BACKGROUND Beige adipose tissue is associated with improved glucose homeostasis in mice. Adipose tissue contains β3-adrenergic receptors (β3-ARs), and this study was intended to determine whether the treatment of obese, insulin-resistant humans with the β3-AR agonist mirabegron, which stimulates beige adipose formation in subcutaneous white adipose tissue (SC WAT), would induce other beneficial changes in fat and muscle and improve metabolic homeostasis.METHODS Before and after β3-AR agonist treatment, oral glucose tolerance tests and euglycemic clamps were performed, and histochemical analysis and gene expression profiling were performed on fat and muscle biopsies. PET-CT scans quantified brown adipose tissue volume and activity, and we conducted in vitro studies with primary cultures of differentiated human adipocytes and muscle.RESULTS The clinical effects of mirabegron treatment included improved oral glucose tolerance (P < 0.01), reduced hemoglobin A1c levels (P = 0.01), and improved insulin sensitivity (P = 0.03) and β cell function (P = 0.01). In SC WAT, mirabegron treatment stimulated lipolysis, reduced fibrotic gene expression, and increased alternatively activated macrophages. Subjects with the most SC WAT beiging showed the greatest improvement in β cell function. In skeletal muscle, mirabegron reduced triglycerides, increased the expression of PPARγ coactivator 1 α (PGC1A) (P < 0.05), and increased type I fibers (P < 0.01). Conditioned media from adipocytes treated with mirabegron stimulated muscle fiber PGC1A expression in vitro (P < 0.001).CONCLUSION Mirabegron treatment substantially improved multiple measures of glucose homeostasis in obese, insulin-resistant humans. Since β cells and skeletal muscle do not express β3-ARs, these data suggest that the beiging of SC WAT by mirabegron reduces adipose tissue dysfunction, which enhances muscle oxidative capacity and improves β cell function.TRIAL REGISTRATION Clinicaltrials.gov NCT02919176.FUNDING NIH: DK112282, P30GM127211, DK 71349, and Clinical and Translational science Awards (CTSA) grant UL1TR001998.

You read that right. Joanne and I visited a Masonic Cemetary. Alone. It was one of the most calming experiences of my life. We were kind of invited, by the town, and when we arrived, we were definitely welcomed by the residents. This all started when, in the brochure listing the “town attractions” that we received in St. Helens, were two cemeteries. The addresses as well as short descriptions were listed, as well as a short missive asking us to please be respectful and not make loud noises. It sounded really creepy and really interesting, so both of us jumped at the chance to drive out there right before sunset. They weren’t what I expected at all… Well, the first one was actually roped off with a “no trespassing” sign hanging from it, so we didn’t go inside. It was right alongside the highway in Oregon, across some old train tracks, visible from the road, and named and marked on a tourist map, yet they didn’t want visitors. I wonder what happened there. In any case, we headed for the other cemetery. This one was removed from the main road, and rumored to be a lot larger. It was also known to be haunted, but visitors were welcome as long as they were respectful. Off the map it was, but when we arrived, it was also gated off. A sad Joanne looks through the gate at the second destination that was cut off from us. Ah, but unlike the other cemetery, this one didn’t have a “no tresspassing” sign. There was a clear path around the sides of the gate, the ground bare of grass and obviously well-traversed. Apparently a lot of people walked around the gate. Maybe they just didn’t want us to drive. We decided to walk. There was even a sign. And a long, winding, steep road through the forest.  It was quite a hike to reach the top of the large hill where the cemetery was supposedly located, but the view was breathtaking. It took us a good ten or fifteen minutes to reach the top, and the road was quite steep. For some reason, to the immediate right of the trail, someone had been excavating land for quite some time, and there was a deep quarry. Why someone would dig a quarry next to a burial ground is beside me. I don’t doubt that the residents were unhappy about it. I wondered if maybe I would feel some spirits, but I didn’t expect what really happened to me. As soon as I stepped off of the road and onto the grass, a calm unlike anything I’ve ever felt descended upon me. It enveloped me in a warm cocoon, and Joanne and I immediately separated and wandered quietly alone between the gravestones. I know, 100%, that not only was I welcomed, but that the residents were happy to have me there. I talked a bit with some of the gravestones, but mostly wandered about, amazed at how much serenity I felt. We must have spent around a half hour wandering quietly alone, together, before we left in order to return to the festivities in town. But I’ll never forget the experience. It was something really, really special. I took some video footage too, but I’m not sure yet whether I want to use it. We’ll see! Someday, I’ll set up a tripod and get a shot of me walking like this. But for now, have Joanne instead. ???? <3

Аналитики из JP Morgan in TF Securities в разное время опубликовали прогнозы относительно будущего модельного ряда iPhone, однако их содержание сходится, что добавляет отчетам достоверности. В частнос...

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Apple today announced that it will begin reopening its retail stores in Germany on May 11, nearly two months after they were closed due to the global health crisis.


In a statement shared with German website Macerkopf, Apple said the stores will initially be focusing on Genius Bar service and support. Enhanced health and safety measures will be implemented, such as body temperature checks prior to entry, limits on how many customers can be in the store at once, social distancing, and reduced hours of operation.

Apple operates 15 retail stores in Germany and will be posting specific hours of operation for each location on its website.

Apple closed all of its retail stores outside of the Greater China region in mid-March. The company has since started to reopen some locations, including in South Korea, Austria, and Australia. All locations in the United States remain closed.

This article, "Apple Stores in Germany to Begin Reopening May 11 With Enhanced Health and Safety Measures" first appeared on MacRumors.com

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Apple in mid-April reopened Apple Garosugil, its lone store in South Korea, located in the Seoul's Gangnam District.


Apple's South Korea reopening has served as a test ground for further store reopenings, and Apple created an instructional video on reopening practices that's now being shared with other retail employees around the world as they prepare to reopen stores. We're not able to share the video, but it provides a good overview of the measures Apple is putting in place to safely operate retail locations.

Retail employees are following a strict set of guidelines that very heavily emphasize social distancing of two meters (or six feet in the United States). Apple is taking the following measures:

• Prior to when work starts, all employees undergo a health screening complete with a temperature check, with the results logged in a daily spreadsheet.


• Daily briefings are done in the mornings in the Forum area at Apple Stores, with employees making sure to sit at least two meters apart.


• Prior to being allowed in the store, customers are also given a temperature check.


• All ‌Apple Stores‌ are providing hand sanitizer, which customers are encouraged to use.


• Stores are limiting the number of people inside, forming lines with customers waiting at least two meters apart.


• Products purchased by customers or returned after repair are delivered from the back in a relay system, being handed off from employee to employee to allow each person to stay in a separated zone without back and forth.


• Product specialists and Genius Bar staff are positioning themselves across tables away from customers in order to maintain distance.


• In the forum area, employees sit one cube away from customers they're interacting with.


• Employees are encouraged to communicate with one another through the Talk app to cut down on unnecessary movement within the store.


• Half of the workstations in the back are empty, with employees working at alternating workstations to keep more distance between them.


• Tables have been rearranged to put products on corners to prevent customers from being near one another.


• Products on tables have been reduced.


• Communal tables and couches have been removed from employee break rooms and have been replaced with individual chairs evenly spaced about the room.


• Operating hours are reduced.


• Employees are all wearing face masks.

After opening its South Korea store on April 16, Apple has reopened its sole store in Vienna, Austria, and 21 stores located in Australia. Stores in Germany will begin reopening on May 11, and all of the newly opened locations are following many of the same guidelines listed above to keep both customers and employees safe.

There's no word yet on when Apple retail stores in the United States will start to reopen, but Apple CEO Tim Cook last week said that stores in North America will begin reopening starting in the month of May.

Apple plans to evaluate data and make reopening decisions on a city by city, county by county basis, following local guidelines and recommendations before opening up a store.
This article, "Apple Preparing Retail Employees to Return to Work With Tips From South Korea Reopening" first appeared on MacRumors.com

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Apple will begin reopening its retail stores in the United States next week, reports CNBC, starting with locations in Idaho, South Carolina, Alabama, and Alaska.


Apple plans to limit the number of customers in the store at a time, and temperature checks will be performed at the door. Apple also has a number of other measures in place to keep customers and employees safe, as we outlined this morning.

"We're excited to begin reopening stores in the US next week, starting with some stores in Idaho, South Carolina, Alabama and Alaska. Our team is constantly monitoring local heath data and government guidance, and as soon as we can safely open our stores, we will."

"Our new social distance protocol allows for a limited number of visitors in the store at one time so there may be a delay for walk-in customers. We recommend, where possible, customers buy online for contactless delivery or in-store pick up."

Reopened Apple Stores will operate on reduced hours and will primarily focus on repairs, with Apple encouraging customers to purchase online where possible.

Most stores are not listing hours at this time with the exception of Apple Boise Towne Square, which reopens Monday at 11:00 a.m.

During last week's earnings call, Apple CEO Tim Cook said that Apple planned to start reopening some stores in the United States in May. Store reopenings are done on a city by city, county by county basis, with Apple taking into account local data and guidelines.

Apple has already reopened stores in South Korea, Austria, and Australia, with plans to also reopen stores in Germany next week.
This article, "Apple to Start Reopening U.S. Stores Next Week" first appeared on MacRumors.com

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Apple's next-generation Apple Watch and watchOS 7 will focus on new mental health capabilities, according to leaker Jon Prosser who recently spoke on the Geared Up podcast. The mention of new ‌Apple Watch‌ features comes towards the end of the podcast.


The next-generation version of the ‌Apple Watch‌, the ‌Apple Watch‌ Series 6, has been rumored to include a blood oxygen sensor, which Prosser says Apple will take advantage of to implement new mental health-related features, such as detecting panic attacks.

What their biggest focus on is right now and I hope it comes this year, it might come next year, but I hope it's coming to WWDC is mental health capabilities. Where they can take the oxygen levels in your blood with your heart rate and determine if you're hyperventilating.

They can identify a panic attack before it happens and warn you on your watch. Especially if you're driving, they'll ask you to pull over and they'll offer breathing exercises once you get pulled over.

Prosser says that while he hopes the feature is released this year, "it might come next year." He also says he hopes for a WWDC unveiling, but if the new feature relies on a blood oxygen sensor in an unreleased version of the ‌Apple Watch‌, it's not likely Apple will unveil the capability until the fall when new ‌Apple Watch‌ models that support it are released.

There is, however, a possibility that it will be revealed at WWDC if older ‌Apple Watch‌ models have a latent ability to detect blood oxygen level, which is not clear at this time, or if the feature does not involve blood oxygen monitoring.

The panic attack detecting rumor was first shared by EverythingApplePro and leaker Max Weinbach back in April, who said that the ‌Apple Watch‌ will also be able to determine when a user is experiencing high levels of stress. Weinbach and EverythingApplePro did not suggest the feature would rely on blood oxygen monitoring, however, and said that it would be available on the ‌Apple Watch‌ Series 4 or later.

Hints that blood oxygen tracking capabilities are coming to a future version of the ‌Apple Watch‌ were found in a leaked version of iOS 14. Blood oxygen monitoring is an important feature because a drop in blood oxygen levels can suggest a serious respiratory or cardiac problem that requires immediate medical attention.

Multiple prior rumors from Bloomberg and other sources have also indicated that the next-generation ‌Apple Watch‌ and watchOS 7 will include sleep tracking features, allowing the ‌Apple Watch‌ to measure sleep quality, length, and other metrics.
This article, "Rumor Claims watchOS 7 Will Have 'Mental Health Capabilities' to Detect Panic Attacks" first appeared on MacRumors.com

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On Wednesday, May 1, 2019, Flayrah contributor 2cross2affliction wrote in the article 'Sonic the Hedgehog' ... the movie ... the trailer:

Fun fact: no movie directly adapted from a video game has ever scored as "fresh" on the review aggregate site Rotten Tomatoes. [...] But, a new challenger approaches! [...] The question of whether this movie is going to be any good, perhaps unfairly, has mostly already been answered by the Internet. The answer so far has been no. No. Just no. Okay, maybe Jim Carrey? But otherwise, why? Why the human teeth? Why ten times?

Whoops. Turns out Sonic the Hedgehog somehow, against the odds, is rated Fresh by Rotten Tomatoes, with a score of 64% positive reviews from 175 professional opinions, as of this writing.

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After the bumper here, the review will get into spoiler territory. I will say that if you are a Sonic fan this movie will give you a sense of pride as it is far better than it should have had any right in being. Taking the franchise’s lore and resetting it to tell its own story, but retaining the strong characterization and quip heavy personalities of Sonic and Robotnik that makes their rivalry such a strong one. It also keeps the first entry simple with the hedgehog and doctor being the only two characters from the universe being in the film. This makes the story stronger since it can develop those two far more and not have to worry about any other kind of side character fan service for now.

Hey, at least now Sonic fans can brag to Mario ones that Mario may still be the king of games, but Sonic blew the plumber’s cinematic pieces out of the water. Not that that was a high bar I suppose. Then again, having better quality games than Sonic these days isn’t one either (the author quips while using a quote from Sonic Forces for his review’s headline).

In the video game Sonic the Hedgehog, timing is everything. While at the heart of the game is a fast paced platformer, its foundation has always been learning the layout of a level and timing your actions appropriately. In a twist, the timing of this film and its release had quite a bit of impact on my view of it.

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Animal Crackers (trailer) is a 94-minute computer-animated children's movie. The brainchild of Scott Sava, it caught the early attention of furry fandom at least as far back as 2015. Concept animation showed a guy haphazardly munching on animal-shaped cookies that turned him into the animals. As time went on, Sava brought in financial backers, a co-director (Tony Bancroft, who'd worked on several Disney movies), and a co-writer (Dean Lorey). The finished product premiered at the Annecy Film Festival in 2017... and then vanished.

It turns out that Sava had made the mistake of not securing a distributor ahead of time. With very little bargaining power, it eventually got shown in China in 2018, and some other countries in 2019.

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Disney has announced that it will be producing a new Robin Hood movie.

Yes, that Robin Hood.

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Fortnite Battle Royale (or just Fortnite) is a “battle royale” shooter that has been around since 2017, and while its getting a bit long in the tooth, it’s still hanging around and still free to play. Last year, the game finally implemented skill-based matchmaking, which means for casual and new players, it’s never been easier to get into. In many ways, it is comparable to Nintendo properties such as Super Smash Bros. or Mario Kart, taking a more traditionally “hardcore” video game genre and making it more accessible with gimmicky gameplay, goofy items, cartoony visuals and massive amounts of RNG.

Of course, the game isn’t exactly furry in and of itself, but the game makes its money selling cosmetic upgrades to player’s in game characters, and quite a few of them feature either characters in animal costumes, or, more recently, straight up anthropomorphic animals. In the time-honored tradition of clickbait listicals, here is my ranking of those skins.

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Bonesy the Dog

Camo the Chameleon

Dodger the Fox

Empress the Cat

Gunner the Dog

Hamirez the Hamster

Kitsune the Fox

Kyo the Robot Cat

Remus the Wolf

Scales the Dragon

Woodsy the Puppet Dog

Erowid Exp113948

Erowid Exp98591

On the Young Turks, Cenk Uygur quotes passages from Bob Woodward's book, "The Price of Politics", quoting statements made by President Obama proving that he intends to cut entitlements like social security, medicare, and medicaid. Continue reading →

Vermont Sen. Bernie Sanders talks about the need for a "serious debate about serious issues," and whether he plans to challenge Hillary Clinton for the Democratic nomination. Sanders also adds that America needs to hear Hillary Clinton's opinions on the TPP, middle class struggles, and the Keystone XL pipeline. Continue reading →

On April 30, 2015 Ed Schultz, host of The Ed Show, interviews Senator Bernie Sanders on his announcement that he will run for President of the United States in the Democratic Primary. Continue reading →

"I think I'm the only candidate who's prepared to take on the billionaire class," Sanders, I-Vt., told ABC's George Stephanopoulos on "This Week." "We need a political revolution in this country involving millions of people who are prepared to stand up and say, enough is enough, and I want to help lead that effort." Continue reading →

Democratic presidential candidate Sen. Bernie Sanders explains why he thinks he thinks his record of “strong and bold leadership” could help him best candidate Hillary Clinton in the Democratic primary. Continue reading →

Bernie Sanders offers a real deal to the middle class and not the raw deal of Hillary Clinton Continue reading →

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Senator Bernie Sanders does not think that Hillary Clinton can stand up and fight for the middle class. Continue reading →

Democratic presidential candidate Bernie Sanders (I-VT) on Tuesday unveiled a plan to address income inequality by taxing Wall Street speculation and using the money to eliminate college tuition. Continue reading →

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Presidential candidate Bernie Sanders says he wants to offer tuition free at public colleges and universities, paid for with a new tax on Wall Street. Ed Schultz and Sanders discuss the senator’s proposal. Continue reading →

THE AMERICAN PEOPLE IN THIS PARTICULAR MOMENT IN OUR HISTORY MUST MAKE A VERY FUNDAMENTAL DECISION, AND THAT DECISION IS DO WE CONTINUE THE STATUS QUO WHICH INCLUDES A 40-YEAR DECLINE OF OUR MIDDLE CLASS AND A HUGE AND GROWING GAP BETWEEN THE VERY, VERY RICH AND EVERYONE ELSE, OR DO WE FIGHT FOR A BOLD AND MEANINGFUL ECONOMIC AGENDA THAT CREATES JOBS, RAISES WAGES, PROTECTS OUR ENVIRONMENT AND PROVIDES HEALTH CARE FOR EVERY AMERICAN Continue reading →

Even though Corporate America has anointed Hillary Clinton as its next President, Senator Bernie Sanders' populist message is already in a week's time raising individual contributions totaling millions of dollars from hundreds of thousands of people! Continue reading →

SANDERS: ... there is more coverage about the political gossip of a campaign, about raising money, about polling, about somebody saying something dumb, or some kid works for a campaign sends out something stupid on Facebook, right? We can expect that to be a major story. But what your job is, what the media's job is, is to say, look, these are the major issues facing the country. We're a democracy. People have different points of view. Let's argue it. Continue reading →

Bernie Sanders does not have to win the Iowa primary; however, if the gets 35%, 40%, or 45% of the vote, that would set him up nicely for the New Hampshire primary, next door to his state of Vermont. Continue reading →

Sen. Bernie Sanders (I-Vt.) warns not to underestimate him in the 2016 Democratic race for the White House. Sanders, who is formally launching his campaign Tuesday, said he has a strong message. Continue reading →

Have you ever observed the mating dance of the birds of paradise? The male moves dramatically, and in response, the female inches away, but ultimately the male conquers the female, and achieves the purpose of this ritualistic, instinctive dance. Well, … Continue reading →

“Thank you all very much for being here and for all the support that you have given me over the years: as the mayor of this great city, as Vermont’s only congressman and now as a U.S. senator. Thanks also … Continue reading →

Chuck Todd tells Andrea Mitchell that Hillary Clinton will win the African-American and Hispanic vote in spite of the intellectual appeal of Bernie Sanders to liberal white voters Continue reading →

Bernie Sanders calls out Hillary Clinton to announce her position on the Trans-Pacific Partnership (TPP) agreement; however, Hillary Clinton refuses to reveal her position, hoping that the agreement will be passed and she won't have to take a position. Continue reading →

The Vermont Senator and Presidential candidate talks Hillary Clinton, the 2016 race, and an essay he wrote in the 70's about sex. Continue reading →

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December 6, 2015, 10:50 AM|Senator Bernie Sanders, I-Vermont, believes there must be an international coalition led by Arab nations in the fight against ISIS. Continue reading →

JONES: You talked about the person we always talk about, Donald Trump. Let's talk about the person we never talk about, we just heard from. Bernie Sanders has incredible momentum. He's had almost a media blackout. We -- I mean, he's almost never the subject of the main conversation. But out in the country, you see a lot of Bernie Sanders support. He got more contributions, individual donors, than anybody in American history. That by itself lets you know something's going on. I think he's going to win Iowa. He may win New Hampshire. Continue reading →

Bernie Sanders would have already won this nominating contest if we had received an accurate accounting of the vote. It is deeply troubling the Senator would be sending out surrogates to talk about his allegiance to the Democratic party and Clinton in general in the face of the Party instituting theft against its own constituents. It is no mystery HOW to win. Count the votes and contest fraud. A tough Sane Progressive call out. Continue reading →

Ralph Nader on Campaign 2016 Ralph Nader talked about his upcoming book, Breaking Through Power: It’s Easier Than We Think, as well as the latest developments in the 2016 presidential election. Continue reading →

Leaders of political revolutions never quit before the official battle begins, and say that they will vote for and support their enemies. When the moment arrived of walking all that endless talk of Bernie Sanders about fighting his political revolution, he caved out of self interest Continue reading →

Chris Hedges speaks the truth about American politics while Robert Reich shows that he is still an establishment Democrat after all, like Bernie Sanders. Continue reading →