ic Monolith stationary phases prepared via cyclic anhydride ring-opening polymerization as tunable platforms for chromatographic applications By pubs.rsc.org Published On :: Anal. Methods, 2024, Accepted ManuscriptDOI: 10.1039/D4AY00251B, PaperAhmad Aqel, Ayman Ghafr, A. Yacine Badjah-Hadj-Ahmed, Zeid Abdullah ALOthmanPolymer monolithic stationary phases were prepared based on a cyclic anhydride as a reactive and tunable platform via ring-opening post-polymerization using primary amines; octadecylamine and benzylamine. The characterization techniques indicated...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic A colorimetric tandem combination of CRISPR/Cas12a with dual functional hybridization chain reaction for ultra-sensitive detection of mycobacterium bovis By pubs.rsc.org Published On :: Anal. Methods, 2024, Accepted ManuscriptDOI: 10.1039/D3AY02200E, PaperQiong Liu, Mei Yang, He Zhang, Wenjie Ma, Xin Fu, Huiqing Li, Sainan GaoTuberculosis caused by Mycobacterium bovis poses a global infectious threat to humans and animals. Therefore, there is an urgent need to develop a sensitive, precise, and easy-to-readout strategy. Here, a...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Detecting Specific Text Input with HTML and CSS By www.impressivewebs.com Published On :: Wed, 20 Oct 2021 01:06:49 +0000 Recently I came across a CodePen demo by a developer/engineer named Jane that was Tweeted out by Šime Vidas. The demo has a neat collection of HTML and CSS tricks rolled into one that I thought was worth examining in detail. The page displays a secret message based on specific text input. Ok, that’s no big deal, right? Well this is done using pure HTML and CSS – no JavaScript. I’ve seen stuff like this before, but I thought it would be cool to break down exactly how this works. There are a few notable things happening in the code so I’ll break down each of the parts. The post Detecting Specific Text Input with HTML and CSS appeared first on Impressive Webs. Full Article CSS HTML5 Web Design Tutorials
ic More 'dead' mobile services? By www.thehindubusinessline.com Published On :: Tue, 19 Mar 2013 16:29:07 +0530 Full Article R Dinakaran
ic QR codes for security in vehicles By www.thehindubusinessline.com Published On :: Tue, 03 Sep 2013 16:32:33 +0530 Full Article R Dinakaran
ic Pictures from the dear departed By www.thehindubusinessline.com Published On :: Thu, 19 Sep 2013 16:09:14 +0530 Full Article R Dinakaran
ic BSNL customer service changing for the better By www.thehindubusinessline.com Published On :: Thu, 09 Jan 2014 15:55:31 +0530 Full Article R Dinakaran
ic Unrealistic expectations: On India and Russia-Ukraine peace By www.thehindu.com Published On :: Mon, 16 Sep 2024 00:37:00 +0530 India’s efforts at peacemaking between Russia and Ukraine have limited potential Full Article Editorial
ic Third front: On the expanding nature of the conflict in West Asia By www.thehindu.com Published On :: Wed, 18 Sep 2024 00:10:00 +0530 Israel’s fighting three enemy militias at once highlights the pressing need for a ceasefire Full Article Editorial
ic Sri Lanka’s verdict: On the Island nation’s ninth Presidential election By www.thehindu.com Published On :: Mon, 23 Sep 2024 00:10:00 +0530 The spirit of the mandate of the presidential poll was clear — for change Full Article Editorial
ic Politicising the laddu: On the Tirupati laddu and its ‘adulteration’ By www.thehindu.com Published On :: Tue, 24 Sep 2024 00:30:00 +0530 The Tirupati laddu issue should be limited to one of quality control Full Article Editorial
ic It is an offence: On Supreme Court clarification on online content on child sex abuse By www.thehindu.com Published On :: Wed, 25 Sep 2024 00:10:00 +0530 Court has done well to clarify law on online content showing child sex abuse Full Article Editorial
ic Rogue state: On Israel’s conflict with Hezbollah By www.thehindu.com Published On :: Thu, 26 Sep 2024 00:10:00 +0530 Israel is choosing war over peace, escalation over compromise Full Article Editorial
ic Kashmir conflict: On the J&K elections By www.thehindu.com Published On :: Thu, 26 Sep 2024 00:20:00 +0530 The political divide between national parties and regional parties is clear Full Article Editorial
ic Judge and prejudice: On conduct in judicial proceedings By www.thehindu.com Published On :: Fri, 27 Sep 2024 00:10:00 +0530 Judicial officers must be mindful of language that reveal bias Full Article Editorial
ic Staying the course: On the fight against air pollution in the Indo-Gangetic plains By www.thehindu.com Published On :: Sat, 28 Sep 2024 00:10:00 +0530 The Centre and the States need to fight air pollution together Full Article Editorial
ic Demand flux: On growth dynamics By www.thehindu.com Published On :: Mon, 30 Sep 2024 00:20:00 +0530 Growth dynamics may falter with waning urban consumption Full Article Editorial
ic Inflection point: On the escalation in the multi-party West Asia conflict By www.thehindu.com Published On :: Thu, 03 Oct 2024 00:20:00 +0530 West Asia needs the intervention of major world powers for peace Full Article Editorial
ic Regulation role: On the 2024 Medicine Nobel By www.thehindu.com Published On :: Tue, 08 Oct 2024 00:36:00 +0530 The discovery of microRNA changed the understanding of gene regulation Full Article Editorial
ic Deep roots: On the 2024 Physics Nobel Prize By www.thehindu.com Published On :: Wed, 09 Oct 2024 00:10:00 +0530 Physics Nobel Prize acknowledges the diverse foundations of AI Full Article Editorial
ic Deeper role: On the U.S. and West Asia conflicts By www.thehindu.com Published On :: Wed, 16 Oct 2024 00:10:00 +0530 The escalating conflict cycle in West Asia could have disastrous consequences Full Article Editorial
ic Canadian frostbite: On the India-Canada diplomatic war By www.thehindu.com Published On :: Thu, 17 Oct 2024 00:20:00 +0530 India must consider the impact of its next steps on its diplomacy and image Full Article Editorial
ic Fate of nations: On the 2024 Economics Nobel By www.thehindu.com Published On :: Sat, 19 Oct 2024 00:10:00 +0530 The 2024 Nobel recognises the need for ‘inclusive’ institutions Full Article Editorial
ic Complicit: On India and the U.S and Canada cases By www.thehindu.com Published On :: Mon, 21 Oct 2024 00:30:00 +0530 India must come clean on its stance on transnational killings Full Article Editorial
ic Growth prescription: On the latest World Economic Outlook By www.thehindu.com Published On :: Thu, 24 Oct 2024 00:20:00 +0530 The IMF’s ‘mediocre’ medium-term outlook merits policy attention Full Article Editorial
ic Building blocks: On the 16th BRICS Summit in Kazan By www.thehindu.com Published On :: Fri, 25 Oct 2024 00:24:00 +0530 The BRICS Summit showed that Russia was not without friends Full Article Editorial
ic Beyond intoxication: On alcohol regulation, judicial verdict By www.thehindu.com Published On :: Mon, 28 Oct 2024 00:20:00 +0530 Batting for States, the Supreme Court of India holds federal balance on regulating alcohol Full Article Editorial
ic Escalation ladder: On conflict between Israel and Iran By www.thehindu.com Published On :: Tue, 29 Oct 2024 00:15:00 +0530 Iran should show strategic restraint; and the world should rein in Israel Full Article Editorial
ic Sun signs: On extreme heat and Tamil Nadu’s policy decision By www.thehindu.com Published On :: Thu, 31 Oct 2024 00:10:00 +0530 States should prepare to assist the vulnerable during extreme heat events Full Article Editorial
ic Pathogenesis of Alzheimer's disease and therapeutic strategies involving traditional Chinese medicine By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00660G, Review ArticleShutang Li, Jinfei YangAs research on AD has progressed, TCM and its active ingredients have increasingly played a crucial role in clinical treatment. This article summarizes extracts from TCM and briefly elucidates their pharmacological mechanisms against AD.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic The role of silicon in drug discovery: a review By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3286-3344DOI: 10.1039/D4MD00169A, Review Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jenny-Lee Panayides, Darren Lyall Riley, Felix Hasenmaile, Willem A. L. van OtterloThis review aims to highlight the role of silicon in drug discovery.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Integrating amino acids into Bcr-Abl inhibitors: design, synthesis, biological evaluation, and in silico studies By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3507-3528DOI: 10.1039/D4MD00417E, Research ArticleYuying Liu, Zeyu Yang, Jie Zhang, Na Guo, Nanxin Liu, Qingqing Zhang, Xintao Dang, Yanchen Li, Jie Zhang, Xiaoyan PanIn continuation of our previous research, a series of novel Bcr-AblT315I inhibitors with tert-leucine or serine as a flexible linker were developed and biological evaluation was performed in vitro.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Synthesis and cytotoxic activity of madecassic acid–silybin conjugate compounds in liver cancer cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3418-3432DOI: 10.1039/D4MD00170B, Research Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Chien Van Tran, Thao Thi Phuong Tran, Anh The Nguyen, Loc Van Tran, Ninh Thi Pham, Luu Thi Nguyen, Dung Thi Nguyen, Michelle D. Garrett, Nga Thi Nguyen, Thao Thi Do, Christopher J. Serpell, Sung Van TranMadecassic acid and silybin have been conjoined to produce hybrid compounds with improved and different activity against liver cancer cells.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Semisynthetic phytochemicals in cancer treatment: a medicinal chemistry perspective By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3345-3370DOI: 10.1039/D4MD00317A, Review ArticleMeghna Arora, Ankit Kumar Singh, Adarsh Kumar, Harshwardhan Singh, Prateek Pathak, Maria Grishina, Jagat Pal Yadav, Amita Verma, Pradeep KumarSemisynthetic phytochemicals in cancer treatment.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic A comprehensive apoptotic assessment of niloticin in cervical cancer cells: a tirucallane-type triterpenoid from Aphanamixis polystachya (Wall.) Parker By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3444-3459DOI: 10.1039/D4MD00318G, Research ArticleAnuja Gracy Joseph, Mohanan Biji, Vishnu Priya Murali, Daisy R. Sherin, Alisha Valsan, Vimalkumar P. Sukumaran, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar MaitiNiloticin, a triterpenoid from Aphanamixis polystachya, induces apoptosis in HeLa cells which is primarily validated through in silico analysis and subsequently in vitro apoptotic evaluation by modulating the apoptotic proteins.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Pyridazinone-based derivatives as anticancer agents endowed with anti-microbial activity: molecular design, synthesis, and biological investigation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3529-3557DOI: 10.1039/D4MD00481G, Research ArticleMohamed K. S. El-Nagar, Mai I. Shahin, Mohammed F. El-Behairy, Ehab S. Taher, Mohamed F. El-Badawy, Marwa Sharaky, Dalal A. Abou El Ella, Khaled A. M. Abouzid, Mai AdelDiscovery of novel pyridazinone derivatives with dual antimicrobial and anticancer activities.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Design, synthesis and biological evaluation of a novel PSMA–PI3K small molecule drug conjugate By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3485-3494DOI: 10.1039/D4MD00246F, Research ArticleShouguo Peng, Haixia Li, Weilu Cui, Tianning Xiong, Jiaqi Hu, Haixiang Qi, Songwen Lin, Deyu Wu, Ming Ji, Heng XuA novel PSMA–PI3K small molecule drug conjugate has been prepared, highlighting its potential in targeted cancer therapy.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Exploring apoptotic induction of malabaricone A in triple-negative breast cancer cells: an acylphenol phyto-entity isolated from the fruit rind of Myristica malabarica Lam. By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3558-3575DOI: 10.1039/D4MD00391H, Research ArticlePothiyil S. Vimalkumar, Neethu Sivadas, Vishnu Priya Murali, Daisy R. Sherin, Madhukrishnan Murali, Anuja Gracy Joseph, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar MaitiMalabaricone A isolated from Myristica malabarica induces apoptosis in triple-negative breast cancer cells through intrinsic and extrinsic pathways, which is validated through in vitro and in silico studies and resembles a potent phyto-entity.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Exploring 7β-amino-6-nitrocholestens as COVID-19 antivirals: in silico, synthesis, evaluation, and integration of artificial intelligence (AI) in drug design: assessing the cytotoxicity and antioxidant activity of 3β-acetoxynitrocholestane By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00257A, Research Article Shahabuddin, Uzma, Mohammad Azam, Mehtab Parveen, Nurul Huda Abd Kadir, Kim Min, Mahboob AlamIn light of the ongoing pandemic caused by SARS-CoV-2, effective and clinically translatable treatments are desperately needed for COVID-19 and its emerging variants.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Introduction to the themed collection on ‘AI in Medicinal Chemistry’ By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3284-3285DOI: 10.1039/D4MD90035A, EditorialJian Zhang, Ola Engkvist, Gerhard HesslerJian Zhang, Ola Engkvist and Gerhard Hessler introduce the RSC Medicinal Chemistry themed collection on ‘AI in Medicinal Chemistry’.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Inhibition of monoamine oxidases by heterocyclic derived conjugated dienones: synthesis and in vitro and in silico investigations By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00608A, Research ArticleSunil Kumar, Bishnu Prasad Pandey, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Rania B. Bakr, Hoon Kim, Bijo MathewA total of 18 heterocyclic derived conjugated dienones (CD1–CD18) were evaluated for their potential monoamine oxidase (MAO)-A/-B inhibitory activity.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Therapeutic upregulation of DNA repair pathways: strategies and small molecule activators By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00673A, Review ArticleJuhyung Song, Cheoljun Park, Francis E. B. Cabanting, Yong Woong JunPotential therapeutic target proteins for upregulating DNA repair system are reviewed, along with reported small-molecule activators.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Synthesis and biological evaluation of novel D-ring fused steroidal N(2)-substituted-1,2,3-triazoles By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00297K, Research ArticleBranislava Tenjović, Sofija Bekić, Andjelka Ćelić, Edward Petri, Julia Scholda, Florian Kopp, Marija Sakač, Andrea NikolićIn this study, a series of 13 new D-ring fused steroidal N(2)-substituted-1,2,3-triazoles were synthesized, characterized and evaluated for their biological activities.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Design and Synthesis of coumarin-based amphoteric antimicrobials with the biofilm interference and immunoregulation effects By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00721B, Research ArticleQun Tang, Haiyang Zhang, Kasemsiri Chandarajoti, Zirui Jiao, Lianhua Nie, Sai Lv, Jiakun Zuo, Wen Zhou, Xiangan HanBacterial infections pose a threat to the health of animals and human being, and the biofilm formation exacerbates the microbial threat. New antimicrobial agents to address this challenge are much...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Modulating polybasic character of galactose-based glycosylated antitumor ether lipids for enhanced cytotoxic response By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00662C, Research ArticleRajat Arora, Ayan Mukherjee, Gilbert Arthur, Mark W. Nachtigal, Frank SchweizerWe describe the multi-step synthesis of different dibasic and tribasic galactosamine-based glycosylated antitumor ether lipids (GAELs) and their cytotoxic response in comparison to doxorubicin and cisplatin.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00594E, Research ArticleNagat Ghareb, Khaled M. Darwish, Mohamed S. Nafie, Ranwa Elrayess, Noha M. Abourobe, Shaimaa A. Fattah, Reem M. Hazem, Eman T. Mehanna, Ranza ElrayessOne benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Design, synthesis and mechanistic insights into triclosan derived dimers as potential anti-plasmodials By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00494A, Research Article Shekhar, Shefali Chowdhary, Joel Mosnier, Isabelle Fonta, Bruno Pradines, Vipan KumarIn pursuit of novel anti-plasmodial agents, a library of triclosan-based dimers both with and without a 1H-1,2,3 triazole core were designed, synthesized and evaluated in order to achieve a multitargeted approach.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Breaking boundaries in diabetic nephropathy treatment: design and synthesis of novel steroidal SGLT2 inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00645C, Research ArticleGeetmani Singh Nongthombam, Semim Akhtar Ahmed, Kangkon Saikia, Sanjib Gogoi, Jagat Chandra BorahVirtual screening and synthetic modification of natural product-derived steroidal precursors as potential SGLT2 inhibitors for the treatment of diabetic nephropathy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Human microbiome derived synthetic antimicrobial peptides with activity against Gram-negative, Gram-positive, and antibiotic resistant bacteria By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00383G, Research Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Walaa K. Mousa, Ashif Y. Shaikh, Rose Ghemrawi, Mohammed Aldulaimi, Aya Al Ali, Nour Sammani, Mostafa Khair, Mohamed I. Helal, Farah Al-Marzooq, Emilia OueisAn AMP-derived short 15-mer peptide and its cyclic derivatives have low micromolar broad spectrum antibacterial activity, with rapid onset of bactericidal effect and a membrane-targeting mode of action.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Amides of moronic acid and morolic acid with the tripeptides MAG and GAM targeting antimicrobial, antiviral and cytotoxic effects By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00742E, Research Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Uladzimir Bildziukevich, Lucie Cerna, Jana Trylčová, Marie Kvasnicova, Lucie Rárová, David Šaman, Petra Lovecká, Jan Weber, Zdenek WimmerA series of amides of the selected plant triterpenoids, moronic acid and morolic acid, with the tripeptides MAG and GAM was designed and synthesized. Two required tripeptides 5 and 10...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
