io How mobile data can help rationalise bus routes By www.thehindubusinessline.com Published On :: Wed, 01 May 2013 16:35:55 +0530 Full Article R Dinakaran
io Missing the obvious By www.thehindubusinessline.com Published On :: Mon, 29 Jul 2013 17:04:17 +0530 Full Article R Dinakaran
io Location tracking - do you need it? By www.thehindubusinessline.com Published On :: Sat, 17 Aug 2013 16:31:13 +0530 Full Article R Dinakaran
io The transformation of BSNL By www.thehindubusinessline.com Published On :: Fri, 03 Jan 2014 15:08:58 +0530 Full Article R Dinakaran
io Weather gods: On ‘Mission Mausam’ By www.thehindu.com Published On :: Sat, 14 Sep 2024 00:10:00 +0530 Attempts at controlling the weather are still in the realm of uncertainty Full Article Editorial
io Last mile woes: On inflation data and the challenges By www.thehindu.com Published On :: Sat, 14 Sep 2024 00:20:00 +0530 Inflation should not be allowed to undermine the economic momentum Full Article Editorial
io Unrealistic expectations: On India and Russia-Ukraine peace By www.thehindu.com Published On :: Mon, 16 Sep 2024 00:37:00 +0530 India’s efforts at peacemaking between Russia and Ukraine have limited potential Full Article Editorial
io Clarity of vision: On eye drops for presbyopia and ‘claims’ By www.thehindu.com Published On :: Tue, 17 Sep 2024 00:15:00 +0530 A useful drug is undone by fantastic claims about its efficacy Full Article Editorial
io Down to the wire: On the run-up to the U.S. presidential election By www.thehindu.com Published On :: Tue, 17 Sep 2024 00:30:00 +0530 The U.S. presidential race is poised on a knife’s edge Full Article Editorial
io Wrong notion: On simultaneous elections By www.thehindu.com Published On :: Fri, 20 Sep 2024 00:10:00 +0530 The idea of simultaneous elections is inherently anti-federal Full Article Editorial
io Pivot to watch: On the U.S. Fed’s rate reduction, its impact By www.thehindu.com Published On :: Sat, 21 Sep 2024 00:10:00 +0530 Full Article Editorial
io Sri Lanka’s verdict: On the Island nation’s ninth Presidential election By www.thehindu.com Published On :: Mon, 23 Sep 2024 00:10:00 +0530 The spirit of the mandate of the presidential poll was clear — for change Full Article Editorial
io Politicising the laddu: On the Tirupati laddu and its ‘adulteration’ By www.thehindu.com Published On :: Tue, 24 Sep 2024 00:30:00 +0530 The Tirupati laddu issue should be limited to one of quality control Full Article Editorial
io It is an offence: On Supreme Court clarification on online content on child sex abuse By www.thehindu.com Published On :: Wed, 25 Sep 2024 00:10:00 +0530 Court has done well to clarify law on online content showing child sex abuse Full Article Editorial
io Kashmir conflict: On the J&K elections By www.thehindu.com Published On :: Thu, 26 Sep 2024 00:20:00 +0530 The political divide between national parties and regional parties is clear Full Article Editorial
io Staying the course: On the fight against air pollution in the Indo-Gangetic plains By www.thehindu.com Published On :: Sat, 28 Sep 2024 00:10:00 +0530 The Centre and the States need to fight air pollution together Full Article Editorial
io Mad doctrine: On Russia’s revision of its nuclear doctrine By www.thehindu.com Published On :: Mon, 30 Sep 2024 00:10:00 +0530 Any threat of use of nuclear weapons must be viewed seriously Full Article Editorial
io Steady but slow: On the VIPER mission, lessons for India By www.thehindu.com Published On :: Tue, 01 Oct 2024 00:30:00 +0530 India’s space programme needs more resources to realise its full potential Full Article Editorial
io The edge of war: On the West Asia situation By www.thehindu.com Published On :: Tue, 01 Oct 2024 00:57:00 +0530 Iran should not give Israel an excuse to widen the war Full Article Editorial
io Heartland murmurs: On the Haryana Assembly elections By www.thehindu.com Published On :: Wed, 02 Oct 2024 00:20:00 +0530 Haryana may throw up surprises after the realignments Full Article Editorial
io Healthy sign: On the voting in the 2024 J&K Assembly elections By www.thehindu.com Published On :: Thu, 03 Oct 2024 00:10:00 +0530 Turnout numbers in the Assembly elections show distinct patterns in south Kashmir Full Article Editorial
io Inflection point: On the escalation in the multi-party West Asia conflict By www.thehindu.com Published On :: Thu, 03 Oct 2024 00:20:00 +0530 West Asia needs the intervention of major world powers for peace Full Article Editorial
io Split decision: On the rivalry between the two NCP factions By www.thehindu.com Published On :: Fri, 04 Oct 2024 00:25:00 +0530 The ECI and the office of the Speaker have not played fair in cases of defection Full Article Editorial
io Caste in jail: On discrimination in prisons By www.thehindu.com Published On :: Sat, 05 Oct 2024 00:10:40 +0530 Time for State governments to end systemic discrimination in prisons Full Article Editorial
io Regulation role: On the 2024 Medicine Nobel By www.thehindu.com Published On :: Tue, 08 Oct 2024 00:36:00 +0530 The discovery of microRNA changed the understanding of gene regulation Full Article Editorial
io Flipping scripts: On the Haryana and J&K election results By www.thehindu.com Published On :: Wed, 09 Oct 2024 00:20:00 +0530 BJP and INDIA bloc emerge clear winners in Haryana and Jammu & Kashmir Full Article Editorial
io Sweet and sour: On the laddu ‘adulteration’ case By www.thehindu.com Published On :: Thu, 10 Oct 2024 00:10:00 +0530 The inquiry into laddu adulteration must not be communalised Full Article Editorial
io Against the odds: On the 2024 Haryana Assembly elections By www.thehindu.com Published On :: Thu, 10 Oct 2024 00:20:00 +0530 The Congress could not counter the caste polarisation in Haryana Full Article Editorial
io Respect the mandate: On the 2024 Jammu and Kashmir elections By www.thehindu.com Published On :: Fri, 11 Oct 2024 00:20:00 +0530 With elections done and dusted, J&K now must return to statehood Full Article Editorial
io Biology transformed: On the Nobel Prize in chemistry By www.thehindu.com Published On :: Mon, 14 Oct 2024 00:28:00 +0530 Nobel for determining protein structure recognises a big advance Full Article Editorial
io The endgame: On the injunction against Google By www.thehindu.com Published On :: Fri, 18 Oct 2024 00:10:00 +0530 The U.S. district court injunction against Google could end its app dominance Full Article Editorial
io Battle of wits: On the Maharashtra and Jharkhand elections By www.thehindu.com Published On :: Fri, 18 Oct 2024 00:20:00 +0530 The Maharashtra and Jharkhand polls will witness intense political battles Full Article Editorial
io Fate of nations: On the 2024 Economics Nobel By www.thehindu.com Published On :: Sat, 19 Oct 2024 00:10:00 +0530 The 2024 Nobel recognises the need for ‘inclusive’ institutions Full Article Editorial
io Allow for deliberation: On the legitimate demands of Ladakh By www.thehindu.com Published On :: Tue, 22 Oct 2024 00:15:00 +0530 The lack of a legislature and regional autonomy in Ladakh has led to the current protests Full Article Editorial
io Culture and society: On upholding Section 6A of the Citizenship Act By www.thehindu.com Published On :: Tue, 22 Oct 2024 00:30:00 +0530 Supreme Court of India verdict on citizenship law for Assam helps avoid fresh problems Full Article Editorial
io Celebration and vigil: On India, kala-azar and trachoma By www.thehindu.com Published On :: Thu, 24 Oct 2024 00:10:00 +0530 India must not let its guard down on kala-azar Full Article Editorial
io Growth prescription: On the latest World Economic Outlook By www.thehindu.com Published On :: Thu, 24 Oct 2024 00:20:00 +0530 The IMF’s ‘mediocre’ medium-term outlook merits policy attention Full Article Editorial
io Neck and neck: On the U.S. presidential election By www.thehindu.com Published On :: Sat, 26 Oct 2024 00:10:00 +0530 Trump and Harris offer U.S. voters vastly different choices Full Article Editorial
io Beyond intoxication: On alcohol regulation, judicial verdict By www.thehindu.com Published On :: Mon, 28 Oct 2024 00:20:00 +0530 Batting for States, the Supreme Court of India holds federal balance on regulating alcohol Full Article Editorial
io Escalation ladder: On conflict between Israel and Iran By www.thehindu.com Published On :: Tue, 29 Oct 2024 00:15:00 +0530 Iran should show strategic restraint; and the world should rein in Israel Full Article Editorial
io Tough task: On the battle lines in the Jharkhand Assembly election By www.thehindu.com Published On :: Wed, 30 Oct 2024 00:20:00 +0530 Coalitional incoherence could stymie the INDIA bloc’s effort to retain power in Jharkhand Full Article Editorial
io Sun signs: On extreme heat and Tamil Nadu’s policy decision By www.thehindu.com Published On :: Thu, 31 Oct 2024 00:10:00 +0530 States should prepare to assist the vulnerable during extreme heat events Full Article Editorial
io Watch: When Jimmy Sheirgill Got Violent By www.rediff.com Published On :: 'As a storyteller, one always looks to create something for the audience which is thrilling, engaging and entertaining and that is exactly what we have endeavoured with Sikandar Ka Muqaddar.' Full Article
io Pathogenesis of Alzheimer's disease and therapeutic strategies involving traditional Chinese medicine By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00660G, Review ArticleShutang Li, Jinfei YangAs research on AD has progressed, TCM and its active ingredients have increasingly played a crucial role in clinical treatment. This article summarizes extracts from TCM and briefly elucidates their pharmacological mechanisms against AD.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
io Design, synthesis, inhibitory activity, and molecular simulations study for D-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3395-3417DOI: 10.1039/D4MD00334A, Research ArticleVu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh ThanhD-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
io Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3495-3506DOI: 10.1039/D4MD00275J, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Thomas J. Cogswell, Laia Josa-Culleré, David Zimmer, Sébastien R. G. Galan, Morgan Jay-Smith, Kate S. Harris, Carole J. R. Bataille, Thomas R. Jackson, Douzi Zhang, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. RussellThe optimisation of a class of AML differentiation agents is described to show improved potency, solubility and stability, reduced off target toxicity, and tumour regression in a murine model in vivo.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
io Integrating amino acids into Bcr-Abl inhibitors: design, synthesis, biological evaluation, and in silico studies By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3507-3528DOI: 10.1039/D4MD00417E, Research ArticleYuying Liu, Zeyu Yang, Jie Zhang, Na Guo, Nanxin Liu, Qingqing Zhang, Xintao Dang, Yanchen Li, Jie Zhang, Xiaoyan PanIn continuation of our previous research, a series of novel Bcr-AblT315I inhibitors with tert-leucine or serine as a flexible linker were developed and biological evaluation was performed in vitro.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
io The synthesis and bioactivities of ROCK2 inhibitors with 1,2-dithiolan-3-yl motif By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3576-3596DOI: 10.1039/D4MD00438H, Research ArticleRuolin Cao, Fangyu Du, Zhiqiang Liu, Pengcheng Cai, Minggang Qi, Wei Xiao, Xuefei Bao, Guoliang ChenRho-associated coiled-coil containing kinase (ROCK) plays an important role in inflammation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
io Synthesis of a celastrol derivative as a cancer stem cell inhibitor through regulation of the STAT3 pathway for treatment of ovarian cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3433-3443DOI: 10.1039/D4MD00468J, Research ArticleMeijuan Liu, Na Li, Zhaoxue Wang, Shuo Wang, Shaoda Ren, Xiaojing LiA synthetic celastrol derivative (Cel-N) attenuates cancer cell stemness, inhibits the STAT3 pathway, and exerts anti-ovarian cancer effects in cell and mouse models.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
io Pyridazinone-based derivatives as anticancer agents endowed with anti-microbial activity: molecular design, synthesis, and biological investigation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3529-3557DOI: 10.1039/D4MD00481G, Research ArticleMohamed K. S. El-Nagar, Mai I. Shahin, Mohammed F. El-Behairy, Ehab S. Taher, Mohamed F. El-Badawy, Marwa Sharaky, Dalal A. Abou El Ella, Khaled A. M. Abouzid, Mai AdelDiscovery of novel pyridazinone derivatives with dual antimicrobial and anticancer activities.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article