the Metal-free synthesis of N-fused quinazolino-quinazoline-diones as a MALAT1 RNA triple helix intercalator By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00614C, Research ArticleVijay Babu Pathi, Pranotosh Das, Abhyuday Guin, Manish Debnath, Biswadip BanerjiThe development of chemical scaffolds that target highly conserved MALAT1 RNA received attention due to its significance in splicing, nuclear organization, and gene expression in disease progression pathways.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
the Enhancing the antimycobacterial efficacy of pyridine-4-carbohydrazide: linkage to additional antimicrobial agents via oxocarboxylic acids By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00663A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Václav Pflégr, Klára Konečná, Jiřina Stolaříková, Jan Ősterreicher, Ondřej Janďourek, Martin KrátkýLinking pyridine-4-carbohydrazide to other antimicrobial agents via oxocarboxylic acids significantly enhances efficacy against mycobacteria with promising selectivity and safety profiles.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
the Synthesis of cationic N-acylated thiazolidine for selective activity against Gram-positive bacteria and evaluation of N-acylation's role in membrane-disrupting activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00626G, Research ArticleAleena Pious, Vignesh Venkatasubramanian, Dharshini Karnan Singaravelu, Subburethinam Ramesh, Fuad Ameen, Anbazhagan VeerappanLipidation modulates the Gram-selective antibacterial activity of QPyNATh.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
the Synthesis, in silico and bio-evaluation studies of new isothiocyanate derivatives with respect to COX inhibition and H2S release profiles By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00495G, Research ArticleYakup Berkay Yilmaz, Tuğba Güngör, Serhat Dönmez, Hazal Nazlıcan Atalay, Pınar Siyah, Serdar Durdağı, Mehmet Ay, Tugba Boyunegmez TumerNew isothiocyanate derivatives (I1–3 and I1a–e) were synthesized and screened for their anti-inflammatory activities and H2S-releasing capacities. Compounds I1 and I1c demonstrated the most potent and selective COX-2 inhibition.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
the meso-Substituted AB3-type phenothiazinyl porphyrins and their indium and zinc complexes photosensitising properties, cytotoxicity and phototoxicity on ovarian cancer cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00601A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Brém Balázs, Bianca Stoean (Vasile), Éva Molnár, Eva Fischer-Fodor, Ovidiu Bălăcescu, Raluca Borlan, Monica Focsan, Adriana Grozav, Patriciu Achimaş-Cadariu, Emese Gál, Luiza GainaNew meso-substituted AB3-type phenothiazinyl porphyrins and ferrocenylvinyl phenothiazinyl porphyrin were synthesised by Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions, respectively.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
the Generation and capture of naphthoquinonynes: a new frontier in the development of trypanocidal quinones via aryne chemistry By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00558A, Research ArticleLaura P. R. Figueroa, Renato L. de Carvalho, Renata G. Almeida, Esther R. S. Paz, Emilay B. T. Diogo, Maria H. Araujo, Warley S. Borges, Victor F. S. Ramos, Rubem F. S. Menna-Barreto, James M. Wood, John F. Bower, Eufrânio N. da Silva JúniorThis article presents A-ring functionalized quinones via a modern and efficient new strategy involving the generation and capture of benzyne quinones and their evaluation against Trypanosoma cruzi.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
the Light enhanced cytotoxicity and antitumoral effect of a ruthenium-based photosensitizer inspired from natural alkaloids By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00600C, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Gennaro Sanità, Maria Laura Alfieri, Barbara Carrese, Serena Damian, Vincenza Mele, Gaetano Calì, Brigida Silvestri, Sebastiano Marra, Susan Mohammadi, Giuseppina Luciani, Paola Manini, Annalisa LambertiBiological assays carried out on melanoma and breast cancer cells highlighted the role of light in boosting the cytotoxic effect of a ruthenium complex featuring a dihydroisoquinoline ligand suggesting applications in photodynamic therapy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
the 3-Thio-3,4,5-Trisubstituted-1,2,4-Triazoles: High Affinity Somatostatin Receptor-4 Agonist Synthesis and Structure-Activity Relationships By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00597J, Research ArticleAlbert Michael Crider, Audrey Hospital, Karin Sandoval, William Neumann, Stephen Kukielski, Lejla Garic, Kristen Ingold, Matthew Dunahoo, Khush Srabony, Rafael Frare, Olivia Slater, Nathan Peel, Maria Kontoyianni, Ken WittSomatostatin receptor-4 (SST4) is a therapeutic target for several conditions, including Alzheimer’s disease, seizures, neuropsychiatric disorders, and pain. Our previous work on 1,2,4-triazole derivatives led to enhanced SST4 binding affinity,...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
the A practical guide for the assay-dependent characterisation of irreversible inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00707G, Review ArticleLavleen K. Mader, Jessica E. Borean, Jeffrey W. KeillorKinetic evaluations for assay dependent characterization of irreversible inhibitors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
the Synthesis and antifungal evaluation of new azole derivatives containing 1,2,3-triazole By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00724G, Research ArticleZhengxiao Huang, Hongjie Chen, Xiao Zhang, Ruirui Wang, Chunyan Hu, Zewei MaoA series of novel azole derivatives containing 1,2,3-triazole have been synthesized with good antifungal effects on sensitive and drug-resistant C. albicans.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
the Property owners block the entrance to Balasubramanya temple in Karur By www.thehindu.com Published On :: Thu, 07 Nov 2024 17:35:45 +0530 Full Article Tiruchirapalli
the HR&CE plans to bring properties around the Vennaimalai Temple under tenants list By www.thehindu.com Published On :: Thu, 07 Nov 2024 19:36:32 +0530 The HR&CE department has cleared 34 properties around the Balasubramanyaswamy Temple at Vennaimalai in Karur district as per the High Court orders Full Article Tiruchirapalli
the Uppiliyapuram, gateway to scenic Pachamalai, lacks bus stand with passengers left to fight the elements By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:20:03 +0530 Buses stop at a busy junction making it difficult for commuters as well as local businessmen; a site is yet to be identified for the bus stand Full Article Tiruchirapalli
the Live Cricket Scores, Cricket News, Analysis, Results & More | The Hindu By www.thehindu.com Published On :: Full Article
the 542: Breaking Up with CSS-in-JS, Mastodon, and Stories on the Web By shoptalkshow.com Published On :: Mon, 21 Nov 2022 08:00:51 +0000 We're talking CSS-in-JS, Token CSS, Matuzo being suspended from Twitter, trying out Mastodon, testing out stable diffusion, stories on the web, and Jake Albaugh's new social network. Full Article All Episodes CSS mastodon stories Twitter
the 543: Zach Leatherman on Eleventy, Mastodon, Twitter, and is-land By shoptalkshow.com Published On :: Tue, 29 Nov 2022 16:30:32 +0000 Zach Leatherman talks with us about what's new with Eleventy, setting up on Mastodon, what's happened with Twitter, and is-land. Full Article All Episodes eleventy mastodon Twitter Web Components
the 555: React Documentary, Front of the Front End, Fast Fallacy, and Best Practices By shoptalkshow.com Published On :: Mon, 06 Mar 2023 09:39:37 +0000 Reacting to the React.js documentary, is there still jobs for front of the front end anymore? The fast fallacy in frameworks, best practices, dealing with too much or too little isolation, and AI test generation. Full Article All Episodes applying for a job React Tests
the 557: ChatGPT, Conferences, Fidgets on the Web, and Modern CSS in Real Life By shoptalkshow.com Published On :: Mon, 20 Mar 2023 07:01:51 +0000 When will AI be able to tell you the risk / reward of cleaning up trees? Are conferences back? Bringing fidgets to the web, internet as an anxiety machine, and Chris is working on talk on modern CSS in real life. Full Article All Episodes AI chatgpt Conferences CSS fidgets
the 563: Getting Pulled by the Algorithm, AI Training Data, and SVG Drawing By shoptalkshow.com Published On :: Mon, 01 May 2023 08:51:30 +0000 There's a special guest on the show who takes aim at the billionaires in web dev, do we know better than the algorithm for news, why is AI training data such a secret, Chris and Dave discover JetBrains, monorepo struggles, and SVG drawing tools. Full Article All Episodes AI JetBrains PHP
the 565: The Hurdy-Gurdy, OKLCH, Edge Dev Tools, and Ad Blocking By shoptalkshow.com Published On :: Mon, 15 May 2023 08:20:15 +0000 Dave doesn't hate the hurdy-gurdy, but it's creation is an interesting parallel to software development. OKLCH follow up, @media, Edge drops new dev tools, CSS and Astro theming, JavaScript devs discover PHP, how many people block ads, and accessibility and grids. Full Article All Episodes Accessibility edge oklch
the 574: Estelle & Eric on CSS The Definitive Guide, 5th Edition By shoptalkshow.com Published On :: Mon, 17 Jul 2023 09:38:57 +0000 Estelle Weyl and Eric Meyer join us to talk about the 5th edition of their book, CSS: The Definitive Guide. We talk about some of CSS' biggest blunders, custom scroll bars, single line comments, shorthand in CSS, useless CSS trivia, and how to get started learning CSS in 2023. Full Article All Episodes CSS outline trivia
the 575: CSS Errors, Proxy and Reverse Proxy, and What’s The Edge? By shoptalkshow.com Published On :: Mon, 24 Jul 2023 09:00:16 +0000 Bluesky adds first class support for urls as a username, text-wrap pretty update, sqwunching text update, should CSS spit out errors, anchor functionality, what does the edge mean, eSports and bowling, how to test websites on slower CPUs, and what does proxy or reverse proxy mean? Full Article All Episodes edge proxy text-wrap
the 580: Chen Hui Jing and the State of CSS Survey for 2023 By shoptalkshow.com Published On :: Mon, 28 Aug 2023 08:13:32 +0000 We're talking the State of CSS Survey, 2023 Edition, with Chen Hui Jing. What was it like helping develop the survey? A bit of follow up on regions, the benefits of being able to tell the browser what you want, language issues in developing and understanding CSS, the struggle for non-majority users, CSS frameworks, and more. Full Article All Episodes CSS survey
the 592: Web Component Therapy, SEO Therapy, and Learning Something New like Swift By shoptalkshow.com Published On :: Mon, 20 Nov 2023 08:30:40 +0000 Talking web components, progressive enhancement, style-able components, having to pay before you get to see a demo, being annoyed at the business of SEO, and subscriptions vs ads. Full Article All Episodes markdown SEO Web Components
the 596: The Year of AI, Arc, and Being Mad About the Right Thing By shoptalkshow.com Published On :: Mon, 18 Dec 2023 09:03:32 +0000 Looking back at the year of AI, using Arc on macOS and now Windows, dreaming of subscriptions, and knowing how to be mad about the right thing. Full Article All Episodes arc OpenAI web3
the 599: Fighting the Algorithm With RSS, Blogging, and the IndieWeb By shoptalkshow.com Published On :: Mon, 22 Jan 2024 10:30:04 +0000 Dave and Chris discuss indie web culture, the role of social media in today's society, and the challenges and strategies of freelancing. Additionally, they discuss a range of topics from content moderation, coding and refining tech skills, to emerging startups and the future of web technology. Full Article All Episodes Blogging Freelancing rss salaries
the 600: Where Will The Web Be 12 Years from Now? By shoptalkshow.com Published On :: Mon, 29 Jan 2024 09:21:23 +0000 We've got your feedback as well as our thoughts on where we all think the web will be in 2036 - as we celebrate 12 years of ShopTalk Show history, we're looking forward to what's to come with ideas around cookie banners, undo, no more passwords, React, Deno, Node, and Mozilla's future, ChatGPT's thoughts, accessibility, blockchain, VR / AR, hoverboards, P3 color space, indie web, JS bundle sizes, and more! Full Article All Episodes future predictions recap show
the 623: Assigning Weight Dynamically, CoPilot vs Other AI, and Monorepos By shoptalkshow.com Published On :: Mon, 08 Jul 2024 08:34:45 +0000 We're talking about assigning a weight to items in a layout, differentiating between banger posts and regular blog posts, using social engineering to get PR's accepted, monorepo thoughts, using CoPilot vs other AI programming support bots, has TypeScript benefited from AI, and what happens if you turn off CoPilot? Full Article All Episodes copilot typescript vs code
the 627: Getting Comfortable with the Struggle and Vibe Driven Development By shoptalkshow.com Published On :: Mon, 05 Aug 2024 08:52:17 +0000 Chris brings some blog posts to talk about including being comfortable with the struggle of developer life, Cloudflare Workers + monorepos, vibe driven development, and questions about database migrations, and whether we think AI free blogs are going to be a rarity in the future? Full Article All Episodes cloudflare workers database struggle
the 629: The Great Divide, Global Design + Web Components, and Job Titles By shoptalkshow.com Published On :: Mon, 19 Aug 2024 08:01:48 +0000 A bit of follow-up on vibe driven development and JavaScript not causing The Great Divide, writing testing automation, global design systems and web components, could PHP be used for web components, what if view transitions are going to be everywhere, and frontend engineer vs design systems engineer job titles and descriptions. Full Article All Episodes design systems engineer PHP view transitions
the 633: Thomas Steiner on AI in Chrome and the Web By shoptalkshow.com Published On :: Mon, 16 Sep 2024 09:30:53 +0000 Thomas Steiner from Project Fugu talks with us about AI in Chrome, the small large language model in use, how features like this are rolled out, the ethics and concerns around sending and sharing data, on device vs web APIs, and ideas for use cases and ways to explore AI on the web. Full Article All Episodes AI Chrome Fugu
the 640: Navigating the Pros and Cons of Web Components By shoptalkshow.com Published On :: Mon, 04 Nov 2024 08:52:16 +0000 Riffing off a Dave Rupert blog post, Chris and Dave talk through the pros and cons of web components, when to use them, when it's a bad idea to use them, what would it take to make the Next.js of web components, and how long until we don't need anymore frameworks? Full Article All Episodes Javascript Web Components
the Building practices for the future By www.thehindu.com Published On :: Fri, 05 Dec 2014 16:08:44 +0530 Sacred Groves in Auroville is being built using ecologically sensitive construction methods and material. Full Article Property Plus
the The re-use mantra By www.thehindu.com Published On :: Fri, 19 Dec 2014 20:11:54 +0530 Mimicking nature’s cleaning process through DEWATS and the Vortex system. Full Article Green Living
the The ABC of composting By www.thehindu.com Published On :: Fri, 27 Feb 2015 16:15:45 +0530 A quick primer on how to manage all that rich organic waste your home generates Full Article Property Plus
the Go local is the mantra By www.thehindu.com Published On :: Fri, 06 Mar 2015 14:48:45 +0530 Angela Brady, director, Brady Mallalieu Architects, London, tells Nidhi Adlakha why we need to focus on creating sustainable cities with low carbon footprints Full Article Green Living
the Don’t trash them By www.thehindu.com Published On :: Fri, 06 Mar 2015 14:59:07 +0530 Here’s how to give used wrapping paper, scrapbooks and old newspapers new life, says Teja Lele Desai Full Article Green Living
the The commodification of water By www.thehindu.com Published On :: Fri, 10 Apr 2015 21:20:54 +0530 Water purification systems in cities and villages may look attractive but do they actually benefit the needy? Full Article Green Living
the The monsoon of 2015 By www.thehindu.com Published On :: Fri, 24 Apr 2015 16:48:51 +0530 We will have to brace ourselves for a likely water deficient scenario from June to September this year. Full Article Property Plus
the Design to beat the heat By www.thehindu.com Published On :: Sun, 03 May 2015 20:42:58 +0530 Keeping the air conditioner on for long will only create heat islands, says Sathya Prakash Varanashi Full Article Design
the The Big 5 for Chennai By www.thehindu.com Published On :: Fri, 08 May 2015 20:45:24 +0530 Here are five smart things that Chennai can do to become a cleaner, greener and healthier city. Full Article Green Living
the It’s all in the material By www.thehindu.com Published On :: Fri, 05 Jun 2015 15:33:29 +0530 Materials have a major say in construction, as their manufacture has to be environment-friendly, making them energy-efficient, says green homes builder Chandrashekar Hariharan. By Ranjani Govind Full Article Green Living
the Unsuccessful malls on the verge of closure By www.thehindu.com Published On :: Fri, 04 Sep 2015 15:40:22 +0530 Poor management practices have resulted in many malls across the country becoming unviable spaces. Full Article Property Plus
the Here comes the squeeze By www.thehindu.com Published On :: Fri, 04 Sep 2015 15:50:28 +0530 While a dip in prices can be good news for home buyers, there is always a risk in investing too early. Full Article Green Living
the The art of dispensing water By www.thehindu.com Published On :: Fri, 04 Sep 2015 16:53:00 +0530 Water-ATMs are becoming the rage all over the country. A look at the mechanism. Full Article Property Plus
the Studying the ‘real’ pulse By www.thehindu.com Published On :: Fri, 04 Sep 2015 16:54:05 +0530 Where is the Bengaluru market heading to? What are the factors that could help bring down the unsold inventory? Full Article Property Plus
the The fight against encroachment By www.thehindu.com Published On :: Fri, 04 Sep 2015 16:58:16 +0530 No one has the right to use precious road space as their private storage yard. Full Article Property Plus
the ‘We want our citizens to breathe fresh air’ By www.thehindu.com Published On :: Fri, 11 Sep 2015 22:03:08 +0530 Dr. John Keung, CEO of Singapore’s Building and Construction Authority, plans to convert 80 per cent of all buildings in his country to green buildings by 2030. Full Article Green Living
the Architecture of the senses By www.thehindu.com Published On :: Fri, 11 Sep 2015 22:10:45 +0530 A building should have greenery, sound of water flowing, feel of natural stone under the feet, the smell of trees, flowers and fresh mud, and a charming yet sensitive design, feels architect Mona Doctor Pingel. A look by Nandhini Sundar. Full Article Green Living
the The green life By www.thehindu.com Published On :: Fri, 16 Oct 2015 14:50:34 +0530 At Sadhana Forest, on the outskirts of Auroville, a community plants trees and lives in rhythm with nature. Sujatha Shankar Kumar reports. Full Article Green Living