The Winnipeg Jets' reign as the only unbeaten NHL team ended with a 6-4 Toronto Maple Leafs' victory handed by John Tavares who scored three goals at the game Monday night at Canada Life Centre.

A young Toronto Maple Leafs fan has caught the attention of the NHL with his Halloween costume this year. With the help of his dad, Grayson Haire, of Trenton, Ont., will wear a 3D version of an Upper Deck MVP Auston Matthews hockey card.

Ukraine attacked Moscow on Sunday with at least 34 drones, the biggest drone strike on the Russian capital since the start of the war in 2022, forcing flights to be diverted from three of the city's major airports and injuring at least one person.

U.S. president-elect Donald Trump spoke with Russian President Vladimir Putin and advised him not to escalate the Ukraine war, a source familiar with the conversation said, but the Kremlin denied the two had spoken.

An Israeli airstrike killed seven people late Monday at a café near the southern Gaza city of Khan Younis, Palestinian medics said, bringing the death toll from Israeli strikes since Sunday night to at least 37.

A driver killed 35 people and severely injured another 43 when he deliberately rammed his car into people exercising at a sports centre in the southern Chinese city of Zhuhai, police said Tuesday.

The impact of Donald Trump's election win on Nov. 5 will be felt globally, especially in China — one of the world's emerging superpowers and one of the United States' biggest trading partners. The relationship could also affect Canada.

U.S. president-elect Donald Trump said on Tuesday he was nominating former Arkansas governor Mike Huckabee as its next ambassador to Israel, tapping a staunchly pro-Israel conservative whose choice could signal future U.S. policy toward conflicts in the Middle East.

A federal judge sentenced a Massachusetts Air National Guard member to 15 years in prison Tuesday for leaking classified military documents about the war in Ukraine, actions prosecutors said put the country's national security at risk, endangered other military members and damaged U.S. relationships with its allies.

Two buildings collapsed on Hamilton’s Gore Park early Monday morning after being boarded up for over a decade. The fire department says no one was injured and the city has issued an emergency demolition order.

The Ontario Liberal Party is pledging to reduce the income tax rate for middle class families and eliminate provincial sales tax on hydro bills, if they win in the 2026 election.

Ontario Provincial Police (OPP) have released dashcam footage of a crash that sent two people to hospital in life-threatening condition, linked to an ongoing investigation into rocks being thrown at moving vehicles in the GTA.

Statistics Canada data reviewed by CBC Toronto shows a dramatic shift in criminal outcomes in Ontario over the last decade. The majority of criminal cases in the province have ended with charges being withdrawn, stayed, dismissed or discharged before a decision at trial since 2020.

Sgt. Harman Dhaliwal, who is from Calgary, says he's proud to be a part of the growing exhibit that highlights the relationship between the Sikh faith and military service.

Some Ukrainians living in Calgary say they're even more worried for their friends and family back home in light of Donald Trump's election win.

The provincial government is seeking contractors to restore hundreds of kilometres of land where fireguards were created during the 2023 wildfire season.

Eyare died of injuries she sustained while moving between back of house spaces, Wilder Institute director of animal care, health and welfare, Colleen Baird said Tuesday.

Charlottetown-born curler Brett Gallant says competing in the Olympics will be a dream come true for him and his fiancée, Jocelyn Peterman, even if COVID-19 protocols will make it difficult for them to see each other.

After COVID-19 challenges forced the cancellation of Canada's mixed doubles trials, several top curlers are anxiously waiting to learn whether they will be chosen to represent the country in the discipline at the Beijing Games.

It's not a complete surprise that curling and other sports have been cancelled because of the COVID-19 pandemic, but it doesn't make it any easier on teams that had their hopes of representing Northern Ontario at a national curling level dashed.

It’s official — Team Galusha will be representing the N.W.T. at the 2022 Scotties Tournament of Hearts in Thunder Bay later this month.

The oft-discussed wild-card setup at the national championships took centre stage again Monday with the release of updated rankings that appeared to determine the play-in game matchup at the Scotties Tournament of Hearts.

Rachel Homan and John Morris join That Curling Show fresh off the news they have been chosen to represent Canada in mixed doubles curling at the Beijing Olympics.

Curling Canada, with the assistance of Own the Podium and the Canadian Olympic Committee, announced Rachel Homan and John Morris as the mixed doubles team for Canada competing at the Beijing Olympics.

Rachel Homan and John Morris weren't the only ones celebrating after their selection to wear the Maple Leaf in mixed doubles curling competition at the Beijing Olympics. The nomination also cleared the path for Team Hollie Duncan to represent Ontario at the national championship.

Newly announced mixed doubles duo Rachel Homan and John Morris, skips Jennifer Jones and Brad Gushue, and broadcasters Mike Harris, Joanne Courtney and Bruce Rainnie all break down a busy week in curling news.

Record revenue of $1.6 billion Record quarterly ADV of 28.3 million contracts - the second consecutive quarter of volume, open interest growth across every asset class CHICAGO, Oct. 23, 2024...

CME Group, the world's leading derivatives marketplace, today announced that open interest in its global benchmark Henry Hub futures contract reached a record 1.73 million contracts on October 30,...

Mosquitoes transmit deadly pathogens from person to person as they obtain the blood meal that is essential for their life cycle. Female mosquitoes of many species are unable to reproduce without consuming protein that they obtain from blood. This developmental stage makes them highly efficient disease vectors of deadly pathogens. They can transmit pathogens between members of the same species and different species that can provide a route for evolving zoonotic viruses to jump from animals to humans. One possible way to develop novel strategies to combat pathogen transmission by mosquitoes is to study the sensory systems that drive mosquito reproductive behaviors, in particular the neural architecture and circuits of mosquito sensory afferent neurons, the central circuits that process sensory information, and the downstream circuits that drive reproductive behaviors. The study of mosquito neuroanatomy and circuitry also benefits basic neuroscience, allowing for comparative neuroanatomy in insect species, which has great value in the current model species-heavy landscape of neuroscience. Here, we introduce two important techniques that are used to study neuroanatomy and neural circuitry—namely, immunofluorescent labeling and neural tracing. We describe how to apply these approaches to study mosquito neuroanatomy and describe considerations for researchers using the techniques.

A researcher may have many reasons for wanting to establish new laboratory colonies from field-collected mosquitoes. In particular, the ability to study the diversity found within and among natural populations in a controlled laboratory environment opens up a wide range of possibilities for understanding how and why burdens of vector-borne disease vary over space and time. However, field-collected mosquitoes are often more difficult to work with than established laboratory strains, and considerable logistical challenges are involved in safely transporting field-collected mosquitoes into the laboratory. Here, we provide advice for researchers working with Aedes aegypti, Anopheles gambiae, and Culex pipiens, as well as notes on other closely related species. We provide guidance on each stage of the life cycle and highlight the life stages for which it is easiest to initiate new laboratory colonies for each species. In accompanying protocols, we provide methods detailing Ae. aegypti egg collection and hatching as well as how to transport larvae and pupae from the field.

CRISPR–Cas9 has revolutionized gene editing for traditional and nontraditional model organisms alike. This tool has opened the door to new mechanistic studies of basic mosquito biology as well as the development of novel vector control strategies based on CRISPR–Cas9, including gene drives that spread genetic elements in the population. Although the promise of the specificity, flexibility, and ease of deployment CRISPR is real, its implementation still requires empirical optimization for each new species of interest, as well as to each genomic target within a given species. Here, we provide an overview of designing and testing single-guide RNAs for the use of CRISPR-based gene editing tools.

Transposon-mediated transgenesis of mosquito vectors of disease pathogens followed the early success of transgenesis in the vinegar fly, Drosophila melanogaster. The P transposable element used in Drosophila does not function canonically in mosquitoes, and repeatable, routine transgenesis in mosquitoes was not accomplished until new transposable elements were discovered and validated. A number of distinct transposons were subsequently identified that mediate the introduction of exogenous DNA in a stable and heritable manner in mosquito species, including members of the genera Aedes, Anopheles, and Culex. The most versatile element, piggyBac, is functional in all of these mosquito genera, as well as in many other insects in diverse orders, and has been used extensively outside the class. Transposon-mediated transgenesis of recessive and dominant marker genes and reporter systems has been used to define functional fragments of gene control sequences, introduce exogenous DNA encoding products beneficial to medical interests, and act as "enhancer traps" to identify endogenous genes with specific expression characteristics.

Anautogenous female mosquitoes, which ingest a blood meal from warm-blooded vertebrates to produce eggs, have become a valuable model organism for investigating signaling pathways and physiological processes that occur during egg development. Different molecular pathways tightly regulate the initiation of egg development and are governed by a balance among different insect hormones. Gravid (mature egg-carrying) females deposit fully developed eggs at the end of each gonotrophic cycle, which is defined as the time interval between the ingestion of a blood meal to oviposition. An intact eggshell protects the oocyte and embryo inside from external factors such as desiccation, physical damage, etc., and the various eggshell proteins are spatially and temporary deposited during oogenesis. Additionally, follicle resorption (oosorption) during blood meal–induced mosquito ovarian follicle development is an adapted physiological process that optimizes reproductive fitness. Mosquito oocytes grow and mature synchronously throughout oogenesis; however, during the later stages of oogenesis, some oocytes may undergo oosorption if sufficient nutrients are unavailable. This introduction highlights how mosquito egg development can be used to investigate follicular resorption and identify proteins involved in eggshell formation in Aedes aegypti mosquitoes.

Volker (OM Montenegro) describes how their outdoor lessons for Roma kids were threatened by bad weather. Then God provided not only the solution - building a carport as a shelter - but also the funds and manpower needed to build it.

When the British public responded to OM’s Just Christmas appeal, OM Montenegro received funds to help families, just at the right time.

God transforms the hearts of teens from two people groups, who normally do not interact, to bring them together for worship, Bible study and friendship.

Mozaik church, pioneered by the OM team in Bar, Montenegro, has recently baptised seven new believers in the Adriatic sea, at the beach.

Even if things don't go quite to plan, the kids' craft sessions at OM Montenegro's Lighthouse centre result in wonderful presents for families.

Pioneering Technology Allows Surgeons to Cut Precisely and Control Bleeding Without Causing Heat Damage to Tissue

Knee replacement doesn’t have to be ‘total’

Quadruped Dinosaur Stomps the Rest of the Competition

Robotics programmers can now use SolidWorks 3D CAD models for more powerful simulations

R&D ‘Sandbox’ Previews Some Potential Capabilities for 3D CAD Software