bullshit. Still, we penned a lengthy post exploring just how full of shit this argument is, and how there's absolutely zero supporting evidence for the claims. The entire house of cards is built on fluff and nonsense, and it's just ethically grotesque to use a disaster to help justify regulatory capture and market failure.

While it's true that the US internet, in general, has held up relatively well during a pandemic, the same can't be said of the so called "last mile," or the link from your ISP's network to your home. Yes, the core internet and most primary transit routes, designed to handle massive capacity spikes during events like the Superbowl, has handled the load relatively well. The problem, as Sascha Meinrath correctly notes here, is sluggish speeds on consumer and business lines that, for many, haven't been upgraded in years:

"Right now, an international consortium of network scientists is collecting 750,000 U.S. broadband speed tests from internet service provider (ISP) customers each day, and we’ve been tracking a stunning loss of connectivity speeds to people’s homes. According to most ISPs, the core network is handling the extra load. But our data show that the last-mile network infrastructure appears to be falling down on the job."

Again, your 5 Mbps DSL line might be ok during normal times, but it's not going to serve you well during a pandemic when your entire family is streaming 4K videos, gaming, and Zooming. And your DSL line isn't upgraded because there's (1) very little competition forcing your ISP to do so, and (2) the US government is filled to the brim with sycophants who prioritize campaign contributions and ISP revenues over the health of the market and consumer welfare. And while there's a contingency of industry-linked folks who try very hard to pretend otherwise, this is a policy failure that's directly tied to mindless deregulation, a lack of competition, and, more importantly, corruption. In short, the complete opposite of the industry's latest talking point.

For years we've been noting how US telcos have refused to repair or upgrade aging DSL lines because it's not profitable enough, quickly enough for Wall Street's liking. Facing no competition and no regulatory oversight, there's zero incentive for a giant US broadband provider to try very hard. Similarly, because our lawmakers and regulators are largely of the captured, revolving door variety, they rubber stamp shitty mergers, turn a blind eye to very obvious industry problems, routinely throwing billions in taxpayer money at monopolies in exchange for fiber networks that are usually only partially deployed -- if they're deployed at all.

Meanwhile, US telcos that have all but given up on upgrading aging DSL lines have helped cement an even bigger Comcast monopoly across vast swaths of America. It's a problem that the telecom sector, Trump FCC, and various industry apologists will ignore to almost comical effect. Also ignored is the fact that this results in US broadband subscribers paying some of the highest prices for broadband in the developed world:

"Numerous studies, including those conducted by the FCC itself, show that broadband pricing is the second-largest barrier to broadband adoption (availability is the first). It’s obvious that if people are being charged a lot for a service, they’re less likely to purchase it. And independent researchers have already documented that poor areas often pay more than rich communities for connectivity. Redlining of minority and rural areas appears to be widespread, and we need accurate pricing data from the FCC to meaningfully address these disparities."

Try to find any instance where Ajit Pai, or anybody in this chorus of telecom monopoly apologists, actually admits that the US broadband market isn't competitive and, as a result, is hugely expensive for businesses and consumers alike. You simply won't find it. What you will find are a lot of excuses and straw men arguments like this latest one, designed to distract the press, public, and policymakers from very obvious market failure. Market failure that was a major problem in normal times, and exponentially more so during a pandemic where broadband is an essential lifeline.

Well, this one hits the sweet spot of topics I keep trying to demonstrate: both a Streisand Effect and Masnick's Impossibility Theorem. As you may have heard, a group of Republican political consultants and strategists, who very much dislike Donald Trump, put together an effort called The Lincoln Project, which is a PAC to campaign against Trump and Trumpian politics. They recently released an anti-Trump campaign ad about his terrible handling of the COVID-19 pandemic, called Mourning in America, which is a reference to Ronald Reagan's famous Morning in America campaign ad for the 1984 Presidential election. The new ad is, well, pretty powerful:

And while it's unlikely to convince Trump fans deep into their delusions, it certainly got under the President's skin. He went on one of his famous late night Twitter temper tantrums about the ad, and later lashed out at the Lincoln Project when talking to reporters. He was super, super mad.

And what did that do? Well, first it got the ad a ton of views. Earlier this week, one of the Lincoln Project's founders, Rick Wilson, noted that the ad had already received 15 million views across various platforms in the day or so since the ad had been released. Also, it resulted in the Lincoln Project getting a giant boost in funding:

The Lincoln Project, which is run by Republican operatives who oppose President Donald Trump, raised $1 million after the president ripped the group on Twitter this week – marking it the super PAC’s biggest day of fundraising yet.

Reed Galen, a member of the Lincoln Project’s advisory committee, told CNBC that the total came after the president’s Tuesday morning Twitter tirade in reaction to an ad titled “Mourning in America,” which unloads on Trump’s response to the coronavirus pandemic. It recently aired on Fox News, which Trump often watches and praises. Galen said it was the Lincoln Project’s best single-day fundraising haul

Not only that, but it has opened up more opportunity for the Lincoln Project team to get their word out. With so much interest in the ad, it opened up opportunities for the project members to get their message in various mainstream media sources. Reed Galen wrote a piece for NBC:

What we accomplished this week was not something to be celebrated. No commercial should have the power to derail the leader of the free world.

And another Lincoln Project founder, George Conway (who, of course, is the husband of Trump senior advisor Kellyanne Conway), wrote something similar for the Washington Post:

It may strike you as deranged that a sitting president facing a pandemic has busied himself attacking journalists, political opponents, television news hosts and late-night comedians — even deriding a former president who merely boasted that “the ‘Ratings’ of my News Conferences etc.” were driving “the Lamestream Media . . . CRAZY,” and floated bogus miracle cures, including suggesting that scientists consider injecting humans with household disinfectants such as Clorox.

If so, you’re not alone. Tens of thousands of mental-health professionals, testing the bounds of professional ethics, have warned for years about Trump’s unfitness for office.

Some people listened; many, including myself, did not, until it was too late.

That's the kind of media exposure you can't buy, but which you get when you have a President who appears wholly unfamiliar with the Streisand Effect.

And that then takes us to the Impossibility Theorem, regarding the impossibility of doing content moderation at scale well. After Trump's ongoing tirade, Facebook slapped a "Partly False" warning label on the video when posted on Facebook. While the whole situation is ridiculous, it's at least mildly amusing, considering how frequently clueless Trumpkins insist that Facebook censors "conservative" (by which they mean Trumpian) viewpoints. Also, somewhat ironic in all of this: the only reason that Facebook now places such fact check labels on things is because anti-Trump people yelled at how Facebook needed to do more fact checking of political content on its site. So, now you get this.

Part of the issue is that Politifact judged one line in the ad as "false." That line was that Trump "bailed out Wall St. but not Main St." Politifact says that since the CARES Act Paycheck Protection Program has given potentially forgivable loans to some small businesses, and because the bill was done by Congress, not the President, that line is "false." And yet, because angry (usually anti-Trump) people demanded that Facebook do more useless fact checking, the end result is that the video now gets a "false" label.

Of course, this shows both the impossibility of doing content moderation well and the silliness of betting big on fact checking with a full "true or false" claim. One could argue that that line has misleading elements, but is true in most cases. Tons of small businesses are shuttering. Many businesses have been unable to get PPP loans, and under the current terms of the loans, they're useless for many (especially if they have no work for people to do, since the loans have to be mostly used on payroll over the next couple months). But does that make the entire ad "false"? Of course not.

And Rick Wilson is super mad about this. He's right to be mad about Politifact's designation, though it's really a condemnation of the religious focus on "true or false" in fact checking, rather than in focusing on what is misleading or not:

But the ad doesn’t actually claim that small businesses received zero help. Rather, it makes the point that Main Street America is still seriously struggling as the economic fallout from the coronavirus pandemic continues.

But Wilson is also mad at Facebook:

Speaking exclusively to Mediaite, Wilson called the decision “the typical fuckery we’ve come to expect from both the Trump camp and their tame Facebook allies.”

“Facebook is perfectly content to allow content from QAnon lunatics, anti-vaxxers, alt-righters, and every form of Trump/Russian — but I repeat myself — disinformation,” he pointed out. “This is a sign of just how powerfully ‘Mourning In America’ shook Donald Trump and his allies. Their attempt to censor our ad isn’t a setback for us; it’s a declaration of an information war we will win.”

Separately, the Lincoln Project also sent out an email to supporters, again blaming Facebook:

... it's no secret that Facebook has stood by and done little to nothing as lie after lie — from the Liar-In-Chief himself — runs wild on their platform.

(Oh, and let's also not forget the conspiracy theories, foreign disinformation campaigns and negligence that got Mark Zuckerberg questioned by the United States Congress.)

But, this? This is an entirely different and dangerous kind of collusion.

And what is Facebook's excuse for playing favorites with its recently-transferred former employees in the Trump campaign?

They say a "fact-checker" labeled our claim that "Donald Trump helped bailout Wall Street, not Main Street" was untrue.

....Really?

The email goes on to justify the "main street" line with a bunch of links, and then again argues that Facebook is "censoring the truth" to help Trump:

Is that "Partly False?" Of course not.

We told the truth about Donald Trump...

He lost his damn mind over it on Twitter...

Attacked us in front of Air Force One...

Then sent his spin machine to discredit us...

And now his allies at Facebook are doing his damage control by censoring the truth he doesn't like.

I get the frustration -- and I find it at least a bit ironic that the whole "fact checking" system was a response to anti-Trump folks mad at Facebook for allowing pro-Trump nonsense to spread -- but this is just another example of the Impossibility Theorem. There is no "good" solution here. We live in a time where everyone's trying to discredit everyone they disagree with, and many of these things depend on your perspective or your interpretation of a broad statement, like whether or not Trump is helping "main street."

We can agree that it's silly that Facebook has put this label on the video, but also recognize that it's not "Trump's allies at Facebook" working to "censor the truth he doesn't like." That's just absurd (especially given the reason the fact checking set up was put together in the first place).

But, hey, outrage and claims of censorship feed into the narrative (and feed into the Streisand Effect), so perhaps it all is just designed to work together.

I believe it is traditional to apologize when one hasn't been blogging for a while, and I am indeed sorry....

Here’s something I put up on Facebook (originally as a reply to someone else’s thing) in March that I should...

4 Classic SPANISH TAPAS using Potatoes

craving more? check out TasteSpotting

Instant Pot Cranberry Cornbread Bites shaped like Christmas Jingle Bells, pair up for the perfect bite of sweet and tart spiced cranberries.

craving more? check out TasteSpotting

Remember when all we had to complain about were crappy rail services?

Bork!Bork!Bork! Welcome to another in The Register's inexplicably long-lived series of digital signage suffering the odd public whoopsie.…

We all need to tighten our belts

For the first time in over three decades, BT has suspended its dividend scheme as the former state-owned teleco grapples with the fallout from the novel coronavirus pandemic, and the financial uncertainty that'll inevitably ensue.…

Middle management is about to learn just how necessary they are

Last night, one of the most senior figures in the IT industry from one of the biggest companies gave the strongest indication that when COVID-19 lockdowns gradually begin to lift, people will not return to the jobs they once had. That means both tech jobs, and how technology supports other business roles.…

John Cena!* Online resources only for free and end users due to the 'unprecedented period'

Video conferencing darling of the hour, Zoom, has tightened up support rules in order to "better serve" users.…

And now to avoid container sprawl costing you plenty

Microsoft has slipped out licensing details for SQL Server running in containers and it will likely encourage developers to be pretty diligent in their use of Redmond’s database.…

If you listen closely, you can hear how the creatures' full-throated call increases in volume when you are on holiday

On Call Friday is here! How is your weekend looking? Same as the last one, and the one before that? Never mind – before breaking into the lockdown lagers, join us for another entry in The Register's tales of those brave souls who are On Call.…

Nice way to get to Alpha Centauri though boffin tells us: 'Such a laser system could be used as a weapon'

Coin-sized pieces of graphene can be accelerated by firing low-powered lasers at them in micro-gravity conditions, say scientists. The technology could be a stepping stone to graphene solar sails, which could propel future spacecraft using starlight or a laser array.…

A review by SomeRandomHEFan (46). An excellent showcase of Humongous Entertainment's sense of humour. And I guess there's an acceptable edutainment game in there somewhere, too.

Drive more reaction when you fabricate your image story at the purpose of decision. A point of decision is where a possibility or purchaser will make a move activity to move to the subsequent stage in the purchasing procedure. Research,… Continue Reading →

At Let Grow, a wise mom named Kate Sundquist admits that while her kids were already good at playing, they certainly weren’t good at filling hours and hours of free time, playing by themselves. (Read the piece here.) So she her and boys created a schedule. “While these routines might seem restrictive or even the […]

“When I was 17, I was in a serious accident and had to be home for months. Looking out at our boring backyard, I daydreamed a plan for my life. It became a blueprint.” So writes Holly Korbey in a lovely piece at Let Grow. There are different kinds of daydreaming, of course, and some don’t […]

Spiegel has a piece Inside the Desperate Battle against Sports Doping. Lots of athletes get away with it. Pretty unfair for the ones who do not cheat. I've made this argument many times: anti-doping efforts are a losing cause. Doping techniques will become harder to detect. They will also become more powerful. But there is hope of a sort on the horizon: In 10 years time we have orders of magnitude more understanding of how genetic variants cause differences in human performance. This is inevitable due to the plunging costs of DNA sequencing. As a result it will become possible to measure a person's genetic potential to perform in various sports. Test the genetic potential. Then report for each athlete...

Nitrozac had to undergo an emergency endodontic procedure, *ouch*, so she is off for a few days to let her recover. We'll be back with a new smile soon, in the meantime, here's one of our fave retros...

Contes de fées aux enfants - Hippocampus l'hippocampe.

Date: April 27, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2017 Doodle game celebrating 50 years of Kids Coding!

Help stop the spread of COVID-19 by following these steps.
 

Learn more here about the latest ways we’re responding, and how our products can help people stay connected during this time.

Location: Global

Tags:

Date: April 28, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2017 Doodle game celebrating Cricket!

Help stop the spread of COVID-19 by following these steps.  
 

Learn more here about the latest ways we’re responding, and how our products can help people stay connected during this time.

Location: Global

Tags:

Date: April 29, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2017 Doodle game celebrating Oskar Fischinger!
 

Help stop the spread of COVID-19 by following these steps.  
 

Learn more here about the latest ways we’re responding, and how our products can help people stay connected during this time.

Location: Global

Tags:

Date: April 30, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2016 Doodle game celebrating Clara Rockmore!
 

Help stop the spread of COVID-19 by following these steps.
 

Learn more here about the latest ways we’re responding, and how our products can help people stay connected during this time.

Location: Global

Tags:

Date: May 1, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2018 Doodle game celebrating Garden Gnomes!
 

Help stop the spread of COVID-19 by following these steps.  
 

Learn more here about the latest ways we’re responding, and how our products can help people stay connected during this time.

Location: Global

Tags:

Date: May 4, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2016 Doodle game celebrating Wilbur Scoville!
 

Help stop the spread of COVID-19 by following these steps.  
 

Learn more here about the latest ways we’re responding, and how our products can help people stay connected during this time.

Location: Global

Tags:

Date: May 5, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2019 Doodle game celebrating Lotería!
 

Help stop the spread of COVID-19 by following these steps.  
 

Learn more here about the latest ways we’re responding, and how our products can help people stay connected during this time.

Location: Global

Tags:

Date: May 6, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2016 Doodle game celebrating Halloween!
 

Help stop the spread of COVID-19 by following these steps.  
 

Learn more here about the latest ways we’re responding, and how our products can help people stay connected during this time.

Location: Global

Tags:

Date: May 7, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2017 Doodle game celebrating the birth of Hip Hop!
 

Help stop the spread of COVID-19 by following these steps.  
 

Learn more here about the latest ways we’re responding, and how our products can help people stay connected during this time.

Location: Global

Tags:

Date: May 8, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2010 Doodle game celebrating PAC-MAN!
 

Help stop the spread of COVID-19 by following these steps.  
 

Learn more here about the latest ways we’re responding, and how our products can help people stay connected during this time.

Location: Global

Tags:

The post Team Spotlight: Getting to Know Ocean Blue’s James Stamatis appeared first on Ocean Blue Fishing Adventures.

The post What’s Cooking: Why Bleeding your Fish is Important? appeared first on Ocean Blue Fishing Adventures.

The post Unpacking After a Fishing Trip: Why is it so Important? appeared first on Ocean Blue Fishing Adventures.

Organ shortage continues to limit the lives of patients who require liver transplantation. While extending criteria for liver organs provides a needed resource, tissue damage from prolonged ischemic injury can result in early allograft dysfunction and consequent rejection. In this issue of the JCI, Nakamura et al. used a mouse transplantation model with prolonged ex vivo cold storage to explore liver graft protection. The authors found that liver grafts with absent carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) exhibited increased ischemia-reperfusion injury inflammation and decreased function in wild-type recipients. The authors went on to correlate CEACAM1 levels with postreperfusion damage in human liver transplant recipients. Notably, this study identified a potential biomarker for liver transplant donor graft quality.

Facioscapulohumeral muscular dystrophy (FSHD) results from expression of the full-length double homeobox 4 (DUX4-FL) retrogene in skeletal muscle. However, even in cases of severe FSHD the presence of DUX4 is barely detectable. In this issue of the JCI, Bosnakovski et al. used an inducible, muscle-specific human DUX4 to reproduce the low-level, sporadic DUX4 expression of human FSHD muscle as well the myopathology seen in human FSHD disease. Notably, dysregulated fibroadipogenic progenitors accumulated in affected muscles, thus providing a mechanism for the replacement of muscle by fibrosis and fat.

Lamin A is a component of the inner nuclear membrane that, together with epigenetic factors, organizes the genome in higher order structures required for transcriptional control. Mutations in the lamin A/C gene cause several diseases belonging to the class of laminopathies, including muscular dystrophies. Nevertheless, molecular mechanisms involved in the pathogenesis of lamin A–dependent dystrophies are still largely unknown. The polycomb group (PcG) of proteins are epigenetic repressors and lamin A interactors, primarily involved in the maintenance of cell identity. Using a murine model of Emery-Dreifuss muscular dystrophy (EDMD), we show here that lamin A loss deregulated PcG positioning in muscle satellite stem cells, leading to derepression of non–muscle-specific genes and p16INK4a, a senescence driver encoded in the Cdkn2a locus. This aberrant transcriptional program caused impairment in self-renewal, loss of cell identity, and premature exhaustion of the quiescent satellite cell pool. Genetic ablation of the Cdkn2a locus restored muscle stem cell properties in lamin A/C–null dystrophic mice. Our findings establish a direct link between lamin A and PcG epigenetic silencing and indicate that lamin A–dependent muscular dystrophy can be ascribed to intrinsic epigenetic dysfunctions of muscle stem cells.

Systemic sclerosis (SSc) is an autoimmune fibrotic disease whose pathogenesis is poorly understood and lacks effective therapies. We undertook quantitative analyses of T cell infiltrates in the skin of 35 untreated patients with early diffuse SSc and here show that CD4+ cytotoxic T cells and CD8+ T cells contribute prominently to these infiltrates. We also observed an accumulation of apoptotic cells in SSc tissues, suggesting that recurring cell death may contribute to tissue damage and remodeling in this fibrotic disease. HLA-DR–expressing endothelial cells were frequent targets of apoptosis in SSc, consistent with the prominent vasculopathy seen in patients with this disease. A circulating effector population of cytotoxic CD4+ T cells, which exhibited signatures of enhanced metabolic activity, was clonally expanded in patients with systemic sclerosis. These data suggest that cytotoxic T cells may induce the apoptotic death of endothelial and other cells in systemic sclerosis. Cell loss driven by immune cells may be followed by overly exuberant tissue repair processes that lead to fibrosis and tissue dysfunction.

Hypoxia-inducible factor (HIF) is strikingly upregulated in many types of cancer, and there is great interest in applying inhibitors of HIF as anticancer therapeutics. The most advanced of these are small molecules that target the HIF-2 isoform through binding the PAS-B domain of HIF-2α. These molecules are undergoing clinical trials with promising results in renal and other cancers where HIF-2 is considered to be driving growth. Nevertheless, a central question remains as to whether such inhibitors affect physiological responses to hypoxia at relevant doses. Here, we show that pharmacological HIF-2α inhibition with PT2385, at doses similar to those reported to inhibit tumor growth, rapidly impaired ventilatory responses to hypoxia, abrogating both ventilatory acclimatization and carotid body cell proliferative responses to sustained hypoxia. Mice carrying a HIF-2α PAS-B S305M mutation that disrupts PT2385 binding, but not dimerization with HIF-1β, did not respond to PT2385, indicating that these effects are on-target. Furthermore, the finding of a hypomorphic ventilatory phenotype in untreated HIF-2α S305M mutant mice suggests a function for the HIF-2α PAS-B domain beyond heterodimerization with HIF-1β. Although PT2385 was well tolerated, the findings indicate the need for caution in patients who are dependent on hypoxic ventilatory drive.

Prenatal alcohol exposure (PAE) affects at least 10% of newborns globally and leads to the development of fetal alcohol spectrum disorders (FASDs). Despite its high incidence, there is no consensus on the implications of PAE on metabolic disease risk in adults. Here, we describe a cohort of adults with FASDs that had an increased incidence of metabolic abnormalities, including type 2 diabetes, low HDL, high triglycerides, and female-specific overweight and obesity. Using a zebrafish model for PAE, we performed population studies to elucidate the metabolic disease seen in the clinical cohort. Embryonic alcohol exposure (EAE) in male zebrafish increased the propensity for diet-induced obesity and fasting hyperglycemia in adulthood. We identified several consequences of EAE that may contribute to these phenotypes, including a reduction in adult locomotor activity, alterations in visceral adipose tissue and hepatic development, and persistent diet-responsive transcriptional changes. Taken together, our findings define metabolic vulnerabilities due to EAE and provide evidence that behavioral changes and primary organ dysfunction contribute to resultant metabolic abnormalities.