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Recent developments in the enzymatic modifications of steroid scaffolds

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00327F, Review Article
Open Access
Huibin Wang, Ikuro Abe
This review highlights the recent advancements in the enzymatic modifications of steroid scaffolds, emphasizing enzymatic hydroxylation, ketoreduction, dehydrogenation, enzymatic cascade reactions, and other modifications.
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de

Synthesis of Deuteriodifluoromethylthiolated Isocoumarins-1- imines and Isocoumarins Enabled by Multi-Component Reagents System (MCRS)

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00328D, Communication
Xuemin Li, Haofeng Shi, Jiaxin He, Jialiang Wu, Fengxia Sun, Yunfei Du
The combining use of BnSCF2D, mCPBA and Tf2O serves as an efficient multi-component reagents system (MCRS) for the synthesis of deuteriodifluoromethylthiolated isocoumarins-1-imines/isocoumarins via intramolecular cyclization/ deuteriodifluoromethylthiolation of 2-alkynylbenzamide/2-alkynylbenzoates. The approach...
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de

TEMPO/PhI(OAc)2 promotes the α-aminophosphinoylation of alcohols with amines and H-phosphine oxides in aqueous medium

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00302K, Communication
Qiang Huang, Xin Jin, Lvjia Wu, Jiangdong Li, Qianlu Xing, Xianheng Wang, Changkuo Zhao
The aminophosphinoylation of alcohols with amines and H-phosphine oxides provides an efficient and mild approach to access various α-aminoalkylphosphine oxides in good yields with good tolerance of functional groups using H2O as a clean solvent.
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de

Design, synthesis, and biological application of A–D–A-type boranil fluorescent dyes

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00297K, Paper
Wei Luo, Yiling Li, Liang Wang, Yanhua Qin, Qiao Cheng, Guochang Hu, Chaoyi Yao, Xiangzhi Song
Acceptor–donor–acceptor boranil fluorescent dyes, CSU-BF-R (R = H, CH3, and OCH3), were developed with strong red fluorescence and large Stokes shifts. CSU-BF-OCH3 could selectively sense intracellular hypochlorous acid in living cells and zebrafish.
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de

Measuring local pH at interfaces from molecular tumbling: A concept for designing EPR-active pH-sensitive labels and probes

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00167B, Paper
Open Access
Maxim A. Voinov, Nicholas Nunn, Roshan Rana, Atli Davidsson, Alex I. Smirnov, Tatyana I. Smirnova
EPR-based local pH measurements based on changes in rotational dynamics of spin-bearing molecules upon protonation.
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de

Facile synthesis of tetrahydroquinoline containing dithiocarbamate derivatives via one-pot sequential multicomponent reaction

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00490F, Communication
SIDDHARTHA KUMAR SENAPATI, Anit Pal, Animesh Das
An efficient sequential multi-component method for the synthesis of tertrahydroquinoline containing dithiocarbamate has been developed. This reaction involved a boronic acid-catalyzed reduction of quinoline to tertrahydroquinoline, followed by nucleophilic addition...
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de

N-Functionalization of beta-aminophosphonates; Cytotoxic effect of the new derivatives

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00243A, Paper
György Keglevich, Petra Regina Varga, Emőke Dinnyési, Zsuzsanna Szalai, Szilvia Bősze, Rita Oláhné Szabó, Laszlo Drahos, Konstantin Karaghiosoff
Beta-Aminophosponates obtained by the Michael addition of primary amines to the double bond of diethyl vinylphosphonate proved to be suitable starting materials (amine components) in the Kabachnik–Fields reaction with formaldehyde...
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de

Sustainable preparation of 2-acylbenzothiazoles under the cooperation of ionic liquids and microwave irradiation

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00315B, Paper
Shoushun Wang, Mengjie Liu, Yiyuan Yue, Xiude Hu, Yalin Zhang, Guodong Shen, Ruiguo Dong, Lilong Shi, Bing Yu, Xianqiang Huang
A series of 2-acylbenzothiazole derivatives were sustainably synthesized for the first time under the cooperation of ionic liquids and microwave irradiation, metal- and extra-additives-free conditions.
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de

Tetrabutylammonium decatungstate (TBADT), a compelling and trailblazing catalyst for visible-light-induced organic photocatalysis

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00171K, Review Article
Bor-Cherng Hong, Ranadheer Reddy Indurmuddam
This review summarizes recent developments in visible-light or near-visible-light photocatalysis reactions enabled by the TBADT catalyst.
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de

Efficient synthesis of SCF3-containing 3-alkenylquinoxalinones via three-component radical cascade reaction

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00363B, Paper
Si-Yu Wang, Chu Liu, Wei Yang, Zhong-Ying Tian, Lin Yuan, Long-Yong Xie
A three-component cascade reaction of quinoxalinones, alkynes and AgSCF3 toward complete E-selective SCF3-containing 3-alkenylquinoxalinones was developed.
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de

DevTools Digest - Chrome 35: Updates to the Developer Tools in Chrome 35

Updates to the Chrome Developer Tools: CSS property quick search, memory stats for heap snapshots, CodeMirror upgrade and more.




de

Piloting through the pandemic

How AirAsia India innovated with a distance-learning training programme for its cockpit crew




de

Pandemic: Contactless technology on an overdrive

As demand for travel rises, industry must meet it while ensuring passenger safety




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Reskilling of airline workforce needed

Industry grapples with skilling/reskilling employees right from pilots to ground handling staff whose skills may be redundant




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Start-up founders onboard pvt jets

JetSetGo in talks with VCs, PEs to raise additional $50 million




de

Demand for more flight schools soars

Pilot shortage is hurting airline operations in India, with the industry expected to need at least 1,000 to 1,500 pilots every year




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Deep tech is helping airlines sustain operations during Covid

Integrated biometric-enabled frameworks for real-time test results, travel details and vaccine status are key to making air travel safe




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Next order of business for Tata Sons

How will Tata Sons turn around all the airlines under its fold, except maybe the Kochi-based Air India Express?




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Short-haul flights redefining air travel

 While the growth of international flights remains muted, demand for narrow-bodied aircraft witnesses a renewed surge 




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First-ever gravity-defying plane swap set for April 24

Two pilots will swap planes mid-air




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Insolvency of aircraft operator: default remedies.

India should adopt Cape Town Convention as part of the domestic legal framework.




de

Deep diving into design philosophies

Airbus and Boeing differ in their approach to automation




de

Decarbonising flying

IATA shares proposes 65 per cent of aviation-emitted carbon will be abated through sustainable aviation fuel




de

UDAN flies high despite the odds

The scheme has made short commutes via flight accessible to over 92 lakh people




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The art of avoiding accidents in air

Flying distance may vary based on flight phases, altitudes and regions




de

Yoke vs. sidestick: Jury still out on what works best for pilots

Why do Airbus commercial aircraft have sidesticks and Boeing have yokes as control units?




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5 things Indian airlines must do to break their way out of pandemic blues

Post pandemic, the airlines must revamp strategies and resort to long-term measures to recover from the crisis 




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Embraer expects capacity dynamics to tilt demand in its favour

The plane maker’s current foray attempts to shed the tentativeness that overshadowed its earlier endeavours




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Post-pandemic, OTAs are coming of age

Are they finally paying up or paying off?




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Zomato users can now schedule order 2 days in advance

Zomato’s order scheduling is available at more than 35,000 restaurants across 30 cities




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Google to develop AI that takes over computers: Report

Google is developing AI technology that takes over a web browser to complete tasks such as research and shopping, The Information reported




de

Microsoft Teams to launch threaded conversations, combined chats and channels features

The app has also added other changes in the interface so users can organise their chats better




de

 Instagram downgrades quality of less popular videos

Last year, Meta had admitted in a blog to having separate encoding configurations for different videos based on how popular they were




de

GitHub unveils multi-model Copilot, Spark for AI developers

Anthropic’s Claude 3.5 Sonnet will be available via GitHub Copilot starting today and Google’s Gemini 1.5 Pro will be available in the coming weeks




de

Google’s moneymaking machine still pumping out massive profits despite multiple threats

Google is still thriving while the company navigates through a pivotal shift to artificial intelligence and battles regulators trying to topple its internet empire




de

Google CEO confirms the next Gemini model coming soon

Gemini 1.5, their last iteration had been released in February this year




de

Microsoft, Meta, Apple, Amazon, and the burden of expectations knock Wall Street sharply lower

Drops for Big Tech companies including Microsoft and Facebook’s parent company Meta Platforms led Wall Street lower




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Chinese researchers develop AI model for military use on back of Meta's Llama

ChatBIT was fine-tuned and "optimised for dialogue and question-answering tasks in the military field", the paper said




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OpenAI CEO Sam Altman says next big AI model launch pushed due to compute challenges

Altman also said that the next update for DALL-E was still in the works with no release date yet




de

Perplexity AI CEO says “still haven’t gotten” a green card amid immigration debate ahead of U.S. Presidential Election 2024

Srinivas went on to work with OpenAI for a year before co-founding Perplexity AI in 2022




de

I Didn’t Realize How Much I Rely on GitHub Codespaces Until This week

How much do I rely on GitHub Codespaces for open source development? Super double-plus much. I can illustrate exactly how much with one short anecdote. Gulp 5 was recently released and I created several PRs across repos in the H5BP organization to update Gulp across the board. I missed one issue with the encoding of […]




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Out-of-pocket expenditure on health in Kerala is highest in country despite increased State investments

National Health Accounts figures show the per capita out-of-pocket expenditure on health in Kerala stands at ₹7,889. However, Kerala also tops the list when it comes to the per capita government spending on health, at ₹4,338




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Karnataka government plans to start 11 medical colleges under contentious PPP model

As of now, the State has 22 government medical colleges in 22 districts while 11 others have no government medical colleges; the PPP model however has been criticised by some experts




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High cataract rate among elderly in Mucherla, Meerkhanpet of Rangareddy district, says survey

HHF’s screening of 200 patients in Mucherla and Meerkhanpet found that 21% had senile cataracts, 18% had immature cataracts, and 15% had refractive errors




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Should men be allowed into operation theatres when their wives are having a baby? Doctors weigh in after YouTuber’s video sparks controversy

YouTuber Irfan recently posted a video on social media that showed him cutting the umbilical cord of his newborn, in the operation theatre of a private hospital in Chennai; consent of the medical personnel involved to being videoed was another aspect doctors say needs discussion




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Centre eyes ‘presumed consent’ for cornea retrieval in hospital deaths

THOTA may be amended to facilitate retrieval of cornea from all Indians who die in hospitals, without family consent. 




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Acute Flaccid Paralysis surveillance as a crucial defence against polio in India | Explained

India needs to continue efforts to maintain its polio-free status, and AFP surveillance has to remain a cornerstone of its strategy




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Air pollution: Centre warns of the rising ill-effects of deteriorating air quality

In a letter to States and UTs, the Director General of Health Services Atul Goel has said to discourage stubble and waste burning, and spread awareness among people about reducing firecrackers during festivities




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30,000 critical care beds, regional centres for National Institute of Virology are among plans under PM-ABHIM: V.K. Paul

Expanding healthcare infrastructure plans also include integrated public health units in 600 districts and 30 branches of the National Centre for Disease Control, Niti Aayog member Dr. Paul has said




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$25-million Pandemic Fund aims to curb ‘zoonotic’ diseases

The Centre will implement the G20 Pandemic Fund, which is aimed at enhancing the country’s “animal health security”, in partnership with the Asian Development Bank (ADB), the World Bank and the Food and Agriculture Organization (FAO).