Nine games into the Washington Capitals' season, Alex Ovechkin is scoring at a rate that would put him past Wayne Gretzky as soon as this spring.

A box found in a Saskatchewan attic, potentially holding millions of dollars worth of hockey cards, is going back up for auction after the original winning bidder never paid up, according to the auction company.

Winnipeg Jets goaltender Connor Hellebuyck, Colorado Avalanche centre Nathan MacKinnon and Buffalo Sabres goaltender Ukko-Pekka Luukkonen have been named the NHL's three stars of the week.

What would you do if you'd just been dealt a devastating, extremely public defeat? If your answer is "drink wine in leggings," then Vice-President and former Democratic U.S. presidential candidate Kamala Harris can do you one better: Drink wine in leggings, sporting a messy bun, while playing Connect 4.

U.S. president-elect Donald Trump spoke with Russian President Vladimir Putin and advised him not to escalate the Ukraine war, a source familiar with the conversation said, but the Kremlin denied the two had spoken.

Italian police have uncovered a large-scale pan-European forgery network making and selling fake artworks attributed to some of the biggest names in modern and contemporary art including Banksy, Pablo Picasso and Andy Warhol.

An Israeli airstrike killed seven people late Monday at a café near the southern Gaza city of Khan Younis, Palestinian medics said, bringing the death toll from Israeli strikes since Sunday night to at least 37.

Tens of thousands of Poles including nationalist opposition chiefs walked through Warsaw on Monday in an annual Independence Day event held by the far right, some shooting red flares and carrying anti-EU, anti-Ukraine and white supremacist banners.

A federal judge sentenced a Massachusetts Air National Guard member to 15 years in prison Tuesday for leaking classified military documents about the war in Ukraine, actions prosecutors said put the country's national security at risk, endangered other military members and damaged U.S. relationships with its allies.

Bob Iaccino, Path Trading Partners

One person is dead after a motorcycle and an SUV collided in Mount Albert, Ont., on Monday, Ontario Provincial Police say.

The Ontario Liberal Party is pledging to reduce the income tax rate for middle class families and eliminate provincial sales tax on hydro bills, if they win in the 2026 election.

Statistics Canada data reviewed by CBC Toronto shows a dramatic shift in criminal outcomes in Ontario over the last decade. The majority of criminal cases in the province have ended with charges being withdrawn, stayed, dismissed or discharged before a decision at trial since 2020.

Brampton has reached a tentative deal with nearly 1,200 city workers who have been on strike since last week, according to Mayor Patrick Brown and the union.

Sgt. Harman Dhaliwal, who is from Calgary, says he's proud to be a part of the growing exhibit that highlights the relationship between the Sikh faith and military service.

A new course offered to nursing students at the University of Calgary is shining a light on the impacts of colonization on the health experiences of Indigenous peoples.

Some Ukrainians living in Calgary say they're even more worried for their friends and family back home in light of Donald Trump's election win.

The provincial government is seeking contractors to restore hundreds of kilometres of land where fireguards were created during the 2023 wildfire season.

The Calgary-based team beat Hamilton Forge FC in a 2-1 nail-biter at home on Saturday, in front of a sold-out crowd of over 7,000 fans at Spruce Meadows.

New rebuilding regulations in Jasper have been approved, but roadblocks — including the sheer number of people that are needed for construction — are popping up.

After Canada Post workers gave a 72-hour notice to strike early Tuesday, some Calgary business owners are worried about what this means for holiday season sales. 

Eyare died of injuries she sustained while moving between back of house spaces, Wilder Institute director of animal care, health and welfare, Colleen Baird said Tuesday.

Charlottetown-born curler Brett Gallant says competing in the Olympics will be a dream come true for him and his fiancée, Jocelyn Peterman, even if COVID-19 protocols will make it difficult for them to see each other.

After COVID-19 challenges forced the cancellation of Canada's mixed doubles trials, several top curlers are anxiously waiting to learn whether they will be chosen to represent the country in the discipline at the Beijing Games.

It's not a complete surprise that curling and other sports have been cancelled because of the COVID-19 pandemic, but it doesn't make it any easier on teams that had their hopes of representing Northern Ontario at a national curling level dashed.

Laura Walker made a game-winning draw Sunday afternoon to win the Alberta women's curling playdowns and secure a berth in the upcoming national championship.

It’s official — Team Galusha will be representing the N.W.T. at the 2022 Scotties Tournament of Hearts in Thunder Bay later this month.

CME Group, the world's leading derivatives marketplace, today announced its new CBL Australian Carbon Credit Unit (ACCU) futures have launched and are available for trading. A total of five...

Record revenue of $1.6 billion Record quarterly ADV of 28.3 million contracts - the second consecutive quarter of volume, open interest growth across every asset class CHICAGO, Oct. 23, 2024...

CME Group, the world's leading derivatives marketplace, today announced it has received approval from the National Futures Association (NFA) to establish a futures commission merchant (FCM). "We...

CME Group, the world's leading derivatives marketplace, today announced that open interest in its global benchmark Henry Hub futures contract reached a record 1.73 million contracts on October 30,...

Indiana University took first place, with the rest of the top five from outside the United States Record participation from nearly 570 teams across 24 countries CHICAGO, Nov. 7, 2024 /PRNewswire/...

Mosquitoes transmit deadly pathogens from person to person as they obtain the blood meal that is essential for their life cycle. Female mosquitoes of many species are unable to reproduce without consuming protein that they obtain from blood. This developmental stage makes them highly efficient disease vectors of deadly pathogens. They can transmit pathogens between members of the same species and different species that can provide a route for evolving zoonotic viruses to jump from animals to humans. One possible way to develop novel strategies to combat pathogen transmission by mosquitoes is to study the sensory systems that drive mosquito reproductive behaviors, in particular the neural architecture and circuits of mosquito sensory afferent neurons, the central circuits that process sensory information, and the downstream circuits that drive reproductive behaviors. The study of mosquito neuroanatomy and circuitry also benefits basic neuroscience, allowing for comparative neuroanatomy in insect species, which has great value in the current model species-heavy landscape of neuroscience. Here, we introduce two important techniques that are used to study neuroanatomy and neural circuitry—namely, immunofluorescent labeling and neural tracing. We describe how to apply these approaches to study mosquito neuroanatomy and describe considerations for researchers using the techniques.

A researcher may have many reasons for wanting to establish new laboratory colonies from field-collected mosquitoes. In particular, the ability to study the diversity found within and among natural populations in a controlled laboratory environment opens up a wide range of possibilities for understanding how and why burdens of vector-borne disease vary over space and time. However, field-collected mosquitoes are often more difficult to work with than established laboratory strains, and considerable logistical challenges are involved in safely transporting field-collected mosquitoes into the laboratory. Here, we provide advice for researchers working with Aedes aegypti, Anopheles gambiae, and Culex pipiens, as well as notes on other closely related species. We provide guidance on each stage of the life cycle and highlight the life stages for which it is easiest to initiate new laboratory colonies for each species. In accompanying protocols, we provide methods detailing Ae. aegypti egg collection and hatching as well as how to transport larvae and pupae from the field.

Sleep is likely a whole-brain phenomenon, with most of the brain probably benefiting from this state of decreased arousal. Recent advances in our understanding of some potential sleep functions, such as metabolite clearance and synaptic homeostasis, make it evident why the whole brain is likely impacted by sleep: All neurons have synapses, and all neurons produce waste metabolites. Sleep experiments in the fly Drosophila melanogaster suggest that diverse sleep functions appear to be conserved across all animals. Studies of brain activity during sleep in humans typically involve multidimensional data sets, such as those acquired by electroencephalograms (EEGs) or functional magnetic resonance imaging (fMRI), and these whole-brain read-outs often reveal important qualities of different sleep stages, such as changes in frequency dynamics or connectivity. Recently, various techniques have been developed that allow for the recording of neural activity simultaneously across multiple regions of the fly brain. These whole-brain-recording approaches will be important for better understanding sleep physiology and function, as they provide a more comprehensive view of neural dynamics during sleep and wake in a relevant model system. Here, we present a brief summary of some of the findings derived from sleep activity recording studies in sleeping Drosophila flies and discuss the value of electrophysiological versus calcium imaging techniques. Although these involve very different preparations, they both highlight the value of multidimensional data for studying sleep in this model system, like the use of both EEG and fMRI in humans.

The establishment of neural connectivity is a major part of neural development. The central nervous system (CNS) midline is the most characterized axon guidance choice point, and work in Drosophila has played a pivotal role in understanding the molecular mechanisms responsible. Axons respond to attractive cues such as Netrin via the Frazzled receptor, and repulsive cues such as Slit via Robo receptors. Both signals are expressed at the CNS midline, affect pioneer axons, and have dramatic effects on the axon scaffold as a whole. Here, we focus on previous research analyzing classic mutants in the Slit/Robo pathway, which can readily be detected with a dissecting microscope. We also discuss analyzing these mutants in a teaching lab situation. The combination of sophisticated genetics and reliable axonal markers in Drosophila allows phenotypic analysis to be performed at the single-cell level. The elaborate architecture of neurons is very sensitive to disruption by genetic mutations, allowing the effects of novel mutations to be easily detected and assessed.

CRISPR–Cas9 has revolutionized gene editing for traditional and nontraditional model organisms alike. This tool has opened the door to new mechanistic studies of basic mosquito biology as well as the development of novel vector control strategies based on CRISPR–Cas9, including gene drives that spread genetic elements in the population. Although the promise of the specificity, flexibility, and ease of deployment CRISPR is real, its implementation still requires empirical optimization for each new species of interest, as well as to each genomic target within a given species. Here, we provide an overview of designing and testing single-guide RNAs for the use of CRISPR-based gene editing tools.

The host associations of mosquitoes vary by species, with some species being relative generalists, whereas others specialize, to varying extents, on a particular subset of the available host community. These host associations are driving factors in transmission dynamics of mosquito-vectored pathogens. For this reason, characterizing the host associations of mosquito species is critical for understanding the epidemiology of mosquito-vectored pathogens. Diverse methods have been used to associate mosquito species with their hosts. These typically include collecting mosquitoes that bite a restrained host (bait) or collecting wild blood-engorged mosquitoes and matching their blood meal to reference samples (blood meal analysis). Blood meal analysis refers to a collection of molecular techniques for determining the taxonomic identity of the source of a mosquito blood meal using cytological, serological, or DNA-based characteristics of the blood meal. Blood meal analyses that are based on DNA markers have advantages over cytological and serological methods and are effective for determining species-level identities of hosts from a broad range of potential host taxa. Here, we discuss effective techniques for analyzing blood meals.

She only came for a week, but impacted lives of several families with children with autism. Isabel Black shares about her experiences in Montenegro.

Can young people be united in faith, irrespective of their ethnic background? The answer is yes!

OM uses a team car to transport teenagers with autism to Montenegro's only special needs school. But a better car is needed to continue.

OMers visit the beachfront cafes for weekly Bible study, seeking to bless the businesses and share God's love all year round.