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Combined Raman and AFM detection of changes in HeLa cervical cancer cells induced by CeO2 nanoparticles – molecular and morphological perspectives

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Analyst, 2020, Advance Article
DOI: 10.1039/C9AN02518A, Paper
Mirjana Miletić, Sonja Aškrabić, Jan Rüger, Borislav Vasić, Lela Korićanac, Abdullah Saif Mondol, Jan Dellith, Jürgen Popp, Iwan W. Schie, Zorana Dohčević-Mitrović
Raman and AFM analyses represent a tool for the evaluation of cytotoxic and anti-proliferative effects in cells induced by CeO2 nanoparticles.
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Light-responsive nanozymes for biosensing

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Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00389A, Minireview
Yufeng Liu, Xiaoyu Wang, Hui Wei
Using light as an external stimulus plays a key role not only in modulating activities of nanozymes, but also in constructing efficient biosensing systems. This minireview highlights recent advances in...
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A high-throughput targeted metabolomics method for the quantification of 104 non-polar metabolites in cholesterol, eicosanoid, and phospholipid metabolism: application in the study of a CCl4-induced liver injury mouse model

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Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00385A, Paper
Mengqi Jia, Zhangxiao Peng, Kaige Yang, Changqing Su, Yan Wang, Chao Yan
Experimental workflow of 104 non-polar metabolites in cholesterol, eicosanoid, and phospholipid metabolisms analysis using UPLC-QqQ-MS.
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Target triggered ultrasensitive electrochemical polychlorinated biphenyl aptasensor based on DNA microcapsules and nonlinear hybridization chain reaction

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Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00065E, Paper
Ting Han, Shaozhen Wang, Feifan Sheng, Sicheng Wang, Tianyue Dai, Xiaojun Zhang, Guangfeng Wang
In this work, we demonstrated an ultrasensitive detection platform for polychlorinated biphenyls (PCBs) based on DNA microcapsules and a nonlinear hybridization chain reaction (NHCR).
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Rapid and sensitive detection of NGAL for the prediction of acute kidney injury via a polydopamine nanosphere/aptamer nanocomplex coupled with DNase I-assisted recycling amplification

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Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00474J, Paper
Yiting Hu, Xie-an Yu, Ying Zhang, Ran Zhang, Xuefei Bai, Mi Lu, Jiwei Li, Lifei Gu, Ji-Hua Liu, Bo-Yang Yu, Jiangwei Tian
A rapid and sensitive method for NGAL detection has been developed to predict acute kidney injury and evaluate the protective effect of drug on renal disease.
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A Novel Strategy of Rhodamine B-based Fluorescent Probe for Selective Response of Glutathione to Serve as Bioimaging in Living Cells

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Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00582G, Paper
Zhipeng Li, Wei Xiong, Xiaojun He, Xiaoliang Qi, Feng Ding, Jianliang Shen
To overcome the reported shortcomings of the glutathione (GSH) detection of rhodamine based fluorescent probes, such as poor selectivity to thiol groups and reversible unstable covalent binding with the thiol...
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Imaging Lipophilic Regions in Rodent Brain Tissue with Halogenated BODIPY Probes

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Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00099J, Communication
David Hartnell, Bradley Schwehr, Kate Gillespie-Jones, Dasuni Alwis, Ramesh Rajan, Huishu Hou, nicole j sylvain, M. Jake Jake Pushie, Michael E Kelly, Massimiliano Massi, Mark Hackett
The effect of halogen substitution in fluorescent BODIPY species was evaluated in the context of staining lipids in situ within brain tissue sections. Herein we demonstrate that the halogenated species...
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Profiling of immune-cancer interactions at the single cell level using microfluidic well array

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Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00110D, Paper
Honglei Tu, Zhuhao Wu, Yu Xia, Hui Chen, Hang Hu, Zhao Ding, Fuling Zhou, Shishang Guo
Cancer immunotherapy has achieved great success in hematological cancers. However, immune cells are highly heterogeneous population and can vary highly on clonal expansion, migration and function status, making it difficult...
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Isothermal cross-boosting extension–nicking reaction mediated exponential signal amplification for ultrasensitive detection of polynucleotide kinase

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Analyst, 2020, Advance Article
DOI: 10.1039/C9AN02569C, Paper
Xiao-Yu Li, Yun-Xi Cui, Yi-Chen Du, An-Na Tang, De-Ming Kong
A novel nucleic acid-based isothermal signal amplification strategy, named cross-boosting extension–nicking reaction (CBENR) is developed and successfully used for rapid and ultrasensitive detection of polynucleotide kinase (PNK) activity.
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Near infrared spectroscopic assessment of loosely and tightly bound cortical bone water

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Analyst, 2020, Advance Article
DOI: 10.1039/C9AN02491C, Paper
Ramyasri Ailavajhala, William Querido, Chamith S. Rajapakse, Nancy Pleshko
NIR spectroscopy can differentiate water loosely bound to bone tissue, and tightly bound to either collagen or mineral.
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Nanodiagnostics to monitor biofilm oxygen metabolism for antibiotic susceptibility testing

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Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00479K, Paper
Megan P. Jewell, Samuel C. Saccomano, Alexa A. David, J. Kirk Harris, Edith T. Zemanick, Kevin J. Cash
A method utilizing oxygen-sensitive nanosensor technology to monitor the oxygen consumption dynamics of living biofilms as they are exposed to antibiotics. This method provides information on the MBIC as well as kinetic response.
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DNA binding fluorescent proteins as single-molecule probes

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Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00218F, Critical Review
Kyubong Jo, Xuelin Jin, Natalia Diyah Hapsari, Seunghyun Lee
DNA binding fluorescent proteins are useful probes for a broad range of biological applications. Fluorescent protein (FP)-tagging allows DNA binding proteins expressed within a living cell to be directly visualized,...
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Simultaneous detection of plant growth regulators jasmonic acid and methyl jasmonate in plant samples by a monoclonal antibody-based ELISA

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Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00203H, Paper
Minghui Yi, Linchuan Zhao, Kang Wu, Chang Liu, Diandian Deng, Kang Zhao, Jianguo Li, Anping Deng
Methyl jasmonate (MeJA) and its free-acid form, jasmonic acid (JA), collectively referred to as jasmonates (JAs), are natural plant growth regulators that are widely present in higher plants.
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Kinetic study of azobenzene E/Z isomerization using ion mobility-mass spectrometry and liquid chromatography-UV detection

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Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00048E, Paper
Salomé Poyer, Chang Min Choi, Claire Deo, Nicolas Bogliotti, Juan Xie, Philippe Dugourd, Fabien Chirot, Jean-Yves Salpin
Liquid chromatography with UV detection and ion mobility-mass spectrometry are evaluated to study the E → Z thermal back relaxation kinetics of azobenzenes.
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Ferguson analysis of protein electromigration during single-cell electrophoresis in an open microfluidic device

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Analyst, 2020, Advance Article
DOI: 10.1039/C9AN02553G, Paper
Kristine Y. Tan, Amy E. Herr
Ferguson analysis of protein electromigration from single-cell lysate in an open microfluidic device to inform optimal assay design.
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Enzyme-activated anchoring of peptide probes onto plasma membranes for selectively lighting up target cells

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Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00487A, Paper
Julan Xia, Sujuan Sun, Xianhua Wu, Yan Huang, Chunyang Lei, Zhou Nie
Enzyme-activated membrane insertion peptide probes were developed for selectively lighting up target cells.
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A portable electrochemiluminescence bipolar electrode array for the visualized sensing of Cas9 activity

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Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00678E, Paper
Rui Guo, Shanwen Hu, Zonghua Wang
A new type of closed BPE-ECL system based on an Au electric circuit at a portable substrate is designed for the visualized sensing of Cas9 Activity in the CRISPR/Cas9 system.
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Analytical science in neurochemistry

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Analyst, 2020, Advance Article
DOI: 10.1039/D0AN90043E, Editorial
Jean-Francois Masson, Parastoo Hashemi, Martyn G. Boutelle
Jean-François Masson, Parastoo Hashemi and Martyn Boutelle introduce the Analyst themed collection on Analytical Science in Neurochemistry.
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Correction: Gold alloy-based nanozyme sensor arrays for biothiol detection

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Analyst, 2020, Advance Article
DOI: 10.1039/D0AN90044C, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Junshu Lin, Quan Wang, Xiaoyu Wang, Yunyao Zhu, Xi Zhou, Hui Wei
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Portable surface-enhanced Raman scattering analysis performed with microelectrode-templated silver nanodendrites

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Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00484G, Paper
Joshua Raveendran, Aristides Docoslis
Using a handheld Raman spectrometer, we demonstrate how silver nanodendritic substrates formed on microelectrode platforms can be used for ultrasensitive detection of target analytes, such as cocaine and melamine. The...
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A polypyrrole-coated eightfold-helical Wells–Dawson POM-based Cu-FKZ framework for enhanced colorimetric sensing

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Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00402B, Paper
Qian Li, Mingqi Xu, Xiao Li, Shuxian Li, Liran Hou, Yuhao Chen, Jingquan Sha
A new Wells–Dawson-type CuFKZP2W18-based hybrid compound containing eightfold helical chains is reported, and its CuFKZP2W18/PPy(15%) composite exhibits excellent peroxidase-like catalytic activity.
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A signal cascade amplification strategy based on RT-PCR triggering of G-quadruplex DNAzyme for a novel electrochemical detection of viable Cronobacter sakazakii

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Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00270D, Paper
Yuanyuan Yuan, Xianyong Wu, Zhanmin Liu, QIqi Ning, Liqiang Fu, Sujuan Wu
Cronobacter sakazakii is an important opportunistic food-borne pathogen, and it can cause severe diseases with main symptoms including neonatal meningitis, necrotizing enterocolitis, and sepsis. For the achievement of practical and...
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Changes in latent fingermark glyceride composition as a function of sample age using UPLC-IMS-QToF-MSE

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Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00379D, Paper
Amanda Frick, Natalie Kummer, Ana Moraleda, Celine Weyermann
The composition of fingermark residue has been an important topic in forensic science, mainly in efforts to better understand and eventually improve the efficacy of latent fingermark detection methods. While...
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iso-μmGene: Isothermal amplification-based portable microfluidic system for simple, reliable and flexibly multiplexed Genetic identification and quantification

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Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00560F, Paper
Runtao Zhong, Shilin Liu, Guohao Zhang, Mengyu Wang, Yeqing Sun
Simple, reliable and flexibly multiplexed genetic identification and quantification of microbial pathogens is in urgent need for early disease diagnosis and timely treatment. This study presented an isothermal amplification-based portable...
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A traceless clean-up method coupled with gas chromatography and mass spectrometry for analyzing polycyclic aromatic hydrocarbons in complex plant leaf matrices

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Analyst, 2020, 145,3266-3273
DOI: 10.1039/D0AN00128G, Paper
Xiangzi Jin, Han Yeong Kaw, Huijie Li, Zhao Wang, Jinhua Zhao, Xiangfan Piao, Donghao Li, Dongri Jin, Miao He
This study developed a traceless clean-up method by combining solid phase extraction (SPE) with gas purge–microsyringe extraction (GP–MSE) to purify sample extracts for the determination of polycyclic aromatic hydrocarbons (PAHs) in plant leaves.
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Accelerated non-crosslinking assembly of DNA-functionalized nanoparticles in alcoholic solvents: for application in the identification of clear liquors

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Analyst, 2020, 145,3229-3235
DOI: 10.1039/D0AN00029A, Paper
Luyang Wang, Guoqing Wang, Yali Shi, Lan Zhang, Ran An, Tohru Takarada, Mizuo Maeda, Xingguo Liang
Accelerated aggregation of DNA-functionalized gold nanoparticles is discovered in alcoholic solvents upon adding full-match DNA and is potentially useful for the identification of Baijiu.
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Rapid and accurate identification of marine microbes with single-cell Raman spectroscopy

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Analyst, 2020, 145,3297-3305
DOI: 10.1039/C9AN02069A, Paper
Yaoyao Liu, Jingjing Xu, Yi Tao, Teng Fang, Wenbin Du, Anpei Ye
Rapid and accurate identification of individual microorganisms using single-cell Raman spectra combining with one-dimensional convolutional neural networks.
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In vitro simultaneous mapping of the partial pressure of oxygen, pH and inorganic phosphate using electron paramagnetic resonance

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Analyst, 2020, 145,3236-3244
DOI: 10.1039/D0AN00168F, Paper
Akihiro Taguchi, Stephen DeVience, Benoit Driesschaert, Valery V. Khramtsov, Hiroshi Hirata
A simultaneous mapping method was established for the partial pressure of oxygen, pH and inorganic phosphate using electron paramagnetic resonance.
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Label-free analytical performances of a peptide-based QCM biosensor for trypsin

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Analyst, 2020, 145,3329-3338
DOI: 10.1039/D0AN00308E, Paper
Zong-Mu Dong, Lu Cheng, Ping Zhang, Guang-Chao Zhao
Peptide chains that can be specifically hydrolyzed by trypsin were synthesized and fabricated with Au NPs-MCA on a QCM electrode for the sensitive quantification of trypsin in a complex matrix.
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Fluorescence chemosensing of meldonium using a cross-reactive sensor array

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Analyst, 2020, 145,3345-3352
DOI: 10.1039/D0AN00209G, Paper
Ergin Yalcin, Cem Erkmen, Tugba Taskin-Tok, Mehmet Gokhan Caglayan
Differential sensing of meldonium was achieved using fluorescent chemosensors.
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A disposable molecularly imprinted electrochemical sensor for the ultra-trace detection of the organophosphorus insecticide phosalone employing monodisperse Pt-doped UiO-66 for signal amplification

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Analyst, 2020, 145,3245-3256
DOI: 10.1039/D0AN00278J, Paper
Liping Xu, Jiebin Li, Jiajia Zhang, Junyong Sun, Tian Gan, Yanming Liu
A disposable electrochemical sensor was fabricated based on monodisperse Pt-doped UiO-66 and a mesoporous molecularly imprinted polymer to specifically detect phosalone.
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Analysis of deoxyribonuclease activity by conjugation-free fluorescence polarisation in sub-nanolitre droplets

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Analyst, 2020, 145,3222-3228
DOI: 10.1039/C9AN02380A, Paper
Jae-Won Choi, Bala Murali Krishna Vasamsetti, Jaebum Choo, Hak Yong Kim
Deoxyribonuclease (DNase) assay using ethidium bromide (EtBr) molecules by conjugation-free fluorescence polarisation under visible light in a droplet-based microfluidic chip.
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Electrochemiluminescence analysis of tryptophan in aqueous solutions based on its reaction with tetraphenylborate anions

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Analyst, 2020, 145,3364-3369
DOI: 10.1039/D0AN00229A, Paper
Yuriy Zholudov, Natalia Lysak, Dmytro Snizhko, Olena Reshetniak, Guobao Xu
A pulsed electrogenerated chemiluminescence is observed upon the oxidation of tryptophan amino acid in aqueous solutions with a tetraphenylborate co-reactant.
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An SDS-PAGE based method for the quantification of carbon black in biological samples

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Analyst, 2020, 145,3370-3375
DOI: 10.1039/D0AN00046A, Paper
Keyang Liu, Bin Wan
Quantification of Carbon Black (CB) in bio-samples was made available through SDS-PAGE gel electrophoresis.
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An ultrasensitive electrochemiluminescence aptasensor for the detection of diethylstilbestrol based on the enhancing mechanism of the metal–organic framework NH2-MIL-125(Ti) in a 3,4,9,10-perylenetetracarboxylic acid/K2S2O8 system

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Published On ::

Analyst, 2020, 145,3306-3312
DOI: 10.1039/D0AN00212G, Paper
Jingxian Li, Xueling Shan, Ding Jiang, Zhidong Chen
A novel electrochemiluminescence (ECL) aptasensor based on PTCA/NH2-MIL-125 for the determination of diethylstilbestrol.
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An electrochemical sensor based on enzyme-free recycling amplification for sensitive and specific detection of miRNAs from cancer cells

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Analyst, 2020, 145,3353-3358
DOI: 10.1039/D0AN00275E, Paper
Lili Jiang, Yuling Yang, Yuhong Lin, Ziyi Chen, Chao Xing, Chunhua Lu, Huanghao Yang, Shusheng Zhang
A catalyzed hairpin assembly and binding-induced formation of the DNA three-way junction for ultrasensitive electrochemical detection of diverse miRNAs is reported.
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Antibody free ELISA-like assay for the detection of transcription factors based on double-stranded DNA thermostability

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Analyst, 2020, 145,3339-3344
DOI: 10.1039/C9AN02631B, Paper
Yue Sun, Zhiyan Li, Choiwan Lau, Jianzhong Lu
Transcription factors (TFs) play critical roles in gene expression regulation and disease development. Herein we report a chemiluminescence assay for the detection of transcription factor based on double-stranded DNA thermostability.
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Trace manganese detection via differential pulse cathodic stripping voltammetry using disposable electrodes: additively manufactured nanographite electrochemical sensing platforms

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Analyst, 2020, 145,3424-3430
DOI: 10.1039/D0AN00018C, Paper
Open Access
Diego P. Rocha, Christopher W. Foster, Rodrigo A. A. Munoz, Gary A. Buller, Edmund M. Keefe, Craig E. Banks
Additive manufacturing is a promising technology for the rapid and economical fabrication of portable electroanalytical devices.
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Highly sensitive and selective optosensing of quercetin based on novel complexation with yttrium ions

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Analyst, 2020, 145,3376-3384
DOI: 10.1039/D0AN00117A, Paper
Nguyen Ngoc Nghia, Bui The Huy, Yong-Ill Lee
A simple and fast method was developed for the determination of quercetin using a Arduino-based portable device.
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An ionic-based carbon dot for enantioselective discrimination of nonaromatic amino alcohols

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Analyst, 2020, 145,3395-3400
DOI: 10.1039/D0AN00399A, Paper
Datong Wu, Fei Pan, Li Gao, Yongxin Tao, Yong Kong
An ionic chiral carbon dot was designed and synthesized for the chiral recognition of nonaromatic amino alcohols.
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Why ammonium detection is particularly challenging but insightful with ionophore-based potentiometric sensors – an overview of the progress in the last 20 years

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Analyst, 2020, 145,3188-3210
DOI: 10.1039/D0AN00327A, Critical Review
Open Access
María Cuartero, Noemi Colozza, Bibiana M. Fernández-Pérez, Gastón A. Crespo
An overview of ionophore-based electrodes for ammonium sensing critically analyzing contributions in the last 20 years and with focus in analytical applications.
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Time-resolved in situ monitoring of photocatalytic reactions by probe electrospray ionization mass spectrometry

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Analyst, 2020, 145,3313-3319
DOI: 10.1039/D0AN00305K, Paper
Zhongbao Han, Xiaoyu Gu, Shirong Wang, Liyan Liu, Ying Wang, Zhen Zhao, Zhan Yu
We report the application of PESI-MS to in situ monitoring of photocatalytic reactions of cationic dyes in suspensions in real-time.
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Model independent peak fitting and uncertainty assignment for high-precision time-of-flight mass spectrometry

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Analyst, 2020, 145,3401-3406
DOI: 10.1039/D0AN00325E, Paper
Aleksey Vladimirovich Chudinov, Marco Rosenbusch, Vyacheslav Ivanovich Kozlovskiy, Valeriy Vladislavovich Raznikov, Peter Schury, Michiharu Wada, Hermann Wollnik
Logarithmic scale splines for smooth extraction of a native peak shape, and uncertainty estimation using direct trials.
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Paper-based platforms with coulometric readout for ascorbic acid determination in fruit juices

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Analyst, 2020, 145,3431-3439
DOI: 10.1039/D0AN00477D, Paper
Estefanía Nunez-Bajo, M. Teresa Fernández-Abedul
Paper-based electrochemical platforms with coulometric readout are employed for fast and low cost determination of ascorbic acid in commercial juice samples.
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Recent developments of nanoenzyme-based colorimetric sensors for heavy metal detection and the interaction mechanism

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Analyst, 2020, 145,3173-3187
DOI: 10.1039/D0AN00339E, Critical Review
Zhengquan Yan, Hua Yuan, Qi Zhao, Lin Xing, Xiaoyu Zheng, Weiguo Wang, Yulei Zhao, Yang Yu, Lei Hu, Wenli Yao
This work highlights the application and interaction mechanism of metal nanoparticles, metal oxides, metal sulfides, graphene-based nanomaterials and G-quadruplex, etc. in nanoenzyme-based colorimetric sensors.
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In situ multiplex detection of serum exosomal microRNAs using an all-in-one biosensor for breast cancer diagnosis

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Analyst, 2020, 145,3289-3296
DOI: 10.1039/D0AN00393J, Paper
Huizhen Wang, Dinggeng He, Kejing Wan, Xiaowu Sheng, Hong Cheng, Jin Huang, Xiao Zhou, Xiaoxiao He, Kemin Wang
Herein, a simple all-in-one biosensor based on a DNA three-way junction has been constructed for in situ simultaneous detection of multiple miRNAs by competitive strand displacement.
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Novel ratiometric electrochemical sensor for no-wash detection of fluorene-9-bisphenol based on combining CoN nanoarrays with molecularly imprinted polymers

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Analyst, 2020, 145,3320-3328
DOI: 10.1039/D0AN00345J, Paper
Zhaoyi Liu, Yong Zhang, Bing Li, Xiang Ren, Hongmin Ma, Qin Wei
A ratiometric molecularly imprinted polymers electrochemical sensor was fabricated based on the direct electrochemical oxidation of BHPF on CoN nanoarray electrode.
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Using the interfacial barrier effects of p–n junction on electrochemistry for detection of phosphate

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Analyst, 2020, 145,3217-3221
DOI: 10.1039/C9AN02579K, Communication
Yu Ding, Minggang Zhao, Jiatuo Yu, Xiaomin Zhang, Zhengming Li, Hui Li
The electrochemical response to phosphate was produced by the induced change of the interfacial barrier of the NiO/ZnO p–n junction foam.
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Rapid detection of 21 β-lactams using an immunochromatographic assay based on the mutant BlaR-CTD protein from Bacillus Licheniformis

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Analyst, 2020, 145,3257-3265
DOI: 10.1039/D0AN00421A, Paper
Yue Li, Xinxin Xu, Liqiang Liu, Hua Kuang, Liguang Xu, Chuanlai Xu
In this study, a gold immunochromatographic assay (GICA) based on a penicillin receptor protein (PBP) is proposed to simultaneously detect penicillin, cephalosporin, and carbapenem antibiotics in milk and chicken.
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Colorimetric identification of lanthanide ions based on two carboxylic acids as an artificial tongue

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Published On ::

Analyst, 2020, 145,3359-3363
DOI: 10.1039/D0AN00357C, Paper
Chi Zhang, Juan Huang, Wei Wei, Zhengbo Chen
We report a colorimetric array, which consists of two carboxylic acids (quinolinic acid (QA), tannic acid (TCA)) as the sensor element and Eriochrome Black T (EBT) as the colorimetric signal readout.
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