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Mémoire sur l'empoisonnement par la strychnine : contenant la relation médico-légale complète de l'affaire Palmer / Ambroise Tardieu.

Paris, [France] : J.B. Baillière, Libraire de l'Académie Impériale de Médicine, 1857.




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Administrative scheme for the County of London made by the London County Council on 18th December, 1934, for discharging the functions transferred to the Council by Part I of the Local Government Act, 1929, and orders made bu the Minister of Health under

England : London County Council, Public Assistance Department, 1935.




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Oh Luna Fortuna : the story of how the ethics of polyamory helped my rescue dog and me heal from trauma / graphic memoir comic by Stacy Bias.

London : Stacy Bias, 2019.




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LGBTK : ne demek?




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Art and value / Bethlem Gallery.




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Veränderbarkeit des Genoms : Herausforderungen für die Zukunft : Vorträge anlässlich der Jahresversammlung am 22. und 23. September 2017 in Halle (Saale) / herausgegeben von: Jörg Hacker.

Halle (Saale) : Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften ; Stuttgart : Wissenschaftliche Verlagsgesellschaft, 2019.




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Tierische Drogen im 18. Jahrhundert im Spiegel offizineller und nicht offizineller Literatur und ihre Bedeutung in der Gegenwart / Katja Susanne Moosmann ; mit einem Geleitwort von Christoph Friedrich.

Stuttgart : In Kommission: Wissenschaftliche Verlagsgesellschaft, 2019.




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Das Apothekenwesen in Baden von 1945 bis 1960 / Ilse Denninger ; mit einem Geleitwort von Christoph Friedrich.

Stuttgart : In Kommission: Wissenschaftliche Verlagsgesellschaft mbH, 2019.




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Trans reproductive justice: a radical transfeminism mini zine

Leith, 2019




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Narcotic antagonists : naltrexone : progress report / editors, Demetrios Julius, Pierre Renault.

Rockville, Maryland : U.S. Dept. of Health, Education, and Welfare, Public Health Service, Alcohol, Drug Abuse and Mental Health Administration, 1976.




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Contemporary research in pain and analgesia, 1983 / editors, Roger M. Brown, Theodore M. Pinkert, Jacqueline P. Ludford.

Rockville, Maryland : National Institute on Drug Abuse, 1983.




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Cocaine use in America : epidemiologic and clinical perspectives / editors, Nicholas J. Kozel, Edgar H. Adams.

Rockville, Maryland : National Institute on Drug Abuse, 1985.




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Methamphetamine abuse : epidemiologic issues and implications / editors, Marissa A. Miller, Nicholas J. Kozel.

Rockville, Maryland : National Institute on Drug Abuse, 1991.




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Drug dependence in pregnancy : clinical management of mother and child / [editor, Lorreta P. Finnegan].

Rockville, Maryland : National Institute on Drug Abuse, 1979.




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Management information systems in the drug field / edited by George M. Beschner, Neil H. Sampson, National Institute on Drug Abuse ; and Christopher D'Amanda, Coordinating Office for Drug and Alcohol Abuse, City of Philadelphia.

Rockville, Maryland : National Institute on Drug Abuse, 1979.




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Addicted women : family dynamics, self perceptions, and support systems.

Rockville, Maryland : National Institute on Drug Abuse, 1979.




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Professional and paraprofessional drug abuse counselors : three reports / Leonard A. LoSciuto, Leona S. Aiken, Mary Ann Ausetts ; [compiled, written, and prepared for publication by the Institute for Survey Research, Temple University].

Rockville, Maryland : National Institute on Drug Abuse, 1979.




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Breast exams : (for when you're getting them cut off) : (because you want to)

[London] : [publisher not identified], [2019]




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Survey of drug information needs and problems associated with communications directed to practicing physicians : part III : remedial ad survey / [Arthur Ruskin, M.D.]

Springfield, Virginia : National Technical Information Service, 1974.




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Evaluation of treatment programs for abusers of nonopiate drugs : problems and approaches. Volume 3 / Wynne Associates for Division of Research, National Institute on Drug Abuse, Alcohol, Drug Abuse and Mental Health Administration, Department of Health,

Washington, D.C. : Wynne Associates, [1974]




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O problema do abuso de drogas prevenção através investigação, pesquisa e educação / Murillo de Macedo Pereira, Vera Kühn de Macedo Pereira.

São Paulo : Governo do Estado de Sao Paulo, Secretaria da Segurança Pública, 1975.




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A pesquisa sobre o problema do abuso de drogas / Murillo de Macedo Pereira.

São Paulo : Serviço Grafíco da Secretaria da Segurança Pública, 1976.




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The university chemical dependency project : final report : November 1 1986 / Steven A. Bloch, Steven Ungerleider.

[Indiana] : Integrated Research Services, Inc., 1986.




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Temas de salud reproductiva : Reproductive health matters.

London : Reproductive Health Matters, 1993-2018.




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New essays on abortion and bioethics / volume editor, Rem B. Edwards.

Greenwich, Conn. : Jai Press Inc., 1997.




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The Most Excellent Order of the British Empire Association (New South Wales) further records, 1979-2012




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Selected Poems of Henry Lawson: Correspondence: Vol.1




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'A pioneer, a trailblazer' - Reaction to McGraw's retirement

Notre Dame coach Muffet McGraw retired after 33 seasons Wednesday. What she did for me in those four years, I came in as a girl and left as a woman.'' - WNBA player Kayla McBride, who played for Notre Dame from 2010-14.




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Statistical convergence of the EM algorithm on Gaussian mixture models

Ruofei Zhao, Yuanzhi Li, Yuekai Sun.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 632--660.

Abstract:
We study the convergence behavior of the Expectation Maximization (EM) algorithm on Gaussian mixture models with an arbitrary number of mixture components and mixing weights. We show that as long as the means of the components are separated by at least $Omega (sqrt{min {M,d}})$, where $M$ is the number of components and $d$ is the dimension, the EM algorithm converges locally to the global optimum of the log-likelihood. Further, we show that the convergence rate is linear and characterize the size of the basin of attraction to the global optimum.




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Drift estimation for stochastic reaction-diffusion systems

Gregor Pasemann, Wilhelm Stannat.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 547--579.

Abstract:
A parameter estimation problem for a class of semilinear stochastic evolution equations is considered. Conditions for consistency and asymptotic normality are given in terms of growth and continuity properties of the nonlinear part. Emphasis is put on the case of stochastic reaction-diffusion systems. Robustness results for statistical inference under model uncertainty are provided.




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Adaptive estimation in the supremum norm for semiparametric mixtures of regressions

Heiko Werner, Hajo Holzmann, Pierre Vandekerkhove.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 1816--1871.

Abstract:
We investigate a flexible two-component semiparametric mixture of regressions model, in which one of the conditional component distributions of the response given the covariate is unknown but assumed symmetric about a location parameter, while the other is specified up to a scale parameter. The location and scale parameters together with the proportion are allowed to depend nonparametrically on covariates. After settling identifiability, we provide local M-estimators for these parameters which converge in the sup-norm at the optimal rates over Hölder-smoothness classes. We also introduce an adaptive version of the estimators based on the Lepski-method. Sup-norm bounds show that the local M-estimator properly estimates the functions globally, and are the first step in the construction of useful inferential tools such as confidence bands. In our analysis we develop general results about rates of convergence in the sup-norm as well as adaptive estimation of local M-estimators which might be of some independent interest, and which can also be applied in various other settings. We investigate the finite-sample behaviour of our method in a simulation study, and give an illustration to a real data set from bioinformatics.




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Bias correction in conditional multivariate extremes

Mikael Escobar-Bach, Yuri Goegebeur, Armelle Guillou.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 1773--1795.

Abstract:
We consider bias-corrected estimation of the stable tail dependence function in the regression context. To this aim, we first estimate the bias of a smoothed estimator of the stable tail dependence function, and then we subtract it from the estimator. The weak convergence, as a stochastic process, of the resulting asymptotically unbiased estimator of the conditional stable tail dependence function, correctly normalized, is established under mild assumptions, the covariate argument being fixed. The finite sample behaviour of our asymptotically unbiased estimator is then illustrated on a simulation study and compared to two alternatives, which are not bias corrected. Finally, our methodology is applied to a dataset of air pollution measurements.




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Non-parametric adaptive estimation of order 1 Sobol indices in stochastic models, with an application to Epidemiology

Gwenaëlle Castellan, Anthony Cousien, Viet Chi Tran.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 50--81.

Abstract:
Global sensitivity analysis is a set of methods aiming at quantifying the contribution of an uncertain input parameter of the model (or combination of parameters) on the variability of the response. We consider here the estimation of the Sobol indices of order 1 which are commonly-used indicators based on a decomposition of the output’s variance. In a deterministic framework, when the same inputs always give the same outputs, these indices are usually estimated by replicated simulations of the model. In a stochastic framework, when the response given a set of input parameters is not unique due to randomness in the model, metamodels are often used to approximate the mean and dispersion of the response by deterministic functions. We propose a new non-parametric estimator without the need of defining a metamodel to estimate the Sobol indices of order 1. The estimator is based on warped wavelets and is adaptive in the regularity of the model. The convergence of the mean square error to zero, when the number of simulations of the model tend to infinity, is computed and an elbow effect is shown, depending on the regularity of the model. Applications in Epidemiology are carried to illustrate the use of non-parametric estimators.




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$k$-means clustering of extremes

Anja Janßen, Phyllis Wan.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 1211--1233.

Abstract:
The $k$-means clustering algorithm and its variant, the spherical $k$-means clustering, are among the most important and popular methods in unsupervised learning and pattern detection. In this paper, we explore how the spherical $k$-means algorithm can be applied in the analysis of only the extremal observations from a data set. By making use of multivariate extreme value analysis we show how it can be adopted to find “prototypes” of extremal dependence and derive a consistency result for our suggested estimator. In the special case of max-linear models we show furthermore that our procedure provides an alternative way of statistical inference for this class of models. Finally, we provide data examples which show that our method is able to find relevant patterns in extremal observations and allows us to classify extremal events.




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Conditional density estimation with covariate measurement error

Xianzheng Huang, Haiming Zhou.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 970--1023.

Abstract:
We consider estimating the density of a response conditioning on an error-prone covariate. Motivated by two existing kernel density estimators in the absence of covariate measurement error, we propose a method to correct the existing estimators for measurement error. Asymptotic properties of the resultant estimators under different types of measurement error distributions are derived. Moreover, we adjust bandwidths readily available from existing bandwidth selection methods developed for error-free data to obtain bandwidths for the new estimators. Extensive simulation studies are carried out to compare the proposed estimators with naive estimators that ignore measurement error, which also provide empirical evidence for the effectiveness of the proposed bandwidth selection methods. A real-life data example is used to illustrate implementation of these methods under practical scenarios. An R package, lpme, is developed for implementing all considered methods, which we demonstrate via an R code example in Appendix B.2.




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Reduction problems and deformation approaches to nonstationary covariance functions over spheres

Emilio Porcu, Rachid Senoussi, Enner Mendoza, Moreno Bevilacqua.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 890--916.

Abstract:
The paper considers reduction problems and deformation approaches for nonstationary covariance functions on the $(d-1)$-dimensional spheres, $mathbb{S}^{d-1}$, embedded in the $d$-dimensional Euclidean space. Given a covariance function $C$ on $mathbb{S}^{d-1}$, we chase a pair $(R,Psi)$, for a function $R:[-1,+1] o mathbb{R}$ and a smooth bijection $Psi$, such that $C$ can be reduced to a geodesically isotropic one: $C(mathbf{x},mathbf{y})=R(langle Psi (mathbf{x}),Psi (mathbf{y}) angle )$, with $langle cdot ,cdot angle $ denoting the dot product. The problem finds motivation in recent statistical literature devoted to the analysis of global phenomena, defined typically over the sphere of $mathbb{R}^{3}$. The application domains considered in the manuscript makes the problem mathematically challenging. We show the uniqueness of the representation in the reduction problem. Then, under some regularity assumptions, we provide an inversion formula to recover the bijection $Psi$, when it exists, for a given $C$. We also give sufficient conditions for reducibility.




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Estimation of a semiparametric transformation model: A novel approach based on least squares minimization

Benjamin Colling, Ingrid Van Keilegom.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 769--800.

Abstract:
Consider the following semiparametric transformation model $Lambda_{ heta }(Y)=m(X)+varepsilon $, where $X$ is a $d$-dimensional covariate, $Y$ is a univariate response variable and $varepsilon $ is an error term with zero mean and independent of $X$. We assume that $m$ is an unknown regression function and that ${Lambda _{ heta }: heta inTheta }$ is a parametric family of strictly increasing functions. Our goal is to develop two new estimators of the transformation parameter $ heta $. The main idea of these two estimators is to minimize, with respect to $ heta $, the $L_{2}$-distance between the transformation $Lambda _{ heta }$ and one of its fully nonparametric estimators. We consider in particular the nonparametric estimator based on the least-absolute deviation loss constructed in Colling and Van Keilegom (2019). We establish the consistency and the asymptotic normality of the two proposed estimators of $ heta $. We also carry out a simulation study to illustrate and compare the performance of our new parametric estimators to that of the profile likelihood estimator constructed in Linton et al. (2008).




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DESlib: A Dynamic ensemble selection library in Python

DESlib is an open-source python library providing the implementation of several dynamic selection techniques. The library is divided into three modules: (i) dcs, containing the implementation of dynamic classifier selection methods (DCS); (ii) des, containing the implementation of dynamic ensemble selection methods (DES); (iii) static, with the implementation of static ensemble techniques. The library is fully documented (documentation available online on Read the Docs), has a high test coverage (codecov.io) and is part of the scikit-learn-contrib supported projects. Documentation, code and examples can be found on its GitHub page: https://github.com/scikit-learn-contrib/DESlib.




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Neyman-Pearson classification: parametrics and sample size requirement

The Neyman-Pearson (NP) paradigm in binary classification seeks classifiers that achieve a minimal type II error while enforcing the prioritized type I error controlled under some user-specified level $alpha$. This paradigm serves naturally in applications such as severe disease diagnosis and spam detection, where people have clear priorities among the two error types. Recently, Tong, Feng, and Li (2018) proposed a nonparametric umbrella algorithm that adapts all scoring-type classification methods (e.g., logistic regression, support vector machines, random forest) to respect the given type I error (i.e., conditional probability of classifying a class $0$ observation as class $1$ under the 0-1 coding) upper bound $alpha$ with high probability, without specific distributional assumptions on the features and the responses. Universal the umbrella algorithm is, it demands an explicit minimum sample size requirement on class $0$, which is often the more scarce class, such as in rare disease diagnosis applications. In this work, we employ the parametric linear discriminant analysis (LDA) model and propose a new parametric thresholding algorithm, which does not need the minimum sample size requirements on class $0$ observations and thus is suitable for small sample applications such as rare disease diagnosis. Leveraging both the existing nonparametric and the newly proposed parametric thresholding rules, we propose four LDA-based NP classifiers, for both low- and high-dimensional settings. On the theoretical front, we prove NP oracle inequalities for one proposed classifier, where the rate for excess type II error benefits from the explicit parametric model assumption. Furthermore, as NP classifiers involve a sample splitting step of class $0$ observations, we construct a new adaptive sample splitting scheme that can be applied universally to NP classifiers, and this adaptive strategy reduces the type II error of these classifiers. The proposed NP classifiers are implemented in the R package nproc.




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Derivative-Free Methods for Policy Optimization: Guarantees for Linear Quadratic Systems

We study derivative-free methods for policy optimization over the class of linear policies. We focus on characterizing the convergence rate of these methods when applied to linear-quadratic systems, and study various settings of driving noise and reward feedback. Our main theoretical result provides an explicit bound on the sample or evaluation complexity: we show that these methods are guaranteed to converge to within any pre-specified tolerance of the optimal policy with a number of zero-order evaluations that is an explicit polynomial of the error tolerance, dimension, and curvature properties of the problem. Our analysis reveals some interesting differences between the settings of additive driving noise and random initialization, as well as the settings of one-point and two-point reward feedback. Our theory is corroborated by simulations of derivative-free methods in application to these systems. Along the way, we derive convergence rates for stochastic zero-order optimization algorithms when applied to a certain class of non-convex problems.




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On the consistency of graph-based Bayesian semi-supervised learning and the scalability of sampling algorithms

This paper considers a Bayesian approach to graph-based semi-supervised learning. We show that if the graph parameters are suitably scaled, the graph-posteriors converge to a continuum limit as the size of the unlabeled data set grows. This consistency result has profound algorithmic implications: we prove that when consistency holds, carefully designed Markov chain Monte Carlo algorithms have a uniform spectral gap, independent of the number of unlabeled inputs. Numerical experiments illustrate and complement the theory.




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Dynamical Systems as Temporal Feature Spaces

Parametrised state space models in the form of recurrent networks are often used in machine learning to learn from data streams exhibiting temporal dependencies. To break the black box nature of such models it is important to understand the dynamical features of the input-driving time series that are formed in the state space. We propose a framework for rigorous analysis of such state representations in vanishing memory state space models such as echo state networks (ESN). In particular, we consider the state space a temporal feature space and the readout mapping from the state space a kernel machine operating in that feature space. We show that: (1) The usual ESN strategy of randomly generating input-to-state, as well as state coupling leads to shallow memory time series representations, corresponding to cross-correlation operator with fast exponentially decaying coefficients; (2) Imposing symmetry on dynamic coupling yields a constrained dynamic kernel matching the input time series with straightforward exponentially decaying motifs or exponentially decaying motifs of the highest frequency; (3) Simple ring (cycle) high-dimensional reservoir topology specified only through two free parameters can implement deep memory dynamic kernels with a rich variety of matching motifs. We quantify richness of feature representations imposed by dynamic kernels and demonstrate that for dynamic kernel associated with cycle reservoir topology, the kernel richness undergoes a phase transition close to the edge of stability.




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Ancestral Gumbel-Top-k Sampling for Sampling Without Replacement

We develop ancestral Gumbel-Top-$k$ sampling: a generic and efficient method for sampling without replacement from discrete-valued Bayesian networks, which includes multivariate discrete distributions, Markov chains and sequence models. The method uses an extension of the Gumbel-Max trick to sample without replacement by finding the top $k$ of perturbed log-probabilities among all possible configurations of a Bayesian network. Despite the exponentially large domain, the algorithm has a complexity linear in the number of variables and sample size $k$. Our algorithm allows to set the number of parallel processors $m$, to trade off the number of iterations versus the total cost (iterations times $m$) of running the algorithm. For $m = 1$ the algorithm has minimum total cost, whereas for $m = k$ the number of iterations is minimized, and the resulting algorithm is known as Stochastic Beam Search. We provide extensions of the algorithm and discuss a number of related algorithms. We analyze the properties of ancestral Gumbel-Top-$k$ sampling and compare against alternatives on randomly generated Bayesian networks with different levels of connectivity. In the context of (deep) sequence models, we show its use as a method to generate diverse but high-quality translations and statistical estimates of translation quality and entropy.




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Ensemble Learning for Relational Data

We present a theoretical analysis framework for relational ensemble models. We show that ensembles of collective classifiers can improve predictions for graph data by reducing errors due to variance in both learning and inference. In addition, we propose a relational ensemble framework that combines a relational ensemble learning approach with a relational ensemble inference approach for collective classification. The proposed ensemble techniques are applicable for both single and multiple graph settings. Experiments on both synthetic and real-world data demonstrate the effectiveness of the proposed framework. Finally, our experimental results support the theoretical analysis and confirm that ensemble algorithms that explicitly focus on both learning and inference processes and aim at reducing errors associated with both, are the best performers.




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Expected Policy Gradients for Reinforcement Learning

We propose expected policy gradients (EPG), which unify stochastic policy gradients (SPG) and deterministic policy gradients (DPG) for reinforcement learning. Inspired by expected sarsa, EPG integrates (or sums) across actions when estimating the gradient, instead of relying only on the action in the sampled trajectory. For continuous action spaces, we first derive a practical result for Gaussian policies and quadratic critics and then extend it to a universal analytical method, covering a broad class of actors and critics, including Gaussian, exponential families, and policies with bounded support. For Gaussian policies, we introduce an exploration method that uses covariance proportional to the matrix exponential of the scaled Hessian of the critic with respect to the actions. For discrete action spaces, we derive a variant of EPG based on softmax policies. We also establish a new general policy gradient theorem, of which the stochastic and deterministic policy gradient theorems are special cases. Furthermore, we prove that EPG reduces the variance of the gradient estimates without requiring deterministic policies and with little computational overhead. Finally, we provide an extensive experimental evaluation of EPG and show that it outperforms existing approaches on multiple challenging control domains.




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Cook commemoration sparks 1970 protest

In 1970, celebrations and commemorations were held across the nation for the 200th anniversary of the Endeavour’s visit




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Have your say on the Highway 404 Employment Corridor Secondary Plan




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Measuring symmetry and asymmetry of multiplicative distortion measurement errors data

Jun Zhang, Yujie Gai, Xia Cui, Gaorong Li.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 2, 370--393.

Abstract:
This paper studies the measure of symmetry or asymmetry of a continuous variable under the multiplicative distortion measurement errors setting. The unobservable variable is distorted in a multiplicative fashion by an observed confounding variable. First, two direct plug-in estimation procedures are proposed, and the empirical likelihood based confidence intervals are constructed to measure the symmetry or asymmetry of the unobserved variable. Next, we propose four test statistics for testing whether the unobserved variable is symmetric or not. The asymptotic properties of the proposed estimators and test statistics are examined. We conduct Monte Carlo simulation experiments to examine the performance of the proposed estimators and test statistics. These methods are applied to analyze a real dataset for an illustration.




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Application of weighted and unordered majorization orders in comparisons of parallel systems with exponentiated generalized gamma components

Abedin Haidari, Amir T. Payandeh Najafabadi, Narayanaswamy Balakrishnan.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 1, 150--166.

Abstract:
Consider two parallel systems, say $A$ and $B$, with respective lifetimes $T_{1}$ and $T_{2}$ wherein independent component lifetimes of each system follow exponentiated generalized gamma distribution with possibly different exponential shape and scale parameters. We show here that $T_{2}$ is smaller than $T_{1}$ with respect to the usual stochastic order (reversed hazard rate order) if the vector of logarithm (the main vector) of scale parameters of System $B$ is weakly weighted majorized by that of System $A$, and if the vector of exponential shape parameters of System $A$ is unordered mojorized by that of System $B$. By means of some examples, we show that the above results can not be extended to the hazard rate and likelihood ratio orders. However, when the scale parameters of each system divide into two homogeneous groups, we verify that the usual stochastic and reversed hazard rate orders can be extended, respectively, to the hazard rate and likelihood ratio orders. The established results complete and strengthen some of the known results in the literature.




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Effects of gene–environment and gene–gene interactions in case-control studies: A novel Bayesian semiparametric approach

Durba Bhattacharya, Sourabh Bhattacharya.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 1, 71--89.

Abstract:
Present day bio-medical research is pointing towards the fact that cognizance of gene–environment interactions along with genetic interactions may help prevent or detain the onset of many complex diseases like cardiovascular disease, cancer, type2 diabetes, autism or asthma by adjustments to lifestyle. In this regard, we propose a Bayesian semiparametric model to detect not only the roles of genes and their interactions, but also the possible influence of environmental variables on the genes in case-control studies. Our model also accounts for the unknown number of genetic sub-populations via finite mixtures composed of Dirichlet processes. An effective parallel computing methodology, developed by us harnesses the power of parallel processing technology to increase the efficiencies of our conditionally independent Gibbs sampling and Transformation based MCMC (TMCMC) methods. Applications of our model and methods to simulation studies with biologically realistic genotype datasets and a real, case-control based genotype dataset on early onset of myocardial infarction (MI) have yielded quite interesting results beside providing some insights into the differential effect of gender on MI.