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Pentadecanoic acid (C15:0, PA) induces mild maternal glucose intolerance and promotes the growth of the offspring partly through up-regulating liver PPARα and MAPK signaling pathways

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03970J, Paper
Jun Wang, Shiqi Zheng, Ziying Li, Yimei Tang, Yanhua Huang, Junwen Wang, Rui Li, Jie Peng
1% PA can induce a mild decrease in the maternal glucose tolerance and lipolysis mainly by activated MAPK and PPARα signaling.
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Abnormal enterohepatic circulation of bile acids caused by fructooligosaccharide supplementation along with a high-fat diet

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03353A, Paper
Fang Zeng, Shi He, Ying Sun, Xue Li, Kaiyang Chen, Hongbin Wang, Shuli Man, Fuping Lu
Fructooligosaccharide (FOS) is a widely used prebiotic and health food ingredient, but few reports have focused on its risk to specific populations.
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Shatianyu (Citrus grandis L. Osbeck) whole fruit alleviated loperamide-induced constipation via enhancing gut microbiota-mediated intestinal serotonin secretion and mucosal barrier homeostasis

Food Funct., 2024, 15,10614-10627
DOI: 10.1039/D4FO02765E, Paper
Mei Deng, Jiamin Ye, Ruifen Zhang, Shuai Zhang, Lihong Dong, Dongxiao Su, Mingwei Zhang, Fei Huang
The effects of Citrus grandis Shatianyu whole fruit powder enriched in flavonoids and dietary fiber on loperamide-induced constipation after a 4-week administration in the diet, together with possible microbiota-mediated mechanisms were explored.
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The influence of magnesium and manganese cations on the chemical and bioactive properties of purple and green basil

Food Funct., 2024, 15,10644-10662
DOI: 10.1039/D4FO02820A, Paper
Izamara de Oliveira, Antonios Chrysargyris, Tiane C. Finimundy, Márcio Carocho, Celestino Santos-Buelga, Ricardo C. Calhelha, Nikolaos Tzortzakis, Lillian Barros, Sandrina A. Heleno
Effects of hydroponic cultivation with enriched concentrations of magnesium (+Mg), manganese (+Mn), combinations of +Mg and +Mn, or decreased concentrations of these minerals (control) on the chemical/bioactive attributes of basil, were investigated.
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Immune-enhancing effect of Weizmannia coagulans BCG44 and its supernatant on cyclophosphamide-induced immunosuppressed mice and RAW264.7 cells via the modulation of the gut microbiota

Food Funct., 2024, 15,10679-10697
DOI: 10.1039/D4FO02452D, Paper
Open Access
Yafang Xu, Yi Wang, Tao Song, Xiaxia Li, Haolin Zhou, Oumarou Zafir Chaibou, Bing Wang, Huajun Li
W. coagulans BCG44 and its supernatant possess potential immunomodulatory activity and modulate gut microbiota dysbiosis in CTX-induced immunosuppression.
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Biological effects and mechanisms of dietary chalcones: latest research progress, future research strategies, and challenges

Food Funct., 2024, 15,10582-10599
DOI: 10.1039/D4FO03618B, Review Article
Yun Liang Zhang, Shuang Jiao Sun, Li Zeng
Chalcones are widely distributed in food and have multiple biological activities; there are limitations and drawbacks in the application of dietary chalcones in food; future research strategies and key issues for dietary chalcones.
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Beyond flavor: the versatile roles of eugenol in health and disease

Food Funct., 2024, 15,10567-10581
DOI: 10.1039/D4FO02428A, Review Article
Yujie Lao, Jingya Guo, Jingjing Fang, Ruixuan Geng, Mengjie Li, Yige Qin, Jiayi Wu, Seong-Gook Kang, Kunlun Huang, Tao Tong
Emerging evidence highlights that eugenol exhibits significant biological activities across various conditions, suggesting it is a promising nutritional supplement with both flavoring properties and therapeutic potential.
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Acute supplementation with a curcuminoid-based formulation fails to enhance resting or exercise-induced NRF2 activity in males and females

Food Funct., 2024, 15,10782-10794
DOI: 10.1039/D4FO02681K, Paper
Open Access
Josh Thorley, Abrar Alhebshi, Ana Rodriguez-Mateos, Zicheng Zhang, Stephen J. Bailey, Neil R. W. Martin, Nicolette C. Bishop, Tom Clifford
Supplementation with a curcuminoid-based formulation for four days did not augment nuclear factor erythroid 2-related factor 2 (NRF2) activity in peripheral blood mononuclear cells at rest and after strenuous plyometric exercise.
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Novel selenium-enriched Pichia kudriavzevii as a dietary supplement to alleviate dextran sulfate sodium-induced colitis in mice by modulating the gut microbiota and host metabolism

Food Funct., 2024, 15,10698-10716
DOI: 10.1039/D4FO02598A, Paper
Huijuan Wang, Yue Chen, Zhouli Wang, Yahong Yuan, Tianli Yue
Inflammatory bowel disease (IBD) poses persistent challenges due to its chronic and recurrent nature, exacerbated by the unsatisfactory outcomes of the traditional treatment approaches.
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Lacticaseibacillus paracasei 207-27 alters the microbiota–gut–brain axis to improve wearable device-measured sleep duration in healthy adults: a randomized, double-blind, placebo-controlled trial

Food Funct., 2024, 15,10732-10745
DOI: 10.1039/D4FO01684J, Paper
Open Access
Jinxing Li, Jincheng Zhao, Xiaolei Ze, Liang Li, Yapeng Li, Zhimo Zhou, Simou Wu, Wen Jia, Meixun Liu, Yun Li, Xi Shen, Fang He, Ruyue Cheng
Probiotics have been reported to exert beneficial effects on sleep through the gut–brain axis.
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Unravelling the potential of yolkin for nutraceutical use: the origin, structure, and functional insights of a hen egg yolk polypeptide complex

Food Funct., 2024, 15,10746-10760
DOI: 10.1039/D4FO03023K, Paper
Open Access
Aleksandra Zambrowicz, Katarzyna Kapczyńska, Paweł Kania, Jakub Stanisław Nowak, Marta Kaszowska, Katarzyna Szymczak-Kulus, Wioletta Kazana-Płuszka, Marta Piksa, Sabina Górska, Dominika Jakubczyk, Józefa Macała, Agnieszka Zabłocka
The nutraceutical potential of yolkin health benefits from hen egg yolk.
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Relationships of dietary habits with prostate cancer risk: results from Mendelian randomization analyses and the National Health and Nutrition Examination Survey

Food Funct., 2024, 15,10823-10837
DOI: 10.1039/D4FO03859B, Paper
Zhen Zhou, Jin Xu, Yang Zhao, Yuanjie Niu
Prior investigations identified correlations between dietary habits and the risk of prostate cancer (PCa); however, the causative dynamics are unclear.
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Integrated transcriptomics and untargeted metabolomics reveal bone development and metabolism of newly weaned mice in response to dietary calcium and boron levels

Food Funct., 2024, 15,10853-10869
DOI: 10.1039/D4FO03657C, Paper
Shuo Li, Xuehai Cao, Tiande Zou, Zirui Wang, Xingping Chen, Jun Chen, Jinming You
Boron supplementation in diets with varying calcium levels modulates bone development and bone parameters in mice by regulating calcium signaling, lipid metabolism, and neural signaling and inflammatory signaling.
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Dietary supplementation with novel selenium-enriched Pichia kudriavzevii regulates gut microbiota and host metabolism in mice

Food Funct., 2024, 15,10896-10912
DOI: 10.1039/D4FO03633F, Paper
Huijuan Wang, Dan Shi, Yue Chen, Zhouli Wang, Yahong Yuan, Tianli Yue
Insufficient selenium intake can lead to serious health problems.
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Gastroprotective effects of Pediococcus acidilactici GKA4 and Lactobacillus brevis GKL93 against ethanol-induced gastric ulcers via regulation of the immune response and gut microbiota in mice

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04106B, Paper
Yun-En Huang, Sheng-Yi Chen, Tsung-Ju Li, You-Shan Tsai, Chin-Chu Chen, Gow-Chin Yen
Pediococcus acidilactici GKA4 and Lactobacillus brevis GKL93 exert gastroprotective effects against ethanol-induced gastric ulcers through multiple mechanisms.
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In vivo mechanism of interaction between trimethylamine lyase expresssion and glycolytic pathways

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO03809F, Paper
Qian Li, Di Wu, Yu Song, Lu Zhang, Ting Wang, Min Zhang
Recent findings have confirmed that the interaction between host and gut microbiota can alter the formation of the disease-associated metabolite, trimethylamine (TMA), via intestinal microbial TMA lyase. Nevertheless, little is...
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Anti-obesity and other health benefits of bioprocessed black rice bran in combination with green tea extract in 3T3-L1 preadipocyte cells and in mice on a high-fat diet

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO03210A, Paper
Ki Sun Kwon, Eun Seok Lee, Kyung Hee Lee, Woon Sang Hwang, Wha Young Lee, Jae Jung Kim, Jeanman Kim, Sang-Jong Lee, Sung Phil Kim, Mendel Friedman
Black rice bran, a waste product from the commercial milling of black rice that removes the bran and germ and leaves the starchy endosperm, contains bioactive anthocyanin, phenolic, and phytosteroid...
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Interaction of oat bran and exercise training improved exercise adaptability via alleviating oxidative stress and promoting energy homeostasis

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03374D, Paper
Rui Dong, Hamad Rafique, Qianwen Niu, Xin Zeng, Maria Cristina Messia, Li Yuan, Lin Shi, Liang Zou, Lu Li, Xinzhong Hu
Interaction of oat bran (OB) diet and moderate intensity exercise training (MlET) reinforced the positive effect on skeletal muscle function.
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Correlation between vitamin D metabolic pathway-related gene polymorphisms and cardiovascular disease

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03234A, Review Article
Jiao Pang, Chunshuo Yang, Jiaqi Liu, Zhilin Wang, Xueshu Tao, Zhipeng Cao
Polymorphisms in key genes in the vitamin D metabolic pathway affect susceptibility to cardiovascular disease (CVD) and play potential roles in the pathogenesis of CVD.
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Enzymatic treatment to decrease the allergenicity of Pru p 3 from peach

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO03052D, Paper
Open Access
Ana Pilar Tobajas, Ana Agulló-García, Jose Luis Cubero, Carlos Colás Sanz, Alba Civera, Clara Esteban, L. Sanchez, M. D. Perez
Pru p 3, a member of the Lipid Transfer Protein family, is considered a major allergen from peach and it often induces serious allergic reactions in peach allergic individuals. The...
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Aspartate restrains thermogenesis by inhibiting the AMPK pathway in adipose tissues

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03614J, Paper
Shengjun Dong, Mengxin Jiang, Qinglei Sun, Junqing Xu, Lei Zhang, Lei Han, Yan-na Li, Zhengtong Zhou, Yingjiang Xu
We evaluated the potential effects of aspartate on brown adipose tissue function.
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Investigating serum concentration profiles of orally ingested short-chain fatty acid supplements

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04028G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Christopher G. Green, Marilyn L. Y. Ong, Samantha N. Rowland, Tindaro Bongiovanni, Lewis J. James, Tom Clifford, Stephen J. Bailey, Liam M. Heaney
HPMC capsules containing acetate, propionate, and butyrate salts exhibit peak serum concentrations of each short-chain fatty acid within 60 min and a return to baseline within 120 min. Seven days of repeated intake does not alter basal serum levels.
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Characterisation and quantification of phenolic, anthocyanidin and terpene species in plant foods and plant food-based complementary products with antioxidant and neuroprotective properties

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02942A, Paper
Naomi May, Jiahua Shi, Helen Clunas, Julianna Lys de Sousa Alves Neri, Celine Kelso, Jody Morgan, Yinghua Yu, Karen Charlton, Katrina Weston-Green
Phytochemicals, including phenolic compounds and terpenes, are of interest for the treatment and prevention of conditions with oxidative stress, inflammatory and neurodegenerative pathologies.
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Selenium-mediated alleviation of skeletal muscle atrophy through enterotype modulation in mice

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03889D, Paper
Yixin Cheng, Xiaofan Liu, Yingao Hao, Shixu Wang, FangFang Wu, Lingzhuo Zhao, Du Peng, Du Yawen, Sun Sheng, Li Jianguo, Guangxu Ren
Selenium element improves dexamethasone-induced skeletal muscle atrophy by affecting enterotype.
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Impact of pH on the fabrication of egg white reinforced soy protein composite microgels for gastrointestinal delivery purposes

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03997A, Paper
Feng Liu, Yi Liu, Suyun Zhang, Gang Liu, Christos Ritzoulis, Yue Zhang
Protein molecules such as soy protein isolate (SPI) and egg white (EW) are highly promising materials for developing hydrogels (especially micro/nanogels) for the encapsulation, protection and controlled release of bioactive substances.
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Investigation of the hypoglycemic bioactive components of Phyllanthi Fructus through biological assessment combined with ultrafiltration affinity mass spectrometry

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04198D, Paper
Yifan Zhang, Qiang Yu, Peng Tan, Shimin Tian, Jun-zhi Lin, Mengqi Li, Li Han, Haozhou Huang, Ding-kun Zhang
Phyllanthi Fructus (PF) is a tropical fruit with the potential to effectively reduce postprandial blood glucose, making it highly promising for the development of functional foods. However, the lack of...
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Protein-bound AGEs derived from methylglyoxal induce pro-inflammatory response and barrier integrity damage in epithelial cells by disrupting the retinol metabolism

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO00364K, Paper
Gang Yu, Jianxin He, Zhongshan Gao, Linglin Fu, Qiaozhi Zhang
Protein-bound advanced glycation end-products (AGEs) induce pro-inflammatory response and barrier integrity damage in epithelial cells by disrupting the retinol metabolism.
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Immunomodulatory properties of hempseed oligopeptides in an LRRK2-associated Parkinson's disease animal model

Food Funct., 2024, 15,11115-11128
DOI: 10.1039/D4FO03167A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Maria Torrecillas-Lopez, Fernando Rivero-Pino, Paula Trigo, Rocio Toscano-Sanchez, Teresa Gonzalez-de la Rosa, Alvaro Villanueva, M. Carmen Millan-Linares, Sergio Montserrat-de la Paz, Carmen M. Claro-Cala
Hemp protein hydrolysate is capable of alleviating neuroinflammation by reducing the expression of pro-inflammatory cytokines, which could have promising effects in Parkinson's disease.
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The quercetin metabolite 4-methylcatechol causes vasodilation via voltage-gated potassium (KV) channels

Food Funct., 2024, 15,11047-11059
DOI: 10.1039/D3FO04672A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Patrícia Dias, Rudy Salam, Jana Pourová, Marie Vopršalová, Lukáš Konečný, Eduard Jirkovský, Jurjen Duintjer Tebbens, Přemysl Mladěnka
One of important metabolites of dietary polyphenols is 4-methylcatechol (4-MC). This compounds causes vasodilation likely due to an effect on voltage-dependent potassium channels (KV) as suggested by our ex vivo and in silico docking study.
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Aronia melanocarpa extract extends the lifespan and health-span of Caenorhabditis elegans via mitogen-activated protein kinase 1

Food Funct., 2024, 15,11020-11035
DOI: 10.1039/D4FO02479F, Paper
Huan Zhang, Zhigang Zhu, Wenjing Wei, Zekun Liu, Huiji Zhou, Yueling Gong, Xinlei Yan, Jun Du, Houkai Li, Liang Chen, Lili Sheng
Aronia melanocarpa (AM) was shown to promote the lifespan and health-span of C. elegans via the PMK-1 pathway, highlighting the potential of AM as a dietary supplement for delaying aging.
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Lacticaseibacillus plantarum postbiotics prepared by the combined technique of pasteurization and ultrasound: effective measures to alleviate obesity based on the SCFAs-GPR41/GPR43 signaling pathway

Food Funct., 2024, 15,11005-11019
DOI: 10.1039/D4FO03591G, Paper
Chao Miao, Linge Wang, Huabing Wang, Yu Shen, Chaoxin Man, Wei Zhang, Yu Zhang, Qianyu Zhao, Yujun Jiang
Postbiotics prepared by ultrasound and pasteurization are used for the alleviation of obesity.
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Up-regulation of myelin-associated glycoprotein is associated with the ameliorating effect of omega-3 polyunsaturated fatty acids on Alzheimer's disease progression in APP–PS1 transgenic mice

Food Funct., 2024, 15,11236-11251
DOI: 10.1039/D4FO03355H, Paper
Yan Shao, Fei Li, Bo Zou, Yanling Jin, Xiaoyang Wang, Liting Wang, Youying Huang, Yu Xie, Wei Sun, Jing X. Kang, Kai Liu, Yi Huang, Wei Huang, Bin Wang
Our study showed that MAG upregulation might be the new regulatory mechanism for omega-3 PUFAs to exert AD protective effects, which is helpful for expanding our understanding of the health-promoting effects of omega-3 PUFAs.
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Allergenicity evaluation of an extensively hydrolyzed infant formula based on cow milk protein

Food Funct., 2024, 15,11036-11046
DOI: 10.1039/D4FO03582H, Paper
Hongbo Li, Lin Yang, Jiayi Li, Quan Gao, Tiantian Liu, Yang Zou, Xiaohong Chen, Hongjuan Li, Jinghua Yu
We developed an extensively hydrolyzed infant formula (EHF) with a protein composition similar to breast milk (whey protein-to-casein ratio of 6 : 4) and evaluated its sensitization in vitro and in vivo.
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Effects of vegetarian diets on blood lipids, blood glucose, and blood pressure: a systematic review and meta-analysis

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03449J, Review Article
Xin Xia, Jinkai Zhang, Xinfang Wang, Ke Xiong, Zhaobao Pan, Jinyu Wang
Our systematic review and meta-analyses showed that vegetarian diets significantly reduced blood lipids and blood glucose and had null effects on blood pressure.
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Mechanistic insights into EGCG's preventive effects on obesity-induced precocious puberty through multi-omics analyses

Food Funct., 2024, 15,11169-11185
DOI: 10.1039/D4FO03844D, Paper
Qiuyun Gu, Qiujv Du, Lina Xia, Xiaoting Lu, Xiaoqing Wan, Ying Shao, Jieyi He, Peiying Wu
Epigallocatechin gallate (EGCG) has demonstrated potential effects on obesity-induced precocious puberty, but the underlying mechanisms remain unclear.
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Association between olive oil consumption and all-cause, cardiovascular and cancer mortality in adult subjects: a systematic review and meta-analysis

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04161E, Paper
Andrea del Saz-Lara, Alicia Saz-Lara, Iván Cavero-Redondo, Carlos Pascual-Morena, Carmen Mazarío-Gárgoles, Francesco Visioli, María-Carmen López de las Hazas, Alberto Dávalos
Fourteen studies were systematically reviewed and seven were included in the meta-analysis. Consumption of OO is associated with a reduction of cardiovascular mortality (16%), all-cause mortality (15%) and cancer mortality (11%) in adult population.
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Corn cob and corn silk-based ingredients exhibit bioaccessible and antioxidant phenolic compounds displaying anti-inflammatory effects in vitro

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO02968B, Paper
Yessica Rubí Hernández-García, Ivan Luzardo-Ocampo, Gaytán-Martínez Marcela, G. Loarca-Pina, Estela Vázquez Barrios, Rocio Campos-Vega
The poor disposal and lack of corncob (CC) and cornsilk (CS) utilization generate environmental problems. This research aimed to develop CC and CS-based ingredients (1:1, 1:2, and 2:1 mixtures), evaluate...
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Lacticaseibacillus paracasei JM053 alleviates osteoporosis in rats by increasing the content of soy isoflavone aglycones in fermented soymilk

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04381B, Paper
Yaping Zheng, Shasha Cheng, Hongxuan Li, Yilin Sun, Ling Guo, Chaoxin Man, Yu Zhang, Wei Zhang, Yujun Jiang
Lacticaseibacillus paracasei JM053 has a high ability to convert soy isoflavones and can be used as a fermentation strain to ferment soymilk, thereby increasing the content of free aglycones in...
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Ergothioneine improves cognitive function by ameliorating mitochondrial damage and decreasing neuroinflammation in a D-galactose-induced aging model

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02321H, Paper
Fangyang Chen, Botao Wang, Xin Sun, Yage Wang, Ruiyan Wang, Kaikai Li
EGT intervention significantly improved D-galactose induced oxidative stress, neuroinflammation, and mitochondrial function, resulting in the alleviation of memory injury.
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Promote millets for nutritional security

Several studies show that consumption of millets reduce the risk of heart disease and have a positive impact on anaemia apart from controlling blood pressure




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Implications of RBI’s securities buyback

It serves in smoothening out debt redemption of the government, and with it keeping the fiscal deficit and interest rates in check




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Iran and the October Surprise of 2024

With the Biden administration going soft on Netanyahu, Democrats’ hold on Arab-American vote seems to be slipping




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A tense US election season coming to an end

While the closing messages from the Donald Trump camp were vitriolic, Kamala Harris was more composed




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Effects of SEBI outsourcing arbitration

The arbitrators who were previously assigned arbitration work are now being assigned conciliation work as well, albeit with a lower fee




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Empower seniors digitally

It’s vital for wellness, full participation in society




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The rise and rise of online food delivery market

The online food delivery market in India is expected to outpace the growth of the food services market itself between 2023 and 2028




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It’s soul searching time in Washington

Amidst the din on illegal migration, mass deportation and abortion, the Harris camp may have missed the economic angle





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Love Sex Aur Dhokha 2 Review

There is startling accuracy to Dibakar Banerjee's portrayal, notes Sukanya Verma.




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Thalaimai Seyalagam Review

If you are looking for an average political thriller with good performances, Thalamai Seyalagam may interest you, suggests Divya Nair.