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Synthesis, in silico and bio-evaluation studies of new isothiocyanate derivatives with respect to COX inhibition and H2S release profiles

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00495G, Research Article
Yakup Berkay Yilmaz, Tuğba Güngör, Serhat Dönmez, Hazal Nazlıcan Atalay, Pınar Siyah, Serdar Durdağı, Mehmet Ay, Tugba Boyunegmez Tumer
New isothiocyanate derivatives (I1–3 and I1a–e) were synthesized and screened for their anti-inflammatory activities and H2S-releasing capacities. Compounds I1 and I1c demonstrated the most potent and selective COX-2 inhibition.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00553H, Research Article
Stefano Tomassi, Benito Natale, Michele Roggia, Luisa Amato, Caterina De Rosa, Carminia Maria Della Corte, Emma Baglini, Giorgio Amendola, Anna Messere, Salvatore Di Maro, Elisabetta Barresi, Federico Da Settimo, Maria Letizia Trincavelli, Fortunato Ciardiello, Sabrina Taliani, Floriana Morgillo, Sandro Cosconati
Non-small cell lung cancer (NSCLC), the leading cause of cancer-related mortality worldwide, poses a formidable challenge due to its heterogeneity and the emergence of resistance to targeted therapies.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Technical, preclinical, and clinical developments of Fc-glycan-specific antibody–drug conjugates

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00637B, Review Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Qiang Yang, Yunpeng Liu
Fc-glycan-specific ADC is a significant advance in site-specific ADCs for cancer therapy. Notably, JSKN003 and IBI343 have demonstrated promising results in phase 1 clinical trials and are advancing into phase 3 studies.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Light enhanced cytotoxicity and antitumoral effect of a ruthenium-based photosensitizer inspired from natural alkaloids

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00600C, Research Article
Open Access
Gennaro Sanità, Maria Laura Alfieri, Barbara Carrese, Serena Damian, Vincenza Mele, Gaetano Calì, Brigida Silvestri, Sebastiano Marra, Susan Mohammadi, Giuseppina Luciani, Paola Manini, Annalisa Lamberti
Biological assays carried out on melanoma and breast cancer cells highlighted the role of light in boosting the cytotoxic effect of a ruthenium complex featuring a dihydroisoquinoline ligand suggesting applications in photodynamic therapy.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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SIGMAP: an explainable artificial intelligence tool for SIGMA-1 receptor affinity Prediction

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00722K, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Maria Cristina Lomuscio, Nicola Corriero, Vittoria Nanna, Antonio Piccinno, Michele Saviano, Rosa Lanzilotti, Carmen Abate, Domenico Alberga, Giuseppe Felice Mangiatordi
Developing sigma-1 receptor (S1R) modulators is considered a valuable therapeutic strategy to counteract neurodegeneration, cancer progression, and viral infections, including COVID-19. In this context, in-silico tools capable of accurately predicting...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Changes in train services notified due to demolition of old bridge near Tiruchi junction




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Data crucial for building climate resilience, says ISRO scientist




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Agro-tourism push needs industry-specific policies, say farmers




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Urban Primary Health Centre stuck in cramped, temporary facility




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Farmers demand withdrawal of Tamil Nadu Land Consolidation Act

The Coordination Committee of All Farmers’ Associations of Tamil Nadu says the State government has created a situation where industries can acquire fertile lands




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Tiruchi Corporation embarks on special drive at night to capture and sterilise street dogs

About 125 stray dogs have been caught and sterilised at Tiruchi animal birth control centres in the last 10 days after the Corporation launched the special drive




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HR&CE plans to bring properties around the Vennaimalai Temple under tenants list

The HR&CE department has cleared 34 properties around the Balasubramanyaswamy Temple at Vennaimalai in Karur district as per the High Court orders




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Consultant to be appointed soon to design Kalaignar grand library in Tiruchi

The centre will offer translation, services for persons with disabilities and children, training and mentorship programmes, besides hosting monthly literary events




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High-level committee formed to facilitate clearances for companies that signed MoU, says Minister

Constant monitoring was being done now from the time of signing of MoUs to providing employment in new industrial units, says Industries Minister T.R.B. Rajaa




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Fishermen seek healthcare and cold storage facilities




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Uppiliyapuram, gateway to scenic Pachamalai, lacks bus stand with passengers left to fight the elements

Buses stop at a busy junction making it difficult for commuters as well as local businessmen; a site is yet to be identified for the bus stand




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Guidelines issued for fertilizer distribution in Karaikal for samba, thaladi paddy cultivation




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EPS’s dream of AIADMK staging a comeback in 2026 election will not materialise: Law Minister Regupathy




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Two doctors posted at Uppiliyapuram UPHC




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Library to hold Group II-A Mains, Group IV TNPSC model test




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Advanced baggage handling system introduced in Tiruchi airport




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Man attempts to end life, kills his wife and daughter




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Art and literary contests lined up for District Central Library’s National Library Week




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Nagapattinam MP presses for new express trains, railway line extensions




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AIADMK ready to join hands with like-minded parties to defeat DMK: Palaniswami




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Live Cricket Scores, Cricket News, Analysis, Results & More | The Hindu




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548: Infinite Canvas, Luro + Figma, and Scraping or Crawling

What's going to happen to homework with AI? Thoughts on infinite canvas which leads into Luro and Sigma integration, and Chris gets nerdsniped and tries to scrap (or should he crawl?) websites for data.




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552: Do You Want to Build a JS Framework? ☃️ CSS Wishlist for 2023

Austin power updates, what do you need if you want to build a new JavaScript framework, and what do we hope CSS brings in 2023?




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557: ChatGPT, Conferences, Fidgets on the Web, and Modern CSS in Real Life

When will AI be able to tell you the risk / reward of cleaning up trees? Are conferences back? Bringing fidgets to the web, internet as an anxiety machine, and Chris is working on talk on modern CSS in real life.




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560: Oh Biscuits! Cascade Layers, Block Links, Emoji Lists, and more CSS!

After a brief visit from Hip Hop Dad Dave, we're talking cascade layers updates, block link practices, search element getting dropped, how to use cite, emoji list accessibility, scrollbar state, and trigonometric functions in CSS.




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561: Web Perf News, Web Sommelier, Data Analytics, and Passkeys

Topics for this one include how do you learn about web performance news? Do you need a web components sommelier? Our thoughts on Syntax going to Sentry, and being able to focus on the things you want to focus on. Passkeys, Arc split screen, and vibe driven development.




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576: Blocks, Components, Linting Images, Engines, and “Web Integrity”

We're talking how we stay online - or not - on vacation, is create-guten-block the future for us WP developers? Can we get a state of the web component address from the President of web components? Have we seen the last new browser engine? And deciding whether to add features or remove them from your app.




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582: Lifetime Plan, Pricing #HotDrama, and CSS Resets

Getting tripped up on audio at conferences, announcing the ShopTalk Show Lifetime Plan, some Once pricing #hotdrama, remembering Molly Holzschlag, web components, Luro launch day thoughts, and a question about using a normalize or sanitize in 2023 prompts a run through of Andy Bell's Modern CSS Reset.




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585: Blog Redesign, Sounds on a Website, Accessibility Tests, and Safari 17

Chris redesigned his blog, using sounds on your website to make it seem fancy, what can't automated accessibility tests test, and what's new in Safari 17.




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588: Elliott Marquez on Web Components and Lit

Elliot Marquez talks with us about the history of Polymer and Lit, why you should pick Lit, working with web components, the shadow dom, managing state, and how Material design is built with web components.




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592: Web Component Therapy, SEO Therapy, and Learning Something New like Swift

Talking web components, progressive enhancement, style-able components, having to pay before you get to see a demo, being annoyed at the business of SEO, and subscriptions vs ads.




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597: How Many VS Code Plugins, Poor Charlie’s Almanack, and Where to Start in 2024?

We're closing in on episode 600 and need your help to celebrate! Listen in to learn how to contribute to the episode. We're also talking GitHub desktop apps and code editors, how many VS Code plugins are needed, reading long form like Poor Charlie's Almanack, InVision shutting down, and answering our first Q of the year: how would you approach learning web development in 2024?




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602: What Does Accessibility Really Mean?

Voiceover pays us a visit, we talk about what accessibility really means, the difficulty of closing a dialogue element, web components at work, and jQuery 4 is out.




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603: Deno, React Alternatives, and Copilot Concerns with Triple Threat Josh Collinsworth

Josh (or Jsoh) stops by to talk about his work at Deno, recent blog posts on Copilot, why Svelte is awesome and React is not, Apple and PWA, and building word games on the web.




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606: Web Sustainability with Michelle Barker

Show DescriptionWe're talking with Michelle Barker about the idea of paying to support bloggers (and podcasters!) via services like Patreon, drumming as a fun side gig from CSS, how big of an issue digital sustainability is, trying to understand the environmental impact of our websites and digital life, wondering why YouTube embeds are still so […]




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613: Recording Live Music, WebC, Open Source, & WordPress Studio

Chris bought recording gear off an Instagram ad, our thoughts on WebC, CodePen upgrades Yarn, thoughts on the commercial value of open source, Automattic releases an app to install WordPress locally, IBM buys Hashicorp, income tax software, and a hack for getting Safari to respect background colors used in a pseudo selector.




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621: Setting Up Prettier and Linting, Comparing Colors, and Accessibility Overlays

We've got follow up on Cloudflare and Cara from last episode, a question about setting up Prettier and auto linting, a cool tool from a listener on comparing colors, a question about using tooling like Craft or more user friendly apps like Webflow when working with clients, and our takes on accessibility overlays.




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Water, unlimited

Anamika Mukherjee writes on what went into creating the water supply system in her home




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A greener life

Though it took many arguments and much labour, Anamika Mukherjee explains that the joy of growing your vegetables makes it all worth it




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Improve quality of indoor air

Outdoor air pollutants are impacting the indoor environment and builders have to take remedial measures, says M.A. Siraj




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Green dream a reality now

Chennai-based green building consultant Sumitra Vasudevan gives tips on how to ensure your home has a low carbon footprint.




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Towards healthier living

Invest in a green home for long-term benefits, says Arvind Jain




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Alternatives and affordability

Each housing project has to be site-specific, culturally appropriate and climatically conforming.




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Guidelines for green urbanisation

The Ministry of Urban Development has proposed environmental guidelines for construction projects in urban areas. Nidhi Adlakha reports




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The green life

At Sadhana Forest, on the outskirts of Auroville, a community plants trees and lives in rhythm with nature. Sujatha Shankar Kumar reports.