In sporadic Alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been developed recently that detect tau in biological specimens, thus providing a means for pre-mortem diagnosis of Alzheimer's disease, which has remained elusive. These assays have been improved by the analysis of relevant post-translational modifications, such as phosphorylation, however opportunity for improvement remains. The present invention addresses this issue by disclosing synthetic methylated peptides derived from the tau protein of paired helical filaments and non-diseased control brain. Alzheimer's disease specificity is provided by the presence or absence of methyl moieties on lysine residues and differences between mono-, di-, and tri-methylation. The methylated peptide is useful as an antigen and a binding partner for identifying compounds that interact with the peptide and the methylated tau protein, including antibodies that can distinguish non-diseased brain from that affected by Alzheimer's disease. The resulting antibodies are useful diagnostically and therapeutically. The compounds that specifically bind to methylated tau proteins are useful for eliminating abnormally methylated tau.

Provided are a detection agent for detecting hydroxy vitamin D, preparation method thereof, and use thereof in 25-hydroxy vitamin D immunological detection. The detection agent comprises a conjugate formed by a 25-hydroxy vitamin D antigen derivative and protein carrier, and magnetic spheres coated by the conjugate. Also provided is a 25-hydroxy vitamin D detection kit comprising the detection agent.

Compositions and methods useful for point of care testing for hemophilia by measuring coagulation factor levels are provided.

Noted restaurateur Reem Assil has decided to close her Fruitvale restaurant, Reem's California.

"From the bottom of our hearts, we'd like to thank everyone who has supported us in keeping our humble oakland restaurant operation a force in our community.…

California today announced its intent to declare bisphenol A a reproductive hazard. Under a state law known as Prop 65, warning signs would be required for consumer items that contain a certain high level of BPA.…

The present invention relates to a process for producing an electrolytic capacitor, the process comprising process steps i) ii): i) providing a capacitor body (1) that comprises an electrode body (2) of an electrode material,a dielectric (3) which at least partially covers the surface of this electrode material, anda solid electrolyte (4) at least comprising an electrically conductive material which at least partially covers the dielectric surface; ii) applying a primer solution e) to the capacitor body (1), followed by an application of a solution or dispersion a) comprising a conjugated polymer b) and a solvent or dispersant d), followed by an at least partial removal of the solvent or dispersant d) for the formation of the polymeric outer layer (5) that is formed onto the capacitor body (1); wherein the primer solution e) comprises at least one monofunctional amine and at least one carboxylic acid.

The invention relates to a device for thermally disconnecting or tripping an overvoltage protection device, comprising: a locking element (A1), on which a first force (F1) acts, and which is fixed in such a way that same is released when a limit temperature is exceeded; and a slider (S1) which is blocked in a first state (Z1) by the fixed locking element (A1), and on which a second force (F2) acts in order to transfer same into a second state (Z2) when the locking element (A1) is released.

A method and system for cooling a device (preferably a micro-device), comprising cooling the device by using a lower critical solution temperature (LCST) mixture. Enhancement of heat transfer rates is achieved during phase separation of a two-component system (two-component mixture) with a LCST. Convective heat transfer rates in small diameter pipes and over a vertical (hot) plate are demonstrated.

An SSD with a package optimized for semiconductor wafers is configured by thinning a plurality of undiced wafers and stacking the wafers. The wafers are connected to each other by TSV. A subset of the wafers include memory circuits. One of the wafer not in the subset includes peripheral circuits. A casing houses the wafers.

A household distribution box comprises a distribution box case; two service lines introduced from a transformer into the distribution box case of a consumer; three main lines installed in the distribution box case and provided with two lines and a second service line; two sub-lines installed in the distribution box case and formed by branching the second service line among the main lines into two lines; a first circuit breaker installed in the distribution box case; a second circuit breaker installed in the distribution box case; and a controller connected to the first circuit breaker.

The present disclosure provides a method and a system for protecting an electrical device. The method includes: acquiring coordinate data of the electronic device; determining whether the coordinate data exceeds a data range corresponding to a preset state of the electronic device; and disabling the electronic device when the coordinate data exceeds the data range corresponding to the preset state.

A ground fault circuit interrupter (GFCI) breaker testing system can include an enclosure having at least one wall that forms a cavity. The system can also include at least one GFCI breaker disposed within the cavity. The system can further include a sensing circuit assembly having at least one switch, where the at least one switch is electrically coupled to the at least one GFCI breaker. The system can also include a user interface assembly disposed, at least in part, outside the cavity, where the user interface assembly is coupled to the sensing circuit assembly, where the user interface assembly instructs the at least one switch to test the at least one GFCI breaker.

A flexible circuit board includes a first circuit substrate, a second circuit substrate and a bonding layer. The first circuit substrate includes a first base layer, a first circuit layer, a second circuit layer and metal coating layer. The first circuit layer includes a signal line and at least two grounding lines. The metal coating layer encloses the signal line. The second circuit substrate includes a third circuit layer. The bonding layer is located between and bonding the first circuit substrate and the second circuit substrate. The second circuit layer, the third circuit layer are electrically coupled with the grounding lines by a plurality of electrically conductive holes. The first base layer, the bonding layer and the second circuit substrate cooperatively enclose a hermetic medium layer receiving the signal line. The hermitic medium layer is filled with air. A method for manufacturing the flexible circuit board is also provided.

In accordance with disclosed embodiments, there are provided methods, systems, and apparatuses for implementing a magnetic particle embedded flexible substrate, a printed flexible substrate for a magnetic tray, or an electro-magnetic carrier for magnetized or ferromagnetic flexible substrates. For instance, in accordance with one embodiment, there are means disclosed for fabricating a flexible substrate having one or more electrical interconnects to couple with leads of an electrical device; integrating magnetic particles or ferromagnetic particles into the flexible substrate; supporting the flexible substrate with a carrier plate during one or more manufacturing processes for the flexible substrate, in which the flexible substrate is held flat against the carrier plate by an attractive magnetic force between the magnetic particles or ferromagnetic particles integrated with the flexible substrate and a complementary magnetic attraction of the carrier plate; and removing the flexible substrate from the carrier plate subsequent to completion of the one or more manufacturing processes for the flexible substrate. Other related embodiments are disclosed.

A package includes a conductive pad, with a plurality of openings penetrating through the conductive pad. A dielectric layer encircles the conductive pad. The dielectric layer has portions filling the plurality of openings. An Under-Bump Metallurgy (UBM) includes a via portion extending into the dielectric layer to contact the conductive pad. A solder region is overlying and contacting the UBM. An integrated passive device is bonded to the UBM through the solder region.

One embodiment provides a deformable housing, including a recess for holding a deformable device; a deformable portion comprising at least two surfaces having a plurality of concave/convex structures; and at least two support parts embedded in the deformable portion. Other aspects are described and claimed.

An electronic device is provided. The electronic device includes a support member including at least a portion formed of a conductive material, an enclosure member configured to receive the support member and including at least a portion of which is formed of a conductive material. The conductive material portion of the enclosure member and the conductive material portion of the support member are insulated from each other.

An enhanced airflow chassis system includes a component chassis that defines a chassis enclosure including a chassis entrance and component slots. First component carriers are mounted to first components and positioned in each of the component slots. Each first component carrier defines first component carrier airflow apertures that direct airflow entering the chassis entrance to the first component mounted to that first component carrier. A backplane located in the chassis enclosure opposite the component slots from the chassis entrance defines backplane airflow apertures and includes a component connector located adjacent each of the component slots that is connected to the first component mounted to the component carrier positioned in that component slot. A chassis venting member positioned between at least two of the component slots defines chassis venting member airflow apertures that direct airflow entering the chassis entrance through the chassis enclosure to a subset of the backplane airflow apertures.

CHRISTINE Cassell (letters 28th April) asks a pertinent question when she enquires where the responsibility for the problem with PPEs for front line NHS workers lies.

I say to all communities pat yourselves on the back for the great job you are doing taking care of each other and supporting each other.

Weeks have passed, and DJs the world over have settled into the reality of sheltering in place. As efforts to combat COVID-19 push on, the masses are staying at home. Clubs have shuttered their doors, bars and restaurants are no more, and non-essential businesses are closed. But in this primetime of social distancing, there has […]

The post Streaming L(o)ive In The Time of COVID-19: What’s the future for DJ live streaming? appeared first on DJ TechTools.

The live streaming scene might feel crowded, but this week Mixcloud has introduced their own endeavor. They’ve launched a streaming platform built specifically for DJs, Mixcloud Live—not only taking on streaming giants like Facebook, Twitch, and Youtube, but also creating much-needed relief for DJ streams that are continually flagged for copyright. The team at Mixcloud […]

The post Mixcloud Launches A DJ Live Streaming Platform With Copyright Figured Out appeared first on DJ TechTools.

The Town’s soccer franchise returns to the pitch this weekend with a new head coach and other fresh faces, kicking off its second season in front of Oakland's loud, loyal fans at Laney College. Last year, professional soccer planted seeds in Oakland. This year, fans hope to see them bloom into something beautiful, preferably with lots of wins on the Laney College pitch.…

Be extra kind to kind people. ARIES (March 21-April 19): Your oracle comes from Aries poet Octavio Paz: "The path the ancestors cleared is overgrown, unused. The other path, smooth and broad, is crowded with travelers.…

The semiconductor device according to the present invention has an upper electrode, a first lower layer wiring that also functions as a lower electrode, an electrical resistance-changing film interposed between the upper electrode and the first lower layer wiring, a second lower layer wiring, and a contact plug, the contact plug connecting to the upper electrode and to the second lower layer wiring. The present invention yields a semiconductor device with which it is possible to dispose elements in high density while maintaining the reliability and manufacturing yield of the electrical resistance-changing element.

A light emitting device and a method for manufacturing the same are disclosed. Herein, the light emitting device comprises: a substrate having a light emitting region and a sealing region surrounding the light emitting region; an OLED unit disposed over the light emitting region; a protection layer disposed over the OLED unit; a support unit disposed over the sealing region, wherein materials of the protection layer and the support unit are the same, and the support unit connects to the protection layer; and a cover disposed over the protection layer and the support unit; wherein a first height is between a surface of the support unit adjacent to the cover and a surface of the substrate, a second height is between a surface of the protection layer adjacent to the cover and the surface of the substrate, and the first height is larger than the second height.

An axial fuel staging injector for a gas turbine includes a body. The body includes an upstream end and a downstream end. The body defines a primary compressed air flow path through which compressed air flows from a compressed air source to a transition duct of a gas turbine combustor. The body includes a plurality of outlets disposed on an interior surface thereof. Each outlet of the plurality of outlets includes a secondary fuel conduit in fluid communication with a secondary fuel source, and includes a first wall that defines a secondary fuel path. The secondary compressed air conduit is in fluid communication with a compressed air source, and includes a second wall disposed about the first wall in a substantially coannular arrangement, wherein the first wall and the second wall define a secondary compressed air flow path. Each outlet is configured to inject a secondary fuel and compressed air into the primary compressed air flow path in a direction transverse to the primary compressed air flow path forming a fuel-air mixture.

A combustor cap module is provided with a retention system to facilitate assembly and disassembly. The combustor cap module further includes a cap face assembly having a cooling plate; a cylindrical sleeve including a connecting surface for attaching the cap face assembly to the retention assembly; and a coupling member mounted in a downstream fuel nozzle opening in the cooling plate. The retention system includes a support plate having an inner panel that defines an upstream fuel nozzle opening. The coupling member extends through the upstream fuel nozzle opening, such that its upstream end extends upstream of the support plate. A retaining ring at least partially encircles the upstream end of the coupling member and is engaged by a spring plate that is removably secured to the support plate at multiple locations. A method for assembling a combustor cap module is also provided.

An apparatus and a system directed to an improved hydraulic circuit for use on implements powered by separate motorized vehicle such as a tractor. The apparatus and system include an implement, such as a bale processing or stacking device, configured with wheels to be a towed vehicle, with the towed vehicle configured to be conveyed by a tow vehicle. Additionally, a hydraulic pump on the tow vehicle is coupled to one or more accumulators on the towed device to provide hydraulic power at varying rates as needed by one or more mechanical operations of the implement vehicle. A hydraulic circuit including check and block valves in concert with a pressure switch on the implement device obtains hydraulic power from the tow vehicle from a hydraulic pump located on the tow vehicle via one or more hydraulic transfer lines from the tow vehicle to the implement.

There is provided coal gasification unit including: a coal gasifier; a char recovery unit; flare equipment; an air flow rate adjustment valve and an oxygen supply flow passage that supply oxygen-containing gas to the coal gasifier; an inert gas supply flow passage that supplies nitrogen gas to an upstream side of the char recovery unit; and a control unit that controls a supply amount of the oxygen-containing gas and a supply amount of the nitrogen gas, in which the coal gasifier has a starting burner, and in which the control unit controls the supply amount of the nitrogen gas prior to starting combustion of starting fuel by the starting burner so that an oxygen concentration of mixed gas in which combustion gas generated by combustion of the oxygen-containing gas and the starting fuel has been mixed with the nitrogen gas becomes not more than an ignition concentration.

A product for use in a turbocharger system. A turbine housing may define a center core that is circular in shape with a circumference. The turbine housing may define a first volute that extends for a length around only a part of the circumference of the center core, and a second volute that may be positioned radially outside the first volute and that may extend entirely around the circumference of the center core. The first volute and the second volute may define first and second exhaust gas passages through the turbine housing that may be asymmetric. All points of the second volute may be radially outside the first volute from the center core over the entire length of the first volute.

An exhaust treatment system comprising a first oxidation catalyst to oxidise nitrogen and/or carbon compounds in an exhaust stream and a first dosage device downstream of said first oxidation catalyst to supply a first additive. A first reduction catalyst device is arranged downstream of said first dosage device for reduction of nitrogen oxides using said first additive, and for the generation of heat, through at least one exothermal reaction with said exhaust stream. A particulate filter arranged downstream of said first reduction catalyst device to catch soot particles and a second dosage device, arranged downstream of said particulate filter to supply a second additive. A second reduction catalyst device is arranged downstream of said second dosage device for reduction of nitrogen oxides in said exhaust stream, through the use of at least one of said first and said second additive.

An exhaust apparatus for a diesel engine rapidly burns an unburned deposit in an upstream exhaust catalyst with heat of a heater. The exhaust apparatus includes a downstream exhaust cleaner, an upstream exhaust catalyst provided in an exhaust passage, upstream of the downstream exhaust cleaner, a heater disposed at an exhaust inlet of the upstream exhaust catalyst, and an engine starter apparatus. A control unit controls the power supply to the heater and an engine start process is performed by the engine starter apparatus. A start command unit is connected to the control unit. When the engine has been stopped and then the start command unit gives the control unit a start command, the control unit powers the heater without performing an engine start process, thereby keeping the engine stopped for a predetermined period of time after the start command has been given, and subsequently performing the engine start process.

The invention relates to a storage tank (1) in a motor vehicle for receiving an aqueous urea solution for the SCR of nitrogen oxide in the exhaust gas. The storage tank (1) comprises a tank body which forms a storage volume (2) for the urea solution. The storage tank (1) furthermore comprises a filling pipe for filling the storage volume (2) and means for venting the storage volume (2) during the refuelling, wherein the filling pipe (3) has a filling head (9) at a remote end, and the filling head (9) forms an orifice stub (10). The orifice stub (10) defines an orifice (11) for receiving a fuel pump nozzle. Said orifice stub furthermore has an external thread for receiving a complementary union thread of a refuelling cylinder for refuelling by the gas displacement method. The orifice stub forms at least one secondary air opening when the refuelling cylinder is attached, and therefore, when a refuelling cylinder is attached, a sealing seat is bridged by the refuelling cylinder and refuelling by the gas displacement method is possible even if counterflow venting through the filling tube (3) does not take place.

A sensor mounting table for mounting sensors to an aftertreatment system may include a sensor mounting plate having a substantially flat mounting surface for mounting one or more sensors associated with the aftertreatment system. The substantially flat mounting surface may be offset from a heat shield of the aftertreatment system. The sensor mounting table may further include an insulative material disposed between at least a portion of the substantially flat mounting surface of the sensor mounting plate and the heat shield. The sensor mounting plate may be configured to be attached to the aftertreatment system to secure the insulative material between the substantially flat mounting surface of the sensor mounting plate and the heat shield.

The heat shield assembly includes an inner-most layer that is directly engagable with an exhaust component and is of a non-ceramic material with a first heat capacity and a first thermal conductivity. The heat shield assembly additionally includes an insulating layer that surrounds the inner-most layer and is of a material that has a second heat capacity which is lower than the first heat capacity and has a second thermal conductivity which is lower than the first thermal conductivity. The direct engagement of the inner-most layer with the exhaust component allows heat to be easily transferred between the exhaust component and the inner-most layer.

A controller is provided, which detects operating conditions of an internal combustion engine on the basis of detection results from a group of sensors and drives an actuator that modifies an opening position of a wastegate valve on the basis of the operating conditions. When driving the wastegate valve to a fully closed opening, the controller initially drives the actuator toward a preset provisional fully closed position, and after determining on the basis of a detection result from a position sensor that an actual opening of the wastegate valve has reached the provisional fully closed opening, switches a target opening to the fully closed opening and drives the actuator accordingly.

A required opening correction amount is calculated based on a target supercharging pressure and an actual supercharging pressure, a target opening is calculated based on a required opening and the required opening correction amount, an actual operating position of a wastegate valve is determined to correspond to a fully closed position when the wastegate valve is in a fully closed condition, an actual opening of the wastegate valve is calculated based on the fully closed position and the actual operating position, an operation amount of an actuator for aligning the target opening with the actual opening is calculated based on the target opening and the actual opening, and when the target opening corresponds to the fully closed condition and the actual operating position is not decreased at or above a prescribed rate, the fully closed position is updated to the actual operating position.

A gas turbine engine system and method of operating gas turbine engines are provided. The gas turbine engine assembly includes a gas turbine engine includes a power shaft configured to rotate about an axis of rotation. The gas turbine engine assembly also includes a first fan and a second fan coupled to the power shaft coaxially with the gas turbine engine. The gas turbine engine assembly also includes a first fan duct configured to direct a first stream of air to the first fan. The gas turbine engine assembly also includes a second fan duct configured to direct a second stream of air to the second fan. The gas turbine engine assembly also includes an exhaust duct configured to direct a stream of exhaust gases of the gas turbine engine in a direction of the axis of rotation.

A system includes a gas turbine system having a turbine combustor, a turbine driven by combustion products from the turbine combustor, and an exhaust gas compressor driven by the turbine. The exhaust gas compressor is configured to compress and supply an exhaust gas to the turbine combustor. The gas turbine system also has an exhaust gas recirculation (EGR) system. The EGR system is configured to recirculate the exhaust gas along an exhaust recirculation path from the turbine to the exhaust gas compressor. The system further includes a main oxidant compression system having one or more oxidant compressors. The one or more oxidant compressors are separate from the exhaust gas compressor, and the one or more oxidant compressors are configured to supply all compressed oxidant utilized by the turbine combustor in generating the combustion products.

The heat exchanger system includes a first heat exchanger assembly including a plurality of airfoil members circumferentially spaced in a flow stream of an annular duct. Each airfoil member including a radially inner end and a radially outer end and a first internal flowpath configured to channel a flow of cooled fluid therethrough. The heat exchanger assembly includes a second heat exchanger assembly including a plurality of fin members extending proximate the flow stream and a second internal flowpath configured to channel a flow of cooled fluid therethrough. The heat exchanger assembly includes a header system including a conduit path configured to couple the first heat exchanger assembly and the second heat exchanger assembly in flow communication. The header system includes an inlet connection configured to receive a flow of hot fluid from thermal loads and an outlet connection configured to direct cooled fluid to thermal loads.

The heat exchanger assembly includes a first internal flow path configured to channel a flow of fluid to be cooled from a first inlet to a first outlet. The heat exchanger assembly also includes a second internal flow path configured to channel a flow of a first coolant from a first inlet to a first outlet. The heat exchanger assembly further includes an external flow path configured to receive a flow of a second coolant proximate a surface of the external flow path.

A method for controlling a pressure control mechanism in a turbofan engine having a precooler permitting heat exchange between ambient air and bleed air includes detecting at least one of an engine failure or a bleed system failure, detecting at least one of an ice condition or an activation of an anti-ice system, and actuating the pressure control mechanism, thereby altering the heat exchange between the ambient air and the bleed air.

In a rotary machine, a method of assembling a rotary machine, and a method of performing maintenance of a rotary machine, a combustor casing as an outer casing configured from upper and lower casings forming a half split shape, an intermediate shaft cover as an inner casing configured from upper and lower casings forming a half split shape and supporting a combustor in the combustor casing, and a pressing support mechanism that presses and supports a portion to be fit of the combustor casing and a fitting portion of the intermediate shaft cover in an axial direction of a rotor are provided, and thus, detachment of the casing is made easy and maintainability of an inside thereof is improved in the method of performing maintenance of a rotary machine.

An assistance device for an aircraft free-turbine turbine engine, the device including first electrical power supply for powering a winding of a starter rotary machine, referred to as a “first” winding, in order to provide first assistance in accelerating the gas generator of the engine. The device further includes a monitor for monitoring the first assistance, and a second power supply for electrically powering a second winding of the rotary machine to provide second assistance in accelerating the gas generator if the monitor observes that the first assistance is insufficient.

A method for operating a stationary gas turbine at partial load, having at least one compressor, at least one expansion turbine and a combustion chamber provided with at least one burner, which gas turbine further includes a hydraulic gap adjuster, wherein the method has the following steps: operating the gas turbine at partial load; operating the a hydraulic gap adjuster; during the operation of the hydraulic gap adjuster, increasing the fuel supply to the burner while increasing the temperature of the combustion gases which are guided to the expansion turbine.

The invention is in the field of engine building technology and may be used in space technology or aviation. Liquid-propellant rockets with Laval nozzles are well known, and they have the following insufficiencies: (1) high fuel consumption rates, which lead to increased dimensions and engine weight and boosters; (2) a relatively low combustion efficiency, because the low mass of the combustion products are emitted into the environment; (3) the large length of the de Laval nozzles with increased expansion ratios increase the dimensions and the engine weight; (4) use of high temperature rocket propellants—combustion products—in the camera and de Laval nozzle. These insufficiencies suppress using liquid-propellant rockets in space technology. The goal of the invention is decreasing the influence of these insufficiencies and obtaining an engine with improved efficiency. The goal is achieved with the creation of an engine with the subsonic discharge of combustion products and the creation of a simple nozzle construction.

The modular platform for offshore constructions, composed of more than two separate buoyancy elements partially immersed in water, which move along with the water wave movement and which, in the part above the water level, are connected to the structural elements forming a rigid horizontal spatial structure, characterized in that the buoyancy element (1) is given the shape of a cuboid or cylinder having at least one vertical hollow (2) to accommodate the structural element, i.e. piston (3), which forms the axis along which the buoyancy element (1) moves, and which is connected to the horizontal structural element (4) fitted to take external loads.

A submersible pumping system has an electric motor, a rotary hydraulic pump driven by the electric motor, and a linear hydraulic pump that is configured to move a production fluid. The rotary hydraulic pump produces a pressurized working fluid that drives the linear hydraulic pump. In another aspect, a method is disclosed for controlling the temperature of an electric motor within a submersible pumping system disposed in a wellbore. The method includes the steps of circulating motor lubricant through a hydraulically driven production pump to reduce the temperature of the motor lubricant.

A hydraulic system for a work machine includes a first control valve including a first direction switch to switch a direction in which the operation fluid is to flow through a first hydraulic actuator and a pressure compensator to maintain a differential pressure to a constant pressure, the differential pressure being a difference between a pressure of the operation fluid to be inputted to the pressure compensator and a pressure of the operation fluid to be outputted from the pressure compensator. And, the hydraulic system includes a second control valve including a second direction switch to switch a direction in which the operation fluid is to flow through a second hydraulic actuator and a flow rate prioritizer to prioritize a flow rate of the operation fluid to be outputted to the second hydraulic actuator.