li Synthesis, in silico and bio-evaluation studies of new isothiocyanate derivatives with respect to COX inhibition and H2S release profiles By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00495G, Research ArticleYakup Berkay Yilmaz, Tuğba Güngör, Serhat Dönmez, Hazal Nazlıcan Atalay, Pınar Siyah, Serdar Durdağı, Mehmet Ay, Tugba Boyunegmez TumerNew isothiocyanate derivatives (I1–3 and I1a–e) were synthesized and screened for their anti-inflammatory activities and H2S-releasing capacities. Compounds I1 and I1c demonstrated the most potent and selective COX-2 inhibition.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
li Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00553H, Research ArticleStefano Tomassi, Benito Natale, Michele Roggia, Luisa Amato, Caterina De Rosa, Carminia Maria Della Corte, Emma Baglini, Giorgio Amendola, Anna Messere, Salvatore Di Maro, Elisabetta Barresi, Federico Da Settimo, Maria Letizia Trincavelli, Fortunato Ciardiello, Sabrina Taliani, Floriana Morgillo, Sandro CosconatiNon-small cell lung cancer (NSCLC), the leading cause of cancer-related mortality worldwide, poses a formidable challenge due to its heterogeneity and the emergence of resistance to targeted therapies.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
li Technical, preclinical, and clinical developments of Fc-glycan-specific antibody–drug conjugates By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00637B, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Qiang Yang, Yunpeng LiuFc-glycan-specific ADC is a significant advance in site-specific ADCs for cancer therapy. Notably, JSKN003 and IBI343 have demonstrated promising results in phase 1 clinical trials and are advancing into phase 3 studies.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
li Light enhanced cytotoxicity and antitumoral effect of a ruthenium-based photosensitizer inspired from natural alkaloids By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00600C, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Gennaro Sanità, Maria Laura Alfieri, Barbara Carrese, Serena Damian, Vincenza Mele, Gaetano Calì, Brigida Silvestri, Sebastiano Marra, Susan Mohammadi, Giuseppina Luciani, Paola Manini, Annalisa LambertiBiological assays carried out on melanoma and breast cancer cells highlighted the role of light in boosting the cytotoxic effect of a ruthenium complex featuring a dihydroisoquinoline ligand suggesting applications in photodynamic therapy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
li SIGMAP: an explainable artificial intelligence tool for SIGMA-1 receptor affinity Prediction By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00722K, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Maria Cristina Lomuscio, Nicola Corriero, Vittoria Nanna, Antonio Piccinno, Michele Saviano, Rosa Lanzilotti, Carmen Abate, Domenico Alberga, Giuseppe Felice MangiatordiDeveloping sigma-1 receptor (S1R) modulators is considered a valuable therapeutic strategy to counteract neurodegeneration, cancer progression, and viral infections, including COVID-19. In this context, in-silico tools capable of accurately predicting...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
li Changes in train services notified due to demolition of old bridge near Tiruchi junction By www.thehindu.com Published On :: Tue, 05 Nov 2024 17:30:53 +0530 Full Article Tiruchirapalli
li Data crucial for building climate resilience, says ISRO scientist By www.thehindu.com Published On :: Tue, 05 Nov 2024 19:40:51 +0530 Full Article Tiruchirapalli
li Agro-tourism push needs industry-specific policies, say farmers By www.thehindu.com Published On :: Wed, 06 Nov 2024 18:37:41 +0530 Full Article Tiruchirapalli
li Urban Primary Health Centre stuck in cramped, temporary facility By www.thehindu.com Published On :: Wed, 06 Nov 2024 20:31:50 +0530 Full Article Tiruchirapalli
li Farmers demand withdrawal of Tamil Nadu Land Consolidation Act By www.thehindu.com Published On :: Thu, 07 Nov 2024 17:59:18 +0530 The Coordination Committee of All Farmers’ Associations of Tamil Nadu says the State government has created a situation where industries can acquire fertile lands Full Article Tiruchirapalli
li Tiruchi Corporation embarks on special drive at night to capture and sterilise street dogs By www.thehindu.com Published On :: Thu, 07 Nov 2024 19:10:58 +0530 About 125 stray dogs have been caught and sterilised at Tiruchi animal birth control centres in the last 10 days after the Corporation launched the special drive Full Article Tiruchirapalli
li HR&CE plans to bring properties around the Vennaimalai Temple under tenants list By www.thehindu.com Published On :: Thu, 07 Nov 2024 19:36:32 +0530 The HR&CE department has cleared 34 properties around the Balasubramanyaswamy Temple at Vennaimalai in Karur district as per the High Court orders Full Article Tiruchirapalli
li Consultant to be appointed soon to design Kalaignar grand library in Tiruchi By www.thehindu.com Published On :: Fri, 08 Nov 2024 18:41:18 +0530 The centre will offer translation, services for persons with disabilities and children, training and mentorship programmes, besides hosting monthly literary events Full Article Tiruchirapalli
li High-level committee formed to facilitate clearances for companies that signed MoU, says Minister By www.thehindu.com Published On :: Fri, 08 Nov 2024 18:56:40 +0530 Constant monitoring was being done now from the time of signing of MoUs to providing employment in new industrial units, says Industries Minister T.R.B. Rajaa Full Article Tiruchirapalli
li Fishermen seek healthcare and cold storage facilities By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:03:17 +0530 Full Article Tiruchirapalli
li Uppiliyapuram, gateway to scenic Pachamalai, lacks bus stand with passengers left to fight the elements By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:20:03 +0530 Buses stop at a busy junction making it difficult for commuters as well as local businessmen; a site is yet to be identified for the bus stand Full Article Tiruchirapalli
li Guidelines issued for fertilizer distribution in Karaikal for samba, thaladi paddy cultivation By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:25:49 +0530 Full Article Tiruchirapalli
li EPS’s dream of AIADMK staging a comeback in 2026 election will not materialise: Law Minister Regupathy By www.thehindu.com Published On :: Fri, 08 Nov 2024 20:25:59 +0530 Full Article Tiruchirapalli
li Two doctors posted at Uppiliyapuram UPHC By www.thehindu.com Published On :: Fri, 08 Nov 2024 20:29:46 +0530 Full Article Tiruchirapalli
li Library to hold Group II-A Mains, Group IV TNPSC model test By www.thehindu.com Published On :: Sat, 09 Nov 2024 17:59:22 +0530 Full Article Tiruchirapalli
li Advanced baggage handling system introduced in Tiruchi airport By www.thehindu.com Published On :: Sat, 09 Nov 2024 18:01:36 +0530 Full Article Tiruchirapalli
li Man attempts to end life, kills his wife and daughter By www.thehindu.com Published On :: Sat, 09 Nov 2024 18:03:18 +0530 Full Article Tiruchirapalli
li Art and literary contests lined up for District Central Library’s National Library Week By www.thehindu.com Published On :: Sat, 09 Nov 2024 18:07:57 +0530 Full Article Tiruchirapalli
li Nagapattinam MP presses for new express trains, railway line extensions By www.thehindu.com Published On :: Sat, 09 Nov 2024 20:34:19 +0530 Full Article Tiruchirapalli
li AIADMK ready to join hands with like-minded parties to defeat DMK: Palaniswami By www.thehindu.com Published On :: Mon, 11 Nov 2024 00:39:42 +0530 Full Article Tiruchirapalli
li Live Cricket Scores, Cricket News, Analysis, Results & More | The Hindu By www.thehindu.com Published On :: Full Article
li 548: Infinite Canvas, Luro + Figma, and Scraping or Crawling By shoptalkshow.com Published On :: Mon, 16 Jan 2023 10:41:42 +0000 What's going to happen to homework with AI? Thoughts on infinite canvas which leads into Luro and Sigma integration, and Chris gets nerdsniped and tries to scrap (or should he crawl?) websites for data. Full Article All Episodes chatgpt infinite canvas Luro
li 552: Do You Want to Build a JS Framework? ☃️ CSS Wishlist for 2023 By shoptalkshow.com Published On :: Mon, 13 Feb 2023 10:07:40 +0000 Austin power updates, what do you need if you want to build a new JavaScript framework, and what do we hope CSS brings in 2023? Full Article All Episodes color CSS Javascript
li 557: ChatGPT, Conferences, Fidgets on the Web, and Modern CSS in Real Life By shoptalkshow.com Published On :: Mon, 20 Mar 2023 07:01:51 +0000 When will AI be able to tell you the risk / reward of cleaning up trees? Are conferences back? Bringing fidgets to the web, internet as an anxiety machine, and Chris is working on talk on modern CSS in real life. Full Article All Episodes AI chatgpt Conferences CSS fidgets
li 560: Oh Biscuits! Cascade Layers, Block Links, Emoji Lists, and more CSS! By shoptalkshow.com Published On :: Mon, 10 Apr 2023 08:53:57 +0000 After a brief visit from Hip Hop Dad Dave, we're talking cascade layers updates, block link practices, search element getting dropped, how to use cite, emoji list accessibility, scrollbar state, and trigonometric functions in CSS. Full Article All Episodes cascade layers cite emoji trigonometric
li 561: Web Perf News, Web Sommelier, Data Analytics, and Passkeys By shoptalkshow.com Published On :: Mon, 17 Apr 2023 08:00:36 +0000 Topics for this one include how do you learn about web performance news? Do you need a web components sommelier? Our thoughts on Syntax going to Sentry, and being able to focus on the things you want to focus on. Passkeys, Arc split screen, and vibe driven development. Full Article All Episodes arc passkey sommelier Web Components
li 576: Blocks, Components, Linting Images, Engines, and “Web Integrity” By shoptalkshow.com Published On :: Tue, 01 Aug 2023 16:59:09 +0000 We're talking how we stay online - or not - on vacation, is create-guten-block the future for us WP developers? Can we get a state of the web component address from the President of web components? Have we seen the last new browser engine? And deciding whether to add features or remove them from your app. Full Article All Episodes Luro Web Components web integrity api
li 582: Lifetime Plan, Pricing #HotDrama, and CSS Resets By shoptalkshow.com Published On :: Mon, 11 Sep 2023 09:33:44 +0000 Getting tripped up on audio at conferences, announcing the ShopTalk Show Lifetime Plan, some Once pricing #hotdrama, remembering Molly Holzschlag, web components, Luro launch day thoughts, and a question about using a normalize or sanitize in 2023 prompts a run through of Andy Bell's Modern CSS Reset. Full Article All Episodes CSS CSS Resets Pricing
li 585: Blog Redesign, Sounds on a Website, Accessibility Tests, and Safari 17 By shoptalkshow.com Published On :: Mon, 02 Oct 2023 08:30:29 +0000 Chris redesigned his blog, using sounds on your website to make it seem fancy, what can't automated accessibility tests test, and what's new in Safari 17. Full Article All Episodes accessibilty sounds
li 588: Elliott Marquez on Web Components and Lit By shoptalkshow.com Published On :: Mon, 23 Oct 2023 08:40:58 +0000 Elliot Marquez talks with us about the history of Polymer and Lit, why you should pick Lit, working with web components, the shadow dom, managing state, and how Material design is built with web components. Full Article All Episodes lit shadow dom
li 592: Web Component Therapy, SEO Therapy, and Learning Something New like Swift By shoptalkshow.com Published On :: Mon, 20 Nov 2023 08:30:40 +0000 Talking web components, progressive enhancement, style-able components, having to pay before you get to see a demo, being annoyed at the business of SEO, and subscriptions vs ads. Full Article All Episodes markdown SEO Web Components
li 597: How Many VS Code Plugins, Poor Charlie’s Almanack, and Where to Start in 2024? By shoptalkshow.com Published On :: Mon, 08 Jan 2024 10:06:30 +0000 We're closing in on episode 600 and need your help to celebrate! Listen in to learn how to contribute to the episode. We're also talking GitHub desktop apps and code editors, how many VS Code plugins are needed, reading long form like Poor Charlie's Almanack, InVision shutting down, and answering our first Q of the year: how would you approach learning web development in 2024? Full Article All Episodes Education episode 600 Github vs code
li 602: What Does Accessibility Really Mean? By shoptalkshow.com Published On :: Mon, 12 Feb 2024 10:20:51 +0000 Voiceover pays us a visit, we talk about what accessibility really means, the difficulty of closing a dialogue element, web components at work, and jQuery 4 is out. Full Article All Episodes accessibilty Jquery
li 603: Deno, React Alternatives, and Copilot Concerns with Triple Threat Josh Collinsworth By shoptalkshow.com Published On :: Mon, 19 Feb 2024 09:22:07 +0000 Josh (or Jsoh) stops by to talk about his work at Deno, recent blog posts on Copilot, why Svelte is awesome and React is not, Apple and PWA, and building word games on the web. Full Article All Episodes Deno GitHub copilot pwa
li 606: Web Sustainability with Michelle Barker By shoptalkshow.com Published On :: Mon, 11 Mar 2024 08:35:40 +0000 Show DescriptionWe're talking with Michelle Barker about the idea of paying to support bloggers (and podcasters!) via services like Patreon, drumming as a fun side gig from CSS, how big of an issue digital sustainability is, trying to understand the environmental impact of our websites and digital life, wondering why YouTube embeds are still so […] Full Article All Episodes energy environment sustainability
li 613: Recording Live Music, WebC, Open Source, & WordPress Studio By shoptalkshow.com Published On :: Mon, 29 Apr 2024 19:44:02 +0000 Chris bought recording gear off an Instagram ad, our thoughts on WebC, CodePen upgrades Yarn, thoughts on the commercial value of open source, Automattic releases an app to install WordPress locally, IBM buys Hashicorp, income tax software, and a hack for getting Safari to respect background colors used in a pseudo selector. Full Article All Episodes Automattic Open Source WebC WordPress Studio
li 621: Setting Up Prettier and Linting, Comparing Colors, and Accessibility Overlays By shoptalkshow.com Published On :: Mon, 24 Jun 2024 08:05:22 +0000 We've got follow up on Cloudflare and Cara from last episode, a question about setting up Prettier and auto linting, a cool tool from a listener on comparing colors, a question about using tooling like Craft or more user friendly apps like Webflow when working with clients, and our takes on accessibility overlays. Full Article All Episodes Accessibility prettier webflow
li Water, unlimited By www.thehindu.com Published On :: Fri, 26 Dec 2014 16:00:55 +0530 Anamika Mukherjee writes on what went into creating the water supply system in her home Full Article Green Living
li A greener life By www.thehindu.com Published On :: Fri, 16 Jan 2015 15:01:25 +0530 Though it took many arguments and much labour, Anamika Mukherjee explains that the joy of growing your vegetables makes it all worth it Full Article Green Living
li Improve quality of indoor air By www.thehindu.com Published On :: Fri, 13 Feb 2015 17:10:54 +0530 Outdoor air pollutants are impacting the indoor environment and builders have to take remedial measures, says M.A. Siraj Full Article Green Living
li Green dream a reality now By www.thehindu.com Published On :: Fri, 24 Apr 2015 16:27:59 +0530 Chennai-based green building consultant Sumitra Vasudevan gives tips on how to ensure your home has a low carbon footprint. Full Article Property Plus
li Towards healthier living By www.thehindu.com Published On :: Fri, 19 Jun 2015 22:23:02 +0530 Invest in a green home for long-term benefits, says Arvind Jain Full Article Property Plus
li Alternatives and affordability By www.thehindu.com Published On :: Fri, 04 Sep 2015 16:56:02 +0530 Each housing project has to be site-specific, culturally appropriate and climatically conforming. Full Article Property Plus
li Guidelines for green urbanisation By www.thehindu.com Published On :: Fri, 02 Oct 2015 21:12:45 +0530 The Ministry of Urban Development has proposed environmental guidelines for construction projects in urban areas. Nidhi Adlakha reports Full Article Property Plus
li The green life By www.thehindu.com Published On :: Fri, 16 Oct 2015 14:50:34 +0530 At Sadhana Forest, on the outskirts of Auroville, a community plants trees and lives in rhythm with nature. Sujatha Shankar Kumar reports. Full Article Green Living