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[ASAP] Ruthenium(II) Complex Containing a Redox-Active Semiquinonate Ligand as a Potential Chemotherapeutic Agent: From Synthesis to <italic toggle="yes">In Vivo</italic> Studies

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Published On :: Thu, 07 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00431

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[ASAP] Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core

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Published On :: Fri, 08 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00192

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[ASAP] Exploration of the Structural Space in 4(3<italic toggle="yes">H</italic>)-Quinazolinone Antibacterials

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Published On :: Fri, 08 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00153

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[ASAP] Drug Research Meets Network Science: Where Are We?

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Published On :: Fri, 08 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.9b01989

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[ASAP] Discovery and Optimization of Glucose Uptake Inhibitors

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Published On :: Fri, 08 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.9b02153

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[ASAP] Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin—Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme

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Published On :: Fri, 08 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00441

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[ASAP] Discovery of a Cyclic Choline Analog That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria

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Published On :: Mon, 30 Mar 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00005

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[ASAP] Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma

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Published On :: Mon, 30 Mar 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00601

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[ASAP] Chimeric Peptidomimetics of SOCS 3 Able to Interact with JAK2 as Anti-inflammatory Compounds

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Published On :: Mon, 30 Mar 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00664

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[ASAP] Progress in the Field of Aldehyde Dehydrogenase Inhibitors: Novel Imidazo[1,2-<italic toggle="yes">a</italic>]pyridines against the 1A Family

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Published On :: Tue, 31 Mar 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00686

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[ASAP] Cancer Immunotherapy through the Inhibition of Diacylglycerol Kinases Alpha and Zeta

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Published On :: Wed, 01 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00118

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[ASAP] Inhibitors of Hypoxia-Inducible Factors as Treatment for Cancer

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Published On :: Wed, 01 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00116

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[ASAP] Glycans Meet Sphingolipids: Structure-Based Design of Glycan Containing Analogues of a Sphingosine Kinase Inhibitor

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Published On :: Wed, 01 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00665

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[ASAP] Peptoid NPhe<sup>4</sup> in AGRP-Based c[Pro<sup>1</sup>-Arg<sup>2</sup>-Phe<sup>3</sup>-Phe<sup>4</sup>-Xxx<sup>5</sup>-Ala<sup>6</sup>-Phe<sup>7</sup>

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Published On :: Wed, 01 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00641

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[ASAP] Therapeutic Potential of Targeted Nanoparticles and Perspective on Nanotherapies

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Published On :: Thu, 02 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00075

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[ASAP] Synthesis of Novel G Factor or Chloroquine-Artemisinin Hybrids and Conjugates with Potent Antiplasmodial Activity

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Published On :: Thu, 02 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00669

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[ASAP] Novel HIV-1 Protease Inhibitors with Morpholine as the P2 Ligand to Enhance Activity against DRV-Resistant Variants

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Published On :: Thu, 02 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00043

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[ASAP] Design, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence Time

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Published On :: Thu, 02 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00045

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[ASAP] Substituted Naphthalenediimide Compounds Bind Selectively to Two Human Quadruplex Structures with Parallel Topology

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Published On :: Thu, 02 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00041

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[ASAP] Escaping from Flatland: Substituted Bridged Pyrrolidine Fragments with Inherent Three-Dimensional Character

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Published On :: Thu, 02 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00039

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[ASAP] Characterization of an Alginate Encapsulated LS180 Spheroid Model for Anti-colorectal Cancer Compound Screening

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Published On :: Fri, 03 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00076

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[ASAP] Structure Optimization of Gatastatin for the Development of ?-Tubulin-Specific Inhibitor

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Published On :: Mon, 06 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00526

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[ASAP] Chiral Analogues of PFI-1 as BET Inhibitors and Their Functional Role in Myeloid Malignancies

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Published On :: Tue, 07 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00625

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[ASAP] Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface

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Published On :: Tue, 07 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00111

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[ASAP] Assembling Pharma Resources to Tackle Diseases of Underserved Populations

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Published On :: Wed, 08 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00051

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[ASAP] Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents

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Published On :: Wed, 08 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00639

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[ASAP] Exploring the Implication of DDX3X in DENV Infection: Discovery of the First-in-Class DDX3X Fluorescent Inhibitor

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Published On :: Thu, 09 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00681

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[ASAP] Discovery of BMS-986251: A Clinically Viable, Potent, and Selective ROR?t Inverse Agonist

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Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00063

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[ASAP] Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction

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Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00594

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[ASAP] New Dual CK2/HDAC1 Inhibitors with Nanomolar Inhibitory Activity against Both Enzymes

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Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00561

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[ASAP] Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents

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Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00129

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[ASAP] Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines

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Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00574

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[ASAP] Design and Synthesis of Tetrazole- and Pyridine-Containing Itraconazole Analogs as Potent Angiogenesis Inhibitors

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Published On :: Mon, 13 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00438

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[ASAP] Potential Cancer Treatment by Agonists of the Stimulator of Interferon Genes

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Published On :: Mon, 13 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00117

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[ASAP] Artemisinin Derivatives with Antimelanoma Activity Show Inhibitory Effect against Human DNA Topoisomerase 1

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Published On :: Tue, 14 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00131

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[ASAP] Complete Regression of Carcinoma via Combined C-RAF and EGFR Targeted Therapy

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Published On :: Tue, 14 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00159

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[ASAP] Discovery of a Potent Dual Inhibitor of Wild-Type and Mutant Respiratory Syncytial Virus Fusion Proteins

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Published On :: Wed, 15 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00008

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[ASAP] Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation

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Published On :: Wed, 15 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00661

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[ASAP] Characterization of Specific <italic toggle="yes">N</italic>-a-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library

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Published On :: Wed, 15 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00029

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[ASAP] Discovery of an Atropisomeric PI3Kß Selective Inhibitor through Optimization of the Hinge Binding Motif

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Published On :: Wed, 15 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00095

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[ASAP] Can Drug Repositioning Work as a Systematical Business Model?

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Published On :: Fri, 17 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00122

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[ASAP] Update to Our Reader, Reviewer, and Author Communities—April 2020

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Published On :: Wed, 22 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00206

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[ASAP] Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor

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Published On :: Mon, 27 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00155

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[ASAP] PROTAC Compounds Targeting a-Synuclein Protein for Treating Neurogenerative Disorders: Alzheimer’s and Parkinson’s Diseases

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Published On :: Tue, 28 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00192

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[ASAP] Development of Selective Steroid Inhibitors for the Glucose-6-phosphate Dehydrogenase from <italic toggle="yes">Trypanosoma cruzi</italic>

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Published On :: Wed, 29 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00106

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[ASAP] P2Y<sub>14</sub> Receptor Antagonists Reverse Chronic Neuropathic Pain in a Mouse Model

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Published On :: Thu, 30 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00115

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[ASAP] Discovery of RO7185876, a Highly Potent ?-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer’s Disease

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Published On :: Fri, 01 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00109

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[ASAP] Ultra-High-Throughput Acoustic Droplet Ejection-Open Port Interface-Mass Spectrometry for Parallel Medicinal Chemistry

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Published On :: Fri, 01 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00066

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[ASAP] Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors

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Published On :: Fri, 01 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00025

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[ASAP] Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase

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Published On :: Fri, 01 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00092