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Interaction of mycophenolic acid and pantoprazole: a pharmacokinetic crossover study / Olesja Rissling

Online Resource




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High throughput screening methods: evolution and refinement / editors: Joshua A. Bittker, Nathan T. Ross

Online Resource




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Drug interactions in infectious diseases: antimicrobial drug interactions / Manjunath P. Pai, Jennifer J. Kiser, Paul O. Gubbins, Keith A. Rodvold, editors

Online Resource




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Miracle cure: the creation of antibiotics and the birth of modern medicine / William Rosen

Hayden Library - RM409.R67 2017




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Polymeric nanoparticles and microspheres / editors, Pierre Guiot, Patrick Couvreur

Online Resource




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The behavioral neuroscience of drug discrimination / Joseph H. Porter, Adam J. Prus, editors

Online Resource




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Antimicrobial peptides: basics for clinical application / Katsumi Matsuzaki, editor

Online Resource




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Microneedles for Transdermal Drug Delivery

Online Resource




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The role of microstructure in topical drug product development Nigel Langley, Bozena Michniak-Kohn, David W. Osborne, editors

Online Resource




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Cancer drug delivery systems based on the tumor microenvironment edited by Yasuhiro Matsumura, David Tarin

Online Resource




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Multiscale modeling of vascular dynamics of micro- and nano-particles: application to drug delivery system / Huilin Ye, Zhiqiang Shen and Ying Li

Online Resource




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Topical antimicrobial testing and evaluation / Darryl S. Paulson

Online Resource




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A Scramble for Virus Apps That Do No Harm

Dozens of tracking apps for smartphones are being used or developed to help contain the coronavirus pandemic. But there are worries about privacy and hastily written software.




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Protecting Homes and Food Sources of Two Critical Bat Species

 Lesser Long-Nosed and Mexican Long-Nosed Bats Receiving Support from Bat Conservation International’s New Program Supported by XTO Energy 




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Communities Encouraged to Take Action to Help Bats Across the Globe During Bat Week

Washington, DC (October 16, 2019) – A coalition of partners across North America announced the launch of Bat Week, an international celebration of




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Political Geography: A Critical Introduction


 

Brings political geography to life—explores key concepts, critical debates, and contemporary research in the field. 

Political geography is the study of how power struggles both shape and are shaped by the places in which they occur—the spatial nature of political power. PoliticalGeography: A Critical Introduction helps students understand how power is related to space, place, and territory, illustrating how everyday life and the world of global conflict



Read More...




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Exporting modules in JavaScript

In my latest entry I explain the difference about exporting a module between server side or CLI environments such Nashorn, SpiderMonkey, JSC, or micro controller and embedded engines such Duktape, Espruino, KinomaJS, and Desktop UI space via GJS.
Using this is a universal way to attach and export properties but when it comes to ES2015 modules, incompatible with CommonJS and with an undefined execution context.
Enjoy




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The missing analysis in JavaScript "Real" Mixins

I love hacks and unusual patterns! As logical consequence, I loved this post about "Real" Mixins!!!
The only hitch about that post is that I believe there are few points closer to a "gonna sell you my idea" discussion than a non disillusioned one.
Let's start this counter analysis remembering what are actually classes in latest JavaScript standard, so that we can move on explaining what's missing in there.

JavaScript embraces prototypal inheritance

It doesn't matter if ES6 made the previously reserved class keyword usable; at the end of the day we're dealing with a special syntactical shortcut to enrich a generic prototype object.

// class in ES2015
class A {
constructor() {}
method() {}
get accessor() {}
set accessor(value) {}
}

// where are those methods and properties defined?
console.log(
Object.getOwnPropertyNames(A.prototype)
// ["constructor", "method", "accessor"]
);
Accordingly, declaring a generic class consists in bypassing the following procedure:

function A() {}
Object.defineProperties(
A.prototype,
{
// constructor is implicitly defined
method: {
configurable: true,
writable: true,
value: function method() {}
},
accessor: {
configurable: true,
get: function get() {},
set: function set(value) {}
}
}
);
If you don't trust me, trust what a transpiler would do, summarized in the following code:

var A = (function () {
// the constructor
function A() {
_classCallCheck(this, _temporalAssertDefined(A, "A", _temporalUndefined) && A);
}
// the enriched prototype
_createClass(_temporalAssertDefined(A, "A", _temporalUndefined) && A, [{
key: "method",
value: function method() {}
}, {
key: "accessor",
get: function get() {},
set: function set(value) {}
}]);

return _temporalAssertDefined(A, "A", _temporalUndefined) && A;
})();
If there is some public static property in the definition, its assignment to the constructor would be the second bypassed part.

The super case

The extra bit in terms of syntax that makes ES6 special is the special keyword super. Being multiple inheritance not possible in JavaScript, we could think about super as the static reference to the directly extended prototype. In case of the previous B class, which extends A, we can think about super variable like if it was defined as such:

// used within the constructor
let super = (...args) => A.apply(this, arguments);

// used within any other method
super.method = (...args) => A.prototype.method.apply(this, args);

// used as accessor
Object.defineProperty(super, 'accessor', {
get: () => Object.getOwnPropertyDescriptor(
A.prototype, 'accessor'
).get.call(this),
set: (value) => Object.getOwnPropertyDescriptor(
A.prototype, 'accessor'
).set.call(this, value)
});
Now that we have a decent understanding on how inheritance works in JavaScript and what it means to declare a class, let's talk about few misleading points sold as pros or cons in the mentioned article.

Prototypes are always modified anyway!

We've just seen that defining a class technically means enriching its prototype object. This already invalidates somehow Justin point but there's more to consider.
When Justin exposes his idea on why current solutions are bad, he says that:
When using mixin libraries against prototype objects, the prototypes are directly mutated. This is a problem if the prototype is used anywhere else that the mixed-in properties are not wanted.
The way Justin describes this issue is quite misleading because mutating prototypes at runtime is a well known bad practice.
Indeed, I believe every single library he mentioned in that post, and he also forgot mine, is not designed to mutate classes prototypes at runtime ... like: not at all!
Every single mixin proposal that is capable of implementing mixins via classes is indeed designed to define these classes at definition time, not at runtime!
Moreover, whatever solution Justin proposed will not guard any class from being modified at runtime later on!
The same way he's defining his final classes during their definitions, mixins-for-classes oriented libraries have exactly the same goal: you define your class and its mixins during the class definition time!
The fact mixins add properties to a prototype is a completely hidden matter that at class definition time is everything but bad.
Also, no property is modified in place, because mixins are there to enrich, not to modify ... and having a prototype enriched means also that it's easier to spot name clashing and methods or properties conflicts ... but I'll come back to that later ...

super actually should NOT work!

The main bummer about the article is that it starts in a very reasonable way, describing mixins and classes, and also analyzing their role in a program.
The real, and only, difference between a mixin and normal subclass is that a normal subclass has a fixed superclass, while a mixin definition doesn't yet have a superclass.
Justin started right at the very beginning, and then degenerated with all sort of contradictions such:
Then finally he's back to Sanity Village with the following sentence:
super calls can be a little unintuitive for those new to mixins because the superclass isn't known at mixin definition, and sometimes developers expect super to point to the declared superclass (the parameter to the mixin), not the mixin application.
And on top of that, Justin talks about constructors too:
Constructors are a potential source of confusion with mixins. They essentially behave like methods, except that overriden methods tend to have the same signature, while constructors in a inheritance hierarchy often have different signatures.
In case you're not convinced yet how much messed up could be the situation, I'd like to add extra examples to the plate.
Let's consider the word area and its multiple meanings:
  • any particular extent of space or surface
  • a geographical region
  • any section reserved for a specific function
  • extent, range, or scope
  • field of study, or a branch of a field of study
  • a piece of unoccupied ground; an open space
  • the space or site on which a building stands
Now you really have to tell me in case you implement a basic Shape mixin with an area() method what the hack would you expect when invoking super. Moreoever, you should tell me if for every single method you are going to write within a mixin, you are also going to blindly invoke super with arbitrary amount of arguments in there ...

So here my quick advice about calling blindly a super: NO, followed by DON'T and eventually NEVER!

Oversold super ability

No kidding, and I can't stress this enough ... I've never ever in my life wrote a single mixin that was blindly trusting on a super call. That would be eventually an application based on mixins but that's a completely different story.
My feeling is that Justin tried to combine at all cost different concepts, probably mislead by his Dart background, since mentioned as reference, where composition in Dart was indeed classes based and the lang itself exposes native mixins as classes ... but here again we are in JavaScript!

instanceof what?

Another oversold point in Justin's article is that instanceof works.
This one was easy to spot ... I mean, if you create a class at runtime everytime the mixin is invoked, what exactly are you capable of "instanceoffing" and why would that benefit anyone about anything?
I'm writing down his very same examples here that will obviously all fail:

// a new anonymous class is created each time
// who's gonna benefit about the instanceof?
let MyMixin = (superclass) => class extends superclass {
foo() {
console.log('foo from MyMixin');
}
};

// let's try this class
class MyClass extends MyMixin(MyBaseClass) {
/* ... */
}

// Justin says it's cool that instanceof works ...
(new MyClass) instanceof MyMixin; // false
// false ... really, it can't be an instance of
// an arrow function prototype, isn't it?!
Accordingly, and unless I've misunderstood Justin point in which case I apologies in advance, I'm not sure what's the exact point in having instanceof working. Yes, sure the intermediate class is there, but every time the mixin is used it will create a different class so there's absolutely no advantage in having instanceof working there ... am I right?

Improving **Objects** Composition

In his Improving the Syntax paragraph, Justin exposes a very nice API summarized as such:

let mix = (superclass) => new MixinBuilder(superclass);

class MixinBuilder {
constructor(superclass) {
this.superclass = superclass;
}

with(...mixins) {
return mixins.reduce((c, mixin) => mixin(c), this.superclass);
}
}
Well, this was actually the part I've liked the most about his article, it's a very simple and semantic API, and it also doesn't need classes at all to be implemented for any kind of JS object!
How? Well, simply creating objects from objects instead:

let mix = (object) => ({
with: (...mixins) => mixins.reduce(
(c, mixin) => Object.create(
c, Object.getOwnPropertyDescriptors(mixin)
), object)
});
It could surely be improved in order to deal with classes too but you get the idea:

let a = {a: 'a'};
let b = {b: 'b'};
let c = {c: 'c'};
let d = mix(c).with(a, b);
console.log(d);
Since the main trick in Justin proposal is to place an intermediate class in the inheritance chain, defining at runtime each time the same class and its prototype, I've done something different here that doesn't need to create a new class with its own prototype or object each time, while preserving original functionalities without affecting them.

Less RAM to use, a hopefully coming soon native Object.getOwnPropertyDescriptors that should land in ES7 and make extraction faster, and the ability to use the pattern with pretty much everything out there, modern or old.
The gist is here, feel free to reuse.

As Summary ...

Wrapping up this post, with latter proposal we can actually achieve whatever Justin did with his intermediate classes approach but following different goals:
  1. Mixins are added to the prototype chain.
  2. Mixins are applied without modifying existing objects.
  3. Mixins do no magic, and don't define new semantics on top of the core language.
  4. super.foo property access won't hopefully work within mixins but it will with subclasses methods.
  5. super() calls won't hopefully work in mixins constructors because you've no idea what kind of arguments you are going to receive. Subclasses still work as expected.
  6. Mixins are able to extend other mixins.
  7. instanceof has no reason to be even considered in this scenario since we are composing objects.
  8. Mixin definitions do not require library support - they can be written in a universal style and be compatible with non classes based engines too.
  9. bonus: less memory consumption overall, there's no runtime duplication for the same logic each time
I still want to thanks Justin because he made it quite clear that still not everyone fully understands mixins but there's surely a real-world need, or better demand, in the current JavaScript community.

Let's hope the next version of ECMAScript will let all of us compose in a standard way that doesn't include a footgun like super through intermediate classes definition could do.
Thanks for your patience reading through this!




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JavaScript Interfaces

In this Implementing Interfaces in JavaScript blog entry I'll show a new way to enrich prototypal inheritance layering functionalities a part, without modifying prototypes at all. A different, alternative, and in some case even better, approach to mixins.




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New lines: critical GIS and the trouble of the map / Matthew W. Wilson

Rotch Library - G70.212.W55 2017




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Affective critical regionality / Neil Campbell

Rotch Library - G71.5.C338 2016




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Report on China's cruise industry / Hong Wang, editor

Online Resource




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The technocratic Antarctic: an ethnography of scientific expertise and environmental governance / Jessica O'Reilly

Dewey Library - G877.O74 2017




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An historical geography of tourism in Victoria, Australia: case studies / Ian D. Clark (editor) ; managing editor, Lucrezia Lopez

Online Resource




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Ecosystem Services for Well-Being in Deltas: Integrated Assessment for Policy Analysis / edited by Robert J. Nicholls, Craig W. Hutton, W. Neil Adger, Susan E. Hanson, Md. Munsur Rahman, Mashfiqus Salehin

Online Resource




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Space, knowledge and power: Foucault and geography / edited by Jeremy W. Crampton and Stuart Elden

Hayden Library - G70.S673 2016




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Report on the Development of Cruise Industry in China (2018): Green book on Cruise industry / Hong Wang, editor

Online Resource




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Description approaches and automated generalization algorithms for groups of map objects / Haowen Yan

Online Resource




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Cross-border tourism in protected areas: potentials, pitfalls and perspectives / Marius Mayer [and 4 others]

Online Resource




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The indestructible brand: crisis management in the age of social media / Venke Sharma and Hushidar Kharas

Online Resource




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How NASA builds teams: mission critical soft skills for scientists, engineers, and project teams / Charles J. Pellerin

Online Resource




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Standing on the shoulders of giants: traditions and innovations in research methodology / edited by Brian Boyd, T. Russell Crook, Jane K. Lê, Anne D. Smith

Dewey Library - HD30.4.S73 2019




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Management studies in crisis: fraud, deception and meaningless research / Dennis Tourish, University of Sussex

Dewey Library - HD30.4.T68 2019




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Industrial control systems security and resiliency: practice and theory / Craig Rieger, Indrajit Ray, Quanyan Zhu, Michael A. Haney, editors

Online Resource




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The lean strategy: using lean to create competitive advantage, unleash innovation, and deliver sustainable growth / Michael Ballé, Daniel Jones, Jacques Chaize, Orest Fiume

Dewey Library - HD58.9.B35 2017




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Crises, inquiries and the politics of blame / Sandra L. Resodihardjo

Online Resource




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Critical risks of different economic sectors: based on the analysis of more than 500 incidents, accidents and disasters / Dmitry Chernov, Didier Sornette

Online Resource




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Risk analysis based on data and crisis response beyond knowledge: proceedings of the 7th International Conference on Risk Analysis and Crisis Response (RACR 2019), October 15-19, 2019, Athens, Greece / edited by Chongfu Huang, Zoe S. Nivolianitou

Online Resource




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Making sense of culture: Cross-cultural expeditions and management practices of self-initiated expatriates in the foreign workplace / Norhayati Zakaria

Dewey Library - HD62.4.N67 2019




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Business and social crisis in Africa / Antoinette Handley, University of Toronto

Dewey Library - HD60.5.A35 H36 2019




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The pocket guide to the Baldrige Award criteria / Mark Graham Brown

Online Resource




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Creative construction: the DNA of sustained innovation / Gary P. Pisano

Dewey Library - HD45.P543 2019




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Crisis, Catastrophe, and Disaster in Organizations: Managing Threats to Operations, Architecture, Brand, and Stakeholders / by Dennis W. Tafoya

Online Resource




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Loonshots: how to nurture the crazy ideas that win wars, cure diseases, and transform industries / Safi Bahcall

Dewey Library - HD53.B34 2019




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Trust: creating the foundation for entrepreneurship in developing countries / Tarun Khanna

Dewey Library - HD60.5.D44 K43 2018




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Crisis, catastrophe, and disaster in organizations: managing threats to operations, architecture, brand, and stakeholders / Dennis W. Tafoya

Online Resource




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A V Rajwade: A banking crisis in the euro zone?

While banks are better capitalised than they were five years back, they could face a shortage of capital, and many have failed the stress tests standard




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NEW ONLINE: Rare Buddhist Scroll

The Library of Congress has restored and made available online the Gandhara Scroll, a manuscript dating back to around the first century B.C., that offers insight into the initial years of Buddhism. The scroll is one of the world’s oldest Buddhist manuscripts.

The scroll originates from Gandhara, an ancient Buddhist region located in what is now the northern border areas of Afghanistan and Pakistan. The scroll tells the story of buddhas who came before and after Siddhartha Gautama, the sage who reached enlightenment under the Bodhi tree in eastern India around the fifth century B.C. and the religious leader on whose teachings Buddhism was founded.

Click here for more information.




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The Hollywood war film : critical observations from World War I to Iraq / Daniel Binns

Binns, Daniel, author




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Irresistible : why we can't stop checking, scrolling, clicking and watching / Adam Alter

Alter, Adam L., 1980- author