Provided herein are methods for the prognosis of prostate cancer progression in a patient by analyzing the gene expression in a tumor sample obtained from the patient the prognosis of prostate cancer progression in a patient by analyzing the gene expression in a tumor sample obtained from the patient. In particular, gene expression levels of GCOM1, MEX3D, TRPM4, ATPAF1, PTRF, GLYATL1, FLNA, OBSCN, STRA13, WHSCl, ARFGAP3, KDM2A, FAM83H, CLDN7, CNOT6, and B3GNT9 are measured. Kits containing means for the measurement of gene expression as described herein and methods for treatment of prostate cancer are also provided.

The present invention concerns cancer biomarkers. In particular, the invention concerns HGF as a biomarker for patient selection and patient prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.

This disclosure relates to methods, computer products, computer-implemented methods, and systems for predicting the probability or risk of prostate cancer recurrence and tumor aggressiveness in a patient. The method is based, in part, on the patient's risk profile that includes the presence/degree of specific copy number variations and predictive clinical factors. The methods and systems can be used to aid in treatment selection.

The invention provides for a proteomic approach for identification of specific bacterial protein profiles that may be used in the development of methods for the diagnosis of bacterial chronic sinusitis. The invention provides for methods for determining the presence of pathogenic bacteria in the upper respiratory tract of a subject using protein profiles of the pathogenic bacteria. The invention also provides for methods of diagnosing a bacterial infection of the upper respiratory tract of a subject using protein profiles of a pathogenic bacteria. In addition, the invention provides for devices, immunoassays and kits for identifying pathogenic bacteria in the upper respiratory tract.

The present invention provides methods for assessing whether a subject is at risk of developing a neurological disorder, diagnosing or confirming whether a subject is afflicted with a neurological disorder, assessing whether PD has progressed in a subject afflicted with PD, assessing whether a neurological disorder is developing in a subject who has been identified as being at risk of developing the neurological disorder, assessing whether a subject afflicted with a neurological disorder is likely to benefit from a therapy, assessing whether a subject afflicted with a neurological disorder has benefited from a therapy, treating a subject afflicted with a neurological disorder, and prophylactically treating a subject who has been identified as being at risk of developing a neurological disorder. The present invention also provides epitopes, compounds and compositions relating to these methods.

A cold rolling mill is described wherein the unstressed shape of metal sheet is continuously sensed during rolling by a plurality of negligible displacement force sensors perpendicularly disposed relative to the pass line at a mill location producing a tensile stress above 4,000 p.s.i. in the metal sheet being rolled. The output signals from those sensors underlying opposite edges of the metal sheet are compared to equalize reduction at the sheet edges while the difference between the force measured by a centrally situated sensor and the average force measured by the sensors underlying opposite edges of the sheet provide a signal indicative of the roll bending force required to produce flat sheet.

A device is disclosed for pressing objects by lifting the objects into a waiting pressing shaft. The shaft includes a forming element at its lower end for forming the object, and the shaft is engaged by its upper end through a pivot member to an air cylinder in a manner which provides a force advantage to the air cylinder. Also, a system for pressing objects is disclosed, in which the press device is employed in conjunction with a turntable for sequential and continuous pressing operations.

A machine for automatically joining front and back parts of buttons employs a turntable with nests that are rotated through a series of stations at which the parts are placed in the nests in a desired orientation, joined, and checked for defects. Orientation of the parts is achieved by video imaging of a first part as it is randomly placed in a nest, and computer-controlled placement of the second part based on the ascertained position of the first part.

A method and apparatus for substantially automatically joining front and back parts of buttons employs a turntable with retaining means that are rotated through a series of stations at which the parts are placed in the retaining means in a desired orientation, joined, and checked for defects. A human operator places button front parts at a first station, and the remaining stations carry out the assembly and quality control steps automatically. Placement at the first station determines the alignment and orientation of the two buttons.

A button making device capable of simply exchanging a first pressed mold, a second pressed mold, and a pressing mold so as to produce buttons of different sizes; a polygonal button whose front surface plate is dome-wise curved and has its shape fixed; and such a button making device, are provided. The button making device has a sliding platform, two pressed molds, a fixed member, a pressing shaft, a pressing mold, and an operation mechanism. The pressed molds are provided on an attachment member which is removably attached to the sliding platform. The pressing mold is removably attached to a lower end of the pressing shaft using magnetic force. The present invention can be used for a button making device which can easily form a metal button by press processing which can be used as an accessory adhered to clothes or the like by a pin or the like.

Rebaudioside M compositions with improved aqueous solubility and methods for preparing the same are provided herein. The rebaudioside M compositions include (i) disordered crystalline compositions comprising rebaudioside M and rebaudioside D, (ii) spray-dried compositions comprising rebaudioside M, rebaudioside D and steviol glycoside mixtures and/or rebaudioside B and/or NSF-02, (iii) spray-dried compositions comprising rebaudioside M, rebaudioside D and at least one surfactant, polymer, saponin, carbohydrate, polyol, preservative or a combination thereof. Sweetened compositions, such a beverages, containing the rebaudioside M compositions with improved water solubility are also provided herein.

Gender specific synthetic nutritional compositions for female or male infants up to 1 month of age wherein, the concentration of alanine, and/or histidine, and/or isoleucine, and/or proline, and/or valine is adapted based on that found in HM produced for an infant of the same gender and age, and nutritional systems comprising them.

The present invention is directed to novel organoleptic compounds, a process of augmenting, enhancing or imparting taste to a material selected from the group consisting of a foodstuff, a chewing gum, a dental product, an oral hygiene product and a medicinal product comprising the step of incorporating an olfactory acceptable amount of such novel organoleptic compounds, and a process of improving, enhancing or modifying a fragrance composition through the addition of an olfactory acceptable amount of such novel organoleptic compounds.

A measurement apparatus and method for in-situ quantitative texture measurement of a food snack. The apparatus includes an acoustic capturing device and a data processing unit. The physical interaction in the mouth with saliva, when a human being eats/drinks a food snack, sends pressure waves that propagate through the ear bone and produce an acoustic signal. The acoustic capturing device records and forwards the signal to a data processing unit. The data processing unit further comprises a digital signal processing module that smoothens, transforms and filters the received acoustic signal. A statistical processing module further filters the acoustic signal from the data processing unit and generates a quantitative acoustic model for texture attributes such as hardness and fracturability. The quantitative model is correlated with a qualitative texture measurement from a descriptive expert panel. Another method includes a food snack fingerprinting using an in-situ quantitative food property measurement.

The invention concerns a sweetened dairy product comprising a dairy material, at least one steviol glycoside, at least one additive selected from a polysaccharide of fructose units and a salt.

This disclosure describes a simple, low cost method to produce a modular dry mix that can easily be modified and customized to produce a wide range of easy to aerate, no ice cream machine needed, ice cream and frozen dairy and non-dairy desserts and products made by this process. The method relies on successive simultaneous particle size reduction and blending steps without the use of traditional mix drying operations. The formulations produced by this process are modular and allow quick and simple ingredient substitutions to create distinct finished products. The process yields mixes that produce stronger, more stable foams that don't leave an oily mouth feel. The disclosure also includes a formulation and process used to make ice cream, and related frozen dairy and non-dairy desserts at room temperature in one step where the ingredients do not need to be aged, or homogenized, and aeration occurs without the need for simultaneous cooling or freezing. The process allows the end-user to control and vary the texture, freezing rate, melting point and eating qualities of the product without the use of traditional, home or industrial ice cream machines and a product made by this process. A product produced from this mix consists of a (protein-concentrate and emulsifier)—stabilized, protein-based foam created by combining a powder mix with one or a combination of a large range of above freezing temp liquids then immediately whisking the mixture at room temp to a target overrun without pre-aging, and then freezing that product statically till desired hardness is achieved. The main execution of this process involves the use of dry powders that are transported and sold dry and then reconstituted by the end user before they are combined without pre-treatment, freezing homogenization or aging. The manufacturing process offers significant advantages over current dry mix production methods which require significant upfront investment and produce hard to customize mixes. The formulation and finished product making portions of the invention offer significant improvement over existing manufacturing methods for frozen desserts and dessert mixes that require simultaneous freezing and aeration in terms of cost, convenience, customizability, shelf-stability and environmental impact.

Cat food products are provided. The cat food product may comprise a single sealed container comprising 10 g to 40 g of a complete and balanced semi-moist or wet cat food, or may comprise a plurality of such sealed containers. Methods of providing a cat food are also provided and comprise filling a container with from 10 g to 40 g of a complete and balanced semi-moist or wet cat food and sealing the container.

The present invention relates to protein compositions. In particular, the invention relates to a method for the production of a composition comprising casein fibrils. Further aspects of the invention area composition comprising casein fibrils, the use of such a composition and a food product comprising the composition.

A storage-stable, flavour composition, wherein said composition comprises a plurality of particles dispersed in a non-aqueous dispersing medium, said particles consisting of a first particle population of encapsulated flavour oil, and a second particle population of micronized acidulant particles.

Gender specific synthetic nutritional compositions for infants up to 1 month of age wherein, the total protein content is adapted based on that found in HM produced for infants of the same gender and age, and nutritional systems comprising them.

Disclosed herein is a nutrient delivery system that provides a nutritional formula for consumption. The nutrient delivery system includes a pod and a nutritional powder comprising at least one phospholipid. The nutritional formula has improved characteristics, such as decreased foaming.

The present invention is directed to a Modular Liquid Infusing, Flavoring and Dispensing Device that provides a means to infuse flavor into liquids for variable periods of time prior to dispensing, and after the brewing process, wherein the system provides a means to control the rate at which the liquid is dispensed, reduces the trauma to the dispensed liquid, and reduces the amount of foaming in the dispensed liquid. The present invention further provides a method for using the Modular Liquid Infusing, Flavoring, and Dispensing Device.

The present invention relates to an emulsified flavor composition for an alcoholic beverage that does not generate a floating matter or a sediment, that maintains a stable emulsified state, that imparts transparent appearance to the alcoholic beverage and that does not impair the taste/flavor of the alcoholic beverage, even when mixed with a concentrated syrup that has an alcohol concentration several times higher than that of the alcoholic beverage during the steps for producing the alcoholic beverage. The emulsified flavor composition for alcoholic beverages of the present invention comprises: (a) an oil-soluble component containing a flavor; (b) a polyglycerol fatty acid ester whose 1% by weight aqueous solution has transmittance of 65% or higher at 600 nm; and (c) lecithin.

The present invention is directed to recombinant thraustochytrids that grow on sucrose and cell cultures comprising the recombinant thraustochytrids as well as methods of producing cell cultures, biomasses, microbial oils, compositions, and biofuels using the recombinant thraustochytrids.

A device that automatically actuates the reversing lever of a ratchet mechanism when the radial direction of the motor is changed. The auto-shift mechanism includes a worm gear that rotates with the motor, and a disc coupled to the worm gear that moves laterally as the worm gear rotates. Axial movement of the disc actuates a reversing lever of a ratchet mechanism by either pulling or pushing the reversing lever. A lost-motion mechanism can absorb an initial amount of torque so that the auto-shift mechanism can run its course prior to applying the torque to a fastener.

A socket wrench with a positioning device contains: a body including an accommodating cavity, a first face, and a second face. A toothed holder is accommodated in the accommodating cavity and has a polygonal groove, a first circular portion, a second circular portion, and a ratchet protrusion between the first circular portion and the second circular portion. The first circular portion is inserted to the first face, the second circular portion is inserted to the second face, and the ratchet protrusion engages with a ratchet device. A positioning device includes at least one retaining element disposed on the first circular portion and horizontally moving in the polygonal groove. The first circular portion has a resilient element and a pressing loop which are fitted on the first circular, and the pressing loop has a recess defined on an inner face thereof to correspond to the at least one retaining element.

A dual-pawl ratchet wrench mechanism is disclosed having a stop mechanism for limiting over-travel of a reversing lever for selecting drive directions. The stop mechanism is formed on a disc is selectively engageable with first and second pawls to move the pawls into and out of engagement with a ratchet gear to determine a torque drive direction, the ratchet gear capable of providing torque to a working piece in the selected drive direction. The design simplifies manufacturing. Additionally, the reversing lever is assembled with the mechanism in a manner to improve sealing.

An apparatus includes a processor and a memory. The memory is configured to store computer-readable instructions that, when executed by the processor, instruct the processor to perform processes including acquiring pattern data, specifying an outline of the embroidery pattern based on the pattern data, creating hole data for causing the sewing machine to form a plurality of holes including one or more first holes and one or more second holes, creating first stitch data for causing the sewing machine to sew one or more stitches for the one or more first holes, and creating embroidery data for causing the sewing machine to form one or more first holes, and sew the one or more stitches for the one or more first holes, and causing the sewing machine to form the one or more second holes, before causing the sewing machine to sew an outline pattern.

A composite material includes a composite body having a composite surface, and a reinforcing element extending through the composite body in a first plurality of stitches and a second plurality of stitches. The first plurality of stitches are aligned relative to the composite surface substantially similarly to each other. The second plurality of stitches are aligned relative to the composite surface substantially dissimilarly to each other.

A girdle band for underwear connection and a processing method thereof, the girder band has a baseband with upper and lower overturning edges, a plurality of snap rings, surface cloth and a shaping layer, and the processing method has the following steps: firstly respectively connecting both surfaces of the lower overturning edge of the baseband with the shaping layer and the first strip of the surface cloth; sewing the bottom surface of the second strip of the surface cloth with the shaping layer; forming the upper and the lower overturning edges; and using an ultrasonic wave cutting machine for cutting the long strip-shaped baseband into girdle band units. The girdle band has the advantages of no sewing joints on the back surface and good appearance effect, and can avoid skin injuries.

Thread tensioner for a sewing machine. In one example embodiment, a thread tensioner for a sewing machine includes a first disk, a second disk, a spring, a knob, and a sensor. The second disk is positioned next to the first disk. The spring is configured to apply tension to a thread positioned between the first disk and the second disk by exerting a force against the second disk. The spring defines a length between a first end and a second end. The knob is configured, when rotated in one direction, to travel along a threaded shaft toward the spring and thereby cause the length of the spring to shorten. The knob is configured, when rotated in another direction, to travel along the threaded shaft away from the spring and thereby allow the length of the spring to lengthen. The sensor is configured to track a current length of the spring.

A device includes a processor and a memory. The memory is configured to store a plurality of group information pieces, the number of thread colors to be used in embroidery sewing and computer-readable instructions. Each of the group information pieces is associated with one more thread colors among a plurality of thread colors. The computer-readable instructions cause the processor, when executed, to perform processes that includes acquiring image data including pixels, replacing a color of each of the pixels with a thread color from the thread colors, calculating a frequency of using each of the thread colors, selecting, until the number of thread colors selected from the thread colors is equal the number of thread colors to be used stored in the memory, one thread color from each of the group information pieces sequentially, based on the group information pieces stored in the memory and on the calculated frequency.

A tension release device for compensating mechanical error of a tension device for a sewing machine includes a rotary arm, a tension release shaft, a guiding member, an actuating member, and a micro-adjustment member, the rotary arm is located at one end of the tension release shaft which is inserted through the base, the tension release shaft is coupled to the guiding member, the guiding member is provided with an arc-shaped guiding flange which includes a first end and a second end higher than the first end. On the actuating member is provided a push portion which protrudes toward and is pushed by the guiding flange of the guiding member, a micro-adjustment hole is formed at one end of the actuating member or at the one end of the control shaft, and the micro-adjustment member is screwed in the micro-adjustment hole and extends toward the tension release shaft.

An embroidery data processor includes a color information acquiring unit configured to acquire color information of a workpiece cloth on which an embroidery pattern composed of a plurality of color-based pattern portions is sewn, a color storage unit configured to store data of defined colors, an assignment unit configured to randomly extract colors from the colors stored by the color storage unit for every color-based pattern portion, the extracted colors being used as thread color data specifying colors of the color-based pattern portions respectively, the assignment unit assigning the extracted colors to the respective color-based pattern portions, and a setting unit configured to set a predetermined extraction range containing a similar color or a contrast color based on the color information acquired by the acquiring unit. The assignment unit is configured to extract the color stored by the color storage unit in the set extraction range.

A punching device including a punching die (5a) that can be connected to the needle bar and a punching matrix (5b) that can be fastened to a needle plate (7) of a sewing machine. The punching matrix (5b) is embodied as a lid of a clippings container (9). The planar object (23) to be processed is displaced via the tambour frame in a punching plane L2, with this punching plane L2 being arranged parallel above the sewing plane L1.

A non-transitory computer-readable medium storing computer-readable instructions that, when executed by a processor of a device, cause the device to acquire pieces of thread color data, acquire image data representing an image, arrange line segments based on the image data, calculate a ratio of a first area occupied by a specific object with respect to the image, identify one or more pieces of first thread color data based on the ratio, identify one or more pieces of second thread color data based on the image data, allocate, to one or more of first line segments corresponding to the first area, first specific thread color data among the first thread color data, allocate, to one or more of second line segments corresponding to the second area, second specific thread color data among the first thread color data and the second thread color data, connect the line segments, and create embroidery data.

A method for fabricating a repair laminate for a composite part having an exposed surface includes applying a bonding material to the exposed surface and forming an uncured ply stack assembly on the bonding material. The uncured ply stack assembly is formed by forming and compacting a series of uncured ply stacks. The ply stack assembly and bonding material are then cured.

A temporary adhesive for reversibly bonding a silicon wafer to a silicon support contains a crosslinkable organopolysiloxanes composition and a fatty acid or salt thereof or fatty acid ester as a release regulator having a density different from the crosslinkable organopolysiloxanes composition of at least 0.1 g/cm3, which upon parting of the wafer from the substrate, the adhesive remains substantially adhered to the substrate.

An adhesive sheet having high adhesion and removability, low metal corrosion, small outgas generation, and particularly suitable for adherence to an electronic part, which sheet includes an adhesive layer provided for at least one surface of a substrate sheet, in which a pressure-sensitive adhesive forming the adhesive layer includes a resin composition mainly formed of an acrylic copolymer obtained by blending a carboxyl group-free acrylic copolymer obtained by copolymerizing the following components (A) to (C) with (D) an isocyanate-based cross-linking agent: (A) 76.999 to 94.999% by mass of an alkyl(meth)acrylate; (B) 5.0 to 23.0% by mass of an ethylenically unsaturated group-containing morpholine-based compound; and (C) 0.001 to 1.5% by mass of a functional group-containing unsaturated monomer; and a ratio M2/M1 of the mole number (M2) of isocyanate groups in the component (D) to the mole number (M1) of functional groups in the component (C) is 1.5 to 15.0.

A thin film forming apparatus and a thin film forming method using the same are disclosed. In one aspect, the thin film forming apparatus comprises a mask that includes a blocking portion and an opening. It also includes an etching source that jets an etching gas through the opening of the mask to etch a thin film according to a pattern. The mask includes a gas blower for blowing a gas around the opening so that the etching gas does not penetrate into a thin film area corresponding to the block portion. When the thin film forming apparatus is used, a normal residual area of a thin film may be safely preserved and patterning may be accurately performed. Thus, the quality of a product manufactured by using the thin film forming apparatus may be improved.

A method of dispensing adhesive onto a stretched elastic strand includes applying a first volume of adhesive onto a first portion of the elastic strand, applying a second volume of adhesive onto a second portion of the elastic strand, and applying a third volume of adhesive onto a third portion of the elastic strand. The second volume is less than the first and third volumes. When the elastic strand is adhered to a substrate to form a personal disposable hygiene product, the first and third portions of the elastic strand define opposing ends of the elastic strand, which are adhered with a larger amount of adhesive to resist creep at the opposing ends. The reduction of adhesive in the second or central portion between the opposing ends significantly reduces the adhesive add on in the personal disposable hygiene product.

The object of the invention is to provide a plasma processing apparatus having enhanced plasma processing uniformity. The plasma processing apparatus comprises a processing chamber 1, means 13 and 14 for supplying processing gas into the processing chamber, evacuation means 25 and 26 for decompressing the processing chamber 1, an electrode 4 on which an object 2 to be processed such as a wafer is placed, and an electromagnetic radiation power supply 5A, wherein at least two kinds of processing gases having different composition ratios of O2 or N2 are introduced into the processing chamber through different gas inlets so as to control the in-plane uniformity of the critical dimension while maintaining the in-plane uniformity of the process depth.

Positioning system of sectors of a device for producing an airplane fuselage in which a lamination mandrel comprises a plurality of sectors borne by a supporting structure and mobile along guides between: an expanded lamination position and a contracted disassembling position. Each guide comprises a fixed part borne by the supporting structure and a mobile part sliding along/with respect to the fixed part in a rectilinear direction H. Between a portion of each mobile part facing towards the respective sector and a stiffening structure of the sector a positioning device is provided which allows adjustment of the position of the sector with respect to the guide in two directions which lie in a plane RP perpendicular to the axis H of the guide.

A system for fluid partitioning for chemical amplification or other chemical processing or separations of a sample, comprising a first dispenser of a first polymeric sheet, wherein the first polymeric sheet contains chambers; a second dispenser of a second polymeric sheet wherein the first dispenser and the second dispenser are positioned so that the first polymeric sheet and the second polymeric sheet become parallel; a dispenser of the fluid positioned to dispense the fluid between the first polymeric sheet and the second polymeric sheet; and a seal unit that seals the first polymeric sheet and the second polymeric sheet together thereby sealing the sample between the first polymeric sheet and the second polymeric sheet and partitioning the fluid for chemical amplification or other chemical processing or separations.

The present invention provides a method for bonding two substrates using a UV radiation curing-redox curing adhesive system having a shadow area and a transparent area, comprising: bonding the shadow area of the substrates using a redox curing adhesive system, and bonding the transparent area of the substrates using a liquid optically clear adhesive containing UV initiators.

The invention relates to a method for connecting a first tube to a second tube, the tubes being interconnected in an overlapping region by means of an adhesive that fills a gap in the overlapping region between the tubes. Said method is characterized in that: a) adhesive is applied to the overlapping region of at least one of the tubes and the adhesive is selected in such a way that it is solid at temperatures of below 30° C. after application to the overlapping region and prior to the connection of the tubes, and cannot be cured without thermal activation; b) the tube having the adhesive in the overlapping region is pushed onto or inside the other tube; c) the tubes are fixed in relation to one another in the overlapping region by a heatable clamp, said clamp being designed in such a way that it can heat the tubes in said region; d) the adhesive is thermally activated by heating the overlapping region with the aid of the heatable clamp, whereby the adhesive cures and connects the two tubes in the overlapping region; and e) the heatable clamp is removed once the adhesive has cured. The invention also relates to a method for producing a refrigerator and to a refrigerator comprising correspondingly joined tube sections.

A composite strip and a method of manufacturing a pre-cured composite strip. A pre-cured composite strip having a thermoset resin may be placed on a surface of a portion of a composite component where a caul plate seam may be expected. Caul plates may be placed on the composite component after placing the pre-cured composite strip to form the caul plate seam. The composite component may be cured after placing the caul plates on the composite component.

A pressure-sensitive adhesive optical film of the invention comprises an optical film and a pressure-sensitive adhesive layer provided on the optical film, wherein the pressure-sensitive adhesive layer has a thickness (μm) standard deviation of 0.12 μm or less. The pressure-sensitive adhesive optical film makes it possible to reduce the problem of visible unevenness caused by a pressure-sensitive adhesive layer.

The invention relates to the use of a hot-melt adhesive having high hardness for adhesive bonding of metal films or foils, paper films or foils, and/or plastic films or foils. The invention further relates to a method for adhesively bonding a metal film or foil, paper film or foil, and/or plastic film or foil onto a substrate.