Type 1 diabetes is an autoimmune-mediated disease that culminates in the targeted destruction of insulin-producing β-cells. CD4 responses in NOD mice are dominated by insulin epitope B:9-23 (InsB_9-23) specificity, and mutation of the key T-cell receptor (TCR) contact residue within the epitope prevents diabetes development. However, it is not clear how insulin self-antigen controls the selection of autoimmune and regulatory T cells (Tregs). Here we demonstrate that mutation of insulin epitope results in escape of highly pathogenic T cells. We observe an increase in antigen reactivity, clonality, and pathogenicity of insulin-specific T cells that develop in the absence of cognate antigen. Using a single TCR system, we demonstrate that Treg development is greatly diminished in mice with the Y16A mutant epitope. Collectively, these results suggest that the tyrosine residue at position 16 is necessary to constrain TCR reactivity for InsB_9-23 by both limiting the development of pathogenic T cells and supporting the selection of Tregs.

These fact sheets provide a sketch of key characteristics of the foreign-born and English Learner (EL) populations in select states. The fact sheets look at the demographics of these states, discuss EL student outcomes as measured by standardized tests, and conclude with an overview of state accountability mechanisms that affect ELs under relevant provisions of the Every Student Succeeds Act and predecessor No Child Left Behind Act.

States are in the midst of designing new policies to hold schools accountable for the education of English Learner (EL) students, as mandated by the federal Every Student Succeeds Act (ESSA). This series of fact sheets sketches the characteristics of immigrant and EL students in 25 states, the gaps between their educational outcomes and those of their peers, and the accountability policies each state is developing.

Martha M. Funnell
Jul 1, 2004; 22:123-127
Feature Articles

Evan M. Benjamin
Jan 1, 2002; 20:
Practical Pointers

A "Shoeless" Joe Jackson baseball card from 1910 sold at auction for $492,000 this week.

Linda Haas
Jan 1, 2014; 37:S144-S153
National Standards

T A Welborn
Mar 1, 1979; 2:154-160
Proceedings of the Kroc Foundation International Conference on Epidemiology of Diabetes and its Macrovascular Complications

William L Clarke
Sep 1, 1987; 10:622-628
Technical Article

The Department of Defense announced this week that effective Aug. 1, retailers on U.S. military installations and bases will no longer sell tobacco products to anyone under the age of 21, including service members.

Joni Beck
Oct 1, 2017; 40:1409-1419
National Standards

ADNOC sold a 20 percent state in its refinery operations to Italy's Eni and 15 percent to OMV, from Austria in one of the biggest refinery transactions ever.

Chevron bought a Houston refinery for $350 million from Petrobras that had cost the Brazilian state oil company over $1.2 billion little over a decade earlier.

OBJECTIVE

To examine whether low baseline diastolic blood pressure (DBP) modifies the effects of intensive systolic blood pressure (SBP) lowering on cardiovascular outcomes in type 2 diabetes mellitus (T2DM).

OBJECTIVE

The aim of this study was to examine the association of circulating retinol-binding protein 4 (RBP4) levels with β-cell function across the spectrum of glucose tolerance from normal to overt type 2 diabetes.

With the U.S. administration calling for the United States to adopt a more “merit-based” immigrant selection system, this conversation focused on what policymakers should consider in designing—and managing—immigrant selection systems in a time of intense labor-market and demographic change.

Since its launch in 2015, the Express Entry system has changed how economic immigration to Canada happens and how it fits into public and political debates. And while it has proven successful in cutting through application backlogs, some challenges remain. This report looks at how and why this points-based system was introduced, what its impact has been, and how it could be further finetuned.

MPI and OECD experts discuss what policymakers should consider in designing and managing immigrant selection systems in a time of intense labor-market and demographic change.

The Trump administration’s plan to create a "merit-based" U.S. immigration system, lessening the longstanding focus on family reunification in favor of more economic migrants, has met with a lackluster response from Democrats and Republicans alike. This Policy Beat article explores how the Trump proposal would reshape immigration to the United States, and how it compares to selection systems in other countries and past debates about changing the U.S. system.

I woke up a few days ago and forgave myself. For everything. It was ok to be me and every decision I had made, good or bad, was part of...

Since the mid-1990s, Australia has moved away from a focus on family reunification to place greater emphasis on workers coming via temporary and permanent channels. The evolution of the country's points-based model for selecting economic migrants and move to a predominately employer-driven system offer lessons for other countries that seek to develop a tailored and targeted immigration selection system.

As technological developments—from automation to artificial intelligence and machine learning—reshape the world of work, governments face the challenge of updating how they attract, select, and retain economic-stream immigrants. This report, concluding a series on building migration systems for a new age of economic competitiveness, lays out the key considerations for "future-proofing" immigrant selection systems.

Neither approach is ideal. The best option is to temper your negative emotions by focusing on positive ones

-- Read more on ScientificAmerican.com

In the interest of promoting democracy, Pakistan's president, Gen. Pervez Musharraf, recently announced that he had to lock up most of his country's democracy activists. And because he wanted the Pakistani Supreme Court to independently rule on whether he could continue as president, Musharraf also...

Social psychologist William B. Swann once had a group of married people evaluate their spouses even as their spouses evaluated them. People with high self-esteem, the psychologist found, felt closer to their partners when they received positive evaluations. People with low self-esteem, however, felt...

Here's a trick question, so think carefully before you answer: If someone mentions the word "beast" to you, which word would you match it with?

Across the United States, nearly 2 million immigrants with college degrees are unemployed or stuck in low-skilled jobs. This skill underutilization, known as “brain waste,” varies significantly by state. These fact sheets offer a profile of these highly skilled immigrants and estimate their forgone earnings and resulting unrealized tax receipts in eight states: California, Florida, Michigan, New York, Ohio, Oregon, Texas, and Washington.

Brussels and Gütersloh, 05.03.2020 — Anticipated reform of the Common European Asylum System (CEAS), which was high on the agenda as nearly 2 million asylum seekers arrived at Europe’s door in 2015-16, quickly fell victim to EU Member State competing views on what constitutes equal burden-sharing, domestic politics around migration and the urgency of first addressing overtaxed national asylum systems.

This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, shared by Hetty McKinnon, founder of Surry Hills community kitchen Arthur Street Kitchen and author of 'Neighbourhood'.

Roger Federer has returned to winning mode 10 months after his last title, as the home tennis hero schooled Japanese wild card Kei Nishikori 6-1, 6-3 to win a fifth Swiss Indoors title in Basel.

When we announced our v13 update, we mentioned a new feature called Email Digests that we’ll explain further in this…

Margaret A. Powers
Apr 1, 2016; 34:70-80
Position Statements

Evan M. Benjamin
Jan 1, 2002; 20:
Practical Pointers

Christine A. Beebe
Jul 1, 2011; 29:123-126
Practical Pointers

Daren Anderson
Jan 1, 2008; 26:22-27
Bridges to Excellence

Martha M. Funnell
Jul 1, 2004; 22:123-127
Feature Articles

CALL FOR PAPERSINTERNATIONAL WORKSHOP Shaping the ‘Socialist Self’? The Role of Psy-Sciences in Communist States of the Eastern Bloc (1948–1989) Date: 6 November 2020 Venue: Prague, Czech Republic Deadline for applications: 30 June 2020 Organizing institutions: CEFRES (French Research Center in Humanities and Social Sciences in Prague) Institute of Contemporary History of the Czech Academy of Sciences Collegium Carolinum … Continue reading CfP: Shaping the ‘Socialist Self’? The Role of Psy-Sciences in Communist States of the Eastern Bloc (1948–1989) →

With the covid-19 pandemic now affecting virtually every country on earth, it is understandable that much of the world’s focus has been on protecting people’s physical health. Hand washing and social distancing is important in the fight against the coronavirus. However, it is important to remember that mental health issues may lead to loss of […]

"Life's beauty is inseparable from its fragility," says psychologist Susan David. In a special virtual conversation, she shares wisdom on how to build resilience, courage and joy in the midst of the coronavirus pandemic. Responding to listeners' questions from across the globe, she offers ways to talk to your children about their emotions, keep focus during the crisis and help those working on the front lines. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and current affairs curator Whitney Pennington Rodgers. Recorded March 23, 2020)

Curtis Jones, a U.S. Army veteran who has led Georgia's Bibb County school system since 2015, has been named the 2019 AASA National Superintendent of the Year.

New take on the traditional story of Hansel and Gretel, with the two children becoming world-famous food critics.

Self-actualization (Psychology)