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How mobile data can help rationalise bus routes




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Missing the obvious




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Location tracking - do you need it?




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The transformation of BSNL




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​Weather gods: On ‘Mission Mausam’

Attempts at controlling the weather are still in the realm of uncertainty




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​Last mile woes: On inflation data and the challenges

Inflation should not be allowed to undermine the economic momentum 




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​Unrealistic expectations: On India and Russia-Ukraine peace

India’s efforts at peacemaking between Russia and Ukraine have limited potential




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Clarity of vision: On eye drops for presbyopia and ‘claims’

A useful drug is undone by fantastic claims about its efficacy




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Down to the wire: On the run-up to the U.S. presidential election

The U.S. presidential race is poised on a knife’s edge




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Wrong notion: On simultaneous elections

The idea of simultaneous elections is inherently anti-federal




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Pivot to watch: On the U.S. Fed’s rate reduction, its impact




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Sri Lanka’s verdict: On the Island nation’s ninth Presidential election

The spirit of the mandate of the presidential poll was clear — for change




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Politicising the laddu: On the Tirupati laddu and its ‘adulteration’

The Tirupati laddu issue should be limited to one of quality control




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It is an offence: On Supreme Court clarification on online content on child sex abuse

Court has done well to clarify law on online content showing child sex abuse




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​Kashmir conflict: On the J&K elections

The political divide between national parties and regional parties is clear 




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Staying the course: On the fight against air pollution in the Indo-Gangetic plains

The Centre and the States need to fight air pollution together 




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​Mad doctrine: On Russia’s revision of its nuclear doctrine

Any threat of use of nuclear weapons must be viewed seriously 




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​Steady but slow: On the VIPER mission, lessons for India

India’s space programme needs more resources to realise its full potential




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​The edge of war: On the West Asia situation

Iran should not give Israel an excuse to widen the war




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​Heartland murmurs: On the Haryana Assembly elections

Haryana may throw up surprises after the realignments




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​Healthy sign: On the voting in the 2024 J&K Assembly elections

Turnout numbers in the Assembly elections show distinct patterns in south Kashmir




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​Inflection point: On the escalation in the multi-party West Asia conflict

West Asia needs the intervention of major world powers for peace 




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Split decision: On the rivalry between the two NCP factions

The ECI and the office of the Speaker have not played fair in cases of defection




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Caste in jail: On discrimination in prisons

Time for State governments to end systemic discrimination in prisons




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​Regulation role: On the 2024 Medicine Nobel

The discovery of microRNA changed the understanding of gene regulation




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​Flipping scripts: On the Haryana and J&K election results  

BJP and INDIA bloc emerge clear winners in Haryana and Jammu & Kashmir




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Sweet and sour: On the laddu ‘adulteration’ case  

The inquiry into laddu adulteration must not be communalised




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​Against the odds: On the 2024 Haryana Assembly elections

The Congress could not counter the caste polarisation in Haryana 




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​Respect the mandate: On the 2024 Jammu and Kashmir elections

With elections done and dusted, J&K now must return to statehood




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Biology transformed: On the Nobel Prize in chemistry

Nobel for determining protein structure recognises a big advance




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The endgame: On the injunction against Google

The U.S. district court injunction against Google could end its app dominance




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Battle of wits: On the Maharashtra and Jharkhand elections 

The Maharashtra and Jharkhand polls will witness intense political battles




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Fate of nations: On the 2024 Economics Nobel

The 2024 Nobel recognises the need for ‘inclusive’ institutions




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​Allow for deliberation: On the legitimate demands of Ladakh

The lack of a legislature and regional autonomy in Ladakh has led to the current protests




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Culture and society: On upholding Section 6A of the Citizenship Act

Supreme Court of India verdict on citizenship law for Assam helps avoid fresh problems




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​Celebration and vigil: On India, kala-azar and trachoma

India must not let its guard down on kala-azar




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Growth prescription: On the latest World Economic Outlook 

The IMF’s ‘mediocre’ medium-term outlook merits policy attention




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Neck and neck: On the U.S. presidential election

Trump and Harris offer U.S. voters vastly different choices 




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​Beyond intoxication: On alcohol regulation, judicial verdict

Batting for States, the Supreme Court of India holds federal balance on regulating alcohol




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​Escalation ladder: On conflict between Israel and Iran

Iran should show strategic restraint; and the world should rein in Israel




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​Tough task: On the battle lines in the Jharkhand Assembly election

Coalitional incoherence could stymie the INDIA bloc’s effort to retain power in Jharkhand




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Sun signs: On extreme heat and Tamil Nadu’s policy decision

States should prepare to assist the vulnerable during extreme heat events




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Watch: When Jimmy Sheirgill Got Violent

'As a storyteller, one always looks to create something for the audience which is thrilling, engaging and entertaining and that is exactly what we have endeavoured with Sikandar Ka Muqaddar.'




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Pathogenesis of Alzheimer's disease and therapeutic strategies involving traditional Chinese medicine

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00660G, Review Article
Shutang Li, Jinfei Yang
As research on AD has progressed, TCM and its active ingredients have increasingly played a crucial role in clinical treatment. This article summarizes extracts from TCM and briefly elucidates their pharmacological mechanisms against AD.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Design, synthesis, inhibitory activity, and molecular simulations study for D-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus

RSC Med. Chem., 2024, 15,3395-3417
DOI: 10.1039/D4MD00334A, Research Article
Vu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh Thanh
D-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia

RSC Med. Chem., 2024, 15,3495-3506
DOI: 10.1039/D4MD00275J, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Thomas J. Cogswell, Laia Josa-Culleré, David Zimmer, Sébastien R. G. Galan, Morgan Jay-Smith, Kate S. Harris, Carole J. R. Bataille, Thomas R. Jackson, Douzi Zhang, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. Russell
The optimisation of a class of AML differentiation agents is described to show improved potency, solubility and stability, reduced off target toxicity, and tumour regression in a murine model in vivo.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Integrating amino acids into Bcr-Abl inhibitors: design, synthesis, biological evaluation, and in silico studies

RSC Med. Chem., 2024, 15,3507-3528
DOI: 10.1039/D4MD00417E, Research Article
Yuying Liu, Zeyu Yang, Jie Zhang, Na Guo, Nanxin Liu, Qingqing Zhang, Xintao Dang, Yanchen Li, Jie Zhang, Xiaoyan Pan
In continuation of our previous research, a series of novel Bcr-AblT315I inhibitors with tert-leucine or serine as a flexible linker were developed and biological evaluation was performed in vitro.
The content of this RSS Feed (c) The Royal Society of Chemistry




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The synthesis and bioactivities of ROCK2 inhibitors with 1,2-dithiolan-3-yl motif

RSC Med. Chem., 2024, 15,3576-3596
DOI: 10.1039/D4MD00438H, Research Article
Ruolin Cao, Fangyu Du, Zhiqiang Liu, Pengcheng Cai, Minggang Qi, Wei Xiao, Xuefei Bao, Guoliang Chen
Rho-associated coiled-coil containing kinase (ROCK) plays an important role in inflammation.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis of a celastrol derivative as a cancer stem cell inhibitor through regulation of the STAT3 pathway for treatment of ovarian cancer

RSC Med. Chem., 2024, 15,3433-3443
DOI: 10.1039/D4MD00468J, Research Article
Meijuan Liu, Na Li, Zhaoxue Wang, Shuo Wang, Shaoda Ren, Xiaojing Li
A synthetic celastrol derivative (Cel-N) attenuates cancer cell stemness, inhibits the STAT3 pathway, and exerts anti-ovarian cancer effects in cell and mouse models.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Pyridazinone-based derivatives as anticancer agents endowed with anti-microbial activity: molecular design, synthesis, and biological investigation

RSC Med. Chem., 2024, 15,3529-3557
DOI: 10.1039/D4MD00481G, Research Article
Mohamed K. S. El-Nagar, Mai I. Shahin, Mohammed F. El-Behairy, Ehab S. Taher, Mohamed F. El-Badawy, Marwa Sharaky, Dalal A. Abou El Ella, Khaled A. M. Abouzid, Mai Adel
Discovery of novel pyridazinone derivatives with dual antimicrobial and anticancer activities.
The content of this RSS Feed (c) The Royal Society of Chemistry