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A Novel Strategy of Rhodamine B-based Fluorescent Probe for Selective Response of Glutathione to Serve as Bioimaging in Living Cells

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00582G, Paper
Zhipeng Li, Wei Xiong, Xiaojun He, Xiaoliang Qi, Feng Ding, Jianliang Shen
To overcome the reported shortcomings of the glutathione (GSH) detection of rhodamine based fluorescent probes, such as poor selectivity to thiol groups and reversible unstable covalent binding with the thiol...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Imaging Lipophilic Regions in Rodent Brain Tissue with Halogenated BODIPY Probes

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00099J, Communication
David Hartnell, Bradley Schwehr, Kate Gillespie-Jones, Dasuni Alwis, Ramesh Rajan, Huishu Hou, nicole j sylvain, M. Jake Jake Pushie, Michael E Kelly, Massimiliano Massi, Mark Hackett
The effect of halogen substitution in fluorescent BODIPY species was evaluated in the context of staining lipids in situ within brain tissue sections. Herein we demonstrate that the halogenated species...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Nanodiagnostics to monitor biofilm oxygen metabolism for antibiotic susceptibility testing

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00479K, Paper
Megan P. Jewell, Samuel C. Saccomano, Alexa A. David, J. Kirk Harris, Edith T. Zemanick, Kevin J. Cash
A method utilizing oxygen-sensitive nanosensor technology to monitor the oxygen consumption dynamics of living biofilms as they are exposed to antibiotics. This method provides information on the MBIC as well as kinetic response.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Changes in latent fingermark glyceride composition as a function of sample age using UPLC-IMS-QToF-MSE

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00379D, Paper
Amanda Frick, Natalie Kummer, Ana Moraleda, Celine Weyermann
The composition of fingermark residue has been an important topic in forensic science, mainly in efforts to better understand and eventually improve the efficacy of latent fingermark detection methods. While...
The content of this RSS Feed (c) The Royal Society of Chemistry




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In vitro simultaneous mapping of the partial pressure of oxygen, pH and inorganic phosphate using electron paramagnetic resonance

Analyst, 2020, 145,3236-3244
DOI: 10.1039/D0AN00168F, Paper
Akihiro Taguchi, Stephen DeVience, Benoit Driesschaert, Valery V. Khramtsov, Hiroshi Hirata
A simultaneous mapping method was established for the partial pressure of oxygen, pH and inorganic phosphate using electron paramagnetic resonance.
The content of this RSS Feed (c) The Royal Society of Chemistry




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An SDS-PAGE based method for the quantification of carbon black in biological samples

Analyst, 2020, 145,3370-3375
DOI: 10.1039/D0AN00046A, Paper
Keyang Liu, Bin Wan
Quantification of Carbon Black (CB) in bio-samples was made available through SDS-PAGE gel electrophoresis.
The content of this RSS Feed (c) The Royal Society of Chemistry




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In situ multiplex detection of serum exosomal microRNAs using an all-in-one biosensor for breast cancer diagnosis

Analyst, 2020, 145,3289-3296
DOI: 10.1039/D0AN00393J, Paper
Huizhen Wang, Dinggeng He, Kejing Wan, Xiaowu Sheng, Hong Cheng, Jin Huang, Xiao Zhou, Xiaoxiao He, Kemin Wang
Herein, a simple all-in-one biosensor based on a DNA three-way junction has been constructed for in situ simultaneous detection of multiple miRNAs by competitive strand displacement.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Nano-crystalline cellulose-coated magnetic nanoparticles for affinity adsorption of glycoproteins

Analyst, 2020, 145,3407-3413
DOI: 10.1039/D0AN00442A, Paper
Jiaying Zhang, Xiangyu Feng, Jing Wang, Guozhen Fang, Jifeng Liu, Shuo Wang
A new core–shell structured nanomaterial based on Fe3O4 nanoparticles and 2,3-dialdehyde nanocrystalline cellulose (DAC) coatings and its high efficiency in the preconcentration of glycoproteins were described in this work.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Selective ratiometric red-emission detection of In3+ in aqueous solutions and in live cells using a fluorescent peptidyl probe and metal chelating agent

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00288G, Paper
Joohee Park, Hyeongseok Yu, See-Hyoung Park, Keun-Hyeung Lee
A ratiometric fluorescent detection method for In3+ in aqueous buffered solution, ground water, and live cells was developed.
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An electrochemical biosensor based on methylene blue-loaded nanocomposites as signal-amplifying tags to detect pathogenic bacteria

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00470G, Paper
Shengjun Bu, Kuiyu Wang, Zhongyi Li, Chengyu Wang, Zhuo Hao, Wensen Liu, Jiayu Wan
Synthesis of new methylene blue–magainin I organic–inorganic nanocomposites as electrochemical signal labels for the detection of bacteria.
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Scientific workflow managers in metabolomics: an overview

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00272K, Critical Review
Aswin Verhoeven, Martin Giera, Oleg A. Mayboroda
Metabolomics workflows for data processing reproducibility and accelerated clinical deployment.
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Biocompatible Alkyne arms containing Schiff base Fluorescence Indicator for Duel detection of CdII and PbII at Physiological pH and its Application to Live Cell Imaging

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00862A, Paper
Jebastin Andrews S.G, Benita Jeba Silviya S, Jeyanthi Dharmaraj, Winfred Jebaraj J, Sathya Devi E, C. Balakrishnan
An alkyne arms containing salen-type Schiff base ligand, 6,6'-((1E,1'E)-(1,2-phenylenebis(azanylylidene))bis(ethan-1-yl-1-ylidene))bis(3-(prop-2-yn-1-yloxy)phenol) (H2L), is reported here as a dual chemosensor for CdII and PbII ions. The ligand, H2L was characterized by various spectral...
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Magnetic molecularly imprinted conducting polymer for determination of praziquantel enantiomers in milk

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00703J, Paper
Tienne Nascimento, Camilla Fonseca Silva, Hanna L Oliveira, Ricky Cássio Santos da Silva, Clébio Soares Nascimento, Keyller Bastos Borges
A new selective adsorbent based on magnetic molecularly imprinted conducting polymer was firstly synthetized and applied to the magnetic solid phase extraction (MSPE) for the determination of PZQ enantiomers in...
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Core–shell magnetic microporous covalent organic framework with functionalized Ti(IV) for selective enrichment of phosphopeptides

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00038H, Paper
Fengjuan Ding, Yameng Zhao, Haiyan Liu, Weibing Zhang
We fabricated a core-shell magnetic Ti4+-functionalized covalent organic framework composite to selectively capture phosphopeptides in biosamples. This method is applicable to achieve rapid, selective and efficient phosphopeptide analysis.
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Influence of Hair Treatments on Detection of Antiretrovirals by Mass Spectrometry Imaging

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00478B, Paper
Mac Gilliland, Nicole R White, Bryan Yam, Joseph N Mwangi, Heather MA Prince, Ann Marie K Weideman, Angela DM Kashuba, Elias Rosen
Analysis of drugs in hair by mass spectrometry imaging (MSI) has great potential as an objective, long-term measure of medication adherence. However, the fidelity of the chemical record in hair...
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[ASAP] A Synthetic Malonyl-CoA Metabolic Oscillator in <italic toggle="yes">Komagataella phaffii</italic>

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00378




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[ASAP] Bacteriophage Inspired Growth-Decoupled Recombinant Protein Production in <italic toggle="yes">Escherichia coli</italic>

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00028





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[ASAP] MymA Bioactivated Thioalkylbenzoxazole Prodrug Family Active against <italic toggle="yes">Mycobacterium tuberculosis</italic>

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00003




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[ASAP] Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00388




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[ASAP] Structure–Activity Relationship of SPOP Inhibitors against Kidney Cancer

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00161




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[ASAP] Bioisosteric Discovery of NPA101.3, a Second-Generation RET/VEGFR2 Inhibitor Optimized for Single-Agent Polypharmacology

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01336




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[ASAP] Dual-Target Inhibitors Based on HDACs: Novel Antitumor Agents for Cancer Therapy

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00491




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[ASAP] A Chemical Switch for Transforming a Purine Agonist for Toll-like Receptor 7 to a Clinically Relevant Antagonist

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00011




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[ASAP] Both <sc>d</sc>- and <sc>l</sc>-Glucose Polyphosphates Mimic <sc>d</sc>-<italic toggle="yes">myo</italic>-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00215




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[ASAP] Structural Fingerprints of an Intact Monoclonal Antibody Acquired under Formulated Storage Conditions via <sup>15</sup>N Direct Detection Nuclear Magnetic Resonance

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00231




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[ASAP] Discovery of Potent Inhibitors against P-Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2-(4-(Pyridin-2-yl)phenoxy)pyridine Analogue

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00337




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[ASAP] Ruthenium(II) Complex Containing a Redox-Active Semiquinonate Ligand as a Potential Chemotherapeutic Agent: From Synthesis to <italic toggle="yes">In Vivo</italic> Studies

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00431




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[ASAP] Progress in the Field of Aldehyde Dehydrogenase Inhibitors: Novel Imidazo[1,2-<italic toggle="yes">a</italic>]pyridines against the 1A Family

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00686




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[ASAP] Peptoid NPhe<sup>4</sup> in AGRP-Based c[Pro<sup>1</sup>-Arg<sup>2</sup>-Phe<sup>3</sup>-Phe<sup>4</sup>-Xxx<sup>5</sup>-Ala<sup>6</sup>-Phe<sup>7</sup>

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00641




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[ASAP] Novel HIV-1 Protease Inhibitors with Morpholine as the P2 Ligand to Enhance Activity against DRV-Resistant Variants

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00043




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[ASAP] Escaping from Flatland: Substituted Bridged Pyrrolidine Fragments with Inherent Three-Dimensional Character

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00039




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[ASAP] Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00639




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[ASAP] Discovery of BMS-986251: A Clinically Viable, Potent, and Selective ROR?t Inverse Agonist

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00063




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[ASAP] New Dual CK2/HDAC1 Inhibitors with Nanomolar Inhibitory Activity against Both Enzymes

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00561




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[ASAP] Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00129




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[ASAP] Potential Cancer Treatment by Agonists of the Stimulator of Interferon Genes

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00117




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[ASAP] Artemisinin Derivatives with Antimelanoma Activity Show Inhibitory Effect against Human DNA Topoisomerase 1

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00131




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[ASAP] P2Y<sub>14</sub> Receptor Antagonists Reverse Chronic Neuropathic Pain in a Mouse Model

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00115




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[ASAP] Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00085




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[ASAP] Synthesis and Evaluation of <sup>11</sup>C- and <sup>18</sup>F-Labeled SOAT1 Inhibitors as Macrophage Foam Cell Imaging Agents

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00127




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17 Tools for Effective Customer Engagement

The one thing that every business that offers a service has in common is its customers. It doesn't matter if you are a freelancer with just one client or a small design agency with a few clients, you have to deal with customers on a day to day basis.




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Email Personalization: Your Secret To Better Engagement

One of the struggles that marketers face is how to send the right message at exactly the right time to target people in a way that will appeal to them. To solve the problem, businesses need to get themselves acquainted with new technologies and the power of personalization. In the past few years, digital marketing […]




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Bauhaus imaginista: a school in the world / edited by Marion von Osten and Grant Watson

Rotch Library - N332.G33 B42724 2019




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Leonardo da Vinci: nature and architecture / edited by Constance Moffatt, Sara Taglialagamba

Rotch Library - N6923.L33 M64 2019




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Art for people's sake: artists and community in Black Chicago, 1965-1975 / Rebecca Zorach

Rotch Library - NX512.3.A35 Z67 2019




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Failed images: photography and its counter-practices / Ernst van Alphen

Rotch Library - TR183.A47 2018




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Panos Charalambous, Eva Stefani, Zafos Xagoraris / curated by Katerina Tselou

Rotch Library - N6488.I8 V433 2019 G8




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Indios antropófagos: a butterfly garden in the (urban) jungle

Rotch Library - N6488.I8 V433 2019 P4




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Pedagogical sketchbook / Paul Klee

Rotch Library - NC703.K58 2019