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Synergy of prediction rule and total synthesis in solving the stereochemical puzzle of eucalactam B

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01777C, Research Article
Chenqi Wang, Junyang Liu, Tao Ye
The absolute configurations of the fungal-derived reduced polyketide eucalactam B were initially predicted using the “Biochemistry-based rule” and later confirmed through its first successful total synthesis.
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Facile one-pot synthesis of novel imidates as multifunctional organic fluorescent materials

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01628A, Research Article
Feng-Ting Liu, Shuo Wang, Yong-Shun Chen, Jun-Ying Miao, Bao-Xiang Zhao, Zhao-Min Lin
A novel one-pot synthesis of multifunctional organic fluorescent imidates from quinolinium salt derivatives, nitrosoarenes and alcohols was presented. This method had a wide substrate scope and excellent isolated yields.
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Mechanistic insight into the dehydrogenation reaction catalyzed by an MLC catalyst with dual ancillary ligand sites

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01767F, Research Article
Gui-Xiang Zhou, Cheng Hou
This study reveals a mechanism in which a ruthenium complex catalyst improves catalytic efficiency and lowers the energy barrier in the dehydrogenation of benzyl alcohol by dynamically switching ligand sites.
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Metal-free visible-light-induced borylative/silylative pyridylation of vinylarenes

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01702A, Research Article
Yiting Zhou, Bin Liu
We present a metal-free and mild three-component reaction involving vinylarenes, NHC–BH3 complexes, hydrosilanes, and 4-cyanopyridine. Remarkably, this reaction was performed with simple and inexpensive benzophenone.
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Palladium-catalyzed synthesis of indene-1-acetates via sequential double carbopalladation and aryloxycarbonylation

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01570C, Research Article
Fei Sun, Yiyi Zheng, Zhongyao Jiang, Mingxia Wu, Zeng Lv, Hongsen Ji, Xin-Xing Wu
A novel palladium-catalyzed cascade reaction of o-iodostyrenes, internal alkynes and formates to access various indene-1-acetates through sequential double carbopalladation and aryloxycarbonylation under a palladium/air system was developed.
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Synthesis of bambusurils with perfluoroalkylthiobenzyl groups as highly potent halide receptors

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01746C, Research Article
Open Access
Matúš Chvojka, Hennie Valkenier, Vladimír Šindelář
Four new fluorinated bambusuril macrocycles were prepared to show exceptional high binding affinity towards halide anions in acetonitrile.
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Photoinduced cobaloxime catalysis for allylic mono- and diphosphinylation of alkenes with hydrogen evolution

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01638F, Research Article
Aijun Zhang, Miao-Miao Li, Lei Guo, Huaixiang Yang, Jiefei Guo, Da Xu, Wei Ding
A highly efficient allylic radical mono- and diphosphinylation of alkenes with secondary phosphine oxides is developed, via visible-light-induced cobaloxime catalysis.
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Visible-light mediated selective phosphonylation modification of tryptophan residues in oligopeptides

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Org. Chem. Front., 2024, 11,6287-6292
DOI: 10.1039/D4QO01028K, Research Article
Wenfang Xiong, Junye He, Jinyao Liu, Peiru Chen, Shiqi Xu, Yipeng Liu, Shiting Chen, Yuanyuan You, Zhenyu Chen, Jinwu Zhao
A direct C2-H phosphonylation strategy driven by visible light for specific modification of tryptophan-containing peptides has been reported, providing a plethora of phosphorylated tryptophan-containing peptides
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Towards the total synthesis of mandelalide B: construction of the tetrahydrofuran/α-hydroxyl lactone fragment

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Org. Chem. Front., 2024, 11,6353-6357
DOI: 10.1039/D4QO01433B, Research Article
Jia-Lei Yan, Jie Yu, Yingying Cheng, Mingze Yang, Zhengshuang Xu, Tao Ye
A stereocontrolled synthesis of the tetrahydrofuran/α-hydroxy lactone fragment of mandelalide B has been accomplished. The synthesis features a Horner-Wadsworth-Emmons fragment assembly strategy and a highly stereospecific iodine-induced cyclization.
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Total synthesis of spiro Ganoderma meroterpenoids spiroapplanatumines B, D, F, and H

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Org. Chem. Front., 2024, 11,6333-6339
DOI: 10.1039/D4QO01147C, Research Article
Jia-Hao Zhang, Wen-Cai Luo, Wen-Tao Chen, Yu-Tao He, Ya-Jian Hu
The first total synthesis of spiroapplanatumines B, D, F, and H as well as the possibly undiscovered natural product spiroapplanatumine R has been achieved.
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Visible-light excited copper activating unactivated alkyl iodides for radical addition/cyclization to access oxindole derivatives

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Org. Chem. Front., 2024, 11,6380-6384
DOI: 10.1039/D4QO01329H, Research Article
Hang Luo, Fangnian Yu, Luqing Lin
The photocopper catalyst facilitates halogen atom transfer to give unactivated alkyl radicals, which is critical for achieving radical cyclization in the absence of an exogenous photocatalyst.
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Iridium/palladium dual photocatalysis for oxidative decarboxylative esterification of alcohols using α-keto acids

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Org. Chem. Front., 2024, 11,6367-6379
DOI: 10.1039/D4QO01452A, Research Article
Subal Mondal, Soumya Mondal, Debabrata Halder, Siba P. Midya, Ankan Paul, Pradyut Ghosh
Herein, we report an unprecedented oxidative decarboxylative C–O cross-coupling reaction for the esterification of feedstock α-keto carboxylic acids and alcohols under mild conditions.
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Transition-metal-catalyzed regiodivergent sulfonylation of aziridrines for the synthesis of β-amino sulfones

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Org. Chem. Front., 2024, 11,6340-6346
DOI: 10.1039/D4QO01376J, Research Article
Qinqiong Zeng, Yujia Gong, Xiaochun He, Xuemei Zhang, Zhong Lian
We developed the first transition-metal-catalyzed, regiodivergent sulfonylation of aziridines, enabling the efficient synthesis of diverse β-amino sulfones under mild conditions with broad substrate compatibility and high regioselectivity.
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A cucurbit[8]uril-mediated host–guest complex for red-light photocatalysis

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Org. Chem. Front., 2024, 11,6327-6332
DOI: 10.1039/D4QO01492H, Research Article
Weiquan Xu, Yinghao Du, He Ma, Xingchen Tang, Jiang-Fei Xu, Xi Zhang
Two-step host–guest complexation can occur between an elongated dye and CB[8], leading to the formation of CB[8]@2TPP and 3CB[8]@2TPP sequentially. Of these species, 3CB[8]@2TPP in particular can act as an efficient red-light photocatalyst.
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Visible light-induced aerobic photooxidative cleavage of C(sp3)–C(sp2) σ-bonds of allylarenes

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Org. Chem. Front., 2024, 11,6385-6392
DOI: 10.1039/D4QO01243G, Research Article
Jinyu Tang, Xi Zhao, Jinxuan Ni, Yanping Huo, Yang Gao, Xianwei Li, Yan Liu, Keiji Maruoka, Qian Chen
A cleavage of C(sp3)–C(sp2) σ-bonds of allylarenes to aromatic aldehydes and ketones has been achieved via a visible light-induced photocatalysis.
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Asymmetric synthesis of (aza)flavanones by the evolution of CarOx ligands

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Org. Chem. Front., 2024, 11,6444-6449
DOI: 10.1039/D4QO01345J, Research Article
Juan Yang, Wenlong Kong, Mingxin Chang, Jixing Lai, Shengkun Li
Amino-pyridine-oxazoline (NHPyOx) is conceived as an unprecedented model via the core-emulating optimization of CarOx ligands.
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Theoretical insights into Pd-catalyzed dual γ-1,1-C(sp3)–H activation of aliphatic carboxylic acids: mechanistic pathways, substituent influence on product selectivity, diastereoselectivity, and additive effects

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Org. Chem. Front., 2024, 11,6393-6410
DOI: 10.1039/D4QO01451K, Research Article
Jiaoyang Liu, Li-juan Huang, Zeang Sun, Juan Li
DFT calculations were employed to explore the detailed reaction mechanism and the origins of the experimentally observed product, regio-, and diastereoselectivities in the Pd-catalyzed dual-γ-1,1-C(sp3)–H activation of aliphatic carboxylic acids.
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Design, synthesis and application of bipyridine-N,N'-dioxide catalysts in asymmetric synthesis of chiral cyclopropanes

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Org. Chem. Front., 2024, 11,6470-6476
DOI: 10.1039/D4QO01532K, Research Article
Xiaoying Cao, Xue Tian, Minmin Liu, Shi-Wu Li
A novel type of highly efficient chiral C2-symmetric bipyridine-N,N'-dioxide ligands was prepared and successfully applied in the synthesis of optically pure 1,2,3-trisubstituted cyclopropanes.
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A general method for E-selective olefination of acylsilanes with isocyanides via silver catalysis

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Org. Chem. Front., 2024, 11,6450-6458
DOI: 10.1039/D4QO01528B, Research Article
Xiu-Xia Liang, Dan-Ni Yang, Xiao-Hui Yan, Peng Wang, Man-Yi Han
A silver-catalyzed olefination reaction between acylsilanes and isocyanides is developed, resulting in E-vinylsilanes with good yields and high stereoselectivities.
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Visible-light-promoted catalytic epoxidation of alkenes under metal-free conditions

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Org. Chem. Front., 2024, 11,6437-6443
DOI: 10.1039/D4QO01265H, Research Article
Dabao Tan, Xiaoyan Cai, Lele Zhang, Boyu Liu, Jianbin Zeng, Feiming Li, Zhixiong Cai, Mingqiang Huang, Xiaoping Chen, Shunyou Cai
In this work, we report a method for the synthesis of functionalized epoxy analogues using the synergistic interaction of 4CzIPN and oxygen under visible light stimulation.
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Carbonate-assisted selectively deoxygenative cross-coupling reaction between aryl and aliphatic aldehydes: a straightforward route to access α-alkylated aryl ketones

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Org. Chem. Front., 2024, 11,6510-6517
DOI: 10.1039/D4QO01517G, Research Article
Yu Sun, Yi Wang, Zhijun Zuo
A novel reductive cross-coupling reaction of two different aldehydes for rapidly assembling α-alkylated aryl ketones has been developed. The inexpensive carbonate served not only as a base but also as an efficient electron donor.
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Anomalous magnetic behaviour induced by a structural phase transition with anisotropic thermal expansion in a spirodiradical

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Org. Chem. Front., 2024, 11,6495-6502
DOI: 10.1039/D4QO01098A, Research Article
Open Access
Takuya Kanetomo, Daigo Matsunaga, Shinichi Ogawa, Masaya Enomoto
A Ge-centred spirodiradical exhibited anomalous magnetic behaviour, influenced by two key structural factors: negative thermal expansion and a structural phase transition.
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Sulfenylation of bioactive maleimides, acrylates and cyclohexenones under ambient organophotocatalysis

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Org. Chem. Front., 2024, 11,6503-6509
DOI: 10.1039/D4QO01342E, Research Article
Debanjana Bag, Rajjakfur Rahaman, Anindya S. Manna, Subhasis Pal, Rajesh Nandi, Shobhon Aich, Narendra Nath Ghosh, Dilip K. Maiti
A novel visible light-induced sulfenylation of biologically important maleimides, acrylates and cyclohexenones has been developed using cheap and easily available organophotoredox catalyst Eosin Y with thiols under ambient conditions.
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Shining light on sulfonium salts and sulfur ylides: recent advances in alkylation under photoredox catalysis

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Org. Chem. Front., 2024, 11,6573-6588
DOI: 10.1039/D4QO01644K, Review Article
Zhe Jin, Tingwei Yu, Hui Wang, Penghao Jia, You Huang
Recent advancements in photoredox alkylation with sulfur ylides, sulfonium salts and related analogues are summarized in this review.
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Dendron-mediated control over self-assembly of chlorophyll rosettes into columnar vs. discrete aggregates

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Org. Chem. Front., 2024, 11,6304-6310
DOI: 10.1039/D4QO01629G, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ryo Kudo, Hiroki Hanayama, Balaraman Vedhanarayanan, Hitoshi Tamiaki, Nobuyuki Hara, Sarah E. Rogers, Martin J. Hollamby, Biplab Manna, Koji Harano, Shiki Yagai
By controlling the π-π stacking of chlorophyll supramolecular rosettes through steric hindrance of alkyl dendrons, it become possible to create chlorophyll tubes and discrete rings that resemble to natural chlorophyll assemblies.
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Recent advances in asymmetric synthesis of chiral benzoheterocycles via Earth-abundant metal catalysis

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Org. Chem. Front., 2024, 11,6534-6557
DOI: 10.1039/D4QO01686F, Review Article
Jinhui Cai, Wenting Zhang, Usman Muhammad, Weishuang Li, Yanjun Xie
This review mainly focus on the assembly of chiral benzoheterocycles, such as dihydrobenzofurans, chromans, indolines, tetrahydroquinolines, etc., via Earth-abundant metal-catalyzed (Cu, Fe, Ni, and Ti) asymmetric synthesis in the last few decades.
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LiTMP-LiBr complex-induced lateral lithiation and cross ester condensation: direct access to isocoumarins from 2-methoxy o-toluate esters

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01678E, Research Article
Open Access
Mintu Rehman, Sajib Daimary, Rasajna Madhusudhana, Rajendar Goreti
LiTMP-LiBr complex promotes cross-ester coupling of 2-methoxy o-toluate esters to directly yield isocoumarin is demonstrated. Method applied to many natural product precursors including synthesis of (+)- and (−)-lunatinins.
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A two-step Kinugasa/Conia-ene-type sequential reaction for the asymmetric synthesis of 8-methylene-2,6-diazaspiro[3.4]octane-1,5-diones

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01388C, Research Article
Shanyue Li, Qicai Ma, Bohua Wu, Haowen Ma, Wei Zhou, Qian Cai
A two-step Kinugasa/Conia-ene-type sequential reaction is developed. The process provided a simple and efficient access to chiral 8-methylene-2,6-diazaspiro[3.4]octane-1,5-diones.
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Copper-catalyzed alkynyldisulfuration of arynes: an efficient access to unsymmetrical disulfides

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Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01844C, Research Article
Shuai Huang, Yumin Zhang, Yuekai Li, Chen-Ho Tung, Xin Li, Zhenghu Xu
This article investigates a copper-catalyzed alkynyl disulfuration reaction of aryne formed in situ to synthesize o‑alkynyl aryl disulfides. The transformation proceeds through the in situ generation of aryne, followed by...
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Enantioselective Addition of 3-hydroxyquinolin-2(1H)-one to Isatin and Pyrazole-4,5-dione Derived Ketimines

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Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01895H, Research Article
Yue Wei, Guishun Bai, Jiamin Wu, Yi Hua, Tao Zhang, Congyong Yue, Hong Wang, Xiaoze Bao
The enantioselective reactivity of 3-hydroxyquinolin-2(1H)-ones was developed through their addition to isatin and pyrazole-4,5-dione derived ketimines, affording novel architectures featuring multiple natural products scaffolds in high yield with excellent enantioselectivities....
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DABSO-Mediated Pummerer Reaction Enables One-Pot Synthesis of Pyrroloquinolines for Accessing Marinoquinolines: Mechanistic, Photophysical and Pharmacological Investigations

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Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01512F, Research Article
Rahimuddin Khan, Dipun Kumar Penthi, Aditi Chatterjee, Chandrakanta Sahoo, Shanti Gopal Patra, Viswanathan Arun Nagaraj, Tabrez Khan
A new one-pot acid- and exogenous oxidant-free synthesis of pyrrolo[2,3-c]quinolines has been developed. The strategy involves chemoselective reduction of the 3-(2-nitrophenyl)-1H-pyrroles (pyrrolnitrin derivatives) and subsequent DABSO-facilitated Pummerer reaction in the...
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Charge Transfer Complex Enabled Mechanochemical Synthesis of Chalcogenoacetylenes via Alkynyl Radicals

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Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01827C, Research Article
Open Access
Fang Tan, Chang-Zhen Fang, Bing-Sheng Qiu, He Sheng, Yong-Liang Tu, Xiang-Yu Chen
Mechanochemistry has become an appealing strategy to enable numerous organic transformations. While significant advances have been achieved, the radical coupling reaction under mechanochemical conditions is still in its infancy. In...
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Copper(II)-catalyzed synthesis of sulfonyl-functionalized quinone-fused cyclopenta[b]indoles via four-component cascade annulation

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01560F, Research Article
Hong Xu, Jie Liao, Fei Ren, Chuan-Rong Zhou, Xiao-Zhuo Liu, Yao Xiao, Dong-Wei Hang, Fuyu Li, Bei Wang, Ji-Yu Wang
Through crucial selective radical tandem process and intramolecular nucleophilic addition, a facile copper-catalyzed four-component cascade has been realized to selectively construct novel sulfonyl-functionalized quinone-fused cyclopenta[b]indole.
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Facile single-step synthesis of pentaaryl-substituted pyrano[3,2-b]pyrrol-5(1H)-ones showing aggregation-induced emission

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01600A, Research Article
Yongfeng Wang, Ruijun Chu, Yanxiao Wang, Mengyuan Zhou, Yuan Chen, Cheng Xu, Jingyu Sun, Guodong Yin
A novel class of heterocyclic AIEgens has been synthesized via a multicomponent reaction of isatins, 2,3-diaryl cyclopropenones, and alkyl bromides.
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Catalytic asymmetric synthesis of chiral sulfilimines via S-C bond formation

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Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01963F, Highlight
Yingying Shi, Shuiyun Zheng, Jiapian Huang, Fu-Sheng He, Min Yang, Jie Wu
As the aza-analogues of sulfoxides, sulfilimines bearing S(IV) stereogenic centers hold tremendous potential in synthetic chemistry and medicinal chemistry. However, the catalytic asymmetric synthesis of chiral sulfilimines are much less...
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Thiocyanoalkylation of Alkenes via Dual Photoredox and Copper Catalysis

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Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01864H, Research Article
Xu Wang, Bi-Yin Xiao, Qi-Xuan Jiang, Wei Huang, Feng-Hua Zhang
Organic thiocyanates are commonly used as an essential organic synthesis intermediate and widely present in various drug molecules and bioactive molecules. Herein, a copper and photoredox catalyzed thiocyanoalkylation reaction of...
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Stereocontrolled synthesis of heterocycles from unactivated alkynes by photoredox/nickel dual-catalyzed cyclization

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01627K, Research Article
Bo-Rong Leng, Feng Yang, Jin-Lian Bai, Yu-Wen Huang, Qing-Quan Liu, Ping Wei, De-Cai Wang, Yi-Long Zhu
We report a nickel/photoredox dual catalysis method for synthesizing heterocyclics from unactivated alkynes and aryl iodides, offering a direct, selective, and green alternative to traditional synthesis with potential in medicinal chemistry.
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Integrating electrocatalysis with biocatalysis for asymmetric synthesis

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01899K, Highlight
Yuqi Lin, Jiage Yu, Ke-Yin Ye
This highlight presents recent advances in asymmetric synthesis that integrate electrocatalysis with biocatalysis and discusses future development directions in this field.
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Visible-light responsive defluorination-acyl fluoride exchange for photoclick labeling based on phenoxazine chromophores

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01870B, Research Article
Lijun Deng, Sitong Li, Cefei Zhang, Yuqiao Zhou, Zhishan Su, Changwei Hu, Xiaohu Zhao, Zhipeng Yu
We developed a new generation of photo-DAFEx reagents to realize photoaffinity labeling for drug discovery under 405 nm light control.
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Metal–ligand cooperation and synergistic palladium catalysis for the dual ligand system [2,2'-bipyridin]-6(1H)–one/PCy3: milder conditions for the undirected C–H arylation of arenes

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01877J, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Cintya Pinilla, Mario García-Zarza, Ana C. Albéniz
The mixture of Pd(OAc)2 and two ligands segregate into distinct active species working synergistically for the C–H arylation of simple arenes.
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Palladium-catalyzed cascade decarboxylative cyclization of alkyne-tethered aryl iodides with o-bromobenzoic acids for the synthesis of fused isoquinolinones

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01573H, Research Article
Zhaolin Quan, Yubo Duan, Zhengkai Chen
A straightforward approach for the preparation of fused isoquinolinone derivatives via palladium-catalyzed cascade decarboxylative cyclization of alkyne-tethered aryl iodides with o-bromobenzoic acids is described.
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Mechanism and origins of regioselectivity of selenium-catalyzed allylic amination reactions

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01794C, Research Article
Xiaoxiao Hu, Dengmengfei Xiao, Yu Chen, Yi Lu, Zhihan Zhang, Peiyuan Yu
The mechanism of selenium-catalyzed allylic amination reactions with different ligands has been explored using density functional theory calculations.
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Synthesis of oxa-bridged carbocycles via rhodium/Lewis acid catalyzed [3 + 3] and [4 + 3] cycloadditions of carbonyl ylides with donor–acceptor strained carbocycles

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01831A, Research Article
Jiale Li, Lingfei Wang, Pei-Nian Liu, Xingguang Li
A method for cooperative rhodium/Lewis acid-catalyzed cycloadditions of carbonyl ylides with donor–acceptor (D–A) strained carbocycles is described. It affords structurally diverse oxa-bridged carbocycles with high efficiency and stereoselectivity.
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Transition-metal-free skeletal editing of benzoisothiazol-3-ones to 2,3-dihydrobenzothiazin-4-ones via single-carbon insertion

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01714E, Research Article
Ke Yang, Qin Li, Yanqi Luo, Dan Yuan, Chunjian Qi, Zhengyi Li, Bijin Li, Xiaoqiang Sun
Transition-metal-free ring expansion of benzoisothiazol-3-ones has been established to construct various 2,3-dihydrobenzothiazin-4-ones via single-carbon insertion.
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Rh-Catalysed Hydroacyloxylation of Cyclopropenes: Regio- and Diastereoselective Synthesis of Acyloxycyclopropanes

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Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01810A, Research Article
Ángel Manu Martínez, Gema Domínguez, Ines Alonso, Marta Palaín, Javier Perez-Castells
Cyclopropyl carboxylates are essential building blocks in biological and medicinal chemistry. However, their accessibility is severely limited by the need to pre-synthesise highly reactive cyclopropane derivatives. Herein, we report an...
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PIFA-Mediated cyclization of methyl(2-(1-phenylvinyl)phenyl)sulfane for the concise, flexible, and scalable de novo synthesis of C3-arylated benzo[b]thiophenes

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Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01589D, Research Article
Xinya Liu, Olivier Provot, Christine Tran, Jean-Francois Soule, Abdallah Hamze
The well-decorated arylated benzo[b]thiophene scaffold is a pivotal structural motif with diverse applications in medicinal chemistry. This paper outlines a de novo synthesis of C3-arylated benzo[b]thiophenes, showcasing its flexibility and...
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Hemilabile P,N-Ligand-Assisted Gold Catalyzed Hiyama Allylation to Access Allylarenes and 1,4-Dienes Derivatives

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Org. Chem. Front., 2025, Accepted Manuscript
DOI: 10.1039/D4QO01879F, Research Article
Yuanhao He, Wanping Ma, Yu Zhong, Yanfei Hu, Mingou Li, Fen Zhao, Zhonghua Xia, Baomin Fan
Oxidant-free gold-catalyzed reactions are emerging as a novel synthetic tool for organic transformations. Here in, we reported a hemilabile P,N-ligand-assisted gold-catalyzed Hiyama cross coupling reaction of aryl and alkenyl iodides...
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Rhodium-catalyzed synthesis of N-substituted 3-acylpyrroles from enaminones and vinylene carbonate

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Org. Chem. Front., 2025, Accepted Manuscript
DOI: 10.1039/D4QO01816H, Research Article
Sheng-Jiao Yan, Jian-Bo Ma, Yi-Mai Yin, Xing-Mei Hu, Bi-Na Shao, Kun Huang, Qing-Sheng Zhao
Skeletal editing is a highly efficient strategy for modifying the core scaffolds of drug molecules, with multi-atomic editing as an emergent approach. Herein, we present a protocol for constructing N-substituted...
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π-extended regioisomeric dithienoacenes fused pyrenes: structures, properties, and application in field-effect transistors

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Org. Chem. Front., 2025, Accepted Manuscript
DOI: 10.1039/D4QO01592D, Research Article
Bin Lu, Shiqian Zhang, Dong Liu, Wendong Jin, Dalin Li, Zhiqiang Liu, Tao He
The development of π-conjugated semiconducting molecules with fused rings has been a focus of research in organic electronics. In this study, optoelectronic and field-effect transistors (FET) properties of two novel...
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Mechanistic insights into rhodium-catalyzed C−H activation and annulation using vinyl acetate to access cinnolines and cinnolin-4(1H)-ones

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Org. Chem. Front., 2025, Accepted Manuscript
DOI: 10.1039/D4QO01734J, Research Article
Yuqin Wang, Yiling Zeng, Ya-Nan Tian, Zheng Liu, Jinhua Wang, Shuyou Chen, Shiqing Li
Transition metal-catalyzed C−H activation and annulation involving vinyl acetate remains a significant challenge, and the mechanistic process following vinyl insertion is ambiguous. Herein, we report the Rh(III)-catalyzed two-fold C−H activation...
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