A method of producing a trailing arm of a torsion beam axle in which an integrated drive unit of a wheel-adjacent electric drive has an electric machine and a transmission. By using the method, the trailing arm is produced in the form of a casting with a box profile. The contours for producing the area that accommodates the transmission, the connection point to the vehicle body, the bore that receives the cross-member which connects the two trailing arms to one another, the U-profile of the trailing arm, the box profile and the area that accommodates the electric machine, are modeled by cores such that the contours for producing the connection point of the trailing arm to the vehicle body, the bore that receives the cross-member and the U-profile of the trailing arm are modeled by one core.

Various embodiments provide systems and methods for casting amorphous alloys. Exemplary casting system may include an insertable and rotatable vessel configured in a non-movable induction heating structure for melting amorphous alloys to form molten materials in the vessel. While the molten materials remain heated, the vessel may be rotated to pour the molten materials into a casting device for casting them into articles.

An inline bitumen froth steam heater system including steam injection and static mixing devices is provided. The system heats and de-aerates input bitumen froth without creating downstream processing problems with the bitumen froth such as emulsification or live steam entrainment. The system is a multistage unit that injects and thoroughly mixes steam with bitumen resulting in output bitumen material having temperature of about 190° F. The system conditions a superheated steam supply to obtain saturated steam at about 300° F. The saturated steam is contacted with bitumen froth flow and mixed in a static mixer stage. The static mixers provide surface area and rotating action that allows the injected steam to condense and transfer its heat to the bitumen froth. The mixing action and increase in temperature of the bitumen froth results in reduction in bitumen viscosity and allows the release of entrapped air from the bitumen froth.

A device for processing a hydrocarbon resource may include a hydrocarbon processing container configured to receive the hydrocarbon resource therein and having a pair of opposing ends with an enlarged width medial portion therebetween. The device may also a spirally wound electrical conductor surrounding the hydrocarbon processing container, and a radio frequency (RF) circuit coupled to the spirally wound electrical conductor and configured to supply RF power to the hydrocarbon resource while tracking a load resonance of the RF circuit. The RF circuit may be configured to generate magnetic fields within the hydrocarbon processing container parallel with an axis thereof.

The invention relates to a process for the purification of crude and apparatus for its implementation. This process comprises a separation into gas and degassed emulsion and separation of the degassed emulsion into water and oil. The invention also relates to a process of separating a hydrocarbon emulsion and apparatus for implementing this. This process comprises washing of the emulsion at an oil/water interface.

Embodiments of extraction unit and an analysis method are provided. In one embodiment, the analysis method includes the steps of providing a feed stream and a species-selective solvent to the distillation column, drawing a vapor sample from the distillation column, condensing the vapor sample, and analyzing at least a portion of the condensed vapor sample.

A device for processing a hydrocarbon resource may include a hydrocarbon processing container configured to receive the hydrocarbon resource therein and having a pair of opposing ends with an enlarged width medial portion therebetween. The device may also include a radio frequency (RF) source, and a first spirally wound electrical conductor surrounding the hydrocarbon processing container and coupled to the RF source. The device may further include a second spirally wound electrical conductor carried within the hydrocarbon processing container. The first spirally wound electrical conductor may be configured to generate magnetic fields with the hydrocarbon processing container that are parallel with an axis thereof.

A device for processing a hydrocarbon resource may include a hydrocarbon processing container configured to receive the hydrocarbon resource therein and having a pair of opposing ends with an enlarged width medial portion therebetween. The device may also include a radio frequency (RF) source, and a spirally wound electrical conductor surrounding the hydrocarbon processing container and coupled to the RF source. The spirally wound electrical conductor may be configured to generate magnetic fields within the hydrocarbon processing container that are parallel with an axis thereof.

Two-stage hydroprocessing uses a common dividing wall fractionator. Hydroprocessed effluents from both stages of hydroprocessing are fed to opposite sides of the dividing wall.

The present invention provides a method and an apparatus for recovery of spent lubricating oil. The evaporation of hydrocarbon fractions from spent lubricating oil is carried out in three steps. The first step is at approximately 150-1030 mbar and between 70-240° C. in which is greater than 99% water, greater than 99% of ethylene glycol and greater than 50% of hydrocarbon molecules with normal boiling point up to 310° C. are evaporated from spent oil. The second step is operated at 6-30 mbar and 200-2900 C in which predominantly gasoil and light vacuum gasoil fractions are evaporated. The third step is operated at 250-320° C. and 0.5-15 mbar in which mainly heavy vacuum gasoil (boiling range of 425 to 570° C. on ASTM D-1160 test) is evaporated from spent oil.

A dial of a circular hosiery knitting machine of the type with a cylinder and dial with yarn cutting device. The dial comprises a dial body which is substantially disk-shaped. The dial is provided with a cutting device, which comprises a plurality of cutting sectors which are distributed around the axis of the dial body and have cutting edges. The cutting sectors are arranged at sectors of the dial body which are intended to be free from needles. The cutting device comprises a cutter which is adapted to abut against the cutting edges of the cutting sectors to cut at least one yarn engaged by one of the cutting sectors in its rotary motion about the axis of the dial body with respect to the cutter.

A compression bandage with a tubular, flexible flat material for surrounding a bodily member and with a number of elastic compression threads, whereby this flat material constitutes a main body that can be stretched in the circumferential direction. A number of elastic compression threads run in the plane of the flat material in the direction of the circumference, and create the compressive effect when the compression bandage is applied. At least parts of at least some of the compression threads protrude outside the flat material, allowing the compressive effect to be adjusted by varying the length of each of the protruding external portions.

Provided is a glove which has good adhesiveness to a rubber or resin coating material and excellent durability and further fits a hand well enabling good work efficiency. The glove is knitted from a covered yarn obtained by winding a sheath yarn around a core yarn and at least a part of the surface thereof is coated with a rubber or resin coating material, wherein the sheath yarn is a crimped yarn made of a high strength fiber having, as a property of a raw yarn, a tensile strength of 1.75 N/tex or more as measured according to JIS L 1013 8.5, and the crimped yarn simultaneously satisfies the following (1) to (3): (1) a degree of bulkiness of 40 cm3/g or more as measured according to JIS L 1013 8.16 A method after hot water treatment at 90° C. for 20 minutes, (2) a bulk compression modulus of 80% or more as measured according to the same method, and (3) a shrinkage/elongation ratio of 20% or more as measured according to JIS L 1013 8.11 A method.

A rotary sinker enabling stitch formation by a knitting machine using a rotor for forming a stitch, a knitting machine including the rotary sinker, and a stitch forming method are provided. The ring sinkers as rotating bodies are capable of rotating about a rotation axis independently of each other. The rotation times of the ring sinkers are set to be different from each other. Thus, the rotation times are adjusted to be different between the ring sinker that holds an old loop and the ring sinker that holds a new loop. Adjustment of the rotation times prevents application of a large tension to the knitting yarn made of low stretch fiber, and a stitch can be formed even with a knitting yarn made of non-stretch or low-stretch fiber.

A reversible garment with a warming side and a cooling side is comprised of a double knit fabric including a first face and a second face. The garment is reversible such that either face may be worn on the exterior of the garment. When the first side of the garment is worn against the body, the garment provides a heating effect by trapping air and body heat while wicking moisture to the outside of the fabric. When the second side of the garment is worn against the body, the garment provides a cooling garment by accelerating moisture movement across the fabric. Indicia are provided on the garment to indicate whether heating or cooling effects will be provided in the first-side-out configuration and the second-side-out configuration.

A double-cylinder circular machine, particularly for knitting hosiery items, with simplified actuation mechanism, comprising a supporting structure which comprises a footing, which supports a lower needle cylinder, and a column which extends substantially vertically, protrudes upwardly from the footing and supports an upper needle cylinder, which is arranged above and coaxially with respect to the lower needle cylinder, and further comprising elements for the actuation of the lower needle cylinder and of the upper needle cylinder with a rotary motion about a common axis, the actuation elements comprising an electric motor which is connected kinematically to the lower needle cylinder and to the upper needle cylinder and is accommodated inside the column.

A knitting head of a knitting machine for manufacturing flexible hoses (1) with a knitted reinforcement layer, which comprises a guide body (14) with a central tubular conduit (15) for the passage of the bearing layer (2) and having a outlet end portion (16) with a first outer peripheral surface (17) having a first predetermined radius (r1), a plurality of knitting needles (18) arranged along the periphery of said end portion (16) of said conduit (15) and having first longitudinal end sections (18') arranged along the circumference of said outer peripheral surface (17) and second longitudinal end sections (18″) arranged over a second cylindrical surface (19) having a second radius (r2) greater than said first radius (r1), at least one disk-shaped cam element (22), which is adapted to rotate at a first rotation speed and has a third predetermined radius (r3). The third radius (r3) is greater than said second radius (r2), connection means (23) being provided for connecting said disk-shaped element (22) to said second end sections (18″) of said needles (18), said connection means (23) having at least one longitudinal portion (24) with a radial dimension decreasing from said third radius (r3) to said second radius (r2).

A knit fabric having a modified knit structure, having a front layer of knit fabric and a back layer of knit fabric, wherein the front layer and back layer are joined together by rows of tuck stitches formed from a yarn having no more than 3% elongation and wherein the knit fabric is puncture resistant, and optionally cut and/or abrasion resistant, and a protective garment made therefrom.

An apparatus for closing a toe end of a tubular hosiery body includes a stitching device having a main body, a fixed reed, a movable reed pivoted to the fixed reed, and a main drive assembly for driving the movable reed to rotate relative to the fixed reed between juxtaposed and stacked positions. A rotary control unit includes a support frame supporting the main body, a rotary disc attached to the main body, a plurality of detent members disposed around the rotary disc, and a plurality of control drive members respectively driving the detent members. The control drive members consecutively operate to consecutively actuate the respective detent members such that the rotary disc together with the stitching device consecutively produces a limited amount of rotation in an intermittent manner.

Sinker cam segments in a circular knitting machine are located with respect to the generally radial direction by a generally radially inwardly facing location surface disposed radially outward of the segments. Each segment's radially outer end defines a contact region that abuts the locating surface. The contact region can be complementary surface contour to that of the locating surface, or a pair of discrete, spaced contact points protruding out from the radially outer end of the segment. The contact region is a reference for positioning the sinker cam segment with respect to the generally radial direction.

A knit sock includes a foot portion having an upper instep area and a lower sole area integrally knit of a body yarn in circumferential courses and axial wales. The lower sole area defines inner and outer arch regions. The inner arch region incorporates a targeted compression zone adapted to reside generally adjacent an inner arch of a wearer's foot. The compression zone includes axially extending compression ridges of variable length spaced apart from a top of the compression zone to a bottom of the compression zone. When the sock is worn, a compression force applied by the foot portion within the targeted compression zone is greater than the compression force in directly adjacent areas of said foot portion.

A cut resistant sweater is provided including a chest portion, sleeves, collar, and closure extending from the top edge of the collar through at least part of the chest portion. The closure includes an opening extending from the top of the collar through at least part of the chest portion, and a strip having a first part of a hook and loop fastener thereon. A second part of the hook and loop fastener is disposed on the sweater in at least two pieces, a piece adjacent to a first side of the opening and a piece adjacent to a second side of the opening. The closure is stiff relative to the collar to support the collar. A method for manufacturing the sweater includes providing a cut resistant yarn, and knitting it into a sweater in the order of cuff of first sleeve, first sleeve, body and collar, second sleeve, and cuff of the second sleeve.

An article of footwear including a full monofilament upper is described. The full monofilament upper incorporates a knitted component including a monofilament knit element. The monofilament knit element is formed by knitting with a monofilament strand. The monofilament knit element is formed of unitary knit construction with the remaining portions of the knitted component, including peripheral portions that are knit using a natural or synthetic twisted fiber yarn. An inlaid tensile element can extend through the knitted component, including portions of the monofilament knit element. The monofilament knit element may be knitted with a monofilament strand according to a variety of knit structures. A fusible strand may be knit with the monofilament knit element. Upon heating, the fusible strand can combine and surround the monofilament strand within the monofilament knit element.

In the case of a single circular knitting machine consisting of a central rotatable needle cylinder (Z), around which a sinker ring (PR) comprising sinkers (P) as well as stationary cam systems (S) are arranged, which act on the needles (1), which are in each case assigned to the sinkers (P) and which can be moved vertically up and down, so as to replace the pitches, which hit one another rigidly, with a sinker grid system, which is flexible per se, which is automatically oriented in the needle gaps, a rocker (44) comprising an upper and a lower control bump (45) being provided in each case on the end of the sinkers (P), which is spaced apart from the needle, the sinker ring (PR), at the end below the sinkers (P), which is spaced apart from the needle, is embodied as a pivot point projection (40) comprising pivot point slits (41), in which the sinkers (P) are accommodated with their pivot inlet (43) so that they are capable of being tilted and the sinkers (P) being are laterally fixed in the needle gaps with sliding noses (47) at the end, which is spaced apart from the needle, transport the last knitting loops to the needle shaft (1) behind the needle latches in response to the knitting loop formation.

The present disclosure is directed to a flexible filament that includes a length of material configured to be used in forming at least a portion of a textile product to have at least a portion of a visual pattern that is visible on at least one of a first side or a second side of the textile product. The material includes a plurality of stitch indicators formed on the material to separate the material into a plurality of segmented regions, at least one of the stitch indicators or the segmented regions forming at least the portion of the visual pattern visible on the at least one of the first side or the second side of the textile product.

There is described herein a knitting technique for creating a garment having one or more 3D textile electrodes integrated therein. The knitting technique involves knitting the item with integrated electrodes and transmission channels in one single step. The electrode is knit using conducting thread while a base fabric is knit using non-conducting thread. The electrode is knit on a first needle bed and the base fabric is knit on a second needle bed opposite to and facing the first needle bed, the two needle beds being separated by a few millimeters. During the knitting process, the surface knit on the first needle bed and the surface knit on the second needle bed may be linked using an isolating thread network that is simply deposited, without forming a mesh, on the fabric, in order to provide the three-dimensional effect.

A two stage scrubber process for ethanol fermentation has a first stage using fusel oil to remove the hazardous air pollutants and recover the majority of the ethanol. A second stage uses water as the scrubbing solvent to recover any residual ethanol that is stripped from the first stage.

The invention relates to a method for determining the residual time until a cooking process of a foodstuff (12) has been finished. At first a set temperature value for a core (14) of the foodstuff (12) is defined. Next the actual temperatures in the core (14) of the foodstuff (12) at predetermined times are measured and the time dependence of the measured temperature in the core (14) of the foodstuff (12) is determined. At last the time dependence of the measured temperature is compared with the set temperature value and “the residual time of the cooking process is estimated. The invention relates further to a corresponding apparatus for determining the residual time until a cooking process of a foodstuff (12) has been finished.

A method of converting a conventional atmospheric frying device to a vacuum frying device is provided. The method includes positioning a hood on top of a conventional frying device to provide an enclosure for drawing a vacuum within the modified devices. In addition, the method can include strengthening the existing vat so that it is capable of withstanding the forces associated with vacuum frying.

The present invention provides a device and method for simulating cooking stuffing in a bird, such as a turkey. Stuffing prepared with the device and method of the invention has both the appearance and taste of cooked-in-the-bird stuffing. In addition, the device and method of the invention allows the user to prepare simulated cooked-in-the-bird stuffing at any time, in any quantity and in less time compared to the several hours usually needed to cook stuffing in a bird. The invention, therefore, provides all the benefits of cooked-in-the-bird stuffing without the safety concerns of bacterial contamination when cooked in a bird.

A device (1) for extracting an ingredient in a cartridge (9) by supplying an extraction liquid such as heated water into such cartridge, includes upstream and downstream cartridge enclosing parts (7,8) relatively movable between an open position for inserting and/or removing such cartridge and a closed position for forming an extraction chamber (11) enclosing such cartridge during extraction; and a cartridge handling arrangement including a cartridge holder (10), in particular a holder fixed to or integral with the upstream part or the downstream part, for receiving and holding such cartridge against gravity when inserted and descending under gravity between the enclosing parts in the open position prior to forming the extraction chamber (11). The handling arrangement further includes at least one cartridge positioning element (39), in particular a pair of positioning elements, that horizontally guides such cartridge (9) upon reception by the holder (10) in a cartridge extraction alignment (3,3') between the upstream and downstream parts (7,8), optionally the positioning element (s) (39) being fixed to or integral with the downstream part (8) and/or having an arched portion (39') for contacting such cartridge.

A coffee machine comprises a frothing device, wherein an internal milk channel leading to a frothing chamber is provided into which opens a bypass air inlet for operable air supply to the frothing device. A flexible milk suction line connects the frothing device with a milk supply container. Means are provided for cleaning the frothing device and the milk suction line with rinsing water from a continuous-flow water heater of the coffee machine. A controlled valve arrangement is provided which feeds rinsing water from the continuous-flow water heater to the bypass air inlet of the frothing device. A milk suction end of the milk suction line is directly or indirectly, fluid-conductively connectable with a residual water pan of the coffee machine prior to feeding rinsing water to the bypass air inlet.

A beverage machine for preparing and dispensing a hot beverage having a pump dispensing system. Hot water passes through a water distributor to infuse material in a filter basket. A coffee tank receives the brewed beverage and maintains it at an appropriate temperature. On demand, a pump dispensing system delivers the beverage through an outlet chamber and spout into a user's cup. The user manipulates a switch to vary the rate at which the pump dispensing system dispenses the beverage.

A system and method for displaying the actual position of one or more food items on a conveyorized oven system on a display monitor. Digital images of each food item are captured, stored and processed into positional imaging data using data transmitted from sensors adjacent to the conveyorized oven system. Characteristic data for each food item may be associated with the positional imaging data. The characteristic and positional imaging data of the food items may be stored or communicated to a display monitor for the user to view.

The disclosure provides methods and compositions for suppressing retroviruses, including novel methods for treating a retroviral infection in a human in need of such treatment, comprising delivering a functional meiosis arrest female protein 1 (MARF1) to cells containing a retroviral provirus, together with novel expression constructs comprising a coding sequence encoding a functional MARF1 operatively linked to a promoter, vectors comprising such constructs, and packaging cell lines for use in making such vectors.

Specific binding members that bind the ED-A isoform of fibronectin for use in methods of diagnosis, detection, imaging and/or treatment of endometriosis, and/or for use in delivery to the neovasculature of endometriotic tissue of a molecule conjugated to the specific binding member. Specific binding members that bind tenascin-C, especially the A1, A2, A3, A4 and/or D domain tenascin-C large isoform, for use in methods of diagnosis, detection, imaging and/or treatment of endometriosis, psoriatic arthritis or psoriasis, and/or for use in delivery to the neovasculature of endometriotic, psoriatic arthritic or psoriatic tissue of a molecule conjugated to the specific binding member.

The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders.

The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing B-Klotho, and or FGF21-like mediated signaling. In embodiments, the antigen binding proteins specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.

Cysteine engineered antibodies useful for the site-specific conjugation to a variety of agents are provided. Methods for the design, preparation, screening, selection and use of such antibodies are also provided.

The invention provides compositions and methods for treating leukemia, for example, acute myeloid leukemia (AML) and B-cell acute lymphoid leukemia (B-ALL). The invention also relates to at least one chimeric antigen receptor (CAR) specific to CD123, vectors comprising the same, and recombinant T cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD123 binding domain. The invention also includes methods of bone marrow ablation for use in treatments necessitating bone marrow reconditioning or transplant.

Described herein are doppel-targeting molecules useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.

The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), such as where the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an Ig light chain (or functional fragment thereof).

Provided herein are methods of treatment to regenerate, restore or rejuvenate a tissue. Methods include making adult somatic and germ cells pluripotent for administration to a patient. Alternatively, created pluripotent cells may be differentiated to the desired tissue type and administered to a patient to repair or enhance the target tissue.

A recombinant vector comprises simian adenovirus 36, simian adenovirus 42.1, simian adenovirus 42.2 and/or simian adenovirus 44 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-36, -42.1, -42.2 or -44 gene(s) is also described. Methods of using the vectors and cell lines are provided.

Materials and methods for treating and preventing American Foulbrood disease in honeybees, such as materials and methods for using phage lysin enzymes to lyse Paenibacillus larvae, are provided herein.

The present invention relates to the use of the miRNA expression profile, particularly of miR-199a-5p, and the target genes regulated thereby for the diagnosis, prognosis and use of miR-199a-5p inhibitors for treating fibroproliferative disorders.

In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobic ally modified oligonucleotide cargo, and uses thereof, are also provided.

Provided herein are compositions and methods for modifying a predetermined nucleic acid sequence. A programmable nucleoprotein molecular complex containing a polypeptide moiety and a specificity conferring nucleic acid (SCNA) which assembles in-vivo, in a target cell, and is capable of interacting with the predetermined target nucleic acid sequence is provided. The programmable nucleoprotein molecular complex is capable of specifically modifying and/or editing a target site within the target nucleic acid sequence and/or modifying the function of the target nucleic acid sequence.

The invention provides diagnostic and therapeutic targets for pulmonary disease, in particular, fibrotic lung disease. The inventors have found that a genetic variant MUC5B gene is associated with increased expression of the gene, increased risk of developing a pulmonary disease, and an improved prognosis and survival among those developing the pulmonary disease.

By a genome-wide gene analysis of expression profiles of known or putative gene sequences in peripheral blood and biopsy samples, the present inventors have identified a consensus set of gene expression-based molecular biomarkers for distinguishing liver transplantation patients who have Acute Rejection (AR), Hepatitis C Virus Recurrence (HCV-R), both AR/HCV-R, or Acute Dysfunction No Rejection (ADNR). These molecular biomarkers are useful for diagnosis, prognosis and monitoring of liver transplantation patients.